... determinations andclinical laboratory tests OP-S participated in the clinical study of patientsand contributed to drafting the manuscript DP-P contributed to immunological determinations andclinical ... the same sample were stained with annexin V labeled with FITC and propidium iodide and analyzed in a FACSCalibur flow cytometer In addition, annexin V staining was combined with mAbs specific for ... Rituximab therapy induced improvements in different clinical parameters of most SLE patients included in this study Disease activity (MEX-SLEDAI index) significantly diminished in 90% of patients...
... RLAT initiation from 250 patientswith schizophrenia The mean number of days spent in the hospital per patient increased from 31 in year -3 to 44 in year -2, to 90 in year -1, and to 141 in year ... WM was involved in the interpretation of data, and critical drafting and revising of the manuscript for important intellectual content All authors (CC, CD, CMK, RDD, LM, and WM) read and approved ... days In a retrospective study at four sites in Germany using a mirror-image design [19], hospitalization rates and duration of inpatient treatment were assessed inpatientswith schizophrenia and...
... one documented RLAT injection recorded in the injection log and were included in the exposure and discontinuation analysis RLAT status could not be determined for the remaining patients Table presents ... is lifelong and requires family, social, and therapeutic interventions, including antipsychotic therapy, to stabilize and support patientsIn the SOURCE study, initiation and continuation of ... summarized using frequencies and percentages Continuous measures were summarized with mean, standard deviation, minimum, maximum, and median Clinical effectiveness data were analyzed in patients...
... endoscopy in outpatients with iron deficiency anemia The aim of our study was to investigate the incidence of GI pathological findings in symptomatic and asymptomatic patientswith IDA and to identify ... the diagnostic yield of endoscopy inpatientswith IDA and to define predictive factors of gastrointestinal (GI) lesions causing IDA and identify clinicaland biochemical variables that predict ... (1.5) Helicobacter, Inflammatory intestinal disease A list of the upper and lower GI pathological conditions associated with IDA is included in Table The patients were interviewed and responded to...
... I clinical study with only six patients completing all three cycles of vaccine and cytokine administration, this precludes any conclusion regarding the clinical efficacy Further complicating interpretations ... survival for patientsin a randomized study failing first line trastuzumab therapy was 25.5 months for patients receiving continuous trastuzumab combined with capecitabine [54] In another randomized ... clinical responses and/ or improved time to relapse when administered in the adjuvant setting in women with Her2-expressing breast cancer as a single agent or in combination with chemotherapy [3-7]...
... rh-HGF administration (day 14) and the observation period (day 28) to evaluate renal involvement, including serum creatinine and histological findings A phase I/II clinical trial for patientswith ... decrease in BP during rh-HGF infusion and renal toxicity induced by repeated rh-HGF dosing, including an increase in urinary excretion of albumin, were potential adverse events in a human study In ... and urinary excretion of albumin and protein was measured before (day 1), during (days and 14), andand 14 days after HGF administration Repeated doses of rh-HGF induced an increase in urinary...
... study examines perceptions of sleep in an international clinical trial aimed at evaluating the efficacy and safety of the pregabalin, a treatment for pain relief inpatientswith painful DPN ... interpretation of findings and reviewed the manuscript Acknowledgements We would like to thank all patientsandclinical investigators who participated in this clinical trial We also thank Christine de la ... 12 years) in Poland to 63 (STD = 10 years) in Australia Patientsin Poland, South Africa and the United Kingdom were slightly younger than in Australia, Germany and Hungary Mean sleep interference...
... angina, where a model mapping clinical measures on to the EQ-5D index explained 37% of the variability in the EQ-5D index and also performed poorly in individuals with EQ-5D index values of about ... to derive mapping models for the EQ-5D index in cardiac patientswith different levels of disease severity by incorporating into these models multiple demographic factors andclinical cardiac ... studies used in our previous study [14] A main dataset was created using data measured at multiple time points on patients participating in randomised clinical trials [5,6,8,16], and cohort study...
... or a DSM-IV diagnosis of substance abuse within months before screening (not including nicotine and caffeine addiction) Additional inclusion and exclusion criteria are presented in the previous ... results The combined open-label, intent-to-treat sample included 1,077 patients from the 1,665 patients who enrolled in the double-blind randomized portion of the clinical trials The intent to treat ... in the inpatient setting, they may help to identify which patients are ready for discharge As experience is gained using symptom and functioning instruments, their use in remission criteria and...
... evaluate the incidence of synchronous appendiceal neoplasm inpatientswith resectable CRC in a university hospital, and to determine the clinical significance of these findings Methods Pathological ... demonstrate the clinical significance of these findings The study was approved by the Institutional Ethics Committee Results Two hundred and ninety-three patients were included in this study The patients ... Cystadenocarcinoma of the appendix: an incidental imaging finding in a patient with adenocarcinomas of the ascending and the sigmoid colon BMC Gastroenterol 2003, 3:30 Lyda MH, Noffsinger A, Belli...
... statistically between the clinical parameters (sex, age, smoking and diabetes history, induction chemotherapy, concurrent chemotherapy regimens and PS) of patientswithand without SARP Several reports ... radiochemotherapy with vinorelbine plus cisplatin or carboplatin inpatientswith locally advanced non-small-cell lung cancer (NSCLC) and an increased risk of treatment complications: Preliminary ... cancer in 2005, and we evaluated clinicaland dosimetric factors associated with severe acute radiation pneumonitis (SARP) in 94 patientswith a diagnosis of locally advanced NSCLC treated with...
... functioning may prove useful as a clinical tool for monitoring progress during treatment and/ or as an outcome measure inclinical trials for MDD This study seeks to validate a new clinical rating ... In addition, further studies are required to investigate the performance of the LEAPS in non -clinical samples of workers andin other clinical populations in specialist and primary care settings ... functioning and productivity inpatientswith MDD Methods Scale Development The Lam Employment Absence and Productivity Scale (LEAPS) was designed to assess work functioning and impairment in a clinically...
... Since occurrence of BMPR2 mutations obviously influences the clinical phenotype genetic testing may become of increasing clinical relevance Patientswith BMPR2 mutation tend to a more severe clinical ... distinct mutation types withclinical presentation Austin et al [17] showed that PAH patients carrying a truncating mutation in the BMPR2 gene developed a more severe disease than patients without ... gene (promoter and coding regions including flanking intronic regions) and the coding regions of the ACVRL1, ENDOGLIN, and the SMAD8 genes did not reveal any defect Especially, no point mutations...
... flow with epinephrine and norepinephrine + dobutamine, as compared with norepinephrine alone NA Epinephrine, norepinephrine in random order to achieve MAP 70–80 mmHg [46] 11 11 Epinephrine 0.3 ... the combination of norepinephrine and dobutamine inpatientswith septic shock on gastric mucosal flow, as assessed using a laser Doppler technique Epinephrine and dobutamine–nor- epinephrine led ... norepinephrine + dobutamine 0.9 ± 0.4 and LD epinephrine ↑ mucosal blood flow NA [45] Epinephrine 0.48 ± 0.33 versus norepinephrine + dobutamine 0.37 ± 0.2 and 13.6 ± HSBF ↓ with epinephrine pHi...
... detect minimal changes in protein levels [15] Three large independent sample sets with adequate clinicaland outcome information were used for training and testing Bioinformaticians were closely involved ... protein synthesis machinery including phosphorylated S6 ribosomal protein and 4EBP1, a group with overexpression of stromal markers including collagen VI, CD31 and caveolin1, and a group defined ... anthracycline and taxane-based therapy Further, in three independent sets, the 10-protein signature had a higher predictive value than clinical variables including tumor size, nodal status and grade in...
... 2007), including both baseline and outcome data “Needs-based MRI” group Up until June 2006, patients at the clinic received an MRI purely on the basis of clinical indications as determined during ... obtained from the standard baseline questionnaire which was included in the patient file: sex, age, severity of low back pain (11point Numeric Rating Scale), leg pain (11-point Numeric Rating ... been introduced into our specialised, outpatient public clinic All patientswith LBP referred to the clinic, who fulfil certain inclusion criteria, have since June 2006 received an up-front routine...
... this in a clinical context in which fluid infusion is unavoidable (that is, inpatientswith septic shock andinpatients immediately after cardiac surgery) Instead of selecting patientswith ... decreased in none of the fluid challenges resulting in increased SV, andin 44% of those in which SV did not increase (P = 0.0003) EDV increased in 28% of fluid challenges resulting in increased SV and ... pulse-pressure variation in cardiac surgery patientsSolid line, all fluid challenges; dotted line, fluid challenges with concomitant increase in central venous pressure; thin solid line, line of identity...
... vitamins A (retinol), D (cholecalciferol) and E (α-tocopherol) inpatientswith CAD MATERIALS AND METHODS The study population included 30 patients having angiographically demonstrated CAD and ... vitamins (retinol, tocopherol and cholecalciferol), and trace elements and heavy metals (Zn, Cu, Fe, Cd, Pb and Mn) inpatientswith CAD and the control group are shown in Table Compared with the ... increase in urine Cu levels inpatients suffering from myocardial infarction (MI) (15) Reunanen et al (1996) found increased levels of serum Cu inpatientswith CAD (14) In contrast, in our study,...
... CABG In the 11 patientswith vessel disease a stenosis > 50% was found in the circumflex artery inpatientsandin the right coronary artery inpatients Complete revascularization in the patients ... Int J Med Sci 2011, ability by the deformation indices two-dimensional strain (2DS) and strain rate (SR), might be an alternative approach inclinical routine Tissue Doppler Imaging (TDI) and ... 24-29 In principle, our findings are confirming previously published studies about infarct detection and size, who described significant differences of the radial and circumferential strain and...