circadian regulation of neural excitability in temporal lobe epilepsy
Báo cáo y học: "Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development" potx
... zeaxanthin Lutein lutein Violaxanthin violaxanthin ABA Figure Circadian co -regulation of metabolic pathways Circadian co -regulation of metabolic pathways (a) Metabolic pathways for the production of ... genes is giving us insight into new aspects of plants physiology influenced by the clock Of special interest is the extensive circadian regulation of all of the hormone and many of the environmental ... detrending, resulting in an increased number of genes identified as circadian [6] To compare the extent of circadian regulation of genes expressed in both datasets, we reanalyzed the Covington...
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Asymmetric cell division in the regulation of neural stem cell self renewel in drosophila melanogaster
... through direct protein-protein interaction Par-6 is a small protein that contains a PDZ domain, a PB1 domain and an atypical CRIB domain Par6 binds aPKC through the PB1 domain, and binds Rho GTPase ... members of the basal targeting machinery (Mira and PON) or in cell fate determination (Numb, Pros and Brat) impair terminal differentiation of GMCs 24 Introduction Figure Models of the origin of Drosophila ... self-renewal, loss of Pins function causes a reduction in neuroblast numbers in the larval brain due to occurrence of GMC/GMC siblings and in turn premature termination of neuroblast lineages (Lee...
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Patterns of hippocampal neuronal loss and axon reorganisation of the dentate gyrus in the mouse pilocarpine model of temporal lobe epilepsy
... viii List of Abbreviations ABC, avidin– biotin complex CB, calbindin CBP, calcium-binding protein CBPs, calcium-binding protein immunopositive neurons CR, calretinin CTB, cholera toxin subunit ... intracellular calcium-binding proteins, containing EF-hand calcium binding motifs, and related to calmodulin and troponin-C The biological roles of Calbindin D28k include calcium regulation and calcium-dependent ... connections of the dentate gyrus may be involved in epileptogenesis in temporal lobe epilepsy The aims of the present study in the mouse pilocarpine model of TLE included: 1) systemic investigation of...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... presence of multiple iPLA2c protein products in mitochondria resulting from usage of different translation initiation codons in rat myocardium Alternative splicing of iPLA2c in mammalian tissues In ... CdxA binding sites Oligonucleotide g177 shares homology with the Oct1 binding site, whereas oligonucleotide g230 did not contain a predicted site for binding of nuclear proteins Utilizing radiolabeled...
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Báo cáo khoa học: Improvement of a monopartite ecdysone receptor gene switch and demonstration of its utility in regulation of transgene expression in plants pdf
... a DNAbinding domain (DBD) and a ligand-binding domain (LBD) The chimeric gene (transactivation domain– DBD–LBD) is expressed under the control of a constitutive promoter In the presence of a specific ... construction of a versatile system for the expression of foreign genes in plants Gene 61, 1–11 Tavva VS, Collins GB & Dinkins RD (2006) Targeted overexpression of the Escherichia coli MinC protein in higher ... flexible ligand binding pocket of ecdysone receptor: a single amino acid change leads to discrimination between two groups of nonsteroidal ecdysone agonists J Biol Chem 279, 27211–27218 Dinkins RD, Pflipsen...
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Báo cáo khoa học: Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells doc
... reported in this work, the decrease in the Vmax of respiration with an increase in the free calcium concentration (Fig 6A) is of interest, and may be explained by an inhibitory effect of increased ... Reversibility of the effects of calcium-induced contraction of cardiomyocytes on the kinetics of regulation of mitochondrial respiration by exogenous ADP The kinetics of respiratory regulation was ... creatine kinase reactions, including mitochondrial creatine kinase [3840] Increase of the free calcium concentration to lm resulted in some decrease of the Vmax, but its value stayed higher in...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... the increased rate of 13C label incorporation into the C6 position of glycogen in the ADM group is indicative of activated 6-phosphofructo-1-kinase, which can lead to increased 13C labeling at ... start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence of transient changes in the ... up -regulation of glucokinase and a down -regulation of glucose-6-phosphatase gene expression, suggesting that this biofactor may also be involved in balancing the uptake and release of glucose from...
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Báo cáo sinh học: "Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets" doc
... biology, in view of proteomic experiments demonstrating that a single miRNA can directly repress the production of hundreds of proteins in mammalian cells, through both downregulation of mRNA ... Switzerland 2Department of Immunology, Page of National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan Laboratory of Experimental Hematology, Bordet Institute, University of Brussels (ULB) ... (group A) is in agreement with previous cloning studies in mouse CD8+ lymphocytes [15,18] showing that a few highly expressed microRNAs prevailed in frequency Interestingly, these microRNAs include...
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báo cáo hóa học:" Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets" pptx
... biology, in view of proteomic experiments demonstrating that a single miRNA can directly repress the production of hundreds of proteins in mammalian cells, through both downregulation of mRNA ... Switzerland 2Department of Immunology, Page of National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan Laboratory of Experimental Hematology, Bordet Institute, University of Brussels (ULB) ... (group A) is in agreement with previous cloning studies in mouse CD8+ lymphocytes [15,18] showing that a few highly expressed microRNAs prevailed in frequency Interestingly, these microRNAs include...
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Báo cáo sinh học: "Multilevel regulation of growth rate in yeast revealed using systems biology" pptx
... decrease in levels of glutamate Instead, there was a corresponding trend in the increase in the transcript and protein levels of the mitochondrial 2-oxoglutarate transporters, and an increase in protein ... gain insights into the importance of mitochondrial energy and nitrogen metabolism in affecting growth rates These insights were possible only by integrating information from transcripts, protein ... abrupt changes in the levels of some yeast transcripts, with increases in expression of key genes involved in glucose transport and vesicle transport and repression of those involved in ethanol metabolism...
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Transcriptional regulation of protein complexes in yeast potx
... complexes in yeast: mining large scale protein-protein interaction screens Bioinformatics 2003, 19:1901-1908 Manke T, Bringas R, Vingron M: Correlating protein-DNA and protein-protein interaction ... Prediction of cis-acting regulatory elements in genes of multiprotein complexes comment Figure (see previous page) Detailed2view of the main clusters in the network linking annotated protein complexes ... 'core' of the binding site, and the number in brackets is the length of the spacer in terms of the number of intervening nucleotides The feature map shows that each upstream sequence contains at...
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Báo cáo y học: "Patterns of neural differentiation in melanomas" docx
... growth inhibition by transforming growth factor-β J Invest Dermatol 2000, 114:1200-1204 Luna LG: Routine staining procedure Manual of histologic staining methods of the Armed Forces Institute of ... average of 1.9 bv/HPF in the tumor At the margins a maximum of 19 bv/HPF and a minimum of bv/HPF are observed In the areas of main tumor growth a maximum of bv/HPF and a minimum of bv/HPF are observed ... synaptophysin contain considerable amounts of the biogenic amines [51,52] Earlier studies have identified the presence of biogenic amines in melanocytes These include catechol amines as well as indole...
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Báo cáo y học: "Clock mutation affects circadian regulation of circulating blood cells" pot
... transcriptional regulation of several circadian output genes as well as in the core circadian clock [11,12] To determine whether intact CLOCK protein is required for the circadian changes in peripheral ... nature of this regulation has prevented elucidation of the underlying mechanisms of circadian changes in circulating blood cells [2] The present study found that a homozygous mutation of the circadian ... the circadian fluctuation of circulating WBC and RBC in mice This finding suggests that Page of (page number not for citation purposes) Journal of Circadian Rhythms 2006, 4:13 http://www.jcircadianrhythms.com/content/4/1/13...
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báo cáo khoa học: "Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thaliana" pdf
... successfully applied for data mining The main strength of GeneTrail was that it offered answers to individual biological questions with its feature of incorporation of individually defined categories (such ... strength of microarray interpretation lies in the possibility of extracting information beyond the single gene level to address questions on the co -regulation of genes, on the identification of gene ... category was found induced in comparisons of - Fe vs + Fe (in wild type and in nas4x1) and in nas4x-1 vs wild type at + Fe, indicating that biotic stress responses were generally induced by Fe deficiency...
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Báo cáo y học: " Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium" doc
... proteincontaining supernatant was collected The protein concentrations were assessed using a bicinchoninic acid (BCA) protein concentration kit (Pierce, Rockford, IL) Equal concentration of protein ... subtracted using MetaMorph image analysis software (Universal Imaging, Downingtown, PA) MUC5AC Staining For MUC5AC staining in large airway and small airway epithelium, brush cells cytospin slides ... Ly6/neurotoxin (Lynx1), the founding member of a family of mammalian prototoxins, modulates nicotinic acetylcholine receptors in vitro by altering agonist sensitivity and desensitization kinetics...
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Báo cáo y học: " Differential regulation of neurotrophin expression in human bronchial smooth muscle cells" pptx
... h of culture (not shown) Effects of IL-1β on neurotrophin mRNA and protein expression We next investigated the ability of the proinflammatory cytokine IL-1β to induce neurotrophin expression in ... involvement of COX in the induction of BDNF but not of NGF To test this, we evaluated the effects of the COXinhibitors indomethacin and NS-398 (both 10 µM) on the secretion of these two neurotrophins ... mediators in BDNF induction Our finding that secretion of BDNF, but not NGF, was inhibited by the unselective COX inhibitor indomethacin and the COX-2 inhibitor NS-398 imply the prostaglandins as...
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Báo cáo y học: "Detection, characterization and regulation of antisense transcripts in HIV-1" ppt
... for min., equilibrated at 50°C for and incubated in the presence of the reaction mix containing 1× RT buffer, µl of 2.5 mM dNTPs, 10 U of SuperAsin RNAse inhibitor (Ambion) and µl RT For certain ... mechanisms including binding to DNA-bound transcription factors [26] Although current model on the action of Tat through TAR binding on sense transcription favours an increase in the processivity of ... presence of the 24-6F primer in the PCR reaction was again controlled for in lanes 1–2 and 5– 6, which showed no clear signal indicative of this primer contamination in the PCR reaction The body of...
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Báo cáo y học: " Effects of body position on autonomic regulation of cardiovascular function in young, healthy adults" pot
... across supine and right- and left-side lying postures [7]; supine and right-side lying postures [8]; supine and sitting postures [9]; supine and standing postures [10-12]; and supine, standing, and ... to the brain We found that HR increased and HRV parameters indicated a shift to sympathetic dominance during the sitting posture In contrast, BP was higher in the prone than in the sitting posture ... significantly greater in the prone position Comparing prone and sitting postures, HRV parameters indicated sympathetic dominance during sitting (supporting work of others), and BP was higher during the prone...
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Báo cáo y học: "Social regulation of gene expression in human leukocytes" pps
... (IFI27), interferon-induced protein 6-16 (G1P3), and interferon-inducible proteins 15 and 44 (G1P2, IFI44) Also down-regulated were genes encoding immunoglobulin light, joining, and heavy region chains ... protein To verify the portrait of increased inflammatory signaling that emerged from functional genomic analyses, we assayed circulating levels of C-reactive protein (CRP) in blood samples obtained ... combinations of promoter length and motif match Bioinformatic indications of a simulatneous decrease in transcription of GR target genes (.53-fold difference) and an increase in transcription of...
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Báo cáo y học: "RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals" docx
... candidates from coding and non-coding subgroups of NAT, which could potentially modulate sense mRNA through two distinct modes of action One of the most exciting findings in genome biology in recent years ... mRNA and shift the balance in favor of the other variant [17,18] Editing is another proposed function of NAT through transformation of the adenosine to inosine nucleotide in pre-mRNA The antisense ... of approximately 21 to 22 nucleotides, termed small interfering RNA (siRNA) The siRNA molecules then interact with a multi-protein complex, termed RNAinduced silencing complex (RISC), resulting...
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