... were incubated with increasing concentrations of the TOP1 inhibitor, camptothecin, inthe presence andinthe absence of 10)5 m MTX The cytotoxic effect of camptothecin alone was enhanced bythe ... (IUPUI, Indianapolis, IN, USA), or the TOP1 inhibitor camptothecin (Sigma, Madrid, Spain), inthe presence or absence of MTX IMPDH activity inhibitors were added simultaneously to MTX Camptothecin, ... cytotoxicity by themselves, according tothe role of FEBS Journal 272 (2005) 696–710 ª 2005 FEBS IMPDH activity in DNA synthesis, which was increased when combining them with MTX Therefore, by...
... underlined H and D residues inthe first motif andthe last H of the second motif are zinc binding ligands Moreover, it has been proposed for other members of the family that the underlined H andthe ... water and acetate atoms were removed Hydrogen atoms were added tothe crystal structure, andthe substrates and atomic partial charges were assigned tothe protein and carbohydrate atoms Atomic interaction ... revealed the presence of three protein bands The position of the main band is in agreement with the predicted molecular mass of the hexahistidine fusion protein (27 kDa) The N-terminal amino acid...
... the language Writing this paper I try to: - Point out the theoretical background including the traditional concepts andthe modern point of view concerning the English –ing participle, the finite ... “shopping”, etc.These words can be formed from any verb by adding -ing and inserting “of” before the noun phrase: The painting of Brown The explaining of the teacher The girl's beautiful dancing ... oneself to accustom(oneself) to resort to face upto sink toin addition to be used to look forward to get used to object to be reduced to For examples: - I am looking forward to meeting her...
... KAVANAGH and A MCELWAIN, 2005 “Origins, Destinations and Catchments: Mapping Travel to Work in Ireland in 2002” Paper presented tothe Statistical and Social Inquiry Society of Ireland, October ... likely tochoose all options in favour of owning a car and travelling by motorised means to work This reflects the importance of public transport provision in influencing modal choice In other ... kilometre variable using information on public transport fares and car operating costs (including fuel) We assume zero costs for the walking and cycling modes (in common with others inthe literature...
... partners and approach to small holding pig farms in Thua Thien Hue and Quang Nam 2.2 Training for interviewers Before starting of the survey, project partner coordinator has instructed to interviewers ... side and feed intake, daily gain, and protein and fat accretion on the other side This indicates that selection for increased survival will definitely influence finishing traits, but also that intense ... administered inthe present invention are not specifically defined For instance, the composition may contain from 10 to 15% by weight of crude proteins and from to 5% by weight of crude fats The...
... but what if the committee doesn't accept it? (Đề nghị chuẩn bị sẵn sàng ủy ban không chấp nhận nó?) B: Don't cross your bridges before you come tothem We will see what happens then (Em đừng ... come to it" để ám tôi/ không lo lắng điều thật xảy Ví dụ: A (man): I'll introduce youto my parents tonight (Anh đưa em mắt bố mẹ anh tối nay.) B (the man's girlfriend): Okay , but they might ... like me (Nhưng bố mẹ anh không thích em) · A: Don't worry We'll cross that bridge when we come to it (Đừng lo, em yêu Đến lúc hay) Vậy bạn chuẩn bị sẵn sàng cho việc bạn bình thản chờ đợi, điều...
... were administered Norepinephrine infusion was adjusted to maintain MAP above 65 mmHg In patients inthe norepinephrine group, a MAP above 65 mmHg was achieved by adjusting the norepinephrine dosage ... this finding may indicate that AVP/ norepinephrine does not result in further deterioration in microcirculatory oxygen supply in skin These findings are in striking contrast tothe results of a ... measurements and documentation WRH conceived the study protocol, and helped to interpret the data andto draft the manuscript BF helped to interpret the data andto draft the manuscript HK conceived the...
... not, then not invest If they are, then continue your research Certain questions you want to ask are: • Do you share the same vision and goals of the CEO of the Company? • Do you believe inthe ... are thinking about investing in DO YOUR HOMEWORK • But what if you didn’t your due diligence? What if you decided to go on a whim? • Imagine investing in stock from an unknown company All you ... HOMEWORK! THE RISK • One thing you want to keep in mind is that there is no such thing as a sure thing • Investing in a private company has many risks, especially when you are talking about your life...
... cancer in humans and are found in industrial and occupational settings such as coal mines, mills, granite quarrying and processing, crushed stone and related industries, and sandblasting operations ... cadmium into the air, surface water, ground water, and topsoil where it can be taken upby both land and water plants and, in turn, transferred to animals Contaminated topsoil that allows uptake into ... water and drain pipes, hosing, flooring, windows, and credit cards Human exposure can occur primarily in workers inthe plastic industry, not by using the end products such as vinyl siding or hosing...
... Turning requires banking, and banking accelerates the plane with the nose down If the storm winds are strong enough, they can force you into a dive, causing the plane to stall and go into a spin ... was monitoring the stormscope, saw a break inthe storm tothe northeast We radioed Athens for a change in course, and within about five minutes things began to calm down Then, with no warning, we ... against the current has to know how to manage the tension between, on the one hand, persevering inthe face of opposition, and on the other, encouraging dissent and responding to it Leading against...
... going to lose it, and when you lose it, you never think you re going to get it backThe best thing you can in your ‘self-talk’ is to remind yourself what you ve done inthe past You ve done this ... in many ways You have to believe in yourself, andyou have to believe in your ability to turn things around.” There is more “Most people try to something they can’t They’re trying to play like ... years slowly pulling backthe string of a bow and I finally let it go.” With the Cup in tow, he will venture across town later inthe week to throw out the first pitch in Game Two of the first ever...
... out there? Do you think it’s going to be a mandatory thing, to have a blog, if you re going to have web presence? A No, I don’t think it’s going to be a mandatory thing, but I think it’s going to ... easy to subscribe to a blog Instead of visiting the blogs you follow one by one, you subscribe to them, and postings to that blog appear in your RSS reader, whether online or on your desktop From ... available tothemto that Q Including blogging, but also the other social networking things? A Including blogging Podcasting is another one, social tagging—all of that is just going to evolve...
... magazine modified the “sports” model of some production car to get the fastest possible standing quarter mile You know how they did it? They cut off all the crap the manufacturer had bolted onto the ... OF BUSINESS STRATEGY ENTERPRISE SOFTWARE VENDORS MUST REINFORCE THEIR BRAND INTHE PRODUCT TO STRENGTHEN OFFLINE RELATIONSHIPS Our brand is the only that (category) (benefit) IN A WORLD ... Consulting “as relevant as general health and safety considerations inthe workplace.” out of 10 people recalled the last time they saw a product they just had to have, and it was because of the...
... of the negotiating table and on the other side is a landlord who owns a single prime coffee-bar site By playing them off against each other, the landlord should be able to dictate the terms and ... them “Marginal” land is of central importance The shifts in bargaining power don’t have to stop there While the farming story can be elaborated indefinitely, the basic principles remain the same ... that bythe time you finish this book, you ll be able to see the same things But please buy it first, before the store manager throws you out Your coffee is intriguing tothe economist for another...
... brought backtothe pain, the pain becomes a problem again in full force Types of Pain Pains vary in regard tothe way your nerves transmit them, the quality of discomfort they cause, andthe types ... that is pinching a nerve inthe spine If the nerve pinched is the nerve that goes out to your big toe, you will feel pain in your big toe even though the actual problem is inthe spine, two or ... down theback of the leg, and out into at least one of your toes This is called sciatica Sometimes back pain arising inthe spine’s joints or disks will also cause pain to be experienced in part...
... an existing file. When the database is shiny and new, you must create the column objects, then add themtothe database object. The act of adding themtothe object actually creates the columns inthe database. When you are using an existing database you must pull the field definitions out of ... only to find all previous apps were now incompatible (The machine running my C program which took a whole floppy continued to keep the business it supported running while much screaming and fingerpointing was going on all around it.) ... data tend to be far more reliable from a data integrity standpoint. All indexes are always kept in sync bythe library/engine. xBASE type files store the indexes off in different files. You can add all of the records you want to an xBASE data file without ever updating an index...
... have been floated by academics and politicians to either merge them into one or eventually fix themand sell themtothe private sector Given the depth of the financial crisis, the best immediate ... and Lehman Brothers the big three of the crisis—wanted to create bonds backed by mortgages so they could sell themto institutional investors inthe United States and overseas Institutional investors ... Your Money Now (Hint: Not in a Vacation Home) The Day the Flipping Stopped The Contrarian Play in Vacation Homes Investing in Foreclosures Stocks: Is Now the Time to Get In? Once You Decide to...
... surreal You begin to feel the difference in everything you do, in almost every step you take In a very real sense, the lack of electricity drains the lifeblood out of youYou certainly begin to feel ... trained workers and engineers inthe coming years Ninety thousand! I don’t know where those workers are coming from, and neither does anyone inthe industry They are not yet loitering inthe ... recently, theutility hasn’t been able to monitor the system in a way that allows it to accurately estimate demand Therefore, they have difficulty determining the supply that needs to go into the system...