0

cholinergic regulation of inflammation

Báo cáo y học:

Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps

Báo cáo khoa học

... Willebrand factor staining) Page of 10 (page number not for citation purposes) Figure Autocrine activation of cortisol and the regulation of fibroblast function of fibroblast function Bone marrow, ... endogenous activation of glucocorticoids via the enzyme 11β-HSD1 is another important component of stromal cell function by providing an autocrine mechanism for the localized regulation of inflammation ... suggest that one of these factors, namely the glucocorticoid-metabolizing enzyme 11βHSD1, is likely to play an important role in tissue-specific and inflammation- specific regulation of fibroblast...
  • 10
  • 438
  • 0
Báo cáo y học:

Báo cáo y học: "κ Regulation of NFκB signalling during inflammation: the role of hydroxylases" potx

Báo cáo khoa học

... accumulation of HIF-1α in cultured cells under conditions of hypoxia as well as in the liver and brain of hypoxic animals IKKβ links the hypoxic Hypoxia is a feature of sites of chronic inflammation, ... responses under conditions of inflammation response and innate immunity since a deficiency in IKKβ leads to ineffective induction of HIF-1α target genes, meaning that resolution of inflammation in the ... irritant-based model of colitis Development of specific PHDIs may be of particular use in the treatment of inflammatory disease, where recent studies using the PHDIs DMOG and FG-4497 resulted in profound protection...
  • 8
  • 355
  • 0
Regulation of cytokines by small RNAs during skin inflammation potx

Regulation of cytokines by small RNAs during skin inflammation potx

Báo cáo khoa học

... administration of anti-IL20 antibodies leads to resolution of psoriasis [40] Regulation of the cytokine network at the RNA level The regulation of cytokine production is the very foundation of the innate ... in the regulation of one of them The study demonstrates the involvement of miR-16 in controlling ARE-mediated mRNA decay of some ARE-containing mRNA species and suggests that cooperation of miR-16 ... universal regulator of ARE-directed cytokine regulation Towards the development of small RNA drugs for treatment of inflammatory skin disease Our knowledge of small RNA-directed gene regulation is...
  • 19
  • 142
  • 0
Báo cáo y học:

Báo cáo y học: " Molecular imaging of transcriptional regulation during inflammation" docx

Báo cáo khoa học

... Carlsen Journal of Inflammation 2010, 7:20 http://www.journal -inflammation. com/content/7/1/20 Page of 11 Table 1: Overview of transgenic reporter mice available for studies of inflammation Regulatory ... Carlsen Journal of Inflammation 2010, 7:20 http://www.journal -inflammation. com/content/7/1/20 Page of 11 Table 1: Overview of transgenic reporter mice available for studies of inflammation (Continued) ... a gene Page of 11 of interest and artificial promoters where a set of selected cis-elements are combined Often combinations of the two strategies are used A promoter is composed of a core promoter...
  • 11
  • 465
  • 0
Báo cáo y học:

Báo cáo y học: "Molecular imaging of transcriptional regulation during inflammationƠ" docx

Báo cáo khoa học

... Carlsen Journal of Inflammation 2010, 7:20 http://www.journal -inflammation. com/content/7/1/20 Page of 11 Table 1: Overview of transgenic reporter mice available for studies of inflammation Regulatory ... Carlsen Journal of Inflammation 2010, 7:20 http://www.journal -inflammation. com/content/7/1/20 Page of 11 Table 1: Overview of transgenic reporter mice available for studies of inflammation (Continued) ... a gene Page of 11 of interest and artificial promoters where a set of selected cis-elements are combined Often combinations of the two strategies are used A promoter is composed of a core promoter...
  • 11
  • 257
  • 0
Báo cáo y học:

Báo cáo y học: " Different regulation of cigarette smoke induced inflammation in upper versus lower airways" pot

Báo cáo khoa học

... exposure to mainstream cigarette smoke Page of (Sanofi-Synthelabo), and a tracheal cannula was inserted A total of × 300 μl, followed by × ml of HBSS, free of ionized calcium and magnesium, but supplemented ... non-inflammatory status with a significant downregulation of inflammation, while lower airway inflammation is clearly present and ongoing Neutrophilic inflammation in the nasal turbinate tissue was ... the up -regulation of the orphan nuclear receptor RORgammat (encoded by RORc) for differentiation from naïve T cells [24], account for the production of several members of the IL-17 family of cytokines,...
  • 9
  • 283
  • 0
Báo cáo y học:

Báo cáo y học: "Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle" doc

Báo cáo khoa học

... differentiation of B cells into antibody-produc- ing cells, upregulation of IL-4-dependent IgE production and stimulation of cytotoxic T-cell differentiation, as well as differentiation of immature ... fibroblasts and epithelial cells of the airways IL-11 has a variety of biological properties including the stimulation of tissue inhibitor of metalloproteinase-1, inhibition of macrophage/ monocyte-derived ... effect, possibly via upregulation of IFN-γ receptor expression [25] Treatment of the cells with dexamethasone inhibited expression of RANTES mRNA and inhibited secretion of RANTES protein The...
  • 13
  • 166
  • 0
Báo cáo y học:

Báo cáo y học: "Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation" ppt

Báo cáo khoa học

... not shown) Expression of MARCH1 in monocytes of healthy controls in the presence of hydrocortisone, and in monocytes of AAS patients after surgery Because of the known role of MARCH1 on HLA-DR ... μl of FITC-mouse IgG1 or IgG2b (Sigma-Aldrich, St Louis, MO, USA), 10 μl of PE-mouse IgG2a or IgG2b (Miltenyi Biotec) and/or 10 μl of APCmouse IgM (Miltenyi Biotec) were used After 20 minutes of ... shift as compared to levels at T1 At T1, the percentage of CD14HIGH monocytes was of 6.02 ± 0.45 and 5.99 ± 0.69, and that of CD14LOW was of 0.80 ± 0.06 and 0.78 ± 0.08 for AAS and CAS patients...
  • 12
  • 199
  • 0
Regulation of intestinal inflammation by mitogen activated protein kinase phosphatase 3

Regulation of intestinal inflammation by mitogen activated protein kinase phosphatase 3

Kỹ thuật - Công nghệ

... Pathogenesis of IBD 2! 1.1.2.! Dextran Sulphate Sodium (DSS)-induced Murine Model of Colitis 5! 1.2.! The Role of Immune Response in Intestinal Inflammation 5! 1.3.! The Role of Intestinal ... to investigate the role of MKP-3 in intestinal inflammation The results showed that overexpression of MKP-3 downregulated the phosphorylation of all three major groups of MAPKs (ERK, JNK and p38) ... understanding of the characteristics of IBD, the exact causes of the disease remain elusive There are several multiple causes of IBD which are known to contribute towards the pathogenesis of the disease...
  • 78
  • 204
  • 0
Regulation of S Phase

Regulation of S Phase

Môi trường

... initiation (Fig 1) The chromatin loading of MCM2-7 depends on the loading of Cdt1 and Cdc6, which in turn depend on the loading of ORC This step- Fig Regulation of the pre-RC The pre-RC functions to ... is also co-dependent with Cdc45, Dpb11, and Sld3; binding of any of Regulation of S Phase 47 these proteins depended on the presence of the others (Kubota et al., 2003; Takayama et al., 2003) ... characterization of Xlinked mutants of Drosophila melanogaster which are sensitive to mutagens Genetics 84:485–506 Brown GW, Kelly TJ (1999) Cell cycle regulation of Dfp1, an activator of the Hsk1...
  • 33
  • 472
  • 1
Regulation of navigation and vessel-source pollution in the Northern Sea Route - Article 234 and state practice

Regulation of navigation and vessel-source pollution in the Northern Sea Route - Article 234 and state practice

TOEFL - IELTS - TOEIC

... accompaniment of the CCGS John A 40 41 42 43 See Arts and 10 of the NSR Regulations; Arts 14 and 15 of the Economic Zone Edict; Arts and 15 of the Environmental Edict; and Art 11 of the Decree of the ... the Decree of the Council of Ministers of the USSR, June 1990, ‘On Measures of Securing the Implementation of the Edict of the Presidium of the USSR Supreme Soviet of 26 November 1984 “On Intensifying ... the NSR Regulations, as stated in Article (quoted above), include regulation of navigation, on the basis of non-discrimination These regulations are to apply to all vessels, regardless of nationality,84...
  • 23
  • 555
  • 0
Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx

Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx

Báo cáo khoa học

... repression of their target genes Indeed, several examples of feedback regulation that involve miRNAs have been reported Below, we attempt to summarize our recent understanding of feedback regulation of ... finding that TPAinduced upregulation of miR-34a depends on the activation of the ERK signal cascade and that miR-34a downregulates MEK1, which is one of the main regulators of ERK signaling, indicates ... expression of estrogen receptor-a (ERa) is autoregulated by miR-18a, -19b and -20b, which in turn are upregulated by the activation of ERa This mechanism of regulation provides a wide range of coordinated...
  • 9
  • 684
  • 0
Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc

Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc

Báo cáo khoa học

... direct dephosphorylation of Ser112 and negative regulation of the ERK pathway via p38 MAPK, both of which lead to impaired phosphorylation of Ser112 [70] After dephosphorylation of Ser112, Ser136 becomes ... translocation of Bax and Bad to mitochondria independently of caspase activation [77,87] Phosphorylation of caspases Phosphorylation of caspases switches the cellular apoptotic signal on and off Caspase ... regulating the activity of an isoform of PP1, PP1a [3] Similarly, activation of caspase-8 and -3 is regulated through their phosphorylation and dephosphorylation Phosphorylation of caspase-8 at Tyr397...
  • 15
  • 784
  • 0
Tài liệu Regulation of cancer cell metabolism docx

Tài liệu Regulation of cancer cell metabolism docx

Sức khỏe giới tính

... splicing The inclusion of exon in the PK mrnA leads to translation of the PKM1 isoform, whereas inclusion of exon 10 produces PKM2 (ReF 71) MyC upregulates the expression of heterogeneous nuclear ... required for the assembly of the cytochrome c oxidase complex of the electron transport chain61 Thus, the loss of p53 might also be a major force behind the acquisition of the glycolytic phenotype ... Publishers Limited All rights reserved REVIEWS of genes that increase glucose metabolism and reduce mitochondrial respiration One of these genes encodes an isoform of PDK (PDK4) that has the same function...
  • 11
  • 410
  • 0
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

Báo cáo khoa học

... general context of a promoter appears to be relevant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent transcription Deregulation is ... promoters, mutation of the CHR leads to a more pronounced deregulation than the alteration of the CDE [40] Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein ... investigating downregulation of the cyclin B2 promoter is that after deletion or mutation of constitutively activating sites, such as the destruction of CCAAT-boxes, small levels of reporter activity...
  • 17
  • 876
  • 0
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

Báo cáo khoa học

... genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have ... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... development Analyses of AP-2a-null mice have demonstrated that AP-2a is a fundamental regulator of mammalian craniofacial development AP-2a knockout mice die perinatally with craniofacial defects,...
  • 9
  • 642
  • 0
Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc

Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc

Báo cáo khoa học

... strict regulation becomes necessary for the correct expression of HSF2 target genes Indeed, when miR18-mediated regulation of HSF2 was disrupted in male germ cells in vivo, expression of HSF2 ... modifications of HSFs in different tissues and organs during development of an organism or differentiation of certain cell types This lack of knowledge severely hampers the understanding of the physiological ... HSEs, the Regulation of HSFs HSFs regulate different types of target genes that are involved in a broad range of cellular processes Therefore, the expression and activity of HSFs need to be under...
  • 14
  • 549
  • 0
Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

Báo cáo khoa học

... the regulation of miR-27 expression Our data suggest that the miR-27 gene family is potentially an important class of negative regulators of adipogenesis and may play a role in the regulation of ... relevant role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 expression levels of both miR-27a ... suggesting that downregulation of miR-27 is not sufficient to promote adipogenesis We performed a time course study to gain further insights into the role of miR-27 during different stages of adipogenesis...
  • 11
  • 848
  • 0
Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx

Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx

Báo cáo khoa học

... molecular weights of 161.8, 28.2 and 13.2 kDa, respectively Regulation of cathepsin B activity The formation of the cathepsin B ⁄ cystatin C complex was seen as a shift of the elution peak of cathepsin ... the presence of various concentrations of 2A2 mAb The binding of 2A2 mAb was followed by native gel electrophoresis Increasing the concentration of 2A2 mAb at a fixed molar ratio of cathepsin ... the conformational changes of the active site of cathepsin B, the results obtained in the present study provide a specific mechanism for the regulation of the activity of cathepsin B, which can...
  • 13
  • 417
  • 0
Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

Báo cáo khoa học

... level of MLL1 mRNA Interestingly, upon downregulation of MLL1, E2-mediated upregulation of HOXC13 was slightly decreased (Fig 4A, lane 3) Similar results were observed for MLL2 and MLL4 downregulation ... ERE2, ERE3 and ERE4 of the HOXC13 promoter As seen in Fig 5A, no significant binding of actin was observed in any of the EREs, irrespective of the absence and presence of E2 Binding of ERa and ERb ... amount of binding of MLL1 was observed in ERE3, no significant E2-dependent binding of any of the MLLs was observed in ERE3 and ERE4 (Fig 5A, lanes 5–8) Significant amounts of constitutive binding of...
  • 12
  • 518
  • 0

Xem thêm