chemistry structure and biosynthesis of heparin heparan sulfate
Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... implications of the cycle of histone acetylation and deacetylation that accompanies cycles of transcription, and highlight the special significance of histone H4 lysine 16 acetylation Active chromatin and ... functions of PARP-1 are activated in the presence of NAD+ it mediates the PARylation of both histones and PARP-1 itself, and thereby promotes decondensation of higher order chromatin structure ... with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130] However, in human cells depletion of MOF, but not Tip60, results in reduced global levels of AcH4-K16 and defective...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were generated by PCR and cloned ... series of GST-fused deletions of the CD2-1 region (Fig 3E) and examined the interactions between bacterially expressed proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the ... in dendrites of cultured hippocampal neurons Fig S4 Domain structure of MAP2 and the alignment of v-KIND-binding core (BD) region of MAP2 CD2 domain (702–744 aa) in human, mouse and Gallus This...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
... patterns and processes at different levels of biological organization: from the life histories of individuals, to the structure and dynamics of populations and communities, to the fluxes and pools of ... measuring and understanding the roles of different kinds of organisms in the flux and storage of elements in ecosystems The total biomass per unit area, W, is simply the sum of the body mass of all ... abundances and turnover of populations, the allocation of resources among coexisting species, and the fluxes and pools of energy and materials in ecosystems These exchanges are direct consequences of...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
... representation of the structure of the PSI domain of barley prophytepsin [25] (N-terminal domain, blue; C-terminal domain, red) (C) Model structure of the PSI domain of cardosin A based on the crystal structure ... by the prosegment, but also by the 13 residues of the N-terminal of the mature enzyme and by the ÔflapÕ The anchorage of the prosegment and of part of the N-terminus in the active site cleft is ... isoforms by the excision of the prosegment and of most of the PSI [21] Conversely to what has been found in vivo [31], heavy and light chains of the processed forms of recombinant cyprosin are...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... pharmacological and physiological properties of the channel In situ hybridization and immunohistochemistry data show overlapping distributions for a variety of subunits, and electrophysiological and other ... analysis of the DNA of different Conus species has already revealed a large number of a-conotoxin sequences [45] and the identification of further specific nAChR ligands is likely The advantage of a ... consisting of the extracellular ligand-binding domain of the a6 subunit and the transmembrane and intracellular domains of the a3 subunit was used in this study PIA selectively blocks rat and human...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... the structure and PDB code shown below each panel (A) Overlap of isoform 337 with the structure of the longer isoform CfAFP-501 using the main chain of residues Thr23fiAsn90 in isoform 337 and ... other and with proteins that have a similar fold Structure of sbwAFP and TmAFP The structure of sbwAFP has been determined by X-ray ˚ crystallography to 2.5 A and by NMR at both 30 °C and °C ... method and PDB code shown below each panel (A) Overlap of X-ray structure with °C NMR structure using the main chain of residues Ser12fiThr70 in the structure alignment (B) Overlap of the X-ray structure...
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Tài liệu Báo cáo khoa học: Complete subunit sequences, structure and evolution of the 6 · 6-mer hemocyanin from the common house centipede, Scutigera coleoptrata pptx
... hemocyanin of which the complete molecular structure is known This allows us to compare structure, and intra- and intermolecular evolution of hemocyanins from Myriapoda, Crustacea and Chelicerata ... composed of 12 HcA, 12 HcB, six HcC and six HcD polypeptides Thus the basic building block of the hemocyanin, the hexamer, most likely contains two copies of each HcA and HcB, and single copies of ... assignment of the HcA clone to the major sequence of the upper hemocyanin band in the SDS/PAGE gel (Fig 1) Two nonmatching amino acids at positions (Glu instead of Cys) and (Ala instead of Pro)...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... longer-chain (and nonglobular) versions of the structure of the Bowman±Birk inhibitor in Fig The X-ray crystal structure pi2 reveals that the /,w angles of most of the residues of the Bowman±Birk ... form of b strand [18] The positive bands at » 1675 cm)1 in the amide I region of the ROA spectra of b- and j-casein, which originate mainly in the peptide C O stretch, are characteristic of disordered ... the theme of PPII structure and rheomorphism is explored by a comparative ROA study, supplemented with DSC, of caseins, synucleins and tau, together with several mutants of a-synuclein and tau...
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Tài liệu Báo cáo khoa học: "The Structure and Process of Talking About Doing" pdf
... study of problem solving action and report: I) the collected of data on problem solving and talk about problem solving, 2) development of a process model of these behaviors, and 3) use of coding ... problem solving from a record of the problem solving report and a record of moves made Then, we use this extracted trace to evaluate our model of the role of point of view in problem solving SUMMARY ... organization of the problem ("point of view"), and systematic multl-utterance structures used to express the forms of inference used to solve the problem ("Justificatlon argument structures")...
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Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... and fD are the mass fractions of monomer and dimer, respectively, and RgM and RgD are the radii of gyration for the monomer and dimer, respectively Missing pieces of crystallographic models were ... 1) Radius of gyration, model fitting and analysis For a mixture of monomeric and dimeric scattering species, the radius of gyration is given by: R2 ¼ fM R2 þ fD R2 g gM gD ð7Þ where fM and fD are ... scattering of monomeric arrestin, the forward scattering from a mixture of monomers and dimers is: Ið0ÞTotal ¼ fM Ið0ÞM þ 2fD Ið0ÞM ð1Þ where fM and fD are the mass fractions of monomer and dimer,...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... solution structure of the C-domain (A) Stereo view of the ensemble of the final 48 calculated structures Twenty-four structures of the closed protein conformer are shown in red, and 24 structures of ... of eRF1 Fig S11 The Ramachandran map plot (/ and w torsion angles for the protein backbone) of all 24 conformers of the NMR families of solution structures of the closed and open conformers of ... structure calculation for the open and closed conformers of the C-terminal domain of human eRF1 Fig S3 NOE map of the minidomain (residues 329– 372) of human eRF1 NMR structure and function of...
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Báo cáo khoa học: Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid pdf
... Comparison of the positions of the tip of domain IV in all available EF-G structures in the PDB The structures were superimposed on the basis of domains I and II Looking from the direction of the ... helices AV and BV at the surface of domain V Gly621 and Gly617 are in the area of contact with the 1095 and 2473 regions of 23S RNA The two helices are facing the ribosome, and the four-stranded b-sheet ... thermophilus EF-G structures, wild type and various mutants, domains III, IV and V display a movement relative to domains I and II, resulting in a shift of the ˚ tip of domain IV of up to A [14,16]...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc
... identification and distribution of TLP genes in nature, the structural and functional characterization of the TLP from various organisms, and the evolution of TLP and transthyretin The identification of TLPs ... structures of these proteins, all tetrameric, showed significant similarity to the published structures of transthyretin By way of example, a comparison of the structure of S dublin TLP with the structures ... in TLP structures as a result of alterations to the formation of hydrogen bonds between strands The carbonyls of residues V104 and P105 (zebrafish TLP numbering), in the middle of b-strand G,...
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Báo cáo khoa học: Eukaryotic class 1 translation termination factor eRF1 ) the NMR structure and dynamics of the middle domain involved in triggering ribosome-dependent peptidyl-tRNA hydrolysis pptx
... comparison of part of the protein backbone structure of the representative solution structure of the human eRF1 M domain and the Ca trace in the crystal structure of RF1 in the whole ribosome structure ... pairwise superimposition of five-residue segments of the crystal structure on the equivalent segments of each member of the family of the solution structure of the M domain of human eRF1 The resulting ... crystal structure of the M domain of the human eRF1 [3] is superimposed on the same set of atoms in the representative solution structure and is shown in red (B) The topology of the M domain of human...
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Báo cáo khoa học: High resolution structure and catalysis of O-acetylserine sulfhydrylase isozyme B from Escherichia coli pot
... to PLP and not mobile (Fig 5), although it participates in the induced fit (Fig 4) The mobility distributions of CysM(K268A), wildtype CysM and CysM(salmo), and those of subunits B and D of CysM(RKE), ... strength of ammonium sulfate prevented citrate binding in form I The structure of CysM in crystal form III is shown in Fig Citrate was bound in two conformations with occupancies of 60% and 40%, ... 2007 FEBS 5383 Structure of the O-acetylserine sulfhydrylase CysM G Zocher et al Fig Stereo ribbon plot of the high resolution structure of the CysM dimer, including the molecular twofold axis (black),...
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Báo cáo khoa học: Structure and function of KH domains docx
... in which the b1-strand and b2-strand are adjacent and parallel to each other, and the b¢-strand is adjacent and antiparallel to the b1-strand (Fig 1) The length and sequence of the variable loop ... Valverde et al Structure and function of KH domains A B C Fig 10 Crystal structure of tandem type II KH domains of NusA in complex with RNA The tandem KH1–KH2 domains of NusA recognize RNA ligand 5¢-GAACUCAAUAG ... comparison is limited, however, because the structure of only one of each type of tandem KH domain has been published Here we compare the structures of the tandem KH1–KH2 domains from protein NusA...
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Báo cáo khoa học: Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas fluorescens potx
... a-helices Residues involved in binding of the cofactor ThDP are located at the C-terminal ends of the b-strands of Dom-c (diphosphates and Mg2+) and of Dom-a¢ of a neighbouring subunit (pyrimidine moiety) ... crystal structure of BAL with bound cofac˚ tor ThDP at 2.6 A resolution, suggest the geometry of the reaction and explain the substrate specificity in structural terms Results and Discussion Structure ... of SeMet-BAL It included residues 2–555 of each subunit as well as four molecules of ThDP and four Mg2+ ions The eight C-terminal residues were disordered in both structures Data collection and...
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Báo cáo khoa học: Structure and function of N-acetylglucosamine kinase Identification of two active site cysteines pptx
... 5B Cysteines C211 and C45, whose Fig Predicted three-dimensional structure of GlcNAc kinase (A) Front view of the threedimensional structure of GlcNAc kinase based on a model of glucokinase ATP ... three-dimensional structure of GlcNAc kinase with respect to the localization of the cysteine residues, a three-dimensional model of glucokinase was used [23] Based on the sequence alignments of glucokinase and ... Ó FEBS 2002 Structure and function of GlcNAc kinase (Eur J Biochem 269) 4213 Fig De novo and salvage pathway of UDP-GlcNAc biosynthesis EXPERIMENTAL PROCEDURES Materials...
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THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT pptx
... CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT 24 THE WHEAT BOOK THE WHEAT BOOK CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT THE STRUCTURE AND DEVELOPMENT OF THE CEREAL ... and structure of the plant evolves as the integration of many consecutive and interacting processes 25 CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT THE WHEAT BOOK DESCRIPTION OF ... formation of florets within each spikelet and, later, the regression and death of some florets and spikelets and the death of some tillers This phase is also the time of greatest dry mass increase and...
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