central versus peripheral sites of action
Tài liệu BIOCHEMICAL TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects doc
... this particular interaction is actually the critical site of action of the defensive compound Further, a particular defensive compound may have multiple molecular sites of action and may well ... the initial use for cardiac insufficiency of digitalis (dried leaves of the foxglove, DZpitalispurpureumn) Determining the molecular sites of action of bioactive medicinal plant constituents ... TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects GIDEON POLYA CRC P R E S S Boca Raton London New York Washington, D.C Library of Congress...
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Báo cáo y học: " Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs" ppt
... antitussive effects of δ-antagonists are at least partly due to the inhibition of GIRK channel currents [23] Next, we will discuss the site of antitussive action of opioids in the CNS Results of in vivo ... effects of codeine are not blocked by naloxone in cats [38] In addition to the NTS, the raphe nuclei may be a candidate for being the site of action of narcotic antitussives, since stimulation of ... neuropeptide release from peripheral and central endings of nonnociceptive afferent nerve seems not to require noxious or nociceptive stimuli but may occur as a result of stimulation of low-threshold...
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Báo cáo khoa học: Contribution of a central proline in model amphipathic a-helical peptides to self-association, interaction with phospholipids, and antimicrobial mode of action ppt
... interaction of PCPs with membranes was predominantly influenced by initial electrostatic interactions, whereas the interaction of PFPs with membranes was most affected by hydrophobic interactions ... selectivity of PCPs and ⁄ or the nonselectivity of PFPs for bacterial versus red blood cells It is likely that the collapse of self-association caused by a central Pro enhances the ability of the ... activity, peptide structure, and interaction with membranes One interesting finding of this study was that introduction of a Pro in the middle position of the sequences of nonselective cytolytic peptides...
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Báo cáo y học: "Decreased effector memory CD45RA+CD62L– CD8+ T cells and increased central memory CD45RA–CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients" ppt
... sizes of the different naïve and memory populations of CD8+ T cells Percentages refer to the proportions of different naïve/memory population of total CD8+ T cells these cells into sites of inflammation ... a selective migration of these cells out of the peripheral blood, decreased survival of these cells, or blockade in their differentiation Perturbations in the homeostasis of memory T cells may ... populations of CD4+ and CD8+ T cells in peripheral blood of RA patients [15]; however, the nature of these cells, the exact phenotype, and the significance was not known at that time Our finding that peripheral...
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Báo cáo y học: " Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder" pps
... onset of action, a symptom reduction of ≥ 50% at week compared to treatment initiation is generally accepted Challenging the idea of a delayed onset of ADs’ action, there is a substantial body of ... Onset of antidepressants’ action For decades, it has been common clinical view that antidepressant response appears with a delay of several weeks [10,11] This hypothesis of a delayed action of ADs ... Psychiatry 2011, 11:16 http://www.biomedcentral.com/1471-244X/11/16 percentage of the variance of final changes of depression severity (HAMD-17) ▪ Changes of peripheral blood parameters/neuropsychological...
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Báo cáo y học: " Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice" ppt
... potential value for defining mechanisms and sites of action of DI and our goals were to investigate if this mouse model could be used to identify the site of action of DI We have implemented both the ... to investigate if these mouse models could be used to identify the site of action of DI and whether it is a good model of response to DI in normal and asthmatic subjects Methods Animals Female ... [16] Fitting the Zrs to an advanced model of respiratory mechanics, the constant phase model [15], allows partitioning of lung mechanics into central and peripheral components The primary parameters...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... major role in the pathogenesis of both types of diabetes mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, ... effects on diabetes, hypertension and wound healing Presumably, one of mechanisms of action is its antioxidant activity The action of EPRT is to produce electrical pressure rather than an electrical ... development of the oxidative stress (68) If our findings are proven by further studies involving a larger number of patients, ultra-low microcurrent therapy might change the concept of management of chronic...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
... of action of some FP methods We did not state the mechanism of action of any FP methods and thus asked women to express their beliefs independently of their actual choices and independently of ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of how a method ... Mechanism of action of emergency contraceptive pills Contraception 2006, 74(2):87-89 Mikolajczyk RT, Stanford JB: The empirical and ethical questions of induced versus natural losses of preimplantation...
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Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc
... 417-488) out of 561, indicates a homotetrameric protein resulting from interaction through a 4864 specific interface (interface B) of two identical dimers that arise from interaction of two identical ... sites, one for ATP, one for ADP and one for BPG [5,12] On the basis of the results obtained from crystallization of a truncated form of cN-II [11], we constructed point mutants for a number of ... disappearance of the heavier inactive peak Furthermore, FPLC analysis of the recombinant wild-type cN-II showed the presence of the tetrameric active form irrespective of the presence of effectors...
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Tài liệu Which Bank Is the “Central” Bank? An Application of Markov Theory to the Canadian Large Value Transfer System doc
... characterization of actual flows in terms of a network Data The data set used in the study consists of all Tranche transactions in the LVTS from October 1st 2005 to October 31st 2006 This data set consists of ... running The participants in the sample consist of members of the LVTS and the Bank of Canada For the purposes of this study we exclude the Bank of Canada since it does not send any significant ... order of magnitude) The BCLs are fairly symmetric since the minimum through the 50th percentile of absolute differences of the BCLs between pairs of banks are zero and even the 75 percentile of the...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... generation of H2O2 in spores [9,15–18] In this work we have gained more information on the cellular targets and the mechanism of action of vis- cotoxins, by examining the interaction of VtA3 with ... isoform, VtA3, with biological membranes and obtain information on its mechanism of action, we have applied different techniques as shown below The exact composition of the lipid membranes of ... any of the voltages assayed in the pulse protocol In the 0.1–1 lm range of added VtA3 (n ¼ 12; 44% of the active patches), we found ion-channel-like activity in the form of square pulses of current...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... combined action of propionyl- Ó FEBS 2004 CoA and acetyl-CoA In the presence of both thioesters one might expect an accumulation of succinyl-CoA in the cell and a deadlock of further reactions of the ... by the action of cycloheximide Cycloheximide binds to the 80S-subunit of eukaryotic ribosomes and prevents the initiation and elongation reaction of protein biosynthesis The mycelium of pregrown ... extract and water to a final volume of 980 lL The reaction was started by the addition of 20 lL of a 100 mM ATP solution (final concentration mM) and the reduction of NAD was monitored at 340 nm The...
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Tài liệu Báo cáo khoa học: Characterization and mode of action of an exopolygalacturonase from the hyperthermophilic bacterium Thermotoga maritima doc
... Hiromi K (1970) Interpretation of dependency of rate parameters on the degree of polymerization of substrate in enzyme-catalyzed reactions Evaluation of subsite afnities of exo-enzyme Biochem Biophys ... activity zone of the cytoplasmic fraction (not shown) No activity on PGA was observed when the corresponding medium fraction was concentrated and similarly analysed Mode of action of PelB To examine ... Subsite mapping On the basis of the assumptions of Hiromi [30] that the intrinsic rate of hydrolysis (kint) in the productive complex is independent of the length of the substrate, Km and Vmax...
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Tài liệu Báo cáo Y học: Identification of syntaxin-1A sites of phosphorylation by casein kinase I and casein kinase II ppt
... The mass spectrometry of radioactive peptides showed the presence of a doubly charged phosphopeptide of mass 974.0 and a singly charged phosphopeptide of mass 1946.3 both of which correspond only ... Both sites are located at the N-terminal domain of syntaxin-1A These sites are remote from the H3 domain required for protein–protein interactions, and known to be crucial in the formation of the ... is the kinase Fig Summary of phosphorylation sites on recombinant syntaxin-1A The figure shows the sites of phosphorylation by CKIa (Thr21) and CKII (Ser14) The masses of the major peptides, in...
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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc
... Scheme shows the reactions of the two-step mechanism of action of TFPI It is shown in the Appendix that Scheme is equivalent to Scheme I of [8] within the area of the applicability of the latter In ... significant amount of the Xa–VIIa–TF complex The mathematical model has shown that the analysis of the inhibition curves of the Scheme A development of Scheme by addition of the reaction of the enzyme–substrate ... the concentration of the limiting component of the complex, TF The criteria for choosing of the values of the kinetic constants The values of the kinetic constants of those reactions whose existence...
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Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc
... into various host cells is a hallmark of CagT4SS activity Despite the molecular characterization of a number of effects in host cells, the exact function of CagA translocation during infection ... the molecular mechanisms of effector protein secretion This minireview describes the composition of the cagPAI and the properties of both conserved and unique components of the Cag-T4SS, together ... potential implications for the current understanding of its mode of action The cagPAI and the Cag type IV secretion apparatus Gene arrangement and variants of the cagPAI The cagPAI, which was originally...
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Báo cáo khoa học: The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase pptx
... Lineweaver–Burke plot of L-ADP inhibition of dGTP-dependent D-ADP reductase in the presence of mM D-ATP (B) Secondary plot of the slope values of A (C) LineweaverBurk plot of L-ADP inhibition of dGTP-dependent ... investigations of interactions of l-nucleosides or l-nucleotides with allosteric sites have been reported (although see [13]) In the present work, we examine the abilities of l-ATP and of l-ADP (Fig ... mostly in the form of active mR16 [2] Earlier we showed that, under similar conditions, addition of dATP led to inhibition of activity, largely as a result of dATP displacement of d-ATP from the...
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Báo cáo khoa học: Homoadenosylcobalamins as probes for exploring the active sites of coenzyme B12-dependent diol dehydratase and ethanolamine ammonia-lyase docx
... mechanism of action of adenosylcobalamin-dependent glycerol dehydratase from Aerobacter aerogenes I Role of structural components of adenosylcobalamin in the formation of the active site of glycerol ... of the Co-C bond [17] (Fig 1A) Difference in the specificity for the adenosyl group among enzymes may reflect the difference of the adenosyl group-binding sites of the enzymes From simulation of ... with those of free counterparts The extents of the Co-C bond cleavage of these analogues were negligible although that of AdoCbl was estimated to be 85% from Fig 3E Upon denaturation of the enzyme-cobalamin...
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Báo cáo khoa học: Exo-mode of action of cellobiohydrolase Cel48C from Paenibacillus sp. BP-23 A unique type of cellulase among Bacillales ppt
... insoluble fraction of either digested sample, indicating that the main activity of Cel48C is that of a cellobiohydrolase, acting processively on these substrates To analyse the exo-mode of action of Cel48C, ... products of hydrolysis of cellopentaose (G5) and is shown as size marker of action and knowledge of their natural substrate may be of great interest to understand the biological role of family ... degradation of cellopentaose produced both cellobiose and cellotriose As in the case of ASC, analysis of the kinetics of cellotetraose digestion showed the presence of minor amounts of cellotriose...
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Global Plan of Action for Children’s Health and the Environment (2010 - 2015) doc
... facilitate the development of a global plan of action to improve children's environmental health (CEH), and regularly monitor and report on its progress This draft Global Plan of Action is designed to ... contribute to the economic and social development of societies To achieve the goal, target areas of work are included in the Global Plan of Action for Children's Health and the Environment: Data ... new observations of CEH hazards and outcomes Develop a standard tool for estimating the cost of diseases due to environmental hazards Develop estimates of the disability effects of environmental...
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