cellular and molecular mechanisms of neural plasticity
Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
... known whether p-BSQ of CS causes apoptosis and emphysematous lung damage We have addressed this question for better understanding of the cellular and molecular mechanisms of emphysema, so that ... and Bcl-2 of the lung extracts of guinea pigs exposed to air or CS supplemented with A, Immunoblots of caspase 3, PARP, A, Immunoblots of caspase 3, PARP, Bax and Bcl-2 of the lung extracts of ... of the art cellular and molecular mechanisms of alveolar destruction in emphysema Proc Am Thorac Soc 2006, 3:503-510 Publish with Bio Med Central and every scientist can read your work free of...
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MORPHOGENESIS THE CELLULAR AND MOLECULAR PROCESSES OF DEVELOPMENTAL ANATOMY pptx
... processes by which cellular organisation emerges in embryos Although we often have very good descriptions of how a particular organ forms and of the nature of the participating cells and molecular constituents, ... two distinct tissues come together, and here we will examine the generation of the neural tube in the newt and the formation of the ducted submandibular glands of the mouse The latter example in ... elongates and closes to form the neural tube.(J) A section through the mid region of a Xenopus embryo after the closure of the neural tube and the formation of the early somites (nt: neural tube;...
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Báo cáo khoa học: Cellular and molecular action of the mitogenic protein-deamidating toxin from Pasteurella multocida pptx
... intoxication of PMT Little is known about the cellular uptake mechanisms of PMT Bacterial protein toxins are known to utilize a number of different entry routes, and the nature of the receptor often ... increased production of diacylglycerol [77], mobilization of intracellular Ca2+ pools [68,71,72,78], interconversion of GRP78 ⁄ BiP [79] and activation of protein kinase C-dependent and -independent ... Ga isoforms, as all of the Ga subunits have analogous active site Gln residues (equivalent to Gln204 of Gai1, Gln205 of Gai2, Gln229 of Ga12 ⁄ 13 and Glu209 of Gaq ⁄ 11) and share significant...
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Cellular and molecular control of skeleton formation in fish insights from osteoblast ablation and functional characterization of lrp5 and SOst
... (HN) B-D and I-K are higher magnification views of cleithrum boxed in A and H, respectively Operculum of a DMSO control (E-G) and Mtz treated larva (L-N) Note: Loss of CFP and absence of mineralization ... mesoderm (Cohn and Tickle, 1996) whereas the cranial neural crest is the origin of craniofacial bones such as skull and maxilla (Bronner-Fraser, 1994; Noden, 1991) Two mechanisms of bone development ... mineralization (Renn and Winkler, 2009) osx transgenic expression was observed in advance of mineralization of the neural and hemal arches and at the edges but not the core of the chordal centrum...
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Báo cáo khoa học: Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry potx
... gH and gL (Fig 2) [8] Fusion of viral envelope FEBS Journal 276 (2009) 7228–7236 ª 2009 The Authors Journal compilation ª 2009 FEBS 7229 Cellular and viral mediators of HSV entry J Akhtar and ... proteins and bind a microtubule-dependent, minus end-directed motor, dynein [9] Although most of the tegument proteins are required for activation and modulation of viral gene expression and shut-off ... Interestingly, both uncleaved and cleaved forms of gBs share mixed features of class I and class II viral fusion proteins, and thereby define a new, hybrid class of viral fusogens [6] Class I...
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Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
... burden of pneumonia, the increasing number of antibiotic- resistant bacteria, and the emergence of new pulmonary pathogens into account, an exact analysis of molecular mechanisms of disease is mandatory ... peptidoglycans of basically all bacteria [117,118] However, as for many of the TLRs and their agonists, there is no formal proof for the binding of the peptidoglycan motifs to the LRR domains of NOD1 and ... liberation of immunodulatory cyto- and chemokines and up-regulation of adhesion molecules mediates the acute immune response by e.g recruitment of leucocytes to the site of infection and modulates...
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Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
... deficiency in thyroid and growth hormones and in vasopressin Necrosis or haemorrhage of the hypothalamus or of the pituitary gland have been reported in sepsis as a result of prolonged hypotension ... treatment [12] The duration of suppression of the hypothalamic–pituitary axis after a single dose of a glucocorticoid depends on the anti-inflammatory potency and duration of the glucocorticoid preparation, ... the renal artery and the aorta form rich plexuses in the cortex and supply the gland The plexuses are continuous with the sinuses of the medulla, which drain into the central vein of the medulla...
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Molecular mechanisms of mechanosensing at cell cell and cell matrix adhesion 2
... signaling and regulation of variety of cellular processes such as cell growth, migration and gene-expression [20] To fulfill such a set of functions, eukaryotic cells have evolved delicate and robust molecular ... molecular mechanisms, often referred to as functional modules, work together to govern these complex and robust processes [2, 17] This thesis work devotes to understand the molecular mechanisms of a ... study the mechanical stability of the rod domains of talin and central domain of α-catenin using both wild type and mutant constructs Both talin vii rod domain and α-catenin central domain undergo...
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Dendritic cells respond differently to live and killed bacteria molecular mechanisms of pathogen recognition by dendritic cells and implications for vaccine development
... the mechanisms of initiation of the immune response to E coli and on aspects of invasiveness, pathogenicity and the persistence of E coli This may provide a strategy for improving the efficacy of ... proliferation and the generation of antibodies (for B cells) and the generation of armed effector T cells such as cytotoxic T cells and helper T cells (Th) (for T cells) Some of these B and T cells ... of some of these ligands has been identified using in vitro systems such as ligand binding assays or knockout mice Some of the known TLR ligands are listed in table 1.4 18 Table 1.4 TLRs ligands...
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Tài liệu Báo cáo khoa học: Isolation and molecular characterization of a novel D-hydantoinase from Jannaschia sp. CCS1 docx
... Purification of HYDBp and HYDJs tot, total proteins; ppt, precipitate fraction; sup, supernatant fraction; puri, purified proteins; M, molecular weight standards For the molecular weight standards, the bands ... positions of the Ca of Ala156 in HYDJs and the Ca of Met156 in HYDBp located in the SGL3, which leads to the increased size of the substrate binding pocket of HYDJs The side chain of Ala156 is ... performed using T-COFFEE [44] Docking simulation of substrate on the active site of HYDJs The substrate binding pockets of HYDJs and the mode of interaction between substrate and enzyme were analyzed...
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Tài liệu Báo cáo khoa học: Biochemical and molecular characterization of hazelnut (Corylus avellana) seed lipoxygenases pdf
... reaction products of the hazelnut LOX were compared with the reaction products of soybean LOX type I and authentic standards of 9- and 13-HODE As shown in Fig 4, 9-HODE is the main product of the hazelnut ... part of the world production adsorbed by the pastry industry Hazelnut seeds contain reasonable levels of linoleic and linolenic acid (about 10 and 0.2%, respectively, of the total fatty acids) and ... C6 and C9 aldehydes (and the corresponding alcohol) were detected in all the samples and, similarly to the pattern of LOX expression and activity, their levels were higher in stage I seed and...
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Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc
... well as in the molecular mechanisms of effector protein secretion This minireview describes the composition of the cagPAI and the properties of both conserved and unique components of the Cag-T4SS, ... important to understand its molecular principles in detail Defining the molecular mechanisms of CagA transport to the bacterial surface and across the target cell membrane will thus be of particular ... potential implications for the current understanding of its mode of action The cagPAI and the Cag type IV secretion apparatus Gene arrangement and variants of the cagPAI The cagPAI, which was originally...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
... FEBS 5213 Molecular mechanisms of Pin1 G Lippens et al Fig Schematic view of the parallel between Pin1 and CKS in protein degradation Top: Model of the SCFCDC4 E3 ligase and the role of Pin1 Pin1 ... monomer and swapped dimer are mainly limited to the conformation of the Glu-Pro dipeptide in the hinge region between the last b-strand and the core of CKS The crystal structure of the complex of ... exact role of Pin1 in human disease, and Molecular mechanisms of Pin1 thereby its potential as a molecular target for novel drugs Acknowledgements We thank two anonymous reviewers and Dr E Appella...
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Báo cáo khóa học: Biochemical and molecular characterization of a laccase from the edible straw mushroom, Volvariella volvacea docx
... and 2,6-DMP were pH 5.6 and 3.4 UÆmg protein)1 and pH 4.6 and 2.8 UÆmg protein)1, respectively In standard assay mixtures, the velocity of ABTS oxidation was maximal at 45 °C The dependence of ... in 450 mL of distilled water After draining off any remaining free water, the straw was mixed with lime (15 g) and wheat bran (15 g) and the material distributed into cellophane bags and autoclaved ... filtration of 7-day cultures of V volvacea was centrifuged (10 000 g, 30 min) and concentrated 40-fold with the Pellicon ultrafiltration system (Millipore) using a 10-kDa molecular mass cut-off membrane...
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Báo cáo khoa học: Functional fine-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein pdf
... partially oxidized and the signal of the reduced species increased as a result of oxidation Identification of the active isoform Because of disulfide scrambling HPLC-purified isoforms rapidly re-equilibrate, ... an association time of 300 s and a dissociation of 180 s under a constant flow rate of 20 lLÆmin)1 at 25 °C The sensorgram profile of each run was subtracted by the signal of the irrelevant peptide ... negative for binding High conservation of the HNE sequence Molecular modeling of the HNE peptide An interesting and important feature of the HNE is its high degree of conservation among field isolates...
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Báo cáo khoa học: Enzymatic characterization and molecular modeling of an evolutionarily interesting fungal b-N-acetylhexosaminidase pot
... blue) and standard (magenta) substrates after ns of MD (C) Overlay of positions of N-propionyl modified (light blue) and standard (magenta) substrates after ns of MD (D) Molecular surface of the ... hydrolysis of N-formyl, N-glycolyl and N-propionyl derivatives of the standard N-acetyl substrate) than A oryzae (2–5% hydrolysis) The cloning and sequencing of PoHex and analysis of the corresponding ... buffer system of Laemmli [21] (Fig 1C, lanes and 9, respectively) Another protein band with a 2470 Fig Optimization of PoHex production and purification (A), (B) Time course of secretion of PoHex from...
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Báo cáo khoa học: Sequences, geographic variations and molecular phylogeny of venom phospholipases and threefinger toxins of eastern India Bungarus fasciatus and kinetic analyses of its Pro31 phospholipases A2 docx
... mutational rates of the exon of the 3FTx genes are much faster than those of the PLA genes, leading to high variation of KBf-3FTx Cloning and cDNA sequencing Venom glands of only one of the KBf specimens ... present in B candidus venom, while 3FTx-RK is 84% identical to bucain [25] of B candidus Calcium binding and kinetic parameter of the P31-PLAs Four PLAs (Va, Vb-2, VI and II) of KBf and Bf contain ... the prey of Bf and king cobra consists mainly of snakes and reptiles, which are distinct from those of other kraits (e.g B candidus and B multicinctus, which prey on small catfishes, eels and rodents...
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Báo cáo khoa học: Purification, characterization and molecular cloning of tyrosinase from the cephalopod mollusk, Illex argentinus docx
... dialyzed solution of AS60 (300 mL) obtained from 100 g of defatted ink powder contained 2.9 g of protein, 0.29 g of hexose, 0.25 g of uronic acid, 0.12 g of methylpentose and 5400 units of tyrosinase ... The molecular masses of the subunits of ST94 and ST94t were similar to those of the proenzymes ( 70–80 kDa) and the activated enzymes by proteolysis ( 60–70 kDa) of a bivalve tyrosinase [34] and ... bond These estimates of the molecular mass of ST94 were supported by the result of gel permeation HPLC (Fig 3) There was a minor band between 140 and 232 kDa in the native-PAGE of Fig 2A (lane 1),...
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Báo cáo khoa học: Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii ppt
... was 1.8°, the standard deviation of the hydrogen bond energies was 0.7 and overall G-factor, a measure of the normality of the structure, was 0.0 Fig SDS/PAGE and activity analysis of recombinant ... in position With the exception of four a-helices and two pairs of short b-strands, the rest of the protein consists almost entirely of loops connecting the b-strands The loops extending from the ... Denaturation and refolding of reCBH and enzyme assay reCBH (1 mg) was denatured by incubation in a solution of M urea/0.1 M Tris/HCl, pH 8.0, in the presence of 100 mM dithiothreitol and mM EDTA,...
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Báo cáo khoa học: Biochemical and molecular characterization of purified chicken pancreatic phospholipase A2 docx
... 50% of its activity in the absence of NaTDC The maximal PLA2 specific activity of 400 UÆmg)1 was measured at pH 9.5 and at 37 °C in the presence of mm NaTDC and mm CaCl2 Pure ChPLA2 lost 80% of ... 4547 A Karray et al A effect of bile salts on ChPLA2 activity, the rate of hydrolysis of PC by ChPLA2 in the presence of various concentrations of bile salts, at pH 9.5 and at 37 °C, was studied ... Lys56; and aD, Ala90–Lys108); (e) two short strands 4550 of an antiparallel b-sheet (b-wing) (b2, Ser74–Ser78; and b3, Glu81–Asn85); and (f) a C-terminal loop containing a short b4-strand (His115–Asn117)...
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