cell cycle specific transcription factors
Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
Ngày tải lên :
16/02/2014, 09:20
... and
human T-cells, B-cells, myeloid cells, monocytic cells
and fibroblasts, but not neuronal cells or embryonic
stem cells, express STAT6, indicating that this gene is
expressed in haematopoietic cells ... effector cell populations exist,
Th1, Th2 and Th17, characterized by their cytokine
repertoire and how they regulate B -cell and T -cell
Keywords
adaptive immunity; fish immunology; T-cells;
transcription ... relationship
between the expression of these transcription factors
and the cytokine genes known to be produced by dif-
ferent T -cell subtypes in mammals. These transcription
factors, together with many of...
- 20
- 689
- 0
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
Ngày tải lên :
16/02/2014, 09:20
... p53. Cell cycle arrest can be medi-
ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C.
CDE ⁄ CHR-dependent cell cycle- gene transcription ... CHR-regulated
promoter.
Cell cycle- dependent transcription of the human
CDC20 ⁄ p55CDC ⁄ Fizzy promoter was reported to
depend on a new element named SIRF (Cell- Cycle
Site-Regulating p55Cdc ⁄ Fizzy -Transcription) . ... Synthesis of
proteins encoded by cyclin B1 and cyclin B2 genes is
Keywords
cell cycle; cell cycle genes homology region
(CHR); cell cycle- dependent element (CDE);
DREAM complex; E2F
Correspondence
K....
- 17
- 876
- 0
cell cycle regulation - Ebook USA ( biotechnology)
Ngày tải lên :
07/10/2012, 16:51
... Division of the cell
cycle into temporally ordered, discrete steps implied different proteins regu-
late specific cell cycle transitions (Hartwell 1974). If so, then factors advancing
cell cycle progression ... restriction point of the cell cycle. Cell Cycle
1:103–110
Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylated
during specific phases of the cell cycle. Cell 58:1097–1105
Burdon ... of
critical cell cycle machinery.
2.3
Cell Cycle Machinery
Recognition that specific protein catalysts are responsible for diverse cellu-
lar processes such as fermentation (late 1800s) suggested that cell...
- 381
- 530
- 1
Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
Ngày tải lên :
26/10/2012, 10:04
... tangles contain the antigenic profile of many cell cycle markers, re-
flecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is
an early and ... suppression of the cell
cycle and cell survival instead of apoptosis and their
presence may be a neuroprotective factor to prolong
the life of the cell after re-entry into the cell cycle, pro-
tecting ... dividing neuronal cells
during development, and is present in smaller
amounts in fully differentiated cells [13]. BRCA1 is
known to regulate transcription, regulate cell cycle
progression,...
- 6
- 440
- 0
Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"
Ngày tải lên :
02/11/2012, 11:12
...
induction of cell cycle arrest and apoptosis. We have investigated its effects on
cell cycle regulation using a gastric cancer cell line, AGS. The effects of CKBM
on cell proliferation, cell cycle ... cell line. CKBM is found to inhibit
cell proliferation through the induction of apoptosis and G2/M cell cycle arrest. To further elucidate the mechanism of CKBM on
apoptosis and G2/M cell cycle ...
AGS cells were seeded in a 6-well plate at a density of 1.2 x 10
6
cells/well. After 2, 4 or 6 hr of CKBM treatment at a
concentration of 5, 10 or 15 % v/v, cells were trypsinized. Then cells...
- 6
- 319
- 0
Cell Cycle Regulation in Mammalian Germ Cells
Ngày tải lên :
25/10/2013, 21:20
... female
Cell Cycle Regulation in Mammalian Germ Cells 347
Table 1 (continued)
Gene Protein Name Effect on germ cell development Refs.
B. Transcriptional and Translational Factors
Ahch Dax1 A transcriptional ... mediating cell cycle regulators, growth factors and
intracellular communication pathways for germ cell development.
5
Cytoplasmic and Apoptotic Factors
During gametogenesis, apoptosis of germ cells ... Probl Cell Differ (42)
P. Kaldis: Cell Cycle Regulation
DOI 10.1007/003/Published online: 20 December 2005
© Springer-Verlag Berlin Heidelberg 2005
Cell Cycle Regulation in Mammalian Germ Cells
Changanamkandath...
- 31
- 377
- 0
Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Ngày tải lên :
25/10/2013, 21:20
... coordinate cell cycle exit with the induction of differentiation
that confers upon pRB its tumor suppressor function.
230 L. Yamasaki
2
The Universality of the Cell Cycle
The discovery of the cell cycle ... Nature 343:665–669
Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231
cycle, and strongly suggested that deregulation of the mechanisms controlling
cell cycle progression could ... PK (2004) Wagging the dogma; tissue-specific cell cycle control in the
mouse embryo. Cell 118:535–538
Palmero I, Peters G (1996) Perturbation of cell cycle regulators in human cancer. Cancer
Surv...
- 30
- 631
- 0
MouseModels of Cell Cycle Regulators - New Paradigms
Ngày tải lên :
25/10/2013, 21:20
... principal cell cycle inhibitor in β cells, as it accumu-
latesinthenucleusofβ cells from obese mice, inhibiting compensatory β cell
expansion (Uchida et al. 2005).
Mouse Models of Cell Cycle Regulators: ... one round of cell division, every cell in metazoans has
to decide whether it will re-enter the cell cycle, exit the cell cycle and en-
ter a quiescence state, and every quiescent cell has to similarly ... re-enter the cycle. All
these crucial decisions are made by a set of information processors (cell cycle
machinery) that integrate extracellular and intracellular signals to coordinate
cell cycle events.
In...
- 58
- 291
- 0
Senescence and Cell Cycle Control
Ngày tải lên :
25/10/2013, 21:20
... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle
Res 1:9–19
Senescence and Cell Cycle Control 259
eliminates telomere-mediated signaling, allowing cells to undergo transform-
ation ... of
retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424:223–228
Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell- cycle control
causing specific inhibition of ... and cell mortality. Cell 85:27–37
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes
premature cell senescence associated with accumulation of p53 and p16
INK4a
.Cell
88:593–602
Sharpless...
- 14
- 347
- 0
The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Ngày tải lên :
25/10/2013, 21:20
... critical regulator of most
cell cycle responses. While each single pocket protein can mediate cell cycle
arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrest
upon growth ... roles in controlling cell cycle
exit upon growth-inhibiting signals. Only ablation of all pocket proteins fully
alleviated a cell cycle arrest upon serum withdrawal, cell- cell contact inhi-
bition, ... pro-
teins at these specific stages of the cell cycle.
4.4
pRb Family Mediated Regulation of E2F by Cellular Localization
Another level of control of the E2F transcriptional activity is added by the...
- 43
- 460
- 0
The ubiquitin-proteasome pathway in cell cycle control
Ngày tải lên :
25/10/2013, 21:20
... a transcription factor that is activated in response to
variety of cellular stresses, evokes a number of responses ranging from cell
cycle arrest to programmed cell death, depending on the cell ... from studies on the early embryonic cell cycles of
Table 1 Cell cycle targets of the anaphase promoting complex
Substrate Organism Specificity factor Cell cycle function
Securin S. cerevisiae ... Probl Cell Differ (42)
P. Kaldis: Cell Cycle Regulation
DOI 10.1007/b136681/Published online: 6 July 2005
© Springer-Verlag Berlin Heidelberg 2005
The ubiquitin-proteasome pathway in cell cycle...
- 35
- 349
- 0
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
Ngày tải lên :
16/02/2014, 09:20
... and several molecular factors
are known to influence the events of this enchondral ossification, especially
transcription factors. Members of the AP-2 family of transcription factors
play important ... promoter sequences,
the AP-2 transcription factors play important roles in
cellular processes, such as morphogenesis, in particular
proliferation, differentiation, cell cycle regulation, and
apoptosis ... binds the promoter of the survival
gene bcl-2 and regulates its transcription in epithelial
cells through transcription factor AP-2. Mol Cell Biol
22, 7877–7888.
44 McPherson LA, Loktev AV & Weigel...
- 9
- 642
- 0
Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
Ngày tải lên :
18/02/2014, 16:20
... phase of the cell- division cycle. Therefore, we tested,
using light microscopy and after DAPI staining, whether
the slow growth yields a cell- cycle phenotype. Cells of
the logarithmically ... asynchronous
cells. To test whether phosphorylated Rio1p is, in fact,
degraded at a certain stage of the cell- division cycle,
whereas the unphosphorylated form is not, we per-
formed cell- cycle arrest ... observed
a cell- cycle phenotype with this mutant. Cytological
approaches investigating cell- cycle stages reveal that
this mutant yeast strain accumulates G
1
cells, whereas
the number of S phase cells...
- 14
- 553
- 0
Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of transcription factors ppt
Ngày tải lên :
18/02/2014, 18:20
... pathological roles in RA.
Other transcription factors
Other transcription factors implicated in the patho-
genesis of RA are the signal transducer and activator
of transcription (STAT) family of ... remarks
Transcription factors play critical roles in the function
of immune effector cells, including cytokine ⁄ chemokine
expression and also in the control of synovial cell apop-
tosis. These cells ... SAA in RA joints binds to RAGE on synovial cells and acti-
vates the NF-jB signaling pathway in these cells.
H. Okamoto et al. Role of transcription factors
FEBS Journal 275 (2008) 4463–4470 ª...
- 8
- 520
- 0