cell cycle regulated transcription
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
Ngày tải lên :
16/02/2014, 09:20
... Subunit 1 (Cks1) is Regulated
During the Cell Cycle by a CDE ⁄ CHR Tandem
Element and is Downregulated by p53 but not by p63
or p73. Cell Cycle 6, 853–862.
37 Yoshida K (2005) Cell- cycle- dependent ... p53. Cell cycle arrest can be medi-
ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C.
CDE ⁄ CHR-dependent cell cycle- gene transcription ... responsible for strong shifts in cell cycle distribu-
tion. A large cell fraction is found in G
2
or appears to
have an 8n DNA content. Many cell cycle- regulated
genes are downregulated upon Lin-9 knockdown...
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
Ngày tải lên :
07/03/2014, 16:20
... upon cell cycle exit. To this effect, HFF cells were
deprived of serum f or 48 h to induce cell cycle exit. Serum
was th en r e-added a nd samples taken as cells progressed
into the cell cycle. ... proliferating
cells
in vivo
The experiments with cultured cells have suggested that
Cdt1 and geminin mRNA and protein are down -regulated
upon cell cycle exit and a re progressively up -regulated upon
Fig. ... ase,
when licensing is legitimate [13]. When cells exit the cell cycle,
licensing in lost, a nd is est ablished again a s cells prepare t o
reenter the cell cycle. While a previous study did not detect...
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cell cycle regulation - Ebook USA ( biotechnology)
Ngày tải lên :
07/10/2012, 16:51
... restriction point of the cell cycle. Cell Cycle
1:103–110
Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylated
during specific phases of the cell cycle. Cell 58:1097–1105
Burdon ... starvation not only blocks cell
cycle progression, but causes cells to exit the cycle and enter G0. However,
if serum is removed after this point, cells continue through the cycle unhin-
dered (Zetterberg ... of
critical cell cycle machinery.
2.3
Cell Cycle Machinery
Recognition that specific protein catalysts are responsible for diverse cellu-
lar processes such as fermentation (late 1800s) suggested that cell...
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Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
Ngày tải lên :
26/10/2012, 10:04
... tangles contain the antigenic profile of many cell cycle markers, re-
flecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is
an early and ... suppression of the cell
cycle and cell survival instead of apoptosis and their
presence may be a neuroprotective factor to prolong
the life of the cell after re-entry into the cell cycle, pro-
tecting ... dividing neuronal cells
during development, and is present in smaller
amounts in fully differentiated cells [13]. BRCA1 is
known to regulate transcription, regulate cell cycle
progression,...
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Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"
Ngày tải lên :
02/11/2012, 11:12
...
induction of cell cycle arrest and apoptosis. We have investigated its effects on
cell cycle regulation using a gastric cancer cell line, AGS. The effects of CKBM
on cell proliferation, cell cycle ... cell line. CKBM is found to inhibit
cell proliferation through the induction of apoptosis and G2/M cell cycle arrest. To further elucidate the mechanism of CKBM on
apoptosis and G2/M cell cycle ...
AGS cells were seeded in a 6-well plate at a density of 1.2 x 10
6
cells/well. After 2, 4 or 6 hr of CKBM treatment at a
concentration of 5, 10 or 15 % v/v, cells were trypsinized. Then cells...
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Cell Cycle Regulation in Mammalian Germ Cells
Ngày tải lên :
25/10/2013, 21:20
... female
Cell Cycle Regulation in Mammalian Germ Cells 347
Table 1 (continued)
Gene Protein Name Effect on germ cell development Refs.
B. Transcriptional and Translational Factors
Ahch Dax1 A transcriptional ... Probl Cell Differ (42)
P. Kaldis: Cell Cycle Regulation
DOI 10.1007/003/Published online: 20 December 2005
© Springer-Verlag Berlin Heidelberg 2005
Cell Cycle Regulation in Mammalian Germ Cells
Changanamkandath ... stage of cell cycle, Ortega et al. 2003;
kinase 2 while females lack follicular development Berthet et al. 2003
due to breakdown at the pachytene stage.
CyclinD2 Cell cycle Absence of germ cells...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Ngày tải lên :
25/10/2013, 21:20
... coordinate cell cycle exit with the induction of differentiation
that confers upon pRB its tumor suppressor function.
230 L. Yamasaki
2
The Universality of the Cell Cycle
The discovery of the cell cycle ... Nature 343:665–669
Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231
cycle, and strongly suggested that deregulation of the mechanisms controlling
cell cycle progression could ... PK (2004) Wagging the dogma; tissue-specific cell cycle control in the
mouse embryo. Cell 118:535–538
Palmero I, Peters G (1996) Perturbation of cell cycle regulators in human cancer. Cancer
Surv...
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MouseModels of Cell Cycle Regulators - New Paradigms
Ngày tải lên :
25/10/2013, 21:20
... principal cell cycle inhibitor in β cells, as it accumu-
latesinthenucleusofβ cells from obese mice, inhibiting compensatory β cell
expansion (Uchida et al. 2005).
Mouse Models of Cell Cycle Regulators: ... one round of cell division, every cell in metazoans has
to decide whether it will re-enter the cell cycle, exit the cell cycle and en-
ter a quiescence state, and every quiescent cell has to similarly ... re-enter the cycle. All
these crucial decisions are made by a set of information processors (cell cycle
machinery) that integrate extracellular and intracellular signals to coordinate
cell cycle events.
In...
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Senescence and Cell Cycle Control
Ngày tải lên :
25/10/2013, 21:20
... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle
Res 1:9–19
Senescence and Cell Cycle Control 259
eliminates telomere-mediated signaling, allowing cells to undergo transform-
ation ... of
retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424:223–228
Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell- cycle control
causing specific inhibition of ... and cell mortality. Cell 85:27–37
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes
premature cell senescence associated with accumulation of p53 and p16
INK4a
.Cell
88:593–602
Sharpless...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Ngày tải lên :
25/10/2013, 21:20
... critical regulator of most
cell cycle responses. While each single pocket protein can mediate cell cycle
arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrest
upon growth ... roles in controlling cell cycle
exit upon growth-inhibiting signals. Only ablation of all pocket proteins fully
alleviated a cell cycle arrest upon serum withdrawal, cell- cell contact inhi-
bition, ... Estes S, Starz M, Vernon JP, Lees JA (1997) E2F activity is regulated
by cell cycle- dependent changes in subcellular localization. Mol Cell Biol 17:7268–7282
Vooijs M, Berns A (1999) Developmental...
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The ubiquitin-proteasome pathway in cell cycle control
Ngày tải lên :
25/10/2013, 21:20
... from studies on the early embryonic cell cycles of
Table 1 Cell cycle targets of the anaphase promoting complex
Substrate Organism Specificity factor Cell cycle function
Securin S. cerevisiae ... Probl Cell Differ (42)
P. Kaldis: Cell Cycle Regulation
DOI 10.1007/b136681/Published online: 6 July 2005
© Springer-Verlag Berlin Heidelberg 2005
The ubiquitin-proteasome pathway in cell cycle ... linking cell
cycle regulation to internal and external signaling pathways via regulated protein kinase
activities.
1
Introduction
The importance of ubiquitin-mediated proteolysis for cell cycle...
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Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
Ngày tải lên :
18/02/2014, 16:20
... phase of the cell- division cycle. Therefore, we tested,
using light microscopy and after DAPI staining, whether
the slow growth yields a cell- cycle phenotype. Cells of
the logarithmically ... asynchronous
cells. To test whether phosphorylated Rio1p is, in fact,
degraded at a certain stage of the cell- division cycle,
whereas the unphosphorylated form is not, we per-
formed cell- cycle arrest ... for cell life, CK2 activity by itself is
apparently unregulated [4,5], although some fluctua-
tion in activity in correlation with cell- cycle progres-
sion has been seen in cultured mammalian cells...
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Báo cáo khoa học: A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis doc
Ngày tải lên :
14/03/2014, 23:20
... staining cells. Scale bars = 200 lm. (F) Quantification of binucle-
ated cells in control and Grx3-KD cells. Total 600 cells counted for control cells and 360 cells counted for Grx3-KD cells. The ... finish cell cycle back to G
1
phase. Cells were harvested at 2-h intervals.
Half of cells were stained with propidium iodide, and analyzed by FACS. Another half of cells were prepared for cell ... Given the complexity of cell
cycle regulation and the numerous intracellular compo-
nents responding to oxidative stress, it is not surprising
that Grx3-mediated cell cycle control may be depen-
dent...
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Báo cáo khoa học: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex doc
Ngày tải lên :
15/03/2014, 09:20
... (a) cells
pulse treated (1 h) with cycloheximide early in the cell
cycle (before RP) immediately suffer a long delay in
the cell division cycle; (b) cells treated late in the divi-
sion cycle ... as
the emergent RP in the mammalian cell cycle) in terms
of the multitude of reaction steps and interactions
between the cell s molecular parts (e.g. cell cycle pro-
teins) [18]. Numerous studies ... restriction
point of the cell cycle. Cell Cycle 1, 103–110.
4 Yao G & Lee TJ, Mori S, Nevins JR & You L (2008)
A bistable Rb-E2F switch underlies the restriction
point. Nat Cell Biol 10, 476–482.
5...
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Báo cáo khoa học: Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells pot
Ngày tải lên :
16/03/2014, 13:20
... HeLa cells
were incubated with nocodazole. Cells
detached from the bottle by shaking were
collected and named mitotic (M) cells.
Residual cells were collected and named G
2
cells. These cells ... treatments; i.e. the
DNA content of G
2
, M cells are almost double that of G
1
cells and the DNA content of S cells ranges between that
of G
1
cells and G
2
or M cells (data not shown). BrdU was
detected ... fluorescence and the reactivity to anti-BrdU sera, the cell- cycle stage was determined in each
cell.
Y. Komamura-Kohno et al. MCM4 phosphorylation in mammalian cells
FEBS Journal 273 (2006) 1224–1239 ª 2006...
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