cd8 cytotoxic t lymphocytes
Báo cáo y học: "Control of mucosal virus infection by influenza nucleoprotein-specific CD8+ cytotoxic T lymphocytes" ppsx
... represent a direct demonstration that CD8+ T cells constitute an effective mechanism for clearance of influenza virus infection in the upper respiratory mucosa Thus, the suggestion that antigen-specific ... human volunteers challenged with an influenza virus [10] In this regard, it is important to emphasize that the function of CD8+ CTL is not to prevent viral infection but rather to mediate clearance ... probably inadequate to protect against a lethal influenza challenge The role of contact-mediated T cell cytotoxicity against cytopathic viruses such as influenza remains controversial Some studies have...
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Báo cáo khoa học: Oligomannose-coated liposomes efficiently induce human T-cell leukemia virus-1-specific cytotoxic T lymphocytes without adjuvant doc
... cultured PBMCs The numbers in the upper right quadrants represent the percentages of tetramer +CD8+ T cells in T lymphocytes (B) Cytotoxic activity of induced HTLV-1-specific CD8+ T cells Using HTLV-1 ... in postallogeneic stem cell transplantation patients The expression of Tax by the host cell targets them for attack by CTL, resulting in the elimination of the infected cell [32] However, the expression ... transplantation patients, which might account for the efficacy of this therapy [31] Therefore, the efficient induction of HTLV-1-specific CTL by OML ⁄ Tax could be adapted to prevent the relapse of ATL...
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Báo cáo khoa học: "Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer" ppt
... search, there are no report to evaluate the correlation between TIL and radiosensitivity, and this is the first one to show the direct link between the density of T cells infiltrating in solid tumor ... with tumor response to CRT [13] This finding is in line with the data in this study, and suggested that the maintenance of circulating lymphocytes number can recruit many anti-tumor lymphocytes ... into the irradiated tumor during CRT, which may lead to improvement of the clinical efficacy of RT in rectal cancer Taken together, our results indicate that the quantitative measurement of TIL...
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Báo cáo y học: "CD8+ T lymphocytes in bronchoalveolar lavage in idiopathic pulmonary fibrosis" ppt
... MRC Phycoerythrin PE Residual Volume RV T lymphocytes TLs Total lung capacity TLC Competing interests The author(s) declare that they have no competing interests Authors' contributions Figure ... patients The study is in compliance with the Helsinki Declaration, was approved by the Institutional Ethics Committee and informed consent was obtained from each patient Pulmonary function tests ... patients Patients and Methods Patients Twenty-seven patients with IPF were included in the study Seventeen (65%) were male, and the mean (SD) age of all patients was 63 (9) years Two patients...
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Báo cáo y học: "Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis" potx
... control treated mice Recent data is suggesting that not only CD4+ T lymphocytes, but also CD8+ T lymphocytes, contribute to allergen-induced airway inflammation Depletion of CD8+ T lymphocytes ... amount of data suggests that CD8+ T lymphocytes contribute to allergen-induced airway inflammation Depletion of CD8+ T lymphocytes prior to allergen challenge has been shown to decrease Th2 cytokines, ... of the study AB carried out flow cytometry measurements and participated in drafting the manuscript JJL participated in the coordination of the study JL conceived the study, and participated...
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Báo cáo y học: " CD8+ T lymphocytes in lung tissue from patients with idiopathic pulmonary fibrosis" pot
... recent data still indicate the contention that the type of the inflammatory response may modulate tissue injury, fibrosis or both [3,4] Animal studies imply that TLs might play a role in the initiation ... symptom in these patients This study shows that the type of the inflammatory infiltrate in lung tissue of patients with UIP/IPF was predominantly mononuclear, and that among the different inflammatory ... shown that the former present a far better prognosis than the latter [43] Recent studies with BAL in scleroderma patients have shown that a subset of them, who present more than 15% lymphocytes...
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Báo cáo khoa học: Identification and characterization of novel PKA holoenzymes in human T lymphocytes pdf
... activity in Cb2-transfected 29 3T cells was precipitated Taken together it is therefore reasonable to assume that Cb2 activity may constitute more than 20% of total PKA activity in T- cells It ... activity, as shown in Fig 4B This demonstrated that precipitates extracted with 8-CPTcAMP contained cAMP-inducible PKA activity that could be inhibited by protein kinase inhibitor (PKI) In the ... human T lymphocytes Table Antibodies used to identify PKA subunits in T cells at the protein level Name Source Antigen Specificity Species Anti-PKAacat Anti-PKAbcat Anti-PKAccat Anti-Cmono Anti Cb2(SNO103)...
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Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot
... differentiation, it will be of interest to see the role of the TFKs in regulating the differentiation of this subset Together, these studies suggest that the TFKs, particularly Itk, but also Rlk ⁄ Txk, ... smaller fraction of Itk and Btk, translocate to the nucleus upon antigen-receptor activation Whether these features contribute to distinct biological roles for Rlk ⁄ Txk is not known TCR signaling ... accumulation of phosphatidylinositol (3,4,5)-triphosphate The initial step in the activation of TFKs upon TCR engagement requires recruitment to the cell membrane In the case of Itk and Tec, recruitment...
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Báo cáo Y học: Interferon-alpha inhibits Stat5 DNA-binding in IL-2 stimulated primary T-lymphocytes doc
... similar to IL-2 [8] These cytokines share the cc in IFNα 0.5h - α–Stat1 α–Stat3 α–Stat4 α–Stat5 - α–Stat3 α–Stat4 α–Stat5 - IL-2/IFNα 0.5h α–Stat1 - α–Stat3 α–Stat4 α–Stat5 Antibody IL-2 0.5h α–Stat1 ... Stat Stat - α–Stat5 IL-2/IFNα 48h IL-2 48h - α–Stat1 - α–Stat5 - α–Stat1 α–Stat5 PHA IFNα 0.5h - α–Stat1 - α–Stat5 - α–Stat1 - α–Stat5 IL-2 0.5h - α–Stat1 Antibody PHA B IL-2/IFNα 0.5h Stat Stat ... phosphorylation of the IL-2Rb chain and thereby inhibits the Stat5 activity It has been noted that activation of Stats may also contribute to the pathogenesis of human leukaemia Constitutive Stat activation...
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báo cáo hóa học:" Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients" pot
... of twelve patients examined Though the number of patients in this study was too few to discuss the exact correlation, it is possible that the CTL induction efficiency might be related to the ... assays and drafted the manuscript TT and YH participated in the design of the study and performed the evaluation of the data TT helped to draft the manuscript SI contributed to the HLA-A24-binding ... an ideal molecular target for cancer immunotherapy With this mind, we attempted to identify a HLA-A24-restricted cytotoxic T- lymphocyte (CTL) epitopes of survivin that were suitable for cancer...
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báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot
... Vivo Cytotoxicity of In Vivo Generated T Cells T2 -cytotoxicity Cumulative cytotoxicity results for all patient samples show that after two cycles of vaccination (the time point associated with the ... substantial generation of tetramer+, CD8+ , T cells In fact, the responses generated to the two DC preparations were atypical only in this particular patient The remaining patients showed the pattern ... SCC-4 cytotoxicity was observed with DCT and DCTI re-stimulated PBMCs compared with PBMCs restimulated without the class I peptides (X: p < 0.001, t- test), thus showing evidence of cytotoxicity...
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Báo cáo hóa học: "Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients" ppt
... on lymphocytes, that of naive Th cells, Treg, TEM and TCM after gating on Th cells, and that of thymicnaive Th cells after gating on naive Th cells The percentage of thymicnaive Treg is obtained ... first gated on lymphocytes and then analyzed for the expression of other surface antigens CD3+ CD8+ cytotoxic T lymphocyte (CTL) population was evaluated in a separate tube Data were collected ... indicated a real decline in newly produced B lymphocytes in the patients compared to controls This result suggests that one of the reasons of the early IgM decrease could be attributed to the reduced...
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Báo cáo sinh học: " Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages" docx
... .Y .T. E Q YAT.D Q YAT.D Q YAT.D QT.YAT.D QT.YAT.D QT.YAT.D QT.YAT.E QT.YAT.E S.QT.Y .T. E S.QT.Y .T. E QT.YAT.D QT.YAT.D Q YAT.E Q YAT.E QT.YAT.D QT.YAT.E QT.YAT.E CRIKQFINMW .I I T .K.R.I.R K.R.I.R .I ... EGDTIK.D KGDTIK.D IGTEQ.D IGTEQ.D SGQDGPK SGQDGPK N STE N STE .IDP.N EGS .D EGS .D VTHSFNC T T T T T T T T T T T T T. L T. L T T T -430 TIIVQLNTSV .E HF.E VEP VEP H.DQP H.DQP H Q H Q H Q H ... that were present in these subtype C infected patient samples were not X4 tropic Coreceptor utilization of chimeric subtype C viruses We then determined the coreceptor utilization of the subtype...
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Báo cáo sinh học: "In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2" pot
... AGG AGT CCA-3’ and 5’-AGA TCC TGC ACA GGA CTG TG-3’ for CCL8; 5’-AGG GCA TGG GTT TTA TTA TAT ATA TAT-3’ and 5’-TTT AAA AAT AAC TGA TAT TCA TGG-3’ for CCL11; 5’-TCA TCT TTC CAC AAT AAC ATA TTT A-3’ ... 5’-GTT TAT TTG AGT ATT GCT GAT CTT T- 3’ for CCL13; 5’-GGA CTT CCT GGA TCC TCC TC-3’ and 5’-AGC AGT CAG CAG CAA AGT GA-3’ for CCL15; 5’-ATG GCC CTG CTA CTG GCC CTC AGC CTG-3’ and 5’- TTA ACT GCT ... GCG CTT CAT CTT GGC-3’ for CCL19; 5’-TGT AGG GCG ACG GTT TTA-3’ and 5’-TCC ACC ACA ACA TGC AG-3’ for CCL25; 5’-GGC CCT GCC CTT ATA GC-3’ and 5’CTA ACT TGG GGT TGA CAT T- 3’ for CXCL1-3; 5’TGT TGA...
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Báo cáo sinh học: "Cytotoxic T lymphocyte responses against melanocytes and melanoma" pdf
... concentration and the negative log of the concentration The peptide concentration at which the curve crossed 40% cytotoxicity was recorded as the RE of that clone All assays were done twice Quantitative ... plots demonstrating CD107 versus CD8 levels in the two patient samples after contact with the target cell lines CD8- positive cells were further gated, showing percentage of CTLs staining positive ... participated in the discussion of results and drafted the manuscript TBS coordinated the pre-testing experiments, contributed to the refinement of experiment protocol and participated in the...
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báo cáo hóa học:" In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2" pptx
... AGG AGT CCA-3’ and 5’-AGA TCC TGC ACA GGA CTG TG-3’ for CCL8; 5’-AGG GCA TGG GTT TTA TTA TAT ATA TAT-3’ and 5’-TTT AAA AAT AAC TGA TAT TCA TGG-3’ for CCL11; 5’-TCA TCT TTC CAC AAT AAC ATA TTT A-3’ ... 5’-GTT TAT TTG AGT ATT GCT GAT CTT T- 3’ for CCL13; 5’-GGA CTT CCT GGA TCC TCC TC-3’ and 5’-AGC AGT CAG CAG CAA AGT GA-3’ for CCL15; 5’-ATG GCC CTG CTA CTG GCC CTC AGC CTG-3’ and 5’- TTA ACT GCT ... GCG CTT CAT CTT GGC-3’ for CCL19; 5’-TGT AGG GCG ACG GTT TTA-3’ and 5’-TCC ACC ACA ACA TGC AG-3’ for CCL25; 5’-GGC CCT GCC CTT ATA GC-3’ and 5’CTA ACT TGG GGT TGA CAT T- 3’ for CXCL1-3; 5’TGT TGA...
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báo cáo hóa học:" Cytotoxic T lymphocyte responses against melanocytes and melanoma" pptx
... concentration and the negative log of the concentration The peptide concentration at which the curve crossed 40% cytotoxicity was recorded as the RE of that clone All assays were done twice Quantitative ... plots demonstrating CD107 versus CD8 levels in the two patient samples after contact with the target cell lines CD8- positive cells were further gated, showing percentage of CTLs staining positive ... participated in the discussion of results and drafted the manuscript TBS coordinated the pre-testing experiments, contributed to the refinement of experiment protocol and participated in the...
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Báo cáo hóa học: "Membrane Surface Nanostructures and Adhesion Property of T Lymphocytes Exploited by AFM" ppt
... with the stimulus-induced changes in immunologic function of T lymphocytes Taken together, this investigation provides complementary and important data to further interpret the relationship between ... presents representative force– distance curves of T lymphocytes that were stimulated with PDB plus ION for 6, 24 and 48 h, respectively The statistical analysis (Fig 3h) suggests that the adhesion ... force Then, we found that the adhesion force of lymphocytes decreased with the increasing of the activation time Our results provide complementary and important data for further interpreting the...
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Báo cáo y học: "Heterogeneity of CD4+ and CD8+ memory T cells in localized and generalized Wegener’s granulomatosis." potx
... further studies have to address functional aspects such as response in vitro to chemotactic gradients, cytokine release and cytotoxic activity of distinct T cell populations Detection of the inducible ... and CD8+ effector memory T cells We further proposed that differences in the chemokine receptor expression might contribute to the recruitment of distinct effector memory T cell populations into ... inflammatory areas, which is consistent with an effector memory T cell phenotype [6–8] Because it remains an important challenge to relate the phenotype of a T cell population to its function, further...
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Báo cáo y học: " γ δ Vγ9/Vδ2 T lymphocytes in Italian patients with Behçet’s disease – evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor β1 expression in active disease" pptx
... they are the first line of host defence and control epithelial cell growth, thus participating in the maintenance of epithelial integrity [10,11] In particular, it has been postulated that they recognize ... engagement, with both TNF receptors II and I being directly involved in cytotoxic activity [37] TNF-α, which has been reported also to be produced by γ/δ T cells [33], hence might stimulate the TNF ... anti-Vδ2 TCR FITC simultaneously We also evaluated the expression of these receptors after stimulation of Vγ9/Vδ2 cells with phosphoantigens with and without the addition of exogenous human TNF-α...
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