cd4 and cd4 natural killer t cell subsets in patients with rheumatoid arthritis and healthy control individuals
Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx
... online http:/ /arthritis- research.com/content/7/3/R493 Figure patients and natural killer T individuals Frequency ofhealthy control (NKT) cells in rheumatoid arthritis (RA) patients and healthy control ... involved in the disease process of RA and that a strategy to boost the regulatory potential of NKT cells might be useful in the treatment of RA Materials and methods Patients and healthy control individuals ... cell subsets in patients with rheumatoid arthritis and healthy control individuals The observed Th1-like bias in NKT cells from RA patients might be due to an increased number of double-negative...
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Báo cáo hóa học: "Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-a 2b treatment" pptx
... week in the 22 patients with melanoma treated with interferon-a 2b (B)Box plot showing circulating regulatory T cell (Treg) levels by week in the 22 patients with melanoma treated with interferon-a ... 22 patients treated with IFN-a 2b, the 22 patients not treated with IFN-a 2b, and the 20 healthy subjects Of the 22 treated patients, 17 (77%) received postoperative adjuvant IFN-a 2b therapy and ... regulatory T cell levels at baseline in patients with melanoma and healthy subjects (A) Box plot showing baseline regulatory T cell (Treg) levels in 22 patients with melanoma prior to interferon-a...
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Báo cáo y học: "The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis" potx
... 4.82% in patients with limited joint manifestations, 7.05% in those with advanced joint involvement, and 10.35% in those with extra-articular manifestations R211 Arthritis Research & Therapy Vol ... T cells contribute to the cell infiltrate and exhibit increased survival after apoptotic stimuli Resistance to apoptosis in CD28– T cells is due to elevated expression of antiapoptotic protein ... proliferative response and resistance to activation-induced cell death In this study, the CD4+ CD28– T- cell frequency in patients with RA and healthy subjects was evaluated The frequency of CD4+ CD28– T...
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Báo cáo y học: "Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies" ppt
... under treatment (a) Spondylarthropathy patient with infliximab + methotrexate (b) Rheumatoid arthritis patient with adalimumab + methotrexate Both responses to latent peptides and lytic peptides ... distribution in control individuals (n = 15), spondylarthropathy (SpA) patients (n = 23), rheumatoid arthritis (RA) patients receiving methotrexate (MTX) (n = 18) and RA patients not receiving ... effect of MTX and anti-TNF drug on EBV-specific T- cell effector functions in patients with RA or SpA At 3month follow-up, neither MTX treatment in RA patients nor anti-TNF therapy in RA and/ or...
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Báo cáo y học: "Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysi" ppsx
... dendritic cell subsets in sepsis patients patients Diminished human leukocyte antigen (HLA)-DR expression on circulating monocyte and dendritic cell subsets in patients with sepsis at baseline and at ... blood with LPS and LTA in septic patients Although we did not determine cytokine secretion in isolated monocyte subsets, we demonstrate reduced intracellular levels of TNFα and IL-6 in both CD16negative ... frequencies in sepsis patients patients with sepsis at baseline and at day 28 compared with controls (a) Monocytes were gated using a forward scatter/side scatter plot and a CD14/CD33 scatter plot, where...
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Báo cáo y học: "The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosus" potx
... hnRNP-A2 in patients with SLE and in healthy control subjects and characterized TCCs specific for this antigen The data obtained suggest that hnRNP-A2 may constitute an important T cell autoantigen in ... vigorous than in healthy controls In contrast, the response to the control antigen tetanus toxoid was similar in patients and controls, demonstrating the specificity of the immune response towards ... patients and two healthy controls) were stimulated with anti-CD3 and antiCD28 mAbs and subsequently incubated with supernatants from two CD8+CD28- and two CD4+ CD28+ TCCs derived from SLE patients...
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Báo cáo y học: "Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis" pdf
... subjects plotted against concentrations of the relative interferon (IFN)-γ in (a) healthy donors (HDs) and (b) patients with RA and of interleukin (IL)-10 in (c) HDs and (d) patients with RA after ... characteristics of the healthy control subjects and patients with RA studied Patients with RA (n = 16) Control group (n = 16) Gender (female/male) To further investigate the impact of catecholamines ... catecholamines on TNF-α and IL-10 production in patients with RA and HDs is in agreement with the unchanged β2R agonist-induced cAMP generation in CD4- and CD8-positive T cells of patients with...
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Báo cáo y học: "Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study" ppt
... introductory intervention period lasted to days for both groups During that period, the patients received instructions in the theory and practical preparation of the diet in question Thereafter, ... months Furthermore, at each visit to the clinic, the patients were questioned about compliance with the study diet Also, between visits, the nurse made phone calls to the patients and the patients ... present in RA, but it is interesting to note that oxLDL is present in foam cells in synovia from patients with RA [47], indicating that oxLDL also could play a role in the pathogenesis of RA Antibodies...
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Báo cáo y học: "Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study" pdf
... related to the fact that most patients had low inflammatory activity However, when separating the patients into those with low DAS28 and those with DAS28 corresponding to moderate activity it was ... CVD in the patients with rheumatoid cachexia In the present cohort of patients we did not find that DAS28 or CRP differed between those with cachexia and the rest of the patients, probably related ... the RA patients had a low intake of total energy As to the diet composition, the patients reported lower carbohydrate intake and higher fat intake than recommended The fat intake consisted of...
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Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" ppsx
... disease activity with available means, including judicious usage of GCs Competing interests The authors declare that they have no competing interests Authors' contributions TET participated in the ... conception and design of the project and in the analysis and interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and ... of patients in the ME group (P = 0.027) but not in the LE group The other individual components that contribute to the definition of the metabolic syndrome (waist circumference, HDL, and fasting...
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Báo cáo y học: "Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis" ppt
... of patients with RA and its signaling transduction pathway We found that the intracellular signaling pathway involving phosphoinositide 3-kinase (PI3K)/Akt and NF-κB might be involved in the ... information for the future molecular targeting of new therapeutic applications in RA Competing interests The author(s) declare that they have no competing interests Available online http:/ /arthritis- research.com/content/7/1/R139 ... 24), patients with cells from patients with rheumatoid arthritis (RA; n = 24), patients with osteoarthritis (OA) (n = 14) and normal individuals (n = 14) Each peripheral blood mononuclear cell...
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Báo cáo y học: " A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab" docx
... destruction Competing interests The authors declare that they have no competing interests Authors' contributions The initial draft of the report was written by HM and PM Patients were recruited ... accordance with the ATTRACT [Anti-TNF Therapy in RA with Concomitant Therapy] protocol [7]) All of these patients were included in the study and followed over year RA activity was evaluated using the ... trial Another option is to perform a historical control study, with controls being active RA patients followed before the advent of TNF-α blocker therapy and who were treated with methotrexate...
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Báo cáo y học: "Expert agreement confirms that negative changes in hand and foot radiographs are a surrogate for repair in patients with rheumatoid arthritis" pot
... Settas J, et al.: Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled ... Conclusion in analysisb Bettera First time point Progression Better Second time point Repair Better and first time point First time point Reader recognized progression Better and first time point Second ... assignment was 85% (κ = 0.69) Exercise III The complete sets of hand and foot films of the 60 patients that included 64 joints-of-interest (four patients had more than one joint of interest) presented...
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Báo cáo y học: "The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis" doc
... inflammation becomes apparent after 24 hours and leads to total destruction of the joint within to 10 days, controlateral joints or joints receiving control 3T3 cells not exhibit signs of inflammation ... blocker rather than anakinra as a first biologic agent to treat RA patients, concordant with a recent consensus statement, and national and international registries [3] Treatment with recombinant IL-1Ra ... dose-escalating, proof-of-concept study in patients with RA – the first of its kind in humans The study's primary objective was to investigate safety and tolerability; therefore, it was not powered to investigate...
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Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" pptx
... disease activity with available means, including judicious usage of GCs Competing interests The authors declare that they have no competing interests Authors' contributions TET participated in the ... conception and design of the project and in the analysis and interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and ... of patients in the ME group (P = 0.027) but not in the LE group The other individual components that contribute to the definition of the metabolic syndrome (waist circumference, HDL, and fasting...
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Báo cáo y học: "Antibodies to cyclic citrullinated protein and erythrocyte sedimentation rate predict hand bone loss in patients with rheumatoid arthritis of short duration: a longitudinal study" pdf
... years followup Of the 163 patients in this study, 128 had X-rays at all four time points, 29 at three time points and six patients at two time points The patients with and without hand X-rays had ... RA patients treated with penicillamine [24] Kalla and colleagues have also shown that DMARD treatment increase the cortical bone mass in RA patients [25] The DMARD-treated patients in this study ... understanding of antiCCP and ESR as important predictors of bone involvement in RA The bone involvement in RA has been shown to start in the inflamed synovium that express receptor activator of...
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Báo cáo y học: "Musculoskeletal ultrasound imaging of the plantar forefoot in patients with rheumatoid arthritis: inter-observer agreement between a podiatrist and a radiologist" pptx
... Thirty two patients with RA were recruited One patient withdrew due to time issues during the visit Thirty one patients completed the study There were 24 female and male patients, 12 seronegative and ... Thirty minutes was allowed for each assessment and thus was limited to two joints within each foot The second MTPJ was selected for investigation because it is in line with the centre of load through ... patients with RA This work forms part of an ultrasound based research programme investigating the clinical relevance of soft tissue inflammation within the forefoot of patients with RA Materials and...
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Báo cáo y học: "Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study" pps
... Competing interests The authors declare that they have no competing interests Authors' contributions DAP participated in the study design, data collection and analysis as well as in writing and ... by TNF inhibitors (42%) and prednisone (37%) Ninety-two patients (58%) in the cohort had a history of smoking At the time of the present analysis, 158 patients in the cohort had completed PFT testing: ... (eight patients) , asthma (eight patients) or rheumatoid lung disease (two patients) Demographic characteristics did not differ among those with and without PFT abnormalities; however, the proportion...
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Báo cáo y học: "The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional study" pdf
... Putte LB, van Riel PL: Modified disease activity scores that include twenty-eightjoint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis ... participated in the design of the study and helped with data analysis and drafting the manuscript All authors read and approved the final manuscript Competing interests The authors declare that ... consecutive rheumatoid arthritis (RA) patients were recruited from the rheumatology outpatient clinics of the Dudley Group of Hospitals NHS Trust, UK All patients met the retrospective application...
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Báo cáo y học: "Disease activity and low physical activity associate with number of hospital admissions and length of hospitalisation in patients with rheumatoid arthritis" pdf
... admitted) stayed as inpatients at the hospital after they were admitted The length of hospitalisation for these 32 patients was: a) between one to five days for eight patients (25% of the 32 patients) , ... admitted to the hospital within one year The number and frequencies for hospital admissions appear in Table Regarding the length of hospitalisation, 32 patients (out of the 94 patients admitted) ... to routine outpatient monitoring appointments or visits for routine day-case therapy Statistical analyses Kolmogorov-Smirnov normality tests were utilised to investigate the normal distribution...
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