... two-fold had increased expression levels in L infantum MTX20.5 but the majority of another set of genes had decreased expression levels in L major MTX60.4 (inserts of Figure 2; Table S1 in Additional ... the expressionof orthologous genes where the expression changes in the two species; the middle panel shows the modulationin the expressionof FBT genes; the lower panel shows the expressionof ... 0.1 1e2 1e3 Signal intensity 1,000,000 2,000,000 1e4 Base pairs Figure ofgeneexpressionin Leishmania cells resistant to methotrexate ModulationModulationofgeneexpressionin Leishmania cells...
... context of CpG (cytosine followed by guanine) dinucleotides Methylation of cytosines in DNA is important in the regulation ofgeneexpression ROS attack frequently results in the conversion of guanine ... expression Using a general protein tyrosine phosphatase inhibitor reduced the inhibitory effect of BCG on GSTT2 expression indicating a possible role for mycobacterial protein tyrosine phosphatase ... [34-36] The pattern of urinary cytokines suggests the predominance of a TH1 type of immune response in the bladder TH1 cytokines are responsible for the initiation and maintenance of inflammatory responses...
... assessments The lamina splendens was not disrupted in any location based on lack of India ink staining, indicat- ing that AC surface integrity was maintained for two weeks in the dogs in this study ... level ofexpression for each gene (± standard error) compared to the house keeping gene GAPDH The increase in ADAMTS geneexpressionin the CrMFC approached significance and was included in the ... determine the feasibility of analyzing changes ingeneexpressionof articular cartilage two weeks after ACL-transection The specific aims of this study were to determine if changes in relevant gene...
... among the IFN-induced genes overexpressed in the JDM muscle samples Increased expressionof several genes, including G1P3 (encoding IFN-induced 6-16) and CDKN1A (p21 cyclin kinase inhibitor), were ... in clinical studies as a measure of diagnosis or clinical outcome [11] Microarray analysis ofgeneexpression at sites of tissue damage The next generation of reports describing global geneexpression ... galactoside-binding, soluble, binding protein 3.8 Up IL1RN Interleukin-1 receptor antagonist 3.5 Up APOBEC3B Phorbolin 1-like 2.0 Up RGS1 Regulator of G-protein signaling 1.8 Up AGRN Agrin > 71.2...
... representation of differences ingeneexpressionof adult and cord blood monocytes in response to LPS Figure Heat map representation of differences ingeneexpressionof adult and cord blood monocytes in ... on the basis of kinetics ofexpressionExpression level (in relative intensity units) is shown of the y-axis and time on the x-axis At the 45 time point, significant differences inexpression level ... for genes selected as HV-genes in cord blood and adult monocytes, belonging to five clusters of highest content A Genes of the same cluster in cord and adult; B Genes of different cluster in cord...
... characterization of genes in each cluster Detail information of genes within each cluster is elaborated in Additional File and Monitoring expression profiles of selected high expressing genes More stringent ... expression profiles in PUSABGD72 The expression profile of individual genein the cluster is denoted by grey line and the mean expression profile is depicted by pink line The number of genes in each cluster ... early expressionof genes involved in protein synthesis in a salt-tolerant rice variety in response to salt stress [8] Genes involved in signal transduction showed a simple pattern of relative expression...
... meaning of the changes ofexpressionof large sets of genes [28] Gene ontologies are definitions of genes using a well defined species-independent vocabulary GO were not available for most of the genes ... based ingeneexpression about which putative CPC genein cotton was more likely involved in fiber development If CPC genes in cotton act as inhibitors of fiber initiation, reducing expressionof ... validated expression profiling data Statistical analyses of GO also validated the expression profiling data by identifying an increase in protein biosynthesis in fiber initials and cell wall remodeling...
... An increase in PAI-1 suppresses the generation of plasmin resulting in hypofibrinolysis and a relative hypercoagulable state [1] Decreased fibrinolytic activity, which may be a consequence of increased ... cells in the body In keeping with the theory of endothelial cell activation having a role in ANFH, coagulation-related geneexpressionin particular serine (or cysteine) peptidase inhibitor, clade ... immunohistochemical findings for the two other genes of interest (COL2A1 and MIA) failed to show enhanced protein expression Discussion The early events in the pathogenesis of ANFH are incompletely understood...
... are engineered to contain genes surrounded by loxP sites, resulting in a recombinant strain of mouse that eliminates a gene s expression only in the cells that express the Cre These lines will ... a combination of axon tracing and geneexpression data to categorize pyramidal neurons in layer of the neocortex in mice, demonstrating that the anatomical distinctions also have gene- expression ... Institutes of Health (NIH) has been working in parallel on the GeneExpression Nervous System Atlas (GENSAT) to establish a resource of targeted knockouts of brain-specific mouse genes with interesting...
... thought to activate Wnt (wingless int) signaling by stabilizing β-catenin, we investigated the expressionof Wnt genes in treated embryos A Q-PCR survey of all 11 Wnt genes in S purpuratus reveals ... Figure Expressionof Wnt genes in lithium and zinc treated embryos Expressionof Wnt genes in lithium and zinc treated embryos Quantitative real-time polymerase chain reaction (Q-PCR) analysis of ... identified 250 genes exhibiting a restricted expression pattern An analysis of global geneexpression using whole-genome tiling arrays indicates that 9,000 genes are expressed in the sea urchin embryo...
... profile (Figure 4b) parallels immunostaining and GFP reporter results showing expressionof this gene family in the C elegans nervous system [43] Transcripts encoding insulin-like peptides (ins) ... neural genes (a) Histogram showing fraction of annotated genes in microarray datasets with known in vivo expressionin neurons The list of annotated genes used for this comparison includes all genes ... binding For example, the JIP3/JSAP1 JNK scaffolding protein, UNC-16, interacts with KLC-2 (kinesin light chain) to regulate vesicular transport in neurons [68] Other members of this interacting...
... activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle J Clin Invest 1994, 94:277-285 Pugh BF: Control ofgeneexpression through regulation of the TATA-binding protein Gene 2000, ... applications of LeFE, to geneexpressionin three breast cancer classes and to in vitro gefitinib sensitivity (see Results), provide further proofs of principle The findings highlight the distinctions ... depends, of course, on the relative cost and benefit of following up the finding The predictions are clearly not as strong in the case of gefitinib as in the other two applications of LeFE presented...
... SLA2/Huntingtin-interacting protein Hip1 Y66H1B.3 462 784 Actin-binding cytoskeleton protein, filamin Y66H1B.2 119 902 Actin-binding cytoskeleton protein, filamin 766 20 Actin-binding protein Coronin, contains WD40 ... Actin regulatory proteins (gelsolin/villin family) Y71G12B.11 122 Talin W03F11.6 afd-1 - 393 Actin filament-binding protein Afadin F08A8.6 tag-138 - 474 Actin-binding protein SLA2/Huntingtin-interacting ... 24 genes encoding proteosome subunits show elevated expressionin the M24 dataset whereas none of these transcripts are enriched in the M0 profile This finding could be indicative of the general...
... interferonstimulated gene 12 (IFI27), interferon-induced protein 6-16 (G1P3), and interferon-inducible proteins 15 and 44 (G1P2, IFI44) Also down-regulated were genes encoding immunoglobulin light, joining, ... glucocorticoids in vitro, including http://genomebiology.com/2007/8/9/R189 decreased expressionof the GR NR3C1 gene, post-translational modification of GR protein, increased expressionof GR antagonists, ... combinations of promoter length and motif match Bioinformatic indications of a simulatneous decrease in transcription of GR target genes (.53-fold difference) and an increase in transcription of...
... knowledge not only of the genes expressed in the diseased tissues of interest, but also on detailed information about the expressionof the corresponding genes across the gamut of normal human tissues ... understanding of both the genes and the organs Interestingly, we also identified a smaller number of genes displaying selectively decreased expressionin some organs, for example, splicing factor ... been used to profile geneexpressionin cancer and other diseases In cancer, for example, microarray profiling has been applied to classify tumors according to their sites of origin [3-5], to discover...
... Testes 0553 Brain, temporal cortex 2272 Brain, occipital cortex 2271 Brain, frontal cortex 2271 Brain, frontal cortex 2272 Brain, occipital cortex 2273 Brain, occipital cortex 2272 Brain, temporal ... Prostate-specific geneexpression cluster, extracted from the hierarchical cluster shown in Figure 1a, displayed as mean-centered relative geneexpression (ratio-fold change scale indicated) (c) The same gene ... (c) The same geneexpression feature as in (b), now displayed as transcript abundance (relative to the average transcript level for all expressed genes), calculated indirectly using the common reference...
... alter geneexpression patterns in postmortem human brains Study ofexpression levels of 14 genes in human brain autopsy and biopsy samples found significant change in one of the genes, indicating ... of genes involved in ubiquitin-dependent protein catabolism may lead to increased degradation of proteins in human brain samples after death This could have consequences for protein studies in ... effect of death on geneexpressionin human brain, postmortem samples maintain the vast majority of the expression differences that exist between brain regions in vivo However, the amplitude of expression...
... candidates from coding and non-coding subgroups of NAT, which could potentially modulate sense mRNA through two distinct modes of action One of the most exciting findings in genome biology in recent years ... expressionof TS, rTSα, HIF and aHIF with that of a relatively low abundance gene product, TATA binding protein (TBP) The S-AS mRNA expression levels were 5% to 13% of that of β2M, as expected for genes ... http://genomebiology.com/2006/7/5/R38 using strand specific intron spanning probes (the schematics for the TS sense-antisense gene and probes are illustrated in Figure 1a) Importantly, the use of intron spanning probes eliminate...
... expression _ ratio _ of _ gene _ i _ in _ experiment_j ) Median _ of _ all _ expression _ ratios _ in _ experiment_j We define the expression level of each genein a given operon of m genes as gi for ... of genes showing high correlation ingeneexpression using either metric However, although microarray data are useful in predicting operons, the ideal condition of perfectly correlated gene expression, ... regulate certain genes within an operon independently, which may require the presence of an internal upstream terminator and promoter, as well as a terminator downstream of the gene This would in effect...
... stimulating proliferation, serum exposure induces a wound healing response in fibroblasts, involving the activation of genes that play a role in intercellular signaling and remodeling of the extracellular ... paracrine CCL5 signaling [23] The expressionof inflammation-related genes in cancer tissue is frequently interpreted as a consequence of an immune response against the tumor Interestingly, the developmental ... properties ofgeneexpression dynamics during a continuous developmental process: starting at the earliest (least differentiated) instance of a series of conditions, genes that are characteristic of...