carcinogens in foods occurrence modes of action and modulation of human risks by genetic factors and dietary constituents
Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot
Ngày tải lên :
08/03/2014, 09:20
... nm), time interval of 360 s and a step-size of 0.003 cm without averaging Multiple scans at different time points were fitted to a single species or Ó FEBS 2002 Binding of apolipoprotein E3 and E4 ... using the direct binding assay as described in Experimental procedures Inset: Linearized plot of the binding data for apoE(263–286) (symbols) shown in panel A The solid line represents the linear ... notably distinct in their maximum binding capacities (Table 2) In particular, the binding footprint for the apoE4 isoform, corresponding to 3.0 amino acids per phospholipid, is almost twofold greater...
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Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
Ngày tải lên :
30/03/2014, 04:20
... enhancement induced by Glc binding; (b) to identify the active site residues involved in the binding of Glc to the super-open state (Fig 1C) of this two domain [large (L) and small (S)] enzyme, and thus ... (C) The Glc binding isotherm at 25 °C was obtained by monitoring the enhancement in ITF of wild-type GST-hGK (s) and wild-type hGK ( ) by increasing concentrations of Glc The solid lines represent ... of glucokinase by D-glucose binding J Molnes et al open (inactive) to the fully-closed (active) conformation The interhelical salt bridges and pairs of residues involved in hydrophobic interactions...
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Báo cáo lâm nghiệp: "Changes in phenolic acids and stilbenes induced in embryogenic cell cultures of Norway spruce by two fractions of Sirococcus strobilinus mycelia" pot
Ngày tải lên :
07/08/2014, 10:21
... containing intracellular proteins – 12.20 mg protein g–1 mycelium fresh weight, according to assays following the method of Bradford (1976) using bovine serum albumin as a standard The final ... embryogenic cultures of Norway spruce (C) and in the cells elicited by mycelium protein fraction (PF) and mycelium wall fraction (WF) in the course of 24 h Means ± Standard Error of two independent experiments ... control) The decline in the levels of isorhapontin and astringin continued 24 h after PF application representing less than 68% and 50%, respectively, of the contents determined in the control...
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Báo cáo y học: "Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer" pps
Ngày tải lên :
09/08/2014, 14:22
... primary MSCs and to investigate whether levels and extent of hypertrophy in vitro is influenced by the choice of transgene Materials and methods Construction and preparation of recombinant adenoviral ... defects in humans [5,6] However, to date, the delivery of MSCs into cartilaginous lesions has neither clinically nor experimentally resulted in sustained regeneration of hyaline cartilage in vivo ... supported in parts by grants AR48566 and AR50249 from to National Institute of Arthritis and Musculoskeletal and Skin Diseases to SCG and CHE, by grant STE 1051/2-1 from the Deutsche Forschungsgemeinschaft...
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báo cáo khoa học: "Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells" doc
Ngày tải lên :
10/08/2014, 22:21
... mechanism involved in ZEA-induced apoptotic death in human leukemic cells ZEA targets mitochondria and/ or lysosomes and induces lipid peroxidation (indicating oxidative stress) and cell death in human ... caltreticulin exposure by flow cytometry as described in Materials and Methods Histogram of FACS analysis represents one of three independent experiments Proteomic profiling of ZEA-treated and untreated ... ZEA-induced apoptosis and necrosis occur in human PBMCs in vitro depending on the concentrations of ZEA [41] The major metabolites of ZEA in various species are alpha and beta zearalenol Alpha and...
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báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc
Ngày tải lên :
11/08/2014, 00:23
... Davidson B: Diagnostic and prognostic role of the insulin growth factor pathway members insulin-like growth factor-II and insulin-like growth factor binding protein-3 in serous effusions Hum ... Plasma insulin-like growth factor-I and serum IGF-binding protein can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American ... http://www.jnanobiotechnology.com/content/9/1/36 Page of 14 Kim JH, Cho YH, Park YL, Sohn JH, Kim HS: Prognostic significance of insulin growth factor-I receptor and insulin growth factor binding protein-3 expression in primary breast...
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Báo cáo khoa hoc:" Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210" pptx
Ngày tải lên :
11/08/2014, 08:20
... A isoform, which lacks a 17 amino acid insert and the KTS insert in the zinc finger region, did not influence GP210 expression in SAOS osterosarcoma cells, in a system using tetracycline-induced ... localization of human α11 integrin A collagen-binding, I domain-containing, β1-associated integrin α-chain present in muscle tissues J Biol Chem 1999, 274:25735-42 von Heijne G: Membrane protein structure ... µg of HeLa and WCCS-1 Loading and RNA quality was controlled by a methyleneblue staining of 18 and 28s rRNA using a 935 bp cDNA probe (nt 4286–5220), a single transcript of 7,3 kb was seen in...
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Luận văn ellipsis in english an analysis of errors made by secondary school students = phân tích lỗi thường gặp của học sinh THPT trong việc sử dụng phép tỉnh lược trong tiếng anh
Ngày tải lên :
20/12/2013, 18:16
... problems in understanding and using English ellipsis The results of four exercises indicate that students' errors belong to two main types: interlingual and intralingual errors The interlingual ... consist of interlingual, intralingual and mixed type The interlingual errors are derived from mother tongue interference The intralingual ones are derived from incomplete application of rule ... easily made in Pre- intermediate and Intermediate levels In Vietnamese, there is no distinction between plural and singular noun in the way of writing or speaking As a result, the learner often writes:...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
Ngày tải lên :
21/02/2014, 00:20
... sequence Binding of the GT oligomer was not a result of DNA interaction with the more abundant components of the nuclear extract, as revealed by Ponceau staining of the immobilized proteins In fact, ... eEF1A in maintaining the viability and proliferative activity of cancer cells One hypothesis may be that these oligomers exert their action by blocking the binding of eEF1A to its ligand in cancer ... amino acid sequence, increasing the number of basic residues of lysine, arginine and histidine, could occur However it seemed probable that the eEF1A isoforms could act as a controlling event in...
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Báo cáo khoa học: Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase potx
Ngày tải lên :
08/03/2014, 08:20
... lation of hPAH at Ser16 by PKA results in a 1.4-fold Wright, H.T (1991) Nonenzymatic deamidation of asparaginyl increase in the basal activity and a 1.7-fold increase in and glutaminyl residues in ... Biochem 270) Fig Effect of L-Phe (A and C) and H4 biopterin (B and D) concentration on the catalytic activity of recombinant wt-hPAH and hPAH(Asn32fiAsp) obtained after h of induction in E coli at 28 ... followed by scintillation counting and analysis of the data by the PEAKFIT software program Each data point represents the average value obtained in three separate experiments, and the two lines...
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Báo cáo khoa học: Metal exchange in metallothioneins – a novel structurally significant Cd5 species in the alpha domain of human metallothionein 1a ppt
Ngày tải lên :
16/03/2014, 06:20
... present in the a domain of human MT 1a (C) Space-filling and ribbon representations of the recombinant Cd4a-rhMT 1a Numbering of metal ions is based on NMR numbering of mammalian MT [11] and cysteine ... shown in Fig 1A This sequence encompasses the metal-binding cysteines between Cys33 and Cys60 of the a domain of native human metallothionein 1a but also includes amino acids not found in the ... (1974) Binding of cadmium and mercury by metallothionein in the kidneys and liver of rats following repeated administration Archiv Toxikol 32, 351–360 Harford C & Sarkar B (1991) Induction of metallothionein...
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Báo cáo hóa học: " Discovery of significant variants containing large deletions in the 5''''UTR of human hepatitis C virus (HCV)" pot
Ngày tải lên :
20/06/2014, 02:20
... deletions of 113 or 116 bp were limited to the region between two strings of C's, with 56% of the sequences containing deletions lacking 113 bp and 44% lacking 116 bp Most of the IRES, including loops ... containing large deletions should prove useful in understanding translation of HCV RNA Methods The in vitro culture system, RT-PCR, sequencing, and bioinformatics were performed as described in ... numbers of EF028185, EF028184, EF028187, and EF028188 Declaration of competing interests All intellectual rights are reserved by the California Institute of Molecular Medicine (CIMM), and all...
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Báo cáo sinh học: "Pitfalls in the phylogenomic evaluation of human disease-causing mutations" potx
Ngày tải lên :
06/08/2014, 19:20
... conservation and protein motifs Finnerty et al [1] examined the impact of amino acid changes in human MSX1 using the multivariate analysis of Journal of Biology 2009, 8:26 26.4 Journal of Biology ... each individual sequence variant Prompted by the clefting phenotype in Msx1-/- mice [6] and by the occurrence of CL/P associated with a heterozygous S105X mutation in four out of twelve members of ... identified by Finnerty et al [1] are shown in Figure 1a (blue arrowheads) They are all located within the most highly conserved regions of the protein (one in the MH1N domain and four in the homeodomain)...
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Báo cáo y học: " Tumour necrosis factor-α stimulates HIV-1 replication in single-cycle infection of human term placental villi " docx
Ngày tải lên :
13/08/2014, 09:20
... soaked in one case with ml of plain histoculture medium and in the two other wells soaked in ml of histoculture medium containing recombinant human TNF-α (R&D systems, Deutschland) in final concentrations ... dose range of 20 to 100 ng of p24 antigen to infect human placental fragments in contrast to the 250 to 400 ng of p24 antigen used by Vidricaire and colleagues to infect cells Finally in our experiments, ... dependent of the dose tested (5 and 50 ng/ml) is consistent with a recent finding demonstrating that the temporal profile of the NF-kB activity is invariant to a wide range of TNF-α doses going from...
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Báo cáo y học: "Tandem repeat copy-number variation in protein-coding regions of human genes" docx
Ngày tải lên :
14/08/2014, 14:21
... by linking LocusLink to both UniGene and GO and also by linking UniGene to EMBL and then linking, via the EMBL accessions, to UniProt and thence to GO Links were subsequently completed by adding ... Distribution offollowing page) of tandem repeats Distribution of copy-numbers of tandem repeats The x-axis indicates the number of tandem repeat loci of a given unit length (indicated by color key) and ... approximately in 5,000 transcripts in dinucleotide tandem repeats [48]: in our survey of 5,304 sequences containing 8,449 dinucleotide repeats, we found an incidence of 36 frameshifting dinucleotide...
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An investigation into the translation of idioms in some english versions of truyện kiều by nguyễn du
Ngày tải lên :
06/07/2015, 16:39
... consisting of alternating lines of six words followed by eight ones 9 So far, there have been English versions of Truyện Kiều including Kim Van Kieu by Lê Xuân Thủy (1968), The Tale of Kiều by Huỳnh ... examine the translation equivalence of idioms in Truyện Kiều in the English versions in terms of syntax and semantics - To identify the similarities and differences in the translation of idioms in ... idioms After examining and analyzing 600 samples including 200 Vietnamese idioms in Truyện Kiều and 400 English translation equivalents in two English versions by Huỳnh Sanh Thông and Vladislav...
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Tài liệu Báo cáo Y học: Study of substrate specificity of human aromatase by site directed mutagenesis pdf
Ngày tải lên :
21/02/2014, 15:20
... produced difficulties in maintaining the overall three-dimensional structure of the steroid Indeed, during the minimization, steric interactions between V370 and the A ring of the androstenedione led ... of NaCl/Pi containing 2–8 ng of purified equine aromatase (standard curve) were mixed with 800 lL of polyclonal antibody Fig Standard curve of ELISA (A) The standard curve was obtained by mixing ... group of the steroid our mutants modified the binding affinity for androstenedione and the inhibitory potential of inhibitors In this case, by introducing a hydroxyl group, accessibility of the...
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Báo cáo Y học: Concentration-dependent reversible activation-inhibition of human butyrylcholinesterase by tetraethylammonium ion pptx
Ngày tải lên :
24/03/2014, 03:21
... Recombinant wild-type and mutant human BuChEs Two amino-acid residues (D70 and Y332) in the PAS and two (W82 and A328) in the CS, known to play a role in the binding of positively charged ligands and ... on the wild-type human BuChE in water reveal after 180 ps very interesting TEA positioning From the starting site in the vicinity of W82 indole ring it moved upward the cleft and accommodated ... concentrations indicating that either the interaction of TEA with the free enzyme is very weak or an Table Characteristic constants for the interactions of various human butyrylcholinesterases and horse...
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báo cáo hóa học:" Research Article Real-Time Multiview Recognition of Human Gestures by Distributed Image Processing" pdf
Ngày tải lên :
21/06/2014, 20:20
... consists of three stages of gestural image processing: (1) feature extraction, (2) feature-based learning/matching, and (3) gesture protocolbased learning/recognition By applying three kinds of feature ... magnitude of processing load The control inputs are pattern scanning interval Sk , pattern matching interval RSk , and the number of effective visual interest points Nvip Here, Sk refers to the jump interval ... deal with slow and unstable frame rate caused by the following factors: (1) increase in pattern matching cost, (2) increased number of recognition agents, and (3) load fluctuations in the third...
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OPTIMAL placement of FACTS devices by genetic algorithm for the increased load ability of a power system
Ngày tải lên :
26/03/2016, 02:38
... University,Kolkata in 2006 He is currently working as Associate Professor in Electrical Engineering in Indian School of Mines, Dhanbad He is in Indian School of Mines, Dhanbad since April, 2007 ... calculating the power flow in each line UPFC positions are determined by identifying the lines carrying large active power The active power flow is very high in lines 6,7& These lines are again connected ... Academy of Science, Engineering and Technology International Journal of Electrical, Computer, Energetic, Electronic and Communication Engineering Vol:5, No:3, 2011 And Voltage magnitude constraints:...
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