cancer genomics from bench to bedside
Báo cáo sinh học: "Guiding cancer immunotherapy from bench to bedside" docx
Ngày tải lên :
18/06/2014, 22:20
... investigators are using autologous dendritic cells or artificial antigen presenting cells pulsed with tumor antigens to expand cytotoxic T cells for melanoma therapy [8,9] Immune therapy of cancer ... therapy protocols have also begun to use NK cells Clinical investigators interested in treating both cancer and hematologic malignancies and leukemia have been using both allogeneic and autologous ... cancer involves arming autologous T cells with T cell receptors (TCR) that have a high affinity to cancer antigens, expanding these genetically modified T cells in vitro and infusing them into...
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PROSTATE CANCER – FROM BENCH TO BEDSIDE pptx
Ngày tải lên :
27/06/2014, 17:20
... Prostate Cancer – From Bench to Bedside for to years and (2) RRP +/-neoadjuvant/adjuvant chemohormonal therapy preferably as part of a clinical trial Recent data from the Memorial Sloan Kettering Cancer ... 34 Prostate Cancer – From Bench to Bedside orchiectomy are also adrenalectomized This operation was conclusively remo-ving the adrenal lifesaving functions of unknown fictive factors; Cycloprostatins ... Impotence following radical prostatectomy: insight into etiology and prevention J Urol, Vol 128, No 3, (Sept 1982), pp 492-7 10 Prostate Cancer – From Bench to Bedside Yossepowitch O, Eggener SE,...
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HUMAN PAPILLOMAVIRUS AND RELATED DISEASES – FROM BENCH TO BEDSIDE A DIAGNOSTIC AND PREVENTIVE PERSPECTIVE potx
Ngày tải lên :
08/03/2014, 19:20
... efforts has shifted from cervical cancer detection to the diagnosis and treatment of cancer precursor lesions However, 41 42 Human Papillomavirus and Related Diseases – From Bench to Bedside A Diagnostic ... contribute to oral cancers [17], 2006) Additionally, these cancers, in contrast to cervical cancer, appear to be preferentially associated with HPV16 [11,14] For instance, in the subset of penile cancer ... appeared to be HPV-negative and normal cervical tissues and they found that miR-21 to be overexpressed in the cervical cancer samples 39 40 Human Papillomavirus and Related Diseases – From Bench to Bedside...
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HUMAN PAPILLOMAVIRUS AND RELATED DISEASES – FROM BENCH TO BEDSIDE RESEARCH ASPECTS pdf
Ngày tải lên :
27/06/2014, 13:20
... which rated from 13% in South/Central America to 22% 26 Human Papillomavirus and Related Diseases – From Bench to Bedside – Research Aspects Table Incidence of HPV infection related to ICC, HSIL ... allowing automation of HPV genotyping assays In addition, new molecular biological tools in the diagnosis and treatment of cervical cancer are included, next to the development of a research tool to ... husband of women with cervical cancer are at higher Human Papillomavirus and Related Diseases – From Bench to Bedside – Research Aspects risk of upper aerodigestive track cancer (Hemminki et al, 2000)...
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HUMAN PAPILLOMAVIRUS AND RELATED DISEASES – FROM BENCH TO BEDSIDEA CLINICAL PERSPECTIVE potx
Ngày tải lên :
27/06/2014, 15:20
... intragenomic regulators (Bouvard et al., 1994) The E2 protein can bind to factors on mitotic chromatin and join the virus genome to host cell chromosomes during mitosis; it contributes to coordinating ... non-inflammatory epithelial environment can also be sufficient to induce a peripheral tolerance to E7 in the cytotoxic T lymphocytes population (Tindle, 2002) E6 also interacts with the adaptor protein ... history of cervical cancer is characterized by slow disease progression, generally taking over 10 years, from the initial infection with HPV, to the diagnosis of cancer In essence, cervical cancer...
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báo cáo khoa học: "ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside" doc
Ngày tải lên :
10/08/2014, 22:20
... growth factor in human hepatocellular carcinoma Hepatology 1998, 28:68-77 Baldo P, Cecco S, Giacomin E, Lazzarini R, Ros B, Marastoni S: mTOR pathway and mTOR inhibitors as agents for cancer therapy ... [36] mTOR is also a central downstream effector of PI3K/AKT pathways.[37] The mTOR signaling pathway has been reported to be deregulated in HCC [38,39] Rapamycin, a mTOR inhibitor, binds to the ... survivin all together integrate leading aberrant STAT signaling activity and contribute to resistance to FLT3 inhibitors The discovery of this novel mechanism of resistance to FLT3 inhibitors, as...
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Báo cáo y học: "Coagulation cascade in sepsis: getting from bench to bedside" pot
Ngày tải lên :
12/08/2014, 19:21
... individual intrinsic response at the bedside For any new therapy resulting from our expanded knowledge of the clotting cascade in the inflammatory response to be tailored to the needs of the individual ... inflammatory response will be required Unless any new therapies have very benign toxicities, the need to assess the need, dosage and response to treatment will mandate sensitive and specific monitoring ... monitoring techniques Bedside or clinical laboratory techniques that could be applicable to most clinical environments would allow the benefit of any new therapies to be applied to the greatest number...
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Oncogene and Cancer – From Bench to Clinic Edited by Yahwardiah Siregar ppt
Ngày tải lên :
16/03/2014, 21:20
... PR receptors are weak prognostic indicators and should not be used to determine whether to treat a patient with adjuvant therapy Newer guidelines from a Oncogene and Cancer – From Bench to Clinic ... guidelines) is to monitor response to therapy in the metastatic breast cancer setting Candidate Protein Biomarkers with possible clinical application in breast cancer i Topo2-alpha (Topo2) DNA topoisomerase ... sought to use serum markers to optimize treatment strategies in breast cancer The authors investigated serum 20 Oncogene and Cancer – From Bench to Clinic Her2 levels (sHer2) in 175 breast cancer...
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Oncogene and Cancer – From Bench to Clinic Edited by Yahwardiah Siregar docx
Ngày tải lên :
23/03/2014, 14:20
... PR receptors are weak prognostic indicators and should not be used to determine whether to treat a patient with adjuvant therapy Newer guidelines from a Oncogene and Cancer – From Bench to Clinic ... guidelines) is to monitor response to therapy in the metastatic breast cancer setting Candidate Protein Biomarkers with possible clinical application in breast cancer i Topo2-alpha (Topo2) DNA topoisomerase ... sought to use serum markers to optimize treatment strategies in breast cancer The authors investigated serum 20 Oncogene and Cancer – From Bench to Clinic Her2 levels (sHer2) in 175 breast cancer...
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Oncogene and Cancer – From Bench to Clinic by Yahwardiah Siregar ppt
Ngày tải lên :
31/03/2014, 19:20
... PR receptors are weak prognostic indicators and should not be used to determine whether to treat a patient with adjuvant therapy Newer guidelines from a Oncogene and Cancer – From Bench to Clinic ... guidelines) is to monitor response to therapy in the metastatic breast cancer setting Candidate Protein Biomarkers with possible clinical application in breast cancer i Topo2-alpha (Topo2) DNA topoisomerase ... sought to use serum markers to optimize treatment strategies in breast cancer The authors investigated serum 20 Oncogene and Cancer – From Bench to Clinic Her2 levels (sHer2) in 175 breast cancer...
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Báo cáo y học: "Bench-to-bedside review: Ventilator strategies to reduce lung injury – lessons from pediatric and neonatal intensive care" ppsx
Ngày tải lên :
12/08/2014, 20:20
... with high-frequency oscillatory ventilation Hematoxylin and eosin; 100× With permission from Yoder and coworkers [63] intermittent mandatory ventilation-treated infants to 56% in HFOV-treated infants ... 0.007 Toronto P = NS Shown are mortality rates for infants with congenital diaphragmatic hernia (CDH) at Children’s Hospital, Boston (n = 285) and The Hospital for Sick Children, Toronto (n = ... order to reduce pulmonary vascular resistance and limit right -to- left shunting The application of ‘gentle ventilation’ principles to the CDH population helped to decrease mortality rates to 31–39%...
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Báo cáo y học: "Bench-to-bedside review: Optimising emergency reversal of vitamin K antagonists in severe haemorrhage – from theory to practice" pptx
Ngày tải lên :
13/08/2014, 11:23
... first 24 to 48 hours [13-15] The increased mortality in patients receiving warfarin appears related to increased in-hospital haematoma expansion and not to the initial volume of haematoma at the ... anticoagulant factors in a patient after perfusion of PCC with pro- and anti-coagulant factors (for example, Proteins C and S) may provide some answers to this issue Factor II is likely to have been ... change attitudes towards INR testing as it is useful to determine whether doses related to INR are related to clinical reality For the moment, INR testing at point-of-care and the bedside has been...
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Báo cáo y học: "Bench-to-bedside review: Mobilizing patients in the intensive care unit – from pathophysiology to clinical trials" pot
Ngày tải lên :
13/08/2014, 16:20
... Critical Care Vol 13 No Truong et al inflammatory cytokines TNF-α and IL-1β [9,62] Taken together, antioxidant formation and a shift toward anti-inflammatory cytokines during moderate exercise may play ... effects on muscle, immobility can lead to a pro-inflammatory state caused by increased systemic inflammation via increases in pro-inflammatory cytokines In addition to immobility, critically ill patients ... production of anti-inflammatory cytokines [9] Typically, IL-6 (which has anti-inflammatory properties) is the first cytokine to rise during exercise, increasing up to 100-fold greater than pre-exercise...
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Báo cáo y học: " Bench-to-bedside review: Carbon monoxide - from mitochondrial poisoning to therapeutic use" doc
Ngày tải lên :
13/08/2014, 16:20
... Egr-1 as a pro-inflammatory regulator in ventilator-induced lung injury Moreover, peroxysome proliferator-activated receptor-gamma, an antiinflammatory nuclear regulator, seems to be involved in the ... antiinflammatory, anti-apoptotic, and anti-proliferative properties Thus, CO has advanced from a toxic waste product to a physiological regulator and the importance of endogenously derived CO to control ... mice for h before aerosol challenge led to a specific reduction of the pro-inflammatory cytokine IL-5 while other pro-inflammatory or anti-inflammatory cytokines were unaffected [81] In the same...
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Báo cáo y học: "Bench-to-bedside review: The MET syndrome – the challenges of researching and adopting medical emergency teams"
Ngày tải lên :
25/10/2012, 10:35
... In this regard, it is important to realise that, in most hospitals, the expertise exists to rapidly deliver the skills and knowledge to the bedside when necessary to deal with critical illness ... septic shock [25-27] It would make sense to apply these concepts to critical illness in general, wherever it may occur in the wards, and to use an RRS to deliver early intervention by specifically ... our institution, where ICU doctors and nurses are no longer viewed as experts confined to the ‘ivory tower’ of the ICU but are now constantly assessing and helping to treat ‘at-risk’ patients in...
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CANCER PREVENTION – FROM MECHANISMS TO TRANSLATIONAL BENEFITS pdf
Ngày tải lên :
28/03/2014, 10:20
... CANCER PREVENTION – FROM MECHANISMS TO TRANSLATIONAL BENEFITS Edited by Alexandros G Georgakilas Cancer Prevention – From Mechanisms to Translational Benefits Edited ... emerging hallmark of cancer cells and plays important roles in cancer progression and metastasis (Hanahan and Weinberg, 2011) With regard to cancer therapy, blockade of CTLA-4 (cytotoxic T lymphocyte-associated ... 2007) 10 Cancer Prevention – From Mechanisms to Translational Benefits Moreover, endothelial progenitor cells can also be recruited and contribute to the formation of new blood vessels Due to the...
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COLORECTAL CANCER BIOLOGY – FROM GENES TO TUMOR potx
Ngày tải lên :
27/06/2014, 13:20
... translation to the patient and hospital bedside - more work needs to be done to find out how to safely and effectively apply what we have discovered to the patient's illness This book about colorectal cancer ... into syndromes with adenomatous polyps, those with hamartomatous polyps and syndromes with polyps of mixed histopathology (Table 1) Syndromes that present with 12 Colorectal Cancer Biology – From ... activity enzyme activity protein function cytokine activity cytokine activity receptor binding cytokine activity null receptor cytokine activity cytokine activity protein function promoter function...
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Báo cáo y học: "Bench-to-bedside review: Genetic influences on meningococcal disease" potx
Ngày tải lên :
12/08/2014, 18:21
... filamentous pili proteins on the bacterial surface bind to the CD46 receptor, after which Opa and Opc proteins can bind to their respective receptors: CD66 and a heparan sulphate proteoglycan receptor ... Thieringer R, Yamamoto S, Fenton MJ, Golenbock DT: CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition Proc Natl Acad Sci USA 1995, 92:9288-9292 29 Poltorak A, Smirnova ... Voort E, de Groot R: The relationship between plasminogen activator inhibitor-1 and proinflammatory and counterinflammatory mediators in children with meningococcal septic shock J Infect Dis 1996,...
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