calcium signaling receptors effectors and other signaling pathways
báo cáo hóa học:" Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways" ppt
... Figure Protein Tyrosine Kinase and other Major Kinases involved in Angiogenic Pathways Protein Tyrosine Kinase and other Major Kinases involved in Angiogenic Pathways Pathways were constructed by ... -independent pathways since MAPK and many other signaling enzymes and proteins identified in this study were upregulated synchronously and were stabilized by PKC (Table 1) The MAPK signaling networks ... kinases, adhesion molecules and other diffusible signaling proteins The abundance of multiple PTKs and other kinases initiates novel angiogenic pathways independent of VEGF -signaling while suppressing...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... nature of the intracellular signaling pathways that link S1P signaling to Cyr61/CCN1 gene expression and showed that the activation of RhoA GTPase and p38 MAP kinase pathways is required for Cyr61/CCN1 ... isolated and hybridized to Cyr61/CCN1, CTGF/ CCN2 and GAPDH cDNA probes and a plasmid vector, which had been slot-blotted on nylon membranes The hybridization signals were measured and standardized ... Ig and equal protein loading is shown by probing the same blot with GAPDH Ig mediated through various protein kinase and monomeric GTP-binding protein signaling pathways including MAP kinases and...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... orthologs in other plant species, including MPK3 and MPK6 in Arabidopsis (group A MAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ (Lycopersicon esculentum SA-induced protein kinase) and LeMPK3 (L ... as hormone signaling, biotic and abiotic stress responses, and development [15,16], whereas high concentrations of ROS can result in oxidative stress and cause irreversible damage and hypersensitive ... involved in various signaling processes and have unique biological functions Cotton (Gossypium hirsutum) is one of the oldest and most important fiber and oil crops Its growth and yield are severely...
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Báo cáo khoa học: A biophysical view of the interplay between mechanical forces and signaling pathways during transendothelial cell migration doc
... Stroka and H Aranda-Espinoza EC, the cytosolic tails of the receptors rearrange A number of intracellular signaling proteins are recruited, resulting in the possible activation of three different pathways ... transendothelial migration K M Stroka and H Aranda-Espinoza kinase, p160ROCK, results in decreased traction forces and migration speed under both static and shear conditions [19] Because cell–cell ... as Rac1 and Cdc42 reach peak activation, leading to cell respreading, elongation, and alignment in the direction of flow Both Cdc42 and Rac1 are required for cell elongation, whereas Rho and Rac1...
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Báo cáo khoa học: Signaling pathways and preimplantation development of mammalian embryos potx
... growth factor (TGF)-b, Hedgehog, and Janus-activated kinase (JAK) ⁄ signal transducer and activator of transcription (STAT) signaling pathways Moreover, these signaling pathways play a central role ... detected in blastocysts, and Wnt1 and -4, Sfrp1 and Dkk1 are highly expressed at this stage [37] Receptors (Fz2, frizzled-2 and Fz4, frizzled-4), intracellular signal transducers and modifiers [Dishevelled ... Wnt-induced complexes with Rac, and Rac can induce JNK ⁄ MAPK signaling Dkk1 and SOX7 are antagonists of Wnt signaling Both are identified as direct targets of the p38 and JNK pathways Perspectives Preimplantation...
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BREAST CANCER – CARCINOGENESIS, CELL GROWTH AND SIGNALING PATHWAYS ppt
... activated and describe its role in development and cancer progression 1.3 EGFR homodimer signaling EGF was the first ligand identified and due its abundance in the mouse salivary gland and relative ... HB-EGF and AREG would be likely mediators of this signaling 10 Breast Cancer – Carcinogenesis, Cell Growth and Signaling Pathways Juxacrine EGFR signaling might be antiproliferative and also ... Cell Growth and Signaling Pathways the signal generation from ErbB2 or ErbB3 require heterodimerization with another ErbB family member (3) The ErbB receptors are stimulated by 15 ligands but the...
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Calcium-sensing receptors regulate cardiomyocyte Ca2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation pdf
... Extracellular calcium sensity and extracellular calcium signaling Physiol Rev 2001, 81:239-297 Wang R, Xu C, Zhao W, Zhang J, Cao K, Yang B, Wu L: Calcium and polyamine regulated calcium- sensing receptors ... and CX drafted the manuscript, FL and ZT participated in the design of the study and did most of the experiments, YZ conceived of the study, HL, HR, HZ, CL and GH participated in its design and ... type and type IP3Rs (B) Western blot analysis of cardiomyocyte lysates using antibodies specific for IP3R, type 1, type and type 3, respectively DAPI and FITC to co-stain nuclei and type IP3 receptors...
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Báo cáo y học: " Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways." ppt
... addition, bortezomib can also inhibit other cell signaling pathways, such as mitogen-activated protein kinase growth signaling, causing inhibition of cell proliferation and induction of cell apoptosis ... hepatic and intestinal regions than other parts of the body (Figure 1A) High extent of luciferase induction in the liver, spleen, lung and intestine by LPS is consistent with IκBα degradation and ... observed a ubiquitous expression and induction of IκBα in the IκBα-luc transgenic mice by LPS We demonstrated involvement of both the NF-κB and the p38 MAP kinase signaling pathways in the induction...
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báo cáo khoa học: " Transcriptional responses to polycyclic aromatic hydrocarbon-induced stress in Arabidopsis thaliana reveal the involvement of hormone and defense signaling pathways" pdf
... phenanthrene and ethylene signaling Without PAH, the ethylene overproducer eto3 and the constitutively -signaling triple mutant grew short hypocotyls and roots, consistent with the standard model ... phenanthrene treatment and 27 other stress and hormone treatments Plant age in weeks and duration of treatment are given in parenthesis; whole plant tissue was analyzed if not otherwise indicated ... sensitivity, and the etr1-6;etr2-3;ein44 [34] triple ethylene receptor mutant which exhibits constitutive ethylene signaling Because the WT and ethylene signaling mutants differ in root and shoot...
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Báo cáo khoa học: "Hyperoxic acute lung injury and ventilator-induced/associated lung injury: new insights into intracellular signaling pathways" docx
... apoptosis and necrosis [6] Disturbance of cell-death pathways, either local (pulmonary) or distal (kidney and intestines), has also been implicated in the pathogenesis of VI/ALI and ensuing MOF [9], and ... components are integrated; what are the morbidity and mortality defining manifestations of VI/ALI and/ or HALI and which, where and when should “outcomedefining” pathways be blocked Competing interests ... volume and hyperoxia coexist appears to be NF-κB independent The molecular implication from their paper is that individual stimuli exert intracellular effects via independent signaling pathways...
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New methods to study proline rich disordered regions and their structural ensembles in protein signaling pathways
... twenty standard amino acids can be classified into several groups: non12 polar aliphatic (G, A, V, L, M and I), non-polar aromatic (F, Y and W), polar acidic (L, R and H), polar basic (D and E) and ... hydrophobicity and high net charge [30] The sequence composition and order influence other biophysical properties of disordered regions, for example, flexibility index, helix propensities and strand propensities ... specificity and other topics in computational biology Additionally, I would like to sincerely thank Narendra Suhas Jagannathan, Arun Chandramohan, Chen Zhao, Wenwei Xiang as well as other members...
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Phospholipid signaling pathways triggered by the antigen receptors in t lymphocytes
... following the engagement of receptors that are coupled to calcium signaling pathway such as antigen receptors on B and T cells, G protein coupled receptors and Fc receptors Ca2+ that is released ... CD4, CD8 and CD28 receptors, and associated signaling molecules such as Lck and PKC are generally concentrated in cSMAC while larger and heavily glycosylated molecules such as CD44, CD45 and CD43 ... MEK1 and MEK2 as MAPKK and ERK1 and ERK2 as MAPK Activated ERK and phosphorylate and regulate the activities of a large number of substrates including various nuclear and cytoplasmic proteins and...
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characterization of signaling pathways and significance of the axon guidance molecule plexin b3 in glioma progression
... and neuropilins 1.1.3 Mechanism of semaphorin and plexin activation 1.1.4 Co -receptors: c-Met and Ron, ErbB2, Integrin and L1 11 1.2 Signaling pathways mediated by semaphorins and ... extracellular domains 1.1.4 Co -receptors: c-Met and Ron, ErbB2, Integrin and L1 In addition to plexins and neuropilins, some other receptor proteins have been involved in the signaling pathways mediated by ... 24 1.2.4 Kinases and kinase receptors in the signaling pathway of plexins 30 1.3 Biological functions of plexins and semaphorins 31 1.3.1 Role of semaphorins and their receptors as the...
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Báo cáo Y học: Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways docx
... (1997) Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways EMBO J 16, 1291– 1304 ... mitogen-activated protein kinase and c-Jun NH2-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R., and alternative pathways Mol Cell Biol 20, ... transfected with ASK1 and either pEGFP-PKR-KR or pEGFP Serum was removed from the medium 24 h after transfection, and the cells were incubated for another 24 h The cells were then fixed and ASK1 was stained...
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Báo cáo khoa học: Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions Comparison with the role of phosphotidylinositol-3 kinase ppt
... sufficient to activate inhibitory signaling pathways normally responsible for ERK, PKB and GSK-3a dephosphorylation Analysis of the effect of calmodulin inhibition on signaling pathways induced by chemoattractants ... such as migration and formation of ROS MATERIALS AND METHODS Reagents and antibodies Platelet-activating factor, fMLP (N-formyl-methionyl-leucyl-phenylalanine), cytochrome c and N-(6-aminohexyl)-5chloro-1-naphtalenesulfonamide ... PKB and GSK-3a, similar to receptor-mediated activation by chemoattractants 4628 S Verploegen et al (Eur J Biochem 269) Ó FEBS 2002 Fig Regulation of neutrophil signaling pathways, by fMLP and...
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Trends in Cell Signaling Pathways in Neuronal Fate Decision Edited by Sabine Wislet-Gendebien potx
... Cell Signaling Pathways in Neuronal Fate Decision Figure Confocal images of the TGF-β ligands, receptors and signaling proteins in the SVZ and DG in the in‐ jured adult mice brain Double and triple ... gremlin and cerberus, thereby regulate the availability, and therefore, active signaling by their associated ligands [20] TGF-β signaling is the archetype for signaling by Role of TGF-β Signaling ... described TGF-beta signaling, Wnt Signal‐ ing, neurotrophin and NF-κ-B signaling and their implication in neuronal fate decision The second objective of this book is to understand how those pathways are...
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Báo cáo Y học: Regulation of stress-activated protein kinase signaling pathways by protein phosphatases pot
... Ó FEBS 2002 Regulation of SAPK signaling pathways (Eur J Biochem 269) 1061 Fig SAPK signaling modules The protein kinase cascades of SAPK signaling pathways and the points where the phosphatases ... contrast, both MKP-5 and M3/6 dephosphorylate both JNK and p38 but not ERK (Table 1) [27,29,30] The high specificity of MKP-2 for ERK and JNK (but not for p38) and that of PAC-1 for ERK and p38 (but not ... [31] On the other hand, MKP-1 and MKP-4 were found to dephosphorylate ERK, JNK and p38 [31,32] These facts indicate an unexpected complexity for the negative regulation of the MAP kinase signaling...
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Báo cáo khoa học: Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways docx
... cell proliferation, differentiation, and stress responses, also featured the functions of significant signaling pathways (Table 2) However, some other signaling pathways have never been reported ... miRNA and GO-related genes (Fig 3) Another functional analysis of miRNAs by KEGG revealed that 13 signal transduction pathways were upregulated and 22 were downregulated (Fig 4) Many of these signaling ... HSCs, were further selected and validated within both activated HSCs and fibrotic liver of rats Results Bioinformatics interpretation revealed the GOs and signaling pathways regulated by miRNAs...
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Báo cáo khoa học: Identification of intracellular target proteins of the calcium-signaling protein S100A12 pdf
... [42], S100A6 [43] and S100B [19], annexin XI binds S100A6 [20], and annexin V and VI bind S100A1 and S100B [18] The annexin II–S100A10 interaction is Ca2+ independent, while other annexin–S100 ... 436 nM and 873 nM), S100A9 (0.23 lM, 0.46 lM, 0.93 lM, 1.85 lM and 3.70 lM), annexin V (0.35 lM, 0.70 lM, 1.39 lM, 2.78 lM and 5.56 lM), GAPDH (1.50 lM, 3.0 lM, 4.5 lM, 6.00 lM, 9.00 lM and 12.00 ... Diagnostics, antiIDH and anti-GAPDH immunoglobulin from Nordic Immunological Laboratories, and anti-annexin V and anti-S100A9 immunoglobulin from Santa Cruz Biotechnology, Inc All other reagents were...
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