cadherin catenin signaling in ovarian cancer progression
báo cáo hóa học:" BMP-2 signaling in ovarian cancer and its association with poor prognosis" pot
... others using Noggin [26] and Chordin [31] support the potential therapeutic role of these antagonists in ovarian cancer progression through the inhibition of BMP signaling It will be of great interest ... using diaminobenzidine containing 0.3% H2O2 as a substrate for peroxidase and nuclei were counterstained with diluted hematoxylin Epithelial zones were scored according to the intensity of staining ... 1/5/8 and Erk MAPKs in ovarian cancer cell lines To investigate the role of BMP-2 in ovarian cancer cells we selected three cell lines, TOV-2223, TOV-1946 and TOV112D, for in vitro assays [33]...
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The regulatory role of mixed lineage kinase 4 beta in MAPK signaling and ovarian cancer cell invasion
... BSA Bovine serum albumin CBD Collagen binding domain CR Conserved region CRIB Cdc42/Rac interactive binding protein DTT Dithiothreitol DLK Dual leucine zipper-bearing kinase DNA ... signal peptide domain (SPD), the propeptide domain (Pro), the catalytic domain containing the Zn2+-binding region and the collagen-binding domain (CBD), a hemopexin-like C-terminus connected to ... serine/threonine kinases and tyrosine kinases Out of the eleven 27 protein kinase conserved regions in MLKs, the first seven have sequence similarity to serine/threonine kinases while the remaining...
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báo cáo hóa học:" Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells" pot
... on a four level scale (0 = no staining, = weak staining, = moderate staining, = intense staining) by a GU pathologist Results Expression Profiling of Ovarian Cancer Patients We sought to establish ... Peters JM: The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochoremicrotubule attachment and in maintaining the spindle assembly checkpoint J Cell Biol 2003, 161(2):281-294 ... patient's cores The TMA staining data, including detailed patient information is summarized in Table On average, the benign tumors contained the highest percentage of cells staining positive for Aurora-A...
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báo cáo hóa học:" ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function" pptx
... sialylation of β1 integrins in three ovarian carcinoma Figure cell lines2 α2–6 sialylation of β1 integrins in three ovarian carcinoma cell lines.A, Lysates from PA1, OV4, and SKOV3 cells were incubated ... hypersialylation could modify integrindependent cell responses through a change in receptor conformation, by masking functional domains within the integrin heterodimer, by affecting integrin interaction with ... the role of this enzyme in ovarian cancer The accumulating evidence indicating that ST6Gal-I-mediated integrin sialylation causes increased cell migration and invasion in multiple tumor types...
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báo cáo hóa học:" Can subjective global assessment of nutritional status predict survival in ovarian cancer?" pptx
... provides useful prognostic information in patients with ovarian cancer In a clinical setting, the SGA is invaluable in identifying malnourished patients in a quick and non-invasive manner Moreover, ... chemotherapy-induced toxicity and a reduction in survival of cancer patients [11,12] ovarian cancer being no exception [13] The prevalence of malnutrition in patients with ovarian cancer has been ... in ovarian cancer To the best of our knowledge, this is the first study to evaluate SGA for its prognostic importance in ovarian cancer patients treated in an integrative cancer treatment setting...
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báo cáo hóa học:" Enhancing the efficacy of cisplatin in ovarian cancer treatment – could arsenic have a role" potx
... trioxide induced cytotoxicity in human ovarian cancer cells are promising Clinically achievable concentrations (2 μM) induced apoptosis in the platinum-resistant human ovarian cancer cell line CI80-13S ... al.: Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines Eur J Cancer ... action binding to tubulin polymers (microtubules) and stabilizing the microtubule against depolymerization [29-32] During this time analogues of cisplatin were investigated in an effort to maintain...
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báo cáo hóa học:" Positron emission tomography in ovarian cancer: 18F-deoxy-glucose and 16α-18F-fluoro-17β-estradiol PET" docx
... accuracy in diagnosis, staging, and management decisions in ovarian cancer In this review article, the role of FDG-PET and FDG-PET/ CT in the diagnosis, staging, and management of ovarian cancer ... gynecologic cancer and in determining the efficacy of hormonal therapy [18,19], as a future PET method for evaluating ovarian cancer Imaging protocol for ovarian tumors FDG is excreted through the urinary ... breast cancer and determine the efficacy of hormonal therapy in these patients [17] In this article, we also discuss our preliminary studies indicating the usefulness of FES-PET imaging in the...
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báo cáo hóa học:" Aberrant STYK1 expression in ovarian cancer tissues and cell lines" pdf
... ovarian cell line and the remaining cell lines were derived from ovarian cancer cell lines (A) Ethidium bromide-induced fluorescence of RT-PCR amplification product from ovarian tumor RNA using ... staining in normal tissue) The remaining benign ovarian tissues as well as one malignant ovary showed no STYK1 immunoreactivity Many of the ovarian cancer tissue sections had weak STYK1 staining ... factors Inoculation of these cells into nude mice induced tumor formation within one week and the cells metastasized after weeks Introducing a tyrosine to phenylalanine point mutation into the...
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báo cáo hóa học:" Mucins in ovarian cancer diagnosis and therapy" ppt
... repetitive domains of peptides rich in serine, threonine, and proline in their backbone Serine and threonine are sites for O- and N-glycosylation Presence of the tandem repeat domain which varies in number, ... of ovarian cancer samples and adjacent normal ovary samples [53] The expression pattern of certain membrane bound mucins in ovarian tumors is shown in Figure Pathological Roles of Mucins in Ovarian ... Mucin gene expression in ovarian cancers Cancer Res 1998, 58:5546-5550 Boman F, Buisine MP, Wacrenier A, Querleu D, Aubert JP, Porchet N: Mucin gene transcripts in benign and borderline mucinous...
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báo cáo hóa học:" Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth" pot
... β -catenin pathway is known to be disrupted in a variety of cancers, including ovarian cancer Activation of the β -catenin signaling pathway leads to nuclear localization of β -catenin which interacts ... ɴ -catenin (94kDa) * * 1.0 0.6 0.4 0.2 c-Myc (65kDa) 1.0 0.6 0.5 0.2 ɴ-actin (42kDa) Control Cisplatin Curcumin Curcumin + Cisplatin Figure Curcumin inhibits nuclear β -catenin signaling (A)Curcumin inhibits ... of cisplatin treatment in cisplatin resistant cells by increasing the sensitivity of cells to apoptotic pathways and modulating nuclear β -catenin signaling Curcumin is in early phase clinical trials...
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báo cáo hóa học:" Scope of nanotechnology in ovarian cancer therapeutics" doc
... al: Gemcitabine plus vinorelbine compared with cisplatin plus vinorelbine or cisplatin plus gemcitabine for advanced non-small-cell lung cancer: a phase III trial of the Italian GEMVIN Investigators ... advanced ovarian cancer: a randomised trial comparing adriamycin or 4’epi-adriamycin in combination with cisplatin and cyclophosphamide Med Pediatr Oncol 1986, 14(1):26-29 Advanced Ovarian Cancer ... Cancer statistics 2009 CA Cancer J Clin 2009, 59:225-249 Chauhan SC, Kumar D, Jaggi M: Mucins in ovarian cancer diagnosis and therapy J Ovarian Res 2009, 2:21 Armstrong DK: Relapsed ovarian cancer: ...
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báo cáo hóa học:" Longitudinal monitoring of CA125 levels provides additional information about survival in ovarian cancer" pdf
... CA125 measurements in managing therapy in ovarian cancer patients continues to be a subject of great research interest A randomized trial was designed by Rustin GJ et al to determine whether there ... our study and lack of information on treatments received by our patients, the specific implications of our findings on managing therapy in ovarian cancer patients are uncertain Prospective studies ... M et al included only patients with suboptimal residual stage III (defined as the presence of at least one tumor mass >2 cm in diameter remaining within the peritoneal cavity following initial...
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báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt
... ErBB2/HER2 [28], potentiating its responsiveness in cancer signaling [7,8] Our recent finding showed that an overexpression of MUC4 increases the expression of HER2 in ovarian cancer cells [8] and ... oncoprotein in pancreatic cancer cells [7] In the present study, we analyzed the expression of the HER2 protein in MUC4transfected ovarian cancer cells The exogenous MUC4 expression in ovarian cancer ... important role in the pathogenesis of ovarian cancer In this study, we have investigated increased expression of HER2 and the cancer stem cell population in MUC4 overexpressed ovarian cancer cells...
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báo cáo hóa học:" HOX genes in ovarian cancer" pot
... tumourgenesis in ovarian cancer cell lines containing genetic alterations in p53, myc and K-ras but not in cell lines containing genetic alterations in p53, myc and Akt In this ras activated cell line, ... suggesting b1 integrin has a role in mediating these changes Intriguingly, these changes in protein level are not reflected at the RNA level, indicating that the effect of HOXA4 on b1 integrin and ... overexpressed in this cell line Invasive EOC cell lines also show overexpression of HOXA4 compared to non-invasive cell lines, suggesting a possible role for HOXA4 in promoting migration and invasion...
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Báo cáo toán học: "Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer" pot
... Normal Normal Normal Normal Normal Normal Normal Normal Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer Cancer UniGene ID N/A Hs.471234 Hs.592304 Hs.348319 ... cytokeratin and vimentin using anti-cytokeratin AE1/AE3 (Boehringer Mannheim, Indianapolis, IN) and anti-vimentin (Boehringer Mannheim, Indianapolis, IN) following the manufacturer’s instructions To ... or remove the ubiquitin moiety from a target protein The deubiquitinating enzymes are also involved in processing of poly-ubiquitin precursors into ubiquitin monomers, targeting or salvage of proteasomal...
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báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps
... been fully investigated in ovarian cancer In the present study, we examined the relationship between the expression of Ets-1 and its targets Ang-2 and maspin in ovarian cancer and their clinical ... staining for Ets-1, Ang-2 and Maspin in ovarian tumor tissues A: Ets-1 expression in ovarian moderately and poorly differentiated serous adenocarcinoma; B: Ets-1 expression in ovarian borderline ... borderline mucinous cystadenoma; C: Ang-2 expression in left ovarian serous papillary cystadenocarcinoma; D: Ang-2 expression in ovarian borderline mucinous cystadenoma; E: Maspin expression in mucinous...
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MECHANISM OF TISSUE TRANSGLUTAMINASE UPREGULATION AND ITS ROLE IN OVARIAN CANCER METASTASIS
... Lorand 1989) Interaction with integrins makes it possible for TG2 to be involved in integrin-dependent signal transduction, including in the focal adhesion kinase (FAK) and GTP-binding proteins Raf-1 ... hinge region, which is between the N-terminal ECM binding domain and the C-terminal LAP binding domain This can be achieved by many proteinases in the serine proteinase family, such as plasmin, ... Immunofluorescence IFN-γ Interferon-gamma IGFBP-3 Insulin-like growth factor-binding protein-3 IκBα Inhibitor of kappa B alpha ILK Integrin-linked kinase IP3 Inositol 1,4,5-trisphosphate xviii i.p Introperitoneal...
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Regulation of WNT beta catenin pathway in the disease progression of osteosarcoma
... cytoplasm In addition to its role in gene regulation, β -catenin is involved in regulating cell-cell adhesion by acting as a structural adaptor protein linking E -cadherin to the actin cytoskeleton in ... Ecadherin binding while the tyrosine kinases Fer, Fyn or Met are capable of inducing phosphorylation of tyrosine residue 142 of β -catenin to disrupt interaction with α -catenin but promotes binding ... Both functions of catenin are deregulated in several cancers, thus leading to the loss of β -catenin/ Ecadherin-mediated cell adhesion and a corresponding increase in β -catenin- dependent transcription...
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Arsenic trioxide in ovarian cancer
... ……………………………………………………………… 4-17 Intracellular GPx level in ovarian cancer cell lines ……………… 4-18 Intracellular CAT level in ovarian cancer cell lines …………… 4-19 Intracellular arsenic concentration in ovarian cancer ... MS-275 in ovarian cancer cell lines after 48 hrs of treatment ……………… Combination indices for the drug combinations in OVCAR-3 cells ……………………………………………………………… Combination indices for the drug combinations ... are involved in cytokine processing and inflammation, at least seven caspases (caspases 2, 3, 6, 7, 8, 9, 10) participate in cell death The caspases that are involved in apoptotic signaling and...
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Role of CC3 in colorectal cancer progression
... GTBP G/T binding protein TIMP Tissue Inhibitor of Metalloproteinases DISC Death-Inducing Signaling Complex Apaf-1 Apoptotic protease-activating factor-1 IAP Inhibition of Apoptosis Proteins Smac ... death-inducing signaling complex; IAPs, inhibition of apoptosis proteins; Smac/DIABLO, second mitochondria-derived activator of caspases/direct IAP-binding protein with low pI 10 Both the intrinsic ... alteration In animals, methylcytosine is mainly found in cytosine-guanine (CpG) 19 dinuleotides(Bird 1986) The presence of 5-methylcytosine in the promoter of specific genes prevents binding of transcription...
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