bơm proton atp synthase
Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx
... addition of ATP, ANT and F0F1 -ATP synthase operate in the reverse mode Provision of exogenous ATP leads to ATP inux to mitochondria, followed by its hydrolysis by the reversed F0F1 -ATP synthase, ... from those of F0F1 -ATP synthase molecules per mitochondrion [20,21] Furthermore, the steady-state ADPATP exchange rates (for ANT) or ADPATP conversion rates (for F0F1 -ATP synthase) not change ... F0F1 -ATP synthase, and decreased binding of the inhibitory protein IF to ATPase IF1 is a naturally occurring protein that inhibits the consumption of ATP by a reverse-operating F0F1 -ATP synthase...
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Tài liệu Báo cáo khoa học: An intermediate step in the evolution of ATPases – a hybrid F0–V0 rotor in a bacterial Na+ F1F0 ATP synthase pdf
... F1F0 ATP synthase operon from the anaerobic, acetogenic bacterium Acetobacterium woodii differs from all other F1F0 ATP synthases by the presence of one V0 subunit c gene (atpE1) and two genes (atpE2 ... bacterial ATP synthase raised the question whether the stoichiometry of V0 : F0-like subunits may be flexible and thus a mechanism to change the action of the enzyme from ATP synthase to ATPase To ... and V-type ATP synthases and ATPases: reversals in function and changes in the H+ ⁄ ATP stoichiometry FEBS Lett 576, 1–4 13 Forgac M (1999) Structure and properties of the vacuolar H+-ATPases J...
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Tài liệu Báo cáo khoa học: A point mutation in the ATP synthase of Rhodobacter capsulatus results in differential contributions of DpH and Du in driving the ATP synthesis reaction pptx
... the ATP synthesis rate of an ATP synthase differently according to whether a Du is present or not To our knowledge, no previous reports of a similar effect exist in the literature on ATP synthases ... transduction in ATP synthase Nature 391, 510–514 22 Vik, S.B., Long, J.C., Wada, T & Zhang, D (2000) A model for the structure of subunit a of the Escherichia coli ATP synthase and its role in proton ... previously [37] Ó FEBS 2002 The aE210K mutation in Rb capsulatus ATP synthase (Eur J Biochem 269) 1987 ATP hydrolysis assays ATP hydrolysis was measured routinely at 30 °C in the following buffer:...
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Báo cáo khoa học: Expression of the Drosophila melanogaster ATP synthase a subunit gene is regulated by a transcriptional element containing GAF and Adf-1 binding sites pptx
... functionally, with highly developed cristae full of ATP synthase complexes For this reason, ATP synthase and in particular the a-F1-ATPase and b-F1-ATPase catalytic subunits have been often used as ... a-F1-ATPase transcript The expression of the a-F1-ATPase gene during development is coordinated with the expression of the nuclearencoded b-F1-ATPase gene and the mitochondrial-encoded ATPase ... d-aminolevulinate synthase (ALAS) and b-F1-ATPase genes [29,34] In both constructs there was a substantial Fig Functional analysis of the D melanogaster a-F1-ATPase promoter Scheme of the a-F1-ATPase promoter...
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Báo cáo khoa học: Structural evidence for a constant c11 ring stoichiometry in the sodium F-ATP synthase doc
... from sodium ATP synthases J Mol Biol 325, 389–397 Seelert H, Dencher NA & Muller DJ (2003) Fourteen ¨ protomers compose the oligomer III of the proton- rotor in spinach chloroplast ATP synthase J ... Electrical power fuels rotary ATP synthase Structure (Camb) 11, 1469–1473 Feniouk BA, Kozlova MA, Knorre DA, Cherepanov DA, Mulkidjanian AY & Junge W (2004) The of ATP synthase: ohmic conductance ... of the rotor ring from the I tartaricus F -ATP synthase has been solved and provides striking details concerning the mechanism of the Fo motor of ATP synthase [8] Of particular interest in this...
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Báo cáo Y học: Membrane embedded location of Na+ or H+ binding sites on the rotor ring of F1F0 ATP synthases ppt
... of ion binding sites in ATP synthases (Eur J Biochem 269) 5585 Fig ATP- dependent ACMA uorescence quenching of E coli ATP synthase in POPC-liposomes Puried E coli ATP synthase was reconstituted ... oligomer of the F1F0 ATP synthase from I tartaricus was performed as described [17] Enrichment of F1F0 ATP synthase from E coli A protocol similar to the purication procedure of the ATP synthase of I ... with cGlu65 of the ATP synthase of I tartaricus or cAsp61 of the ATP synthase of E coli and is therefore suitable for uorescence investigations Reconstitution of the E coli ATP synthase into POPC-liposomes...
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Báo cáo khoa học: NMR investigations of subunit c of the ATP synthase from Propionigenium modestum in chloroform/methanol/water (4 : 4 : 1) pot
... Molecular basis for the coupling ion selectivity of F1F0 ATP synthases: probing the liganding groups for Na+ and Li+ in the c subunit of the ATP synthase from Propionigenium modestum Biochemistry 36, ... H+-coupled ATP synthesis in the Escherichia coli host cells J Mol Biol 253, 726–738 15 Fillingame, R.H (1990) Molecular mechanism of ATP synthesis by F1F0-type H+-transporting ATP synthases In ... Escherichia coli ATP synthase is 10 Proc Natl Acad Sci USA 98, 4966– 4971 22 Rastogi, V.K & Girvin, M.E (1999) Structural changes linked to proton translocation by subunit c of the ATP synthase Nature...
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Báo cáo khoa học: Arginine-induced conformational change in the c-ring ⁄a-subunit interface of ATP synthase ppt
... discussed below mol ATP/ mol enzyme 800 600 wt cG25I cG68C cT67C 400 200 Discussion 0 10 20 30 40 50 60 Time (s) Fig ATP synthase activities in the wild-type I tartaricus ATP synthase and c subunit ... whole atp operon (atpIBEFHAGDC) of I tartaricus [24] with the following modifications: the start codons of atpF and atpA were changed from TTG to ATG, a Bsu15I single site was introduced between atpE ... movements to c-ring rotation in ATP synthase FEBS Lett 555, 29–34 12 Rastogi VK & Girvin ME (1999) Structural changes linked to proton translocation by subunit c of the ATP synthase Nature 402, 263–268...
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Báo cáo khoa học: Efficient ATP synthesis by thermophilic Bacillus FoF1-ATP synthase ppt
... ATP synthesis by thermophilic ATP synthase N Soga et al ATP is synthesized Conversely, when the PMF is lower, F1 wins, and protons are pumped back by reverse rotation of Fo ATP- driven ... The Authors Journal compilation ª 2011 FEBS N Soga et al A ATP synthesis by thermophilic ATP synthase 400 pmol ATP A 100 μM 10 s 400 pmol ATP mM 10 s mM Luciferin emission Luciferin emission 30 ... Yoshida M (2005) ATP- driven stepwise rotation of FoF1 -ATP synthase Proc Natl Acad Sci USA 102, 1333–1338 Kinosita K Jr, Adachi K & Itoh H (2004) Rotation of F1-ATPase: how an ATP- driven molecular...
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Báo cáo khoa học: Pigment epithelium-derived factor binds to cell-surface F1-ATP synthase pdf
... cell-surface PEDF binding to F1 -ATP synthase F1-ATPase ⁄ ATP synthase b-subunit, and inhibits endothelial extracellular ATP synthesis activity The findings imply that F1Fo -ATP synthase may act as a receptor ... taurus F1 -ATP synthase b-subunit (Table S1) Until recently, F1Fo -ATP synthase expression was assumed to be strictly confined to mitochondria, where it generates most of the cellular ATP Current ... cells, and that PEDF can inhibit this extramitochondrial ATP synthase, which catalyzes ATP synthesis The interactions between PEDF and ATP synthase might be a critical biochemical step for the angiostatic...
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Báo cáo khoa học: N-terminal deletion of the c subunit affects the stabilization and activity of chloroplast ATP synthase doc
... molecular mechanism of ATP synthesis by F1F0 -ATP synthase Biochim Biophys Acta 1553, 188–211 Weber J & Senior AE (2003) ATP synthesis driven by proton transport in F1F0 -ATP synthase FEBS Lett 545, ... impaired the ATP hydrolytic ability, despite differences between Mg2+ATPase and Ca2+-ATPase The deletion of 12 residues resulted in a greater decrease in Ca2+-ATPase activity About 6% of ATP hydrolytic ... Relative ATPase activity of reconstituted abc assemblies Mg2+-ATPase (black columns) and Ca2+-ATPase (gray columns) activities were analyzed as described in Experimental procedures The ATPase activities...
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Báo cáo Y học: Probing the rotor subunit interface of the ATP synthase from Ilyobacter tartaricus pptx
... Senior AE (2003) ATP synthesis driven by proton transport in F1F0 -ATP synthase FEBS Lett 545, 6170 Dimroth P, von Ballmoos C, Meier T & Kaim G (2003) Electrical power fuels rotary ATP synthase Structure ... of the rotary motor in ATP synthase Science 286, 17001705 18 Zhang Y & Fillingame RH (1995) Subunits coupling H+ transport and ATP synthesis in the Escherichia coli ATP synthase CysCys cross-linking ... of the F -ATP synthase D Pogoryelov et al A B Fig Protein sequence alignments of amino acid stretches structurally located at the F1Fo interface of the central stalk domain of F -ATP synthases...
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Báo cáo khoa học: Identification of critical residues of subunit H in its interaction with subunit E of the A-ATP synthase from Methanocaldococcus jannaschii potx
... Assignment of subunits E and H in A -ATP synthase S Gayen et al A B Fig Topological model of the subunits in the methanogenic A1A0 ATP synthase (A) Pyrococcus horikoshii A -ATP synthase subunit A (orange, ... Go1 A -ATP synthase subunit B (green, pdb 2c61 [18]), the bovine mitochondrial F -ATP syn¨ thase c subunit (violet; pdb 1e1q, chain G [30]), which is homologous to subunit D of the A -ATP synthase, ... V-type ATPase J Bioenerg Biomembr 35, 323–336 Cross RL & Muller V (2004) The evolution of A-, F-, ¨ and V-type ATP synthases and ATPases: reversals in function and changes in the H+ ⁄ ATP coupling...
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Báo cáo khoa học: The GxxxG motif of the transmembrane domain of subunit e is involved in the dimerization/oligomerization of the yeast ATP synthase complex in the mitochondrial membrane doc
... rotary mechanism of ATP synthase Curr Opin Struct Biol 10, 672–679 Senior, A.E., Nadanaciva, S & Weber, J (2002) The molecular mechanism of ATP synthesis by F(1)F(0) -ATP synthase Biochim Biophys ... of e19A, eG15L and eG19L ATP synthases We next sought whether the mutations in the dimerization motif of subunit e affected the dimerization/oligomerization of the ATP synthases Therefore, the ... ratios and analysed by BN/PAGE The gels were incubated with ATP- Mg2+ and Pb2+ to reveal ATPase activity supramolecular species of the ATP synthase in the mitochondrial digitonin extracts of mutant...
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Báo cáo Y học: Reconstitution of Fo of the sodium ion translocating ATP synthase of Propionigenium modestum from its heterologously expressed and purified subunits pdf
... the ATP synthase Biochim Biophys Acta 1458, 374–386 16 Kaim, G (2001) The Na+-translocating F1Fo ATP synthase of Propionigenium modestum: mechanochemical insights into the Fo motor that drives ATP ... Voltage-generated torque drives the motor of the ATP synthase EMBO J 17, 5887–5895 19 Kaim, G & Dimroth, P (1999) ATP synthesis by F-type ATP synthases is obligatorily dependent on the transmembrane ... the structure and functioning of the Escherichia coli ATP synthase J Exp Biol 203, 29–33 Yoshida, M., Muneyuki, E & Hisabori, T (2001) ATP synthase – a marvellous rotary engine of the cell Nat...
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ATP synthase
... ATP synthase người: Sau danh sách gen mã hóa thành phần ATP synthase: ATP5 A1, ATP5 AL1 ATP5 B, ATP5 BL1 ATP5 C2, ATP5 D, ATP5 E, ATP5 F1, ATP5 G1, ATP5 G2, ATP5 G3, ATP5 H, ATP5 HP1, ATP5 I, ATP5 J, ATP5 J2, ... ATP5 HP1, ATP5 I, ATP5 J, ATP5 J2, ATP5 L, ATP5 L2, ATP5 O, ATP5 S ATP6 , ATP6 AP1, ATP6 AP2 ATPSBL1, ATPSBL2 MT -ATP6 , MT -ATP8 SỰ TIẾN HÓA CỦA ATP SYNTHASE: Sự tiến hóa ATP synthase cho ví dụ tiến hóa kiểu ... giống trình enzim ATP synthase bảo tồn tất giới sinh vật F -ATP synthase cho thấy số lượng lớn giống chức chế để V-ATPase Tuy nhiên, F -ATP synthase tạo ATP tận dụng gradient proton VATPase có trách...
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CÓ PHẢI CÁC THUỐC ỨC CHẾ BƠM PROTON CÓ TÁC DỤNG NHƯ NHAU KHÔNG? Những bệnh docx
... bộc lộ Các nguyên tử sulfur gắn kết đồng hóa trị với nguyên tử sulfur nhóm cystein men H+K+ATPase (bơm proton) làm bất hoạt men Từ đó, ức chế giai đọan cuối trình tạo acid Một PPI có tốc độ hoạt ... chế bơm proton 100% sau phút & kéo dài suốt 45 phút trình nghiên cứu Omeprazole ức chế 43% tiết acid vào giai đọan đầu & phải sau 45 phút ủ với tế bào ức chế tiết acid đạt 83% Cường độ ức chế bơm ... Tất PPI có chế tác dụng ức chế men H+K+ATPase(Error! Reference source not found.) Tuy nhiên, PPI có khác tính chất dược lý, điều tạo nên...
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- thuốc ức chế bơm proton
- cách dùng thuốc ức chế bơm proton
- các thế hệ thuốc ức chế bơm proton
- chỉ định của thuốc ức chế bơm proton
- khuyến cáo mới nhất về thuốc ức chế bơm proton
- cơ chế thuốc ức chế bơm proton
- nhóm thuốc ức chế bơm proton
- thuốc ức chế bơm proton ppi
- thuốc ức chế bơm proton là gì
- các thuốc ức chế bơm proton
- de tai ve thuoc uc che bom proton
- potential mechanism for the anti angiogenic effect of atp synthase inhibition
- là bơm proton làm việc theo kiểu hai chiều
- một số hình ảnh mô tả cấu trúc của atp synthase
- trò sinh lý atp synthase
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