by in paragraph a removing the words public comment and adding in their place the words submission of public comments or objections
Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
... (Fig 2) These additional features hinder binding along the whole interdomain interface, although they both are displaced upon binding of the ligand The N-terminal trunk and the first binding loop ... occluding loop is rather flexible and will adapt to structural features of the inhibitors as well as to the packing constraints of the environment The larger and wider the features of the ligands ... occluding loop residues can adopt a variety of conformations, whereas the rest of the structure of cathepsin B appears to be rigid A comparison of the interaction constants of the binding of chagasin...
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Báo cáo y học: "Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)" ppt
... pannus formation and necrosis/erosion of cartilage (both summarized as destruction) The final arthritis score was evaluated for each animal by calculating the sum of the values for inflammation and ... by means of the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway [5,6] The binding of these cytokines to their receptors activates a distinct pair of JAK molecules, ... at mRNA level was also significantly elevated at day and of the acute phase of AIA These data imply that activation of the STAT-1 pathway plays an important role in our Th1 cell-mediated arthritis...
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fisher - how to smell a rat; the five signs of financial fraud (2009)
... particular are sheltered from the real world and most of their financial decisions are made by their managers They feel isolated and unable to deal with the real world because the real world makes ... recent cases and history’s biggest cases, and they all have one thing in common—financial fraud sign number one: The money manager also had custody of the assets In other words, the money manager or ... swear they haven’t changed Their long-term goals certainly haven’t But what they say they want has The bull market made them confident, but the bear market made them daunted And that’s when a artist...
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Ebook : HYDRAULIC STRUCTURES 4TH EDITION BY P. NOVAK, A.I.B, MOFFAT, C. NALLURI AND R. NARAYANAN
... Iain Moffat, Chandra Nalluri and Rangaswami Narayanan to be identified as the Authors of this Work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988 All ... thousands of eBooks please go to www.eBookstore.tandf.co.uk.” © 1990, 1996, 2001, 2007 Pavel Novak, Iain Moffat, the estate of Chandra Nalluri and Rangaswami Narayanan The right of Pavel Novak, Iain ... edition; particular thanks for the constructive comments and help provided by Professor J Lewin in redrafting Chapter (Gates and valves) The authorship of individual chapters remains the same as in...
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Báo cáo y học: "NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor" docx
... emulsion intradermally at the base of the tail After 21 days (day 0), the same amount of the antigen emulsified in the same adjuvant was intradermally injected at the base of the tail as a booster ... TN and NM participated in the design of the study and helped to draft the manuscript TK conceived of the study, and participated in its design and drafted the manuscript All authors read and approved ... dehydroxymethylepoxyquinomicin (b) Radiographic scores of the ankle joints were determined as described in Materials and methods, and were normalized to the normal mice Values are expressed as the mean ± standard...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... [106,107] A step forward in the analysis of Fe(III)-OO(H) as a potential catalyst was thought to be offered by the use of mutated P450s, bearing alanine or some other amino acid in place of the highly ... J.N., Corina, D & Akhtar, M (1996) The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 1 4a- demethylase of Candida albicans (other names are: lanosterol 1 4a- demethylase, ... species as the predominant catalyst in a host of crucial biological oxidations, has a great deal of weight, accumulating evidence points at the participation in substrate turnover of alternative active...
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Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf
... evidence that the A- chain would affect both the conformation and the catalytic activity of the thrombin B-chain, thus corroborating the belief of an extraordinary conformational plasticity of this ... residue in the A- chain of thrombin [1,2] Measurements of the pH dependence of both steady-state amidase activity and binding of the high-affinity inhibitor a- NAPAP showed pKa values of the catalytic ... [17] Stabilization within the A- chain and between the A- and B-chains occurs mainly through salt bridges and H bonds involving charged side chains The A- chain is intramolecularly cross-linked by...
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Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc
... obtained by P1 transduction using strain CE1224 as the recipient and strains IQ85 and strain MM152, respectively, as donor strains To obtain strain CE1513, strain MM88 was used as Table Bacterial ... using the PhoE forward primer (5¢-GCCGGAATTCTAATATGAAAAAGAGCACTCT GGC-3¢) and the 94PhoE reverse primer (5¢-CGCGGA TCCTTTTTGCTGTCAGTATCAC-3¢), pNN7 and pNN8 as the templates, respectively, and ... understandable, as the SecB-binding sites, which are located in the mature domain of the PhoE precursor [3], are not affected in the G-10L mutant precursor Thus, in the absence of SRP, SecB can target...
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Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx
... protein assay kit (Biorad Laboratories) Densitometric analysis Each band, when mentioned, was analysed by alpha digidoc 1201 software (Alpha Innotech Corporation, San Leandro, CA, USA) The same sized ... incubated in the absence of any of these agents On termination of incubation, the glucose released in the medium was assayed as described in Materials and methods, and the values were normalized to the ... circulating levels of insulin and glucagon [14] Insulin triggers the activation of a series of phosphorylation cascades that are lost in insulin-resistant states, thereby preventing insulin from correctly...
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Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
... amidinium end The contact area of the Nt amidinium end (NAE) was investigated by evaluating the interaction energies and hydrogen positions of the end fragment and the bases of base pair T8 -A2 5 ... calculations of the interaction between (A) the amidinium end and bases A2 5, T8 and G9; and (B) the guanidinium end and bases A5 , T28 and A6 Intermolecular geometry constraint according to the crystal structure ... (HF) and correlation parts, suggesting an attractive interaction of Nt with base pair A2 5-T8 The interaction of the NAE with A2 5 is very strong with substantial HF and correlation parts, indicating...
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
... proteases, serpins and cofactors Again, TM acts as a molecular switch by excluding an interaction between thrombin and PAI-1 thereby protecting the serpin from inactivation Furthermore, these findings propose ... Probably the main physiologic consequence of this interaction is an inactivation of the PAI-1 pool in the vascular wall by thrombin, making it no longer available for interaction with u-PA and ... theoretical insight into the effect of the second-order rate constants and concentrations of TM and PAI-1 on the rate of thrombin/ PAI-1 complex formation For various combinations of kon and...
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Báo cáo khoa học: Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants ppt
... resistance We then investigated the resistances of this double deletant and the corresponding Dpdr12 and Dazr1 single gene deletes to acetate and sorbate Growth on plates containing increasing ... more sensitive to acetate at pH 4.5 [2] Another study reported that Azr1p, a plasma membrane transporter of the major facilitator superfamily, also confers acetate resistance [12] We therefore ... fragment was then Sal1-digested and cloned into the SalI site located between the ADH1 promoter and terminator of expression vector pAD4M [14] The correct DNA sequence of the TAT2 insert of the...
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báo cáo sinh học:" A model for integrating strategic planning and competence-based curriculum design in establishing a public health programme: the UNC Charlotte experience" doc
... health behaviour and administration into all public health disciplines and to establish undergraduate and doctoral programmes in public health that would serve the needs of state and local agencies ... in the strategic assessment As summarized in Figure 5, the Department has had a string of rapid successes and ambitious plans for attaining status as a school of public health in the next decade ... Notable achievements include the graduation of the first MSPH class in the spring of 2006, designation of attaining school of public health status as a campus priority in Fall 2008, graduation of...
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Báo cáo khoa học: " Water extraction by tree fine roots in the forest floor of a temperate Fagus-Quercus forest" pdf
... between fine root abundance and water forest floor and mineral soil extraction in profile? The study is part of a comparative analysis of the water and nutrient cycles in three forest and heathland ... also in terms of water storage (in mm per profile) The spatial variability of &thetas; in the forest floor is characterized by an annual mean coefficient of variance of the moisture samples of ... throughfall and stand microclimatological data as well as the humus moisture content at a weekly interval as input data After solving the water balance equation, the resulting term is taken as the water...
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Báo cáo khoa học: "Job stress and job satisfaction of physicians, radiographers, nurses and physicists working in radiotherapy: a multicenter analysis by the DEGRO Quality of Life Work Group" ppt
... dealing with patient's death and suffering [11] These imbalances with increasing demand of human and material resources on the one hand side and a lack of sufficient financial sources on the other ... compassion As in Germany and Austria health care workers and in particular physicians are in short supply opinion leaders in health care politics and hospital administrators should try to focus their ... staging and radiotherapy treatment planning of head and neck carcinoma Radiat Oncol 2008, 18(3):29 Sharma N, Neumann D and Macklis R: The impact of functional imaging on radiation medicine Radiat...
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Báo cáo khoa học: " A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI" pptx
... was the treating physician of the patient JG supervised the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... of this case report and accompagnying images A copy of the written consent is available for review by the Editor -in- Chief of this journal Author details Department of Pediatric and Adolescent ... Hospital, Paris, France Authors’ contributions CM collected the data and wrote the manuscript FD analysed the imaging studies and contributed to the legend of figures and correction of the manuscript...
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Báo cáo khoa học: " Intensity Modulated Radiotherapy (IMRT) in the postoperative treatment of an adenocarcinoma of the endometrium complicated by a pelvic kidney" pot
... salpingo oophorectomy, and lymphadenectomy or lymph node sampling In this case, the surgical approach was not radical in intent because the uterine neoplasia was an incidental finding Therefore, ... was significant morbidity related to the procedure, especially regarding the graft vasculature, and the urinary tract In one case an adenocarcinoma of the uterine cervix in a transplanted patient ... on the border of the RT field Other reports of auto-transplantation followed by RT for inguinal-pelvic irradiation in a vulvar cancer patient, and for adjuvant treatment of a stage III operated...
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