bronchoconstriction airway inflammation and airway remodeling
Báo cáo y học: "Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines" pot
Ngày tải lên :
12/08/2014, 11:22
... recapitulated in animal models of allergic airway inflammation, and has been linked to increased airway IL-13 [20] In our hands the model of sub-chronic airway inflammation that we utilized did not ... IL-13, and other Th2 cytokines, by H R antagonists could have a meaningful therapeutic effect on inflammation, remodeling and airway dysfunction in a subchronic model of allergic lung inflammation ... separate peripheral and central airway measures Newtonian airway resistance, a measure of central airway resistance, was significantly increased in the vehicle animals at both 25 and 50 mg/ml Mch...
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Báo cáo y học: " Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of b-receptor affinity in murine models of asthma" pdf
Ngày tải lên :
12/08/2014, 13:22
... Figures and 5, we conclude that the airway constriction elicited by inhaled allergen is very small and probably does not carry much biological significance in the airways of mice The increase in H and ... sensitized and challenged with OVA Balb/C mice were anesthetized and connected to a flexiVent and then received inhalation challenges of aerosolized OVA The OVA inhalation was repeated times and the ... immunomodulatory and anti-inflammatory CCSP was not affected by albuterol treatment Protein and IgG1 It has been shown that various challenges to the airway mucosa can induce plasma extravasation [23] and...
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Báo cáo y học: " Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18 J Foster Harris1, Jay Aden1, C Rick Lyons2 and " doc
Ngày tải lên :
12/08/2014, 15:20
... sustained pulmonary inflammation in the lung and airway remodeling observed in chronic diseases such as asthma and chronic bronchitis Understanding the resolution process and factors that may ... neutrophilic inflammation and airway damage In summary, the present study shows that LPS-induced airway inflammation follows classic stages of resolution for PMNs, macrophages, lymphocytes and certain ... analysis of airway epithelia Both the proximal and distal axial airway sections at generations and 11, respectively, were analyzed for each of our data sets Histochemical staining and analysis...
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Báo cáo y học: " Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD" potx
Ngày tải lên :
12/08/2014, 15:21
... induced by inflammation after smoking cessation are less evaluated It was also suggested, that various metalloproteinases (MMPs), especially MMP-2 and MMP-9, mediate airway inflammation and remodelling ... analyse the patterns of airway inflammation in COPD patients depending on their smoking status, and compare it to smokers without airways obstruction ('healthy' smokers) and healthy never-smokers ... controversial Thus, we aimed to analyse airway inflammatory cell patterns in smokers and ex-smokers with COPD and to compare whether it differs from 'healthy' smokers and neversmokers Also, according...
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Báo cáo y học: "Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling" pptx
Ngày tải lên :
12/08/2014, 16:20
... function, increases AHR, and induces airway inflammation in dogs [3], guinea pigs [4], and humans [5-7] Chronic airway inflammation is associated with airway remodeling that includes airway wall thickening ... hyperplasia, and hypertrophy; and myofibroblast and goblet cell hypertrophy [8-11] Airway wall thickening and airway reactivity were inversely associated in patients with asthma, suggesting that airway ... deposition and smooth muscle cell hyperplasia and hypertrophy in mice subjected to long-term ozone exposure These changes suggest that chronic airway remodeling may be associated with AHR and airway inflammation...
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Báo cáo y học: " Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness" pptx
Ngày tải lên :
12/08/2014, 18:21
... feature of airway inflammation Such an increased mucus production in the airways is associated with reduced airway caliber, occlusion of small airways, reduced FEV1 [40], impaired gas exchange and compromised ... lobe (left and right) were fixed in 4% paraformaldehyde for 16 hours and embedded in paraffin for light microscopy Haematoxylin and eosin stained sec- Quantification of macrophages and airway smooth ... between control and 5-day exposed rats (P = 0.789) ** Significantly different from control, 5-day and 20-day exposed rats and * indicates significantly different from control and 1-day and 5-day exposed...
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Báo cáo y học: " Regional differences in the pattern of airway remodeling following chronic allergen exposure in mice" pptx
Ngày tải lên :
12/08/2014, 16:20
... indices of airway remodeling differs depending on the airway generation [9-11] present and characterize methods for assessing allergeninduced airway remodeling in the small and medium airways of ... same airway was repeated for 10, 15, 20, 25, 30, and 35 μm band depths Medium and small airways were arbitrarily defined by determining the mean airway area of all airways collected The airways ... heterogeneity of airway remodeling we compared remodeling events between large (primary bronchus), medium, and small airways using optimized band depths (see above and ref [18]) A) AirwayOVAweeks...
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Báo cáo y học: "Small airway remodeling in acute respiratory distress syndrome: a study in autopsy lung tissue" ppsx
Ngày tải lên :
14/08/2014, 07:21
... and the morphological parameters Figure Lung histology from ARDS and control patients Representative photomicrographs of distal airway and alveolar tissue from ARDS (A and C) and control (B and ... (A and B), anti-fibronectin (C and D), anti-versican (E and F) and anti-MMP-9 (G and H) ARDS airways show higher content of collagen I, fibronectin and versican and higher MMP-9 expression by ... composition In chronic airway inflammatory lung diseases, airway remodeling is correlated with marked changes in airway mechanics and symptoms related to airway obstruction [14] Although airway obstruction...
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Recent Advances in Immunology to Target Cancer, Inflammation and Infections Edited by Jagat R. Kanwar ppt
Ngày tải lên :
07/03/2014, 20:20
... agnetic bead sorting and anti(Netherlands) CD4 and anti-CD8 antibodies Positive CD4+ T helper cell IL-2 reactivity was restricted to patients infected by HPV and related types -16 and showed a strong ... Willemsen, Johan Garssen, Lộon M.J Knippels and Belinda vant Land Chapter 14 Immune System and Environmental Xenobiotics - The Effect of Selected Mineral Fibers and Particles on the Immune Response ... cervical cancer and its diagnostic importance, vaccines for therapyprovidinginsightsontheclinicalstudiesconductedandevaluated.Thiswill surely highlight the understanding of the disease and gap that...
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Báo cáo Y học: Nucleotide excision repair and chromatin remodeling pptx
Ngày tải lên :
31/03/2014, 21:21
... damage recognition and dual incision (XPA, XPC-hHR23B, RPA, TFIIH, XPG and XPF–ERCC1) and other factors for repair DNA synthesis and ligation (PCNA, RFC, DNA polymerase a or d and DNA ligase I) ... recruitment of TFIIH, XPG, and XPA-RPA (5) NER endonucleases, XPG and ERCC1-XPF make dual incisions at the 3¢ and 5¢ sites, respectively (6) DNA polymerase d and/ or e, PCNA, RFC and RPA fill in the gap ... linker DNA [36] ACF, ATP-utilizing chromatin assembly and remodeling factor, consists of ISWI and Acf1 in addition to a few other polypeptides and is well conserved from Drosophila to human [47–49]...
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cell migration in inflammation and immunity
Ngày tải lên :
10/04/2014, 11:13
... synthetic LD78β isoforms The Mr and purity of synthetic unfolded (A–C) and folded (D and E) LD78β(1–70) (A and D), LD78β(3– 70) (B and E), and LD78β(5–70) (C and F) were determined by electrospray ... spacer and separating gels contain respectively 5% T (w/v% of acrylamide monomer + bisacrylamide) and 5% C (5% bisacrylamide in total acrylamide), 10% T and 3.3% C, and 13% T and 5% C, and proteins ... conditions and silver stained (C) The higher Mr bands on the left half of the gel and the lower M r bands on the right half of the gel correspond to proteins purified from the 0.4 M and 0.5 M...
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chromatin and chromatin remodeling enzymes, part b
Ngày tải lên :
11/04/2014, 01:17
... is calculated from the and 00 and known Re (30.1 nm) of the T3 internal standard For the unknown band(s) of interest, the and 00 are determined experimentally and the Re in each running ... regulators, methods for the preparation and analysis of histone modifying and ATP-dependent chromatin remodeling enzymes, and assays for transcription and DNA repair on chromatin templates We ... Visualization and 3D Structure Determination of Defined Sequence Chromatin and Chromatin Remodeling Complexes By Rachel A Horowitz-Scherer and Christopher L Woodcock Recent progress in preparing and purifying...
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chromatin and chromatin remodeling enzymes, part c
Ngày tải lên :
11/04/2014, 01:19
... HHT1 and HHT2 (for histone H three), HHF1 and HHF2 (for histone H four), HTA1 and HTA2 (for histone H two A) and HTB1 and HTB2 (for histone H two B) HHT1 and HHT2 encode identical H3 proteins, and ... assays of histones and chromatin regulators, methods for the preparation and analysis of histone modifying and ATP-dependent chromatin remodeling enzymes, and assays for transcription and DNA repair ... P Jambeck, M E Churchill, and C D Allis, Genes Dev 12, 627 (1998) 11 T Jenuwein and C D Allis, Science 293, 1074 (2001) 6 chromatin modification and remodeling [1] and histone modifiers are examined...
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chromatin and chromatin remodeling enzymes, part a
Ngày tải lên :
11/04/2014, 02:02
... assays of histones and chromatin regulators, methods for the preparation and analysis of histone modifying and ATP-dependent chromatin remodeling enzymes, and assays for transcription and DNA repair ... human, and its deposition has been shown to be replication independent (reviewed in Smith22) It is thought to help specify centromere 19 C von Holt, W N Strickland, W F Brandt, and M S Strickland, ... H4 class and the more diverse H2A and H2B classes.2 The H3 class comprises two subclasses that are markedly distinct in sequence and in function: replication-dependent H3 (the major H3) and centromeric...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... indomethacin) reduced brain inflammation and Aβ levels in addition to the deposition of Aβ in brain [13,14] Despite this evidence, and the considerable theoretical and therapeutic interest, the ... purposes) Journal of Neuroinflammation 2004, 1:21 concentrations were determined spectrophotometrically and expressed as pg/mg tissue IL-1β levels were measured by a standardized sandwich ELISA kit following ... 450 nm Oxidized protein standards, internal controls and blanks were always assayed at the same time and in the same way All samples were always determined in triplicate and in a blind fashion Immunoblot...
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báo cáo hóa học: " Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions" pptx
Ngày tải lên :
19/06/2014, 22:20
... inflammation and subsequent tissue damage in MS remain largely unexplored In this study we investigated correlations between the regulation of IL-16, regulation of CD4+Th1 inflammation, and inflammation- induced ... Journal of Neuroinflammation 2006, 3:13 Here we present our findings on the expression and distinct regulation of pro- and secreted IL-16 in acute, subacute and chronic MS lesions, and in normal-appearing ... of Neuroinflammation 2006, 3:13 http://www.jneuroinflammation.com/content/3/1/13 medium and heavy chains, suggesting inflammationinduced changes in axonal cytoskeleton in MS lesions and NAWM...
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báo cáo hóa học: " Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury" potx
Ngày tải lên :
19/06/2014, 22:20
... burn injury per se might result in microgliosis and loss of vulnerable neuronal populations from inflammation- induced cell death Inflammation and apoptosis are two of the most important underlying ... is observed in diverse states of inflammation that are associated with tissue injury and actin release, including hemorrhagic shock [24], early sepsis, trauma, and rheumatoid arthritis [25] In ... the animals (9-10 mice per group) were sacrificed at 8, 24, 48 and 72 h postburn (pb) Tissue and plasma samples were collected and stored at -80°C Survival rate Survival rates were recorded for...
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Báo cáo y học: "Stem cells, inflammation and allergy" ppsx
Ngày tải lên :
08/08/2014, 21:20
... Mouse and human expression of shared molecules between inflammation and stem cells Mouse and human expression of shared molecules between inflammation and stem cells Comparison of mouse and human ... either upper airway challenge, lower airway challenge, or upper and lower airway challenges with ovalbumin This increase correlated with a boost in mature eosinophils in the blood and tissue, ... of inflammation, particularly in the lung [6] Indeed, Denburg and colleagues have shown that eosinophil precursors are elevated in the bone marrow during development of upper and lower airway inflammation, ...
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Báo cáo y học: "Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus" ppsx
Ngày tải lên :
09/08/2014, 01:22
... WHR and HBR contributed equally to this work YL carried out data analysis and interpretation, and the study design, and assisted in manuscript preparation PYL participated in date analysis and ... of data and patient recruitment WHR carried out the study design and data interpretation, and assisted in patient recruitment and preparation of the manuscript HBR conceived of the study and coordinated ... FcγRIII/ CD16 and FcγRII/CD32 on circulating monocytes from SLE patients, and the relationship of FcγR expression levels to renal involvement and chemokine production Materials and methods Study...
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Báo cáo y học: "β Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis" ppt
Ngày tải lên :
09/08/2014, 01:23
... Institute (Geneva, Switzerland) Water and food were provided ad libitum and all experiments were approved by the Institutional Animal Care and Use Committee of Switzerland Induction and treatment of arthritis ... 5-µm sagittal serial sections of whole hind paws were cut and stained with hematoxylin and eosin and examined for the degree of synovitis and bone erosions by microscopic evaluation in a blinded ... Ltd), IL-18 (MBL Ltd, Nagoya, Japan), and IL-8 (CLB, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands) by sandwich ELISA β Evaluation of apoptotis...
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