both the mean and range charts shift
Báo cáo khóa học: Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells potx
... on the binding of HB-19 Similarly, the iron-binding hTf had no effect On the other hand, bLf inhibited the binding of HB-19 to cells In accordance with the involvement of both lobes of hLf in the ... nucleolin, the bLf N-t and, at a somewhat lower extent, the bLf C-t, were also inhibitory (Fig 6B) These observations further confirm the interaction of Lf with surface nucleolin and illustrate that the ... Numbers at the ends of the strips correspond to the first and last amino acid residues of polypeptides The dotted lines show the approximate locations of the four structural domains: N1 and N2 domains...
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Báo cáo hóa học: "INEQUALITIES INVOLVING THE MEAN AND THE STANDARD DEVIATION OF NONNEGATIVE REAL NUMBERS" doc
... compact set and F is a continuous function on Ᏹ Then, there exists x0 ∈ Ᏹ such that F(x0 ) = minx∈Ᏹ F(x) The proof is based on the application of the necessary condition given in the preceding theorem ... [0,1] Thus, the theorem has been proved Theorem 2.10 If y1 ≥ y2 ≥ y3 ≥ · · · ≥ yn ≥ 0, then p p m y2 + √ s y2 ≤ n−1 s y2 p+1 , m y2 p+1 + √ n−1 (2.73) 14 Inequalities on the mean and standard deviation ... differentiable If the function J has at u a relative minimum with respect to the set U and if the constraints are qualified, then there exist numbers λi (u), ≤ i ≤ m, such that the Kuhn-Tucker conditions...
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Báo cáo khoa học: " Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death" docx
... both mitochondria and the ER, Bcl-2 ActA targeted to mitochondria, Bcl-2 cb5 expressed at the ER, and Bcl-2 ΔTM localized in the cytosol The Bcl-2 homology domains BH1-BH4 are indicated together ... critical reagents and participated in the design of the study DA conceived and designed the experiments, analyzed data and wrote the paper All authors read and approved the final manuscript Acknowledgements ... mitochondrial membrane [15] They have also been found localized at the ER, where they regulate apoptosis in response to a range of cellular stresses, and also in the nucleus [15], where they may fulfill...
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Báo cáo y học: "Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome" pot
... the DIS and in the NC protein The results of Fig 4B show that either the E18G or G31K substitution in NC was independently able to facilitate complete Pr55Gag processing in the SD2 virus In the ... mutations in the DIS (A423G), and NC (E18G and G31K) regions Next, we tested the ability of the two NC mutations to restore vRNA incorporation Fig 2B shows that the presence in SD2 of either E18G ... in Materials and Methods A Non-denaturing Northern analysis of the SD2 variant in conjunction with compensatory mutants in the DIS, CA, and p6 B Non-denaturingNorthern analysis of the SD2 variant...
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Tài liệu Báo cáo khoa học: The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo pdf
... For both RARa and RARb, the 30 kDa proteolytic fragments (marked by a diamond) of the receptors were protected from digestion by the presence of either retinoid (A, lanes and 6; B, lanes and ... in both RARa and RARb in a limited proteolysis assay in the same manner as at-RA Taken together, these observations indicate that S-4o9cDH-RA functions as a bona fide ligand for both RARa and ... with either at-RA or S-4o9cDH-RA (Fig 5A,B, lanes and 6) In the presence of either compound, the receptors demonstrated a different digestion pattern compared with the controls, resulting in the...
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Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt
... expression vectors for the Grb4 SH2 and RGS3 PDZ domains The DNA sequences encoding the Grb4 SH2 and the RGS3 PDZ domains were individually deduced from the amino All the peptides, either with or without ... from the differences of the 13Ca and 13Cb chemical shifts of the We next address the questions of whether secondary tyrosine phosphorylations would affect the Grb4 SH2 domain binding to the ephrinB2(301–333)-pY304 ... Taken together, both the NMR and fluorescence polarization experiments Table The effect of tyrosine phosphorylations on the binding affinity of ephrinB2(301–333) to the SH2 domain of Grb4 and to the PDZ...
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Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt
... investigated the effect of PF-4 on another angiogenic factor of prime importance, VEGF, and compared the mechanisms by which PF-4 inhibits the DNA synthesis induced by VEGF165 and VEGF121 The DNA synthesis ... substrate of KDR kinase, is then phosphorylated and activated, leading to the activation of protein kinase C (PKC), followed by the serine/ threonine kinase, Raf1 and then the threonine/tyrosine kinase, ... vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation J Biol Chem 275, 5096–5103 32 Kroll, J & Waltenberger, J (1997) The vascular endothelial...
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Tài liệu The Golden Mean and the Physics of Aesthetics pdf
... that the occurrence of the numbers 3, 7, and 22, in this series is not a coincidence and the above construction was behind the identification of the 22 micronotes in the Indian theory of music The ... dimensions and (b) as a spiral If the stimulation inside the brain corresponding to an input spreads through a spiral function, then the pleasantness of the golden mean would be clear On the other hand, ... of universal standard for ‘beauty,’ either in the human face or in the arts.” (Livio, 2002b) In this note I first present the background to the golden mean and its relationship to the Mount Meru...
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Báo cáo khoa học: The stop transfer sequence of the human UDPglucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms docx
... both the retrieval mechanism mediated by the KSKTH motif at the C-terminus of the CT and by 1064 a static retention mediated by the hydrophobic domain of the TMD Furthermore, we showed that the ... Indeed, the CD4–TMD26 staining pattern overlapped with the ER and Golgi markers, calnexin and GM130, respectively (Fig 5B) In the case of CD4–TMD21, staining was observed in both the ER and the perinuclear ... result from the properties of the TMD and its interaction with the membranes It has been demonstrated that TMD of the yeast Sec12p and UBC6 (ubiquitin-conjugating enzyme 6) and of the rabbit cytochrome...
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Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region pot
... investigated the influence of the ARE and the CRID on the poly(A) status of the human IFN-b mRNA in natural conditions of IFN-b synthesis Materials and methods Reagents All the reagents and enzymes used in ... encoding the HA epitope was inserted at the end of the IFN-b coding sequence to distinguish the products resulting from the expression of the DNA constructs and the endogenous gene (Fig 2) These ... (Fig 3B, compare lanes and 3) However, deletion of both the ARE and the CRID (pIFNCRIDHAAU-) led to a blockade of the deadenylation process (Fig 3B, compare lanes and 7) These results demonstrate...
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The a and b adapters are used as priming sites for both amplification
... “A” and “B” adapters are ligated to the blunt ends using DNA ligase • The strands are denatured using sodium hydroxide to release the ssDNA template library (sstDNA) The Adapters • The A and ... for both amplification and sequencing since their composition is known • The B adapter contains a 5’ biotin tag used for mobilization • The beads are magnetized and attract the biotin in the ... to the number of nucleotides incorporated • Therefore, if the intensity of a single read is times the intensity of a previous read, there are times the amount of incorporated nucleotides in the...
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Báo cáo khoa học: Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon doc
... polyxylan that has been shown to modify both the symptoms and the progression of osteoarthritis in both humans and animals [21] We and others have shown that the calcium salt of pentosan polysulfate ... shows that the rate of [35S]sulfate appearing in the medium was suppressed by the inclusion of the sulfated polysaccharides At the end of the culture period, both CaPPS and heparin reduced the appearance ... and it is therefore likely that the outcome of the inhibition of aggrecanase activity in tendon is the retention of large proteoglycans within the extracellular matrix of the tissue [22–27] The...
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Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
... required for the interaction with the middle domain, which mediates the dimerization of HSP90, and the other, the identification of the minimal region of the C-terminal domain for the client binding ... between HSP90a and HtpG and between GRP94 and HtpG On the other hand, a complex was not formed between HSP90a and GRP94 as reported previously [22] Table Interaction between the middle and C-terminal ... HtpG Our hypothesis that the C-terminal 35 amino acids were not essential for the dimerization was verified by the data shown in Fig On the other hand, the second assumption that the 35 amino...
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Báo cáo khoa học: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm pdf
... between the two enzymes, showed no correlation between their nuclear localization and CREB-repression activities On the other hand, both the nuclear and cytoplasmic SIK1 mutants inhibited the ACTH-induced ... distributed diffusely both to the nucleus and to the cytoplasm of resting Y1 cells On the other hand, SIK1(I607A/L610A) was localized mainly in the cytoplasm These findings suggest that these hydrophobic ... of the N-terminal regions and of the C-terminal regions were separately amplified by PCR and then ligated to these fragments To amplify fragments containing residues 1–572, 1–585 and 1–612, the...
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Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt
... can inhibit the SERCA Ca2+ pumps by reducing both the affinity of Ca2+ binding and phosphoryl transfer and postulate that the drug binds to and interferes with the Ca2+ entry pathway of the Ca2+-ATPase ... added The filters were then counted for both 3H and 45Ca2+ The amount of [3H]glucose trapped on each filter was used to calculate the wetting volume and was subtracted from the total Ca2+ bound to the ... spectrophotometer and the absorbance was monitored at 422 and 390 nm, and the difference taken Ca2+-binding to the ATPase was measured using the dual labeling technique of Longland et al [13] ATPase...
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american gridlock why the right and left are both wrong commonsense 101 solutions to the economic crises
... of the Dialogue of the Deaf At least five developments over the past half-century have contributed to today’s Dialogue of the Deaf These range from the culture wars of the 1960s and 1970s, to the ... hastened the end of civilized discussion as the gulf between the Left and Right grew, and as the attacks of the one on the other grew ever more vitriolic Much of what happened reflected the way ... rhetoric of the opposite party This development in turn has widened the gulf between Left and Right and thereby amplified the Dialogue of the Deaf Alas, the Media Was the Message As these developments...
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market efficiency and market anomalies three essays investigating the opinions and behavior of finance professors both as researchers and as investors
... their theoretical model The χ2 statistic, however, can be misleading depending on the complexity of the model (the more complex the model, the better the fit), the size of the sample (the larger the ... efficiency and advances in asset pricing As I develop the theory, I explain the necessary conditions and then discuss the empirical implications of the model The results ultimately corroborate the theory ... determine whether the overall fit of the model is adequate and whether the latent variables are reliably reflected by the observed variables selected to manifest them in the model The χ2 from the model...
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technicians of the sacred a range of poetries from africa america asia europe and oceania jan 1985
... download the previous chapter’s source code solution, and then make the modifications for the current chapter on your own The Trailhead I go hiking in the mountains almost every weekend I love the ... of you: the editor, the syntax, the tools As you continue to progress, you begin to catch sight of the wide range of features that the technology offers You gain more and more mastery, and with ... access the local filesystem and the Internet From there, learn how to use the device to shoot photos, record sound and video, and use the captured data in your app Next, see the wide variety of options...
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