... domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.EMBO Rep 10, 285–292.11 Jin Y, Blue E & Gallaher PJ (2006) Control of death- associated protein ... the lysosomal proteasecathepsin B negatively regulates protein levels of DAPK [12] and the alternative splice variant of DAPK, s-DAPK, promotes the destabilization of DAPK in a proteasome-independent ... microtubulenetwork.The death domain is a signalling module present inmany proapoptotic proteins. The death domain of DAPK is one of the key domains central to its signallingfunction and was identified as one of...
... viroporins of RNA viruses (such as 6Kprotein of Sindbis virus, E protein of mouse hepatitisvirus, M2 protein from influenza A, 2B and 3A pro- teins of poliovirus, or p7 and NS4A of hepatitis ... theCMV IE promoter and EGFP gene with the VP3 geneunder control of the MPyV late promoter.Proteins fused to the EGFP tag were prepared by inser-tion of sequences of MPyV minor proteins VP2, ... cells. In the late phase of SV40 infection, production of a late protein, VP4 (125amino acids from the C-terminus of VP3), which trig-gers the lytic release of virus progeny, was recentlydescribed...
... new, active form of DKB in which the system designer can assess process and property trade-offs on the basis of estimated properties as an active part of the system design process. An example ... extensive legacy property data. In addition to early prediction of conventional DKB property minimums, accurate prediction of the full property probability distribution supports improved probabilistic ... development of probabilistic modeling approaches for the reliable early prediction of DKB minimum properties, with greatly reduced reliance on test data. Adopting a mechanistic approach in which property...
... as a pro -death mechanism in phenomena such as autophagic cell death [12–15]. Intuitively, an excess of autophagyabove a threshold can be the mechanism by whichautophagy functions as a pro -death ... initially suggesting that auto-Fig. 1. Pro- survival and pro -death roles of autophagy. Autophagypromotes starvation survival and inhibits neurodegeneration, agingprocess, hypoxia injury, and possibly ... decision between pro- survival and pro -death is determined by the level of activation. A better understanding of autophagy signaling pathways will be helpful to elucidate how the level of autophagy...
... vitro antifungal properties of chitosan and its role in protection of soybean from a sudden death syndrome (SDS) were evalu-ated. Chitosan inhibited the radial and submerged growth of F. solani ... with sudden death syndrome. Plant Dis. 73, 581–584.Rupe, J.C., Gbur Jr., E.E., 1995. EVect of plant age maturity group and theenvironment on disease progress of sudden death syndrome of soy-bean. ... diseases of horticultural commodities. Crop Prot.25, 108–118.Bell, A.A., Hubbard, J.C., Liu, L., 1998. EVects of chitin and chitosanon the incidence and severity of Fusarium yellows of celery....
... back-ground. A detailed molecula r profiling of the tumorcells of each patient as well as the definition of biomar-kers which predict the drug response will be of utmostimportance to choose the ... inhibition of pro- liferation, cell death induction, or both. There fore, in anext step, we examined whether the anti-neoplasticeffects of ErPC3 and ionizing radiation include induc-tion of cell death, ... down-regulation of p-Akt may berequired for the anti-neoplastic action of small moleculeinhibitors of the PI3K/Akt pathway in prostate cancercells.Combined effects of ErPC3 and ionizing radiation inprostate...
... greaterincidence of serious hemorrhage with rhAPC than wasevident in the PROWESS trial. The results of the ADDRESStrial, designed with the purpose of prospectively studying theeffect of rhAPC in ... high risk ofdeath but onlygoes as far as identifying patients with APACHE II ≥ 25 as anexample of such a group. Patients at high risk ofdeath fromsevere sepsis would indeed seem the appropriate ... priorias having either high or low clinical assessment of risk of death. Unfortunately we do not know what the assessments of risk ofdeath were because clinicians treating the patientwere...
... dictionary was developed for professionals in the field of healthpromotion and health education and in related professions. It identi-fies a wide range of terms and health and professional organizations ... School Health Program“An organized set of policies, procedures, and activities designed to protect,promote, and improve the health and well-being of students and staff,thus improving a student’s ... and delineation of specific health-related behavioralproblems that can likely affect the outcome of a health program, based onthe PRECEDE/PROCEED Model of health education program planningTerms9c02.qxd...
... because of some difficulties.2.5.1 Scale of operation In general, most software outsourcing companies are of small scale and facing up with dispersed, unprofessional development. The scope of software ... the provider, the project to be undertaken, the process of the project and the relationship with the provider. These aspects include potential risks such as expertise and manpower of provider, ... exported US$ 725 million of software products out of total production of some US$ 9.6 billion.Vietnam in fact is not a much developed country especially in the field of software outsourcing and...
... prevention and treatment of obesity. 3. Nutrient composition of soy protein Soybeans provide one of the most abundant plant sources of dietary protein. The protein content of soybeans varies ... isoflavones, 0.1-5 mg total isoflavones/g soy protein [35]. Isolated soy protein and other soy protein prod-ucts, such as tofu and soy milk, provide about 0.1-2 mg isoflavones/g soy protein. Green soybeans ... value of soy protein is roughly equivalent to that of animal protein of high biological value [28]. For example, iso-lated soy protein has a protein digestibility-corrected amino acid score of...
... Centre of Infection and Immunology and Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China Corresponding address: Prof. C.H. Cho, Department of Pharmacology, ... investigated whether AP could protect the bone marrow and the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric ... processing and analysis system at a 200x magnification (Q500IW, Leica Imaging Systems, Cambridge, UK). Assessment of cell proliferation To determine the number of proliferative cells, proliferating...
... in vivo detection of interactions of proteins, enables identification of protein-protein interactions between a soluble bait and its interacting prey [5]. However, such a screening system is ... round of screening. Half of the colony was streaked on SD/-Trp agar plate and the other half inoculated into 20àl of PCR mix. PCR products were sequenced to determine the identity of the ... number of cellular membrane proteins have been isolated in this study. These include a resident protein of endoplasmic reticulum (thioredoxin-related transmembrane protein 2), an adaptor protein...
... therelatively recent handing over of the process of dying and the acts of disposal togroups of specially trained deathwork professionals. Making use of the sociologistGoffman (1959), I wanted to look ... bycontemporary death customs and rituals in the production and reproduction of representations of death. Our deathways exist in time and place and I have attempted to give a brief socialhistory of British ... over to a deathwork professional. During the Victorian era funeralsbecame an occasion for the display of wealth. Bradbury traces some vicissitudes inthe history of the deathwork professionals...
... purpose of the ESP programme is to help the learners be able to use English for their professional purposes, especially to read professional documents in their specific fields. The ESP programme ... works. The results of evaluation enable the different kinds of decision to be made about the programme, such as: to decide whether to continue the programme or not or to improve the programme to ... aims at improving to the current programme as well as to future programme.In summary, it is necessary to evaluate aspects of a language programme in order to understand how the programme works...
... efficiency of grain production is the result of several processes operating atdifferent spatial scales but the influence of each of these processesdiffers between the scales. From the comparison of ... logarithm of the production of the ith grid cell(i =1,2, , N), xiis a (1  k) vector of the logarithm of the produc-tion inputs associated with the ith grid cell, b is a (k  1) vector of unknown ... intensity of rice pro- duction with large number of people engaged in rice productionand post-production activities including processing, storage, andtransport. Also Chinese cereal production...