blood brain barrier as a complex trait with genetic and physiological components prospects
Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
... rats appeared ill as demonstrated by exudates around nose and eyes, tachypnea and decreased spontaneous movement Sham-operated rats seemed grossly normal and were active within their cages Changes ... determination of plasma magnesium levels at baseline (T0) and 24 hours (T24) after the induction of sepsis, and an equal volume of saline was given Mean arterial pressure was recorded at baseline and 2, ... involve a disturbance of plasma and brain neutral amino acid transport across the blood brain barrier (BBB), similar to those seen in porto-systemic encephalopathy This process has been related...
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Báo cáo Y học: Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles A possible role in membrane secretion pptx
... N.I., Lasierra, P., Larrad, L., Pineiro, A. , Alava, M .A & Naval, J (1999) Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles J Immunol 163, 1274–1281 27 Mather, ... were transfected with plasmids containing MFG-E8-L (A and B), MFG-E8-S (C and D), DC1 (E and F) and DC2 (G and H) or empty plasmid (I and J) Transfectants were fixed and stained with the antiserum ... serum and peroxidase-labeled goat anti-(rabbit IgG) Ig as the secondary antibody, and peroxidase activity was measured Scanning electron microscopy Samples for scanning electron microscopy analysis...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... cerebral vasculature by anandamide provides a new mechanism that may explain the therapeutic action of increased anandamide tone in neuroinflammatory diseases like MS Additional material Additional ... A, Bari M, Granata F, Gasperi V, De Stefano ME, FinazziAgrò A, Strom R: Regulation by cannabinoid receptors of anandamide transport across the blood- brain barrier and through other endothelial ... VCAM-1 As suggested in the cardiovascular endothelium [51,52] in the brain endothelium AEA and other endocannabinoids like 2-AG, would be synthetized and released from a nearby source such as astrocytes...
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Agency and Consciousness in Discourse: Self-other Dynamics as a Complex System ppt
... Lai Ping, Carlo Prevignano, Duane Savage-Rumbaugh, Susan SavageRumbaugh, Zhang Shaojie, Jared Tagliatela, Godfrey Tanner, Amy Tsui, Theo van Leeuwen, Eija Ventola, and David Wallace To my daughter, ... imagination and treats him to the same deictic words as before so that he may see and hear what can be seen and heard there (and touch, of course, and perhaps even smell and taste things) Not with ... diverse scalar levels of semiotic and material organization Michael Halliday, Ruqaiya Hasan, and Jay Lemke deserve a very special mention for their generosity and support – both intellectual and personal...
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the blood – brain barrier
... growth factors such as basic fibroblast growth factor and heparin binding proteases and protease inhibitors (214) Therefore regulated release of growth factors and proteases from the basal lamina reservoir ... ZO-1 is a component of the human and rat blood- brain barrier Neurosci Letts 129, 6–10 90 Yamamoto, T., Harada, N., Kano, K., et al (1997) The Ras target AF-6 interacts with ZO1 and serves as a peripheral ... regions along the plasma membrane associated with caveolin-1 (102) Caveolin-1 interacts with and regulates the activity of several signal transduction pathways and downstream targets (103) Several...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
... experimental animals were approved by the local Animal Care and Use Committee and were performed in a facility approved by Association for Assessment and Accreditation of Laboratory Animal Care Cerebral ... release by BECs through MAPK signaling pathways may be a therapeutic target in HIV-associated neurological dysfunction Abbreviations ANOVA: Analysis of variance; BBB: Blood- brain barrier; BEC: Brain ... by SD and MAF-D Writing was a joint effort with WAB overseeing and editing final draft All authors have read and validated the final manuscript Acknowledgements The authors thank Dr Maria A Deli...
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báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot
... Angelidou, A. , Alysandratos, K D., Zhang, B., Asadi, S., Francis, K., Toniato, E., and Kalogeromitros, D.: Mast cell activation and autism Biochim.Biophys.Acta 2011, 24 Kempuraj, D., Asadi, S., Zhang, ... approaches directed to the core symptoms of ASD and/ or brain mast cell activation and inflammation [23] Use of select, natural, flavonoids, may be useful because of their anti-oxidant and anti-inflammatory ... anti-inflammatory ability [65] Luteolin is a flavone contained in chamomile and chrysanthemum Increasing evidence indicates that luteolin has potent antioxidant, free radical scavenger, anti-inflammatory...
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Hình thái và chức năng của hàng rào máu não (blood brain barrier)
... thông qua hai enzym cyclo-oxygenase lipo-oxygenase từ acid arachidonic HETE hydroxyeicosatetranoic acid, PG prostaglandin, LT leukotrienes, HHT hydroxyheptadecatetranoic acid, Tx thromboxane, HPETE ... bệnh sinh sốt AA phóng thích từ phospholipid màng tế bào hoạt h a men phospholipase A2 AA bị biến đổi hai enzym khác Thông qua đường cyclo-oxygenase, AA bị chuyển h a thành prostaglandins (PGs) ... giống guanylate kinase kết hợp màng tế bào (Membrane- Associated Guanylate Kinase-Like Proteins MAGUK) gọi tắt MAGUK protein MAGUK protein có đặc tính là: protein tỷ trọng 95 kDa, hậu synap, có...
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Báo cáo y học: " Primary pulmonary mucinous cystadenocarcinoma presenting as a complex bronchocele: a case report" ppsx
... Hoshikawa Y, Chida M, Sato M, Sasano H, Kondo T: Pulmonary mucinous cystadenocarcinoma: report of a case and review of the literature Ann Thorac Surg 2003, 76:1738-1740 Higashiyama M, Doi O, Kodama ... DRL and MW reviewed and edited the manuscript All authors read and approved the final manuscript References Gowar FJS: An unusual mucosal cyst of the lung Thorax 1978, 33:796-799 Iwasaki T, Kawahara ... Kawahara K, Nagano T, Nakagawa K: Pulmonary mucinous cystadenocarcinoma: an extremely rare tumor presenting as a cystic lesion of the lung Gen Thorac Cardiovasc Surg 2007, 55:143-146 Gao ZH, Urbanski...
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Báo cáo y học: "False positive diagnosis of malignancy in a case of cryptogenic organising pneumonia presenting as a pulmonary mass with mediastinal nodes detected on fluorodeoxyglucose-positron emission tomography: a case report" ppsx
... metastases to mediastinal nodes The patient underwent mediastinoscopy and thoracotomy and the histological diagnosis after the operation was a cryptogenic organising pneumonia Case presentation ... increased uptake inPET/CT consolidation with areas oftomAxial series showing dense images lobe and focal uptake in a Axial series showing dense consolidation with areas of increased uptake in ... fungal colonisation was found in the resected lung Although COP has been associated with a variety of infections including fungal infections, we are not aware of any association with ABPA The...
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Báo cáo khoa học: " Renal blood flow in sepsis: a complex issue" pptx
... enhance our knowledge in this area as the search for effective therapies to prevent and treat the devastating disease of ARF associated with sepsis continues New data indicate that this understanding ... that reduced perfusion to microvascular beds, and worsening hypoxia in these zones of the kidney, is not leading to a cycle of continued inflammatory response and the associated endothelial and ... the regional microvasculature Additionally, the role of potential therapies to minimize inflammation, endothelial dysfunction and the resulting interactions between endothelium and white blood cells...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... assessed for each experimental group Statistical analysis All values are expressed as mean ± standard deviation Data were analysed with a one-way analysis of variance, and individual group means were ... by C 5a blockade Pituitary glands were surgically removed, total RNA was isolated and analysed for POMC and GH by quantitative real-time PCR mRNA expression for both, POMC and GH was dramatically ... when breakdown of the BBB was analysed by EB extravasation 24 hours after CLP Animals treated with preimmune IgG displayed robust EB extravasation in the cerebral and pituitary areas (panel f),...
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Báo cáo y học: " Endothelial Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study" pptx
... Elastase -a -antitrypsin complex (EA) levels [26] were measured by ELISA according to the instructions of the manufacturer (Sanquin) Plasminogen activator activity (PAA%) was measured by an amidolytic ... P value was below 0.01 Conclusions We have shown that transfusion is associated with pulmonary and systemic inflammation as well as with activation of coagulation and impaired fibrinolysis, an ... transfusion was associated with longer mechanical ventilation in the ICU The finding that blood transfusion is associated with inflammation and activation of coagulation and impaired fibrinolysis...
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Application of biologically active micelles in drug delivery across the blood brain barrier
... neurons also connect closely against the endothelial cells and contain vasoactive neurotransmitters and peptides (Gaillard et al., 2000; Janzer and Raff, 1987) 2.1.2.1 Astrocytes Astrocytes are glial ... 170 XII ABBREVIATIONS ABC avidin-biotinylated horseradish peroxidase complex AJ adherent junction AMT absorptive mediated transcytosis BBB blood brain barrier BCEC brain capillary endothelial cells ... that could cross the BBB in pharmaceutical market Lipid carriers that have been used include dihydropyridine, adamantane and fatty acylcarriers, such as N-docohexaenoyl (Bodor, 1994; Shashoua and...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
... BRAIN CANCER AND OTHER BRAIN DISEASES A brain tumor is a mass of unnecessary cells growing in the brain [94] There are two basic kinds of brain tumors: primary brain tumors and metastatic brain ... make PLGA and PLA-PEG nanoparticles of small enough size and appropriate surface coating to deliver therapeutic agents and contrast materials across the blood brain barrier for chemotherapy and medical ... modality in most diseases of the brain and spine and has attained major importance in imaging diseases of the musculoskeletal system MR imaging in 34 the head and neck and pelvis has attained a...
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Flavor enhancement as a tool for increasing pleasantness and intakeof a snack product among the elderly
... flavor and in overall flavor, and stronger in after-taste than the sample with a regular aroma concentration The heightened aroma concentration caused a slight off-flavor described as ‘artificial’ ... Preliminary data analysis revealed no significant main effects and only one significant interaction of day and aroma on the pleasantness ratings of the young, implicating an increase in pleasantness ... a small food reward after the last evaluation session Samples The sample material was a fermented oat bran product (Yosaw, Bioferme, Finland), which is a cereal-based snack food similar to flavored...
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Hydromagnetic convective flow past a vertical porous plate through a porous medium with suction and heat source
... Unsteady free convective MHD flow and mass transfer past a vertical porous plate with variable temperature Bull Cal Math Soc.2005, 97 (2), 137-146 [15] Ogulu A. , Prakash J Heat transfer to unsteady ... friction at the wall against Kp for different values of magnetic parameter M and heat source parameter S are entered in Tables and respectively From Table 1, we observe that a growing magnetic parameter ... transfer to unsteady magneto-hydrodynamic flow past an infinite vertical moving plate with variable suction Das and his co-workers [16] estimated the mass transfer effects on unsteady flow past...
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A contrastive analysis of encouraging as a speech act in english and vietnamese
... English as an international language in this century, there are a great number of the Vietnamese people who learn and speak English In fact, in learning English as a foreign language, the Vietnamese ... International LTD, Green, Georgia, M (1989), “Pragmatics and Natural Language Understanding, Lawrence Erlbaum Associates, Publishers, Hisdale, New Jersey Hove and London.”[43] In the book, the author ... theoretical bases about pragmatics, mentions and discusses speech acts Thomas, J (1995), “Meaning in interaction: An introduction to Pragmatics, Longman.” [73] This book accords a central place to...
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