biosynthesis of parathyroid hormone
Báo cáo y học: " Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation" pps
... transformation of cells in vitro [17,18] About 80% of ATLL patients develop humoral hypercalcemia of malignancy (HHM), a life-threatening paraneoplastic syndrome that occurs in a wide variety of cancers ... conjunction with other oncogenes The goal of this study was to investigate the expression of PTHrP, its receptor, and MIP-1α during the early stages of immortalization of human lymphocytes by HTLV-1 Using ... levels of PTHrP mRNA and protein expression were likely due to differences in translation efficiency, processing of the mature protein, and/or its secretion from the cells Regulation of Page of 12...
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Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... is different in all of the tetrameric PDCs of known three-dimensional structure Binding of the cofactors ThDP and Mg2+ The homo-tetrameric IPDC binds four molecules of the cofactors ThDP and Mg2+ ... free of cofactors A molecular mass of 60 000 Da per subunit resulted from SDS/PAGE, which corresponded to the value calculated from the nucleotide sequence of the structural gene The identity of ... content of 45% The structure of IPDC was solved by molecular replacement using a dimer of ZmPDC as an initial search model and refined to final Rfree/ R-values of 23.6%/20.5% The stereochemistry of...
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Tài liệu Báo cáo khoa học: Biosynthesis of riboflavin Screening for an improved GTP cyclohydrolase II mutant pdf
... Biosynthesis of riboflavin – generation of an improved cyclohydrolase II M Lehmann et al C D A B E Fig Pathway of riboflavin biosynthesis (A) GTP cyclohydrolase II (B) Sequence of deaminase, ... that the first reaction step of the enzyme-catalyzed trajectory is the covalent guanylation of the enzyme under release of pyrophosphate [12] Carbon of the purine system of intermediate is then hydrolytically ... range of three- to four-fold, compared with that of the wildtype protein Notably, the steady-state parameters of the B subtilis wild-type protein were similar to those of GTP cyclohydrolase II of...
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Tài liệu Báo cáo Y học: Identification of a set of genes involved in the biosynthesis of the aminonucleoside moiety of antibiotic A201A from Streptomyces capreolus pdf
... in the biosynthesis of the aminonucleoside moiety of A201A Here we report the sequencing of a total of 6946 bp, which include the ata genes most likely implicated in the biosynthesis of this ... identical to those of the similar genes of the pur cluster In Actinomycetes, this approach has led to the functional characterization of genes implicated in the biosynthesis of a variety of antibiotics ... variety of these enzymes synthesize 4-keto-6-deoxy-GDP-D-mannose, a key intermediate in the biosynthesis of many deoxyhexoses as GDP-D-rhamnose [31,32], which is a moiety of A201A Upstream of ata12...
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Báo cáo khoa học: Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone A retrobiosynthetic NMR study with root cultures of Swertia chirata docx
... The biosynthesis of mangostin: the origin of the xanthone skeleton J Chem Soc Chem Commun., 619–620 12 Bennet, G.J., Lee, H.-H & Das, N.P (1990) Biosynthesis of mangostin Part 1: the origin of ... fragment of phosphoenolpyruvate after decarboxylation (in blue) (Fig 1) Ó FEBS 2003 Biosynthesis of 1,3,5,8-tetrahydroxyxanthone (Eur J Biochem 270) 2955 Fig Labelling pattern of the B and C ring of ... the biosynthesis of ring C of 1,3,5,8-tetrahydroxyxanthone can be subjected to a rigorous test by prediction of the 1,3,5,8-tetrahydroxyxanthone labelling pattern from the labelling patterns of...
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Báo cáo khoa học: Biosynthesis of riboflavin 6,7-Dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe pot
... trichloroacetic acid, and the supernatant Ó FEBS 2002 Biosynthesis of riboflavin (Eur J Biochem 269) 523 Fig Sequence alignment of lumazine synthases Elements of secondary structure found in S cerevisiae ... absorption spectrum of the complex differed substantially from that of free riboflavin in several respects The absorption band of riboflavin at 370 nm showed a bathochromic shift of about 20 nm (Fig ... case of the W27Y mutant, the absorption and CD spectra of the riboflavin/enzyme complex differed substantially from those of the wild-type protein (Figs and 4B) Whereas the general shape of the...
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Báo cáo Y học: Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid ppt
... Luffa cells (A) Time course of accumulation of bryonolic acid and total sterol in cultured Luffa cells Mean of three replicates Bar indicates SD (B) Time course of levels of isomultiflorenol synthase ... was compared with that of the cycloartenol synthase responsible for sterol biosynthesis in cultured Luffa cells, which showed sophisticated regulation of triterpenoid biosynthesis M AT E R I ... contents of bryonolic acid and total sterols were calculated from the peak area of their trimethylsilylated products relative to that of the internal standard Sterol content was the total content of...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... of the biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of FadD26 in the biosynthesis ... and PGL biosynthesis [9], and the presence of lower amounts of PpsA–E in the bacterial cell would decrease the production rates of both classes of lipids In such a case, introduction of a wild-type ... production of PGL-tb (Fig 4B) A close examination of the DIM + PGL locus organization revealed that fadD29 is located upstream of Rv2949c, a gene required for the biosynthesis of p-HBA, a precursor of...
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Báo cáo khoa học: Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae) docx
... Oxidation of farnesol is related to the biosynthesis of insect juvenile hormone [28,29] As far as we know, there is no report of the presence of farnesal and its related compounds (e.g juvenile hormones) ... oxidation of geraniol is one of the key steps in the production of neral [12] The low amount of the enzyme may be due to its specific role in alarm pheromone biosynthesis Citral, a mixture of neral ... Neral has the basic skeleton of most of the mite monoterpenes Because of this, neral is thought to be a key compound in the monoterpene biosynthesis of mites Neral is one of the most widely distributed...
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Báo cáo khoa học: Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase – role of the catalytic center in mRNA recognition potx
... downregulation of LHR is paralleled by a specific, transient disappearance of its mRNA transcripts [7,10] Further studies on the mechanism of rapid degradation of LHR mRNA led to the identification of a ... of LHR mRNA to MVK The inhibitory effect of mevalonate was found to be less pronounced when compared with that of ATP There was a significant decrease at a concentration of ATP or mevalonate of ... studies have shown that binding of MVK to LHR mRNA suppresses the translation of mRNA in vitro [14] As the mutation of any of the four amino acids at the active site of MVK decreases its binding...
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Báo cáo khoa học: Biosynthesis of isoprenoids – studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase pdf
... (based on the concentration of 1) during a period of 24 h at 37 °C, irrespective of the presence or absence of IspC Using an equilibrium mixture of [U-13C5]-1 and of the component resonating ... absence of any detectable excess of the 13C13C coupling satellites beyond the natural abundance level for the signals of C-3 and C-4 of a hypothetical product 1c The hypothetical positions of the ... absence of fragment exchange, where they reflect the presence of about 1.1% 13C in those carbon atoms of the reactant that were not labeled On the basis of the quantitative evaluation of the 13...
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Báo cáo khoa học: Hidden stereospecificity in the biosynthesis of divinyl ether fatty acids ppt
... observed in the biosynthesis of colneleic acid (Table 1, Fig 2) Stereospecificity of hydrogen eliminations from C8 in the biosynthesis of colneleic acid isomers Stereospecificity of hydrogen eliminations ... [22] and prostacyclin synthase [22] In the case of divinyl ether biosynthesis, the initial step is believed to consist of cleavage of the O-O bond of the hydroperoxide to provide an alkoxy radical, ... Stereospecificity of hydrogen eliminations from C14 in the biosynthesis of etheroleic acid isomers It has been shown previously that biosynthesis of colneleic acid from 9(S)-HPOD catalyzed by divinyl...
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Báo cáo khoa học: RNAi-mediated knockdown of juvenile hormone acid O-methyltransferase gene causes precocious metamorphosis in the red flour beetle Tribolium castaneum pdf
... using a variety of candidate substrates, are needed to elucidate the functions of TcMT1 and TcMT2 Significant role of TcJHAMT in the regulation of JH biosynthesis and maintenance of the larval status ... Ventral view of pupae that were injected with dsRNA of EGFP or TcMT3 on day of the third larval instar (day 0_3rd) Scale bar, 500 lm (B) Dorsal and ventral views of adults injected with dsRNA of EGFP ... significance of JHAMT in JH biosynthesis In this study, the red flour beetle Tribolium castaneum was chosen to analyse the in vivo function of JHAMT In this species, RNAi-mediated knockdown of a gene of...
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Báo cáo khoa học: Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR, HR3, E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera ppt
... B1 isoform) of other insect EcRs and a strong degree of identity was confined to the two ends of N-terminal region of the A/B domain Using a B1 isoform-specific probe from the A/B region of PIEcR, ... molecular mass of bybridizing RNAs Results Effects of JH II on 20E-induced late responses in IAL-PID2 cells We first tested the sensitivity of cells to JH II by studying the effects of this hormone on ... ends of the B1 isoform specific segment in the N-terminal region (Fig 4) There was no similarity to the N-terminal specific regions of either the A or the B2 isoform (data not shown) All of these...
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Báo cáo khoa học: Biosynthesis of isoprenoids A bifunctional IspDF enzyme fromCampylobacter jejuni pot
... relative mass of 42 kDa as judged by polyacrylamide gel electrophoresis MALDI-TOF mass spectrometry afforded a relative mass of 41 870 Da, in close agreement with the calculated mass of 41 971 Da ... activities of 6.6 lmolÆmin)1Æmg)1 (Table 4) were found with Ca2+ Ni2+ and Cu2+ could not serve as cofactors The Km value for was 19 lM (Table 4) A systematic analysis of the genomic localization of ispD ... and may form part of an operon In all cases of fused ispD and ispF domains as well as of directly linked ispD and ispF genes, the ispD module is invariably located at the 5¢ end of the ensemble...
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Báo cáo khoa học: Biosynthesis of platelet glycoprotein V expressed as a single subunit or in association with GPIb-IX doc
... the biosynthesis of platelet GPV, a subunit of the GPIb–V–IX Ó FEBS 2004 Biosynthesis of platelet glycoprotein V (Eur J Biochem 271) 3675 Fig Surface expression and intracellular processing of ... expression of GPV as measured by flow cytometry (Fig 1A), despite selection of a strongly expressing clone by a series of amplifications in the presence of increasing concentrations of methotrexate ... Ó FEBS 2004 Biosynthesis of platelet glycoprotein V (Eur J Biochem 271) 3673 Fig Distribution of GPV in CHO/GPV cells in the absence of GPIb–IX (A) GPV expression on the surface of platelets...
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Báo cáo khoa học: Biosynthesis of riboflavin in Archaea 6,7-Dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii pdf
... Construction of an expression plasmid for modified lumazine synthase of Bacillus subtilis Fig Terminal reactions in the pathway of riboflavin biosynthesis The coding region of the ribH gene of B subtilis ... Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin J Bacteriol 136, 657–667 Hollander, I & Brown, G.M (1979) Biosynthesis of riboflavin: reductase and deaminase of Ashbya ... terminal reaction steps of the riboflavin biosynthesis, thus producing riboflavin from one molecule of structure and two molecules of structure The unusual molecular topology of that enzyme complex...
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Báo cáo Y học: Biosynthesis of vitamin B2 An essential zinc ion at the catalytic site of GTP cyclohydrolase II ppt
... Replacement of any of the three cysteine residues in GTP cyclohydrolase II resulted in proteins that were devoid of zinc within the limit of experimental accuracy (Table 3) The conversion of GTP into ... antimicrobial and antiprotozoal spectrum of activity Later, trimethoprim, an inhibitor of dihydrofolate reductase, was introduced for the treatment of bacterial infections, often in combination with sulfonamides ... riboflavin and tetrahydrofolate pathway start from GTP (Fig 1) The first step of each pathway involves the hydrolytic opening of the imidazole ring of the substrate with formation of formate as a byproduct...
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Báo cáo Y học: Endogenous cardiac glycosides, a new class of steroid hormones pot
... proliferation as well as the expression of isoforms of Na+/K+-ATPase When infused for weeks in rats, ouabain and digoxin differentially affected the expression of isoforms of the sodium pump in different ... OUABAIN IS A NEW STEROID HORMONE Identification of ouabain as endogenous inhibitor of the sodium pump There is now much evidence that ouabain is a new steroid hormone of the adrenal cortex and ... synthesis of catecholamines and that catecholamines stimulate the release of renin Increased concentrations of Na+ increase the synthesis of angiotensin converting enzyme (ACE) [107] Stimulation of...
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Báo cáo khoa học: Biosynthesis of D-arabinose in mycobacteria – a novel bacterial pathway with implications for antimycobacterial therapy pdf
... scheme of biosynthesis of D-arabinofuranosyl residues of the cell-wall arabinogalactan and lipoarabinomannan in mycobacteria, including a feedback mechanism and possible sites of action of ethambutol, ... beginning of a fruitful search that has led to the identification of the d-arabinose pathway, and to a better understanding of cell-wall biosynthesis and of the mechanism of action of ethambutol ... lipid-linked sugars of mycobacteria In spite of several claims of the existence of activated nucleotide and 1-phosphate derivatives of d-arabinose [35–37], water-soluble activated forms of d-arabinose,...
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