biomarkers of disease activity
Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" ppsx
... possible influence of gender on the clinical status and disease activity measures of RA appears to be of value Therefore, we explored possible associations of gender and disease activity measures, ... sites in 25 countries as of April 2008 Gender differences were analyzed for American College of Rheumatology Core Data Set measures of disease activity, DAS28 (disease activity score using 28 ... cohort, RA disease activity measures appear to be worse in women than in men However, most of the gender differences in RA disease activity may originate from the measures of disease activity rather...
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Báo cáo y học: "Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity" pot
... Evaluation of the efficacy of long-term therapy shows that, after years of infliximab therapy, the majority of patients had a low level of disease activity and that approximately half of the patients ... at each of weeks 0, 6, 14, and 22: 28 and 66/68 swollen/tender joint counts, ESR, CRP, HAQ, physician's global assessment of disease activity, patient's global assessment of disease activity, ... infliximab at year 4, 62% had a low level of disease activity, as defined by a DAS28 score of less than 3.2 Nearly half (49.5%) of these patients had minimal disease activity (DAS28 less than 2.85 or...
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Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" potx
... possible influence of gender on the clinical status and disease activity measures of RA appears to be of value Therefore, we explored possible associations of gender and disease activity measures, ... sites in 25 countries as of April 2008 Gender differences were analyzed for American College of Rheumatology Core Data Set measures of disease activity, DAS28 (disease activity score using 28 ... cohort, RA disease activity measures appear to be worse in women than in men However, most of the gender differences in RA disease activity may originate from the measures of disease activity rather...
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Báo cáo y học: "Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis" doc
... for RA patients and leads to improved control of disease activity Thus, therapeutic drug monitoring of infliximab may improve the control of disease activity in RA Competing interests DM and J-PV ... conventional laboratory marker testing Control of disease activity was categorized as 'optimal', 'acceptable', or 'inadequate' by a combination of disease activity score for 28 joints (DAS28) and physician ... therapeutic strategy and improves the control of disease activity in RA The secondary objective was to study whether this improvement in control of disease activity is related to changes in infliximab...
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Báo cáo y học: " Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency" pdf
... may not be representative of functional extracellular proteolytic activity in vivo In the past five years, three different concepts of biomarkers of protease activity of extracellular matrix degradation ... FEV1, Kco and baseline value of each of the biomarkers was assessed by the Spearman's rank correlation coefficient Results Analysis of change over time of any of the three biomarkers for a given treatment ... 15 to day 44 for each of the treatment groups was calculated for each of the three different biomarkers To test for a treatment effect of hyaluronic acid on each of the biomarkers, the differences...
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báo cáo hóa học: " Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity" ppt
... patient's UC activity We expect that the future combination of improved survey questions for UC activity assessment and biomarkers of UC inflammation will result in better assessment of disease activity ... unresponsive symptom domains Discussion Conventional assessment of disease activity in ulcerative colitis is done using any one of a number of disease activity indices that measure various symptoms and signs ... investigation and validation as representative of UC disease activity This will be undertaken in develop- ment of questions for assessment of disease activity based on these frequent and responsive...
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Báo cáo y học: "Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus" potx
... signs of disease activity defined as a SLEDAI peak score of at least (median 16) for a median time of 16.1 months (range 5–27 months) The term ‘flare’ was used to describe the time-point of highest ... g of albumin per 24 hours), haematuria and/or cellular casts by urine analyses at some time during the study On the occasion of each blood sampling, disease activity was assessed by the SLE disease ... markers of disease activity in rheumatoid arthritis than in SLE [15] Relations between anti-C-reactive protein autoantibody (anti-CRP) levels and systemic lupus erythematosus disease activity...
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Báo cáo y học: "Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy" pps
... histopathological features in SpA reflect global disease activity independently of SpA subtype, disease duration, and treatment Prediction of global disease activity in individual SpA samples Since the ... rate (ESR) of 28 ± 24 mm/hour The mean duration of disease was 5.5 ± 5.4 years, and 23 of the 82 patients were being treated with a disease- modifying antirheumatic drug (DMARD); none of the patients ... chance of being real) were considered significant Finally, histological parameters that not only are correlated with disease activity but also contribute significantly to the prediction of the disease...
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Báo cáo y học: "Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score" potx
... Changes in (a) Disease Activity Score (DAS)28, (b) Simplified Disease Activity Index (SDAI) and (c) Clinical Disease Activity Index (CDAI) in relation to the achieved American College of Rheumatology ... aspects of validity of the CDAI [29]: correlational validity refers to comparison with other measures of disease activity; discriminant validity in this setting relates to the correlation of changes ... in the assessment of RA disease activity [38] On the other hand, joint counts are also required for other composite disease activity scores, and the CDAI allows elimination of at least one variable...
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Báo cáo y học: "Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients" docx
... (hydrochloroquine 200 to 400 mg/day) For each patient, disease activity and disease- related damage were assessed at the time of blood donation using the SLE Disease Activity Index 2000 (SLEDAI-2K) [16] and ... Correlation of chemokine score with disease activity, as assessed using SLEDAI-2K and hypocomplementaemia To investigate whether the expression of IFN-inducible chemokines might be related to SLE disease ... be related to SLE disease activity, we compared chemokine scores in SLE patients with different levels of disease activity, as assessed using SLEDAI-2K and the level of complement C3 SLE patients...
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Báo cáo y học: "Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity" pps
... Ankylosing Correlationand clinical index of disease T Lymphocyte Antigen- 4Spond(sCTLA-4) and clinical index of disease activity Bath Ankylosing Spondylitis Disease Activity Index in 165 patients with ... clinical index of disease activity SLEDAI in one study [16], but not in a second [15] In systemic sclerosis, patients exhibited high levels of serum sCTLA-4 that correlated with disease activity [16] ... with disease activity These high levels of circulating sCTLA-4 in SpA were not explained by altered intracellular expression of CTLA-4, but by a preferential expression of the spliced form of CTLA-4...
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Báo cáo y học: "Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort" pdf
... interquartile ranges In spite of the high number of patients and because of the uneven frequency of early RA and UA data, we used nonparametric tests for statistical analysis of continuous variables ... determine whether markers of B-cell activation can serve as predictive factors of long-term clinical activity The main limitations of this study were the short duration of follow-up (1 year) so ... [21,22] The originality of the present study is to also assess markers of activation of alloreactive B cells in early arthritis, such as total levels of immunoglobulins, FLCs of immunoglobulins,...
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Báo cáo y học: "Physical function, disease activity, and health-related quality-of-life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis" potx
... [7] – were used in the long-term follow-up of adalimumab treatment The Bath AS Disease Activity Index (BASDAI) was included as a measure of disease activity [36] Available online http://arthritis-research.com/content/11/4/R124 ... quality of life Recent research has suggested that the ASQOL is a psychometrically sound and responsive measure of disease- specific quality of life in patients with AS and differences of one to ... availability of TNF antagonists (infliximab, adalimumab, and etanercept), AS patients have experienced improvements in the signs and symptoms of their disease In clinical trials of TNF antagonists,...
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Báo cáo y học: "Increased levels of circulating microparticles in primary Sjögren''''s syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity" pdf
... Correlation of MP level with disease activity of pSS and other AIDs As MPs can reflect the state of cellular stimulation, we hypothesized that the level of MPs could be associated with AID activity ... state of cell activation in these diseases However, because the level of MPs increases less in patients with more severe disease, the interest of using MP levels for monitoring disease activity ... We found no association or correlation of level of these biomarkers with disease activity Discussion In the present study, we investigated the plasma level of circulating MPs in patients with the...
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Báo cáo y học: "ACR70-disease activity score remission achievement from switches between all the available biological agents in rheumatoid arthritis: a systematic review of the literature" doc
... dissociation However, comparing the changes in disease activity and response to tocilizumab using the Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) in three clinical ... efficacy of etanercept when infliximab had been ineffective Twenty-five RA patients were enrolled; 18 of them discontinued infliximab because of lack of efficacy, and 22 completed 12 weeks of etanercept ... 62% of infliximab-treated patients achieved an ACR20 response compared with 29% of etanercept-treated patients, and 30.7% of group achieved ACR50 compared with 14.3% of group DAS28 values of Available...
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Báo cáo y học: "Early Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector" pps
... detected in serum samples from these mice B Reduced disease activity in adeno IL-10 gene transfected mice A combinatorial index of disease, or disease acticvity index (DAI), defined as stool blood, ... benefit of adenoviral gene delivery We found that compared to adeno-null or untreated mice, adenoviral IL-10 gene transfection after induction of clinical disease reversed the course of the disease ... 7–10 when adenoviral administration of IL-10 was given on day Disease activity in control mice continued at the same level as the adeno-null mice on DSS Disease activity was slightly higher in adeno-null...
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Báo cáo y học: "Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis" pps
... evaluation of disease activity and response to therapy in lupus nephritis Distinction of disease activity from organ damage in SLE remains a challenge Indirect assessment of disease activity such ... Microscopic examination of a kidney biopsy, with classification and estimation of indices of renal disease activity and chronicity, today offers the best possibility to estimate renal disease and its ... study also confirms previous findings of associations between anti-CRP and lupus disease activity as assessed by common clinical and laboratory disease activity measures, such as complement and...
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Báo cáo y học: " Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients" potx
... disease activity (3.2 5.1) The DAS28 specifies the disease activity measuring the number of tender and swollen joints, the ESR and VAS of general ... University of Wuerzburg We differentiated the patients according to EULAR criteria in patients in remission (DAS28 ≤2.6), patients with low disease activity (2.6
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Báo cáo y học: "Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis" pot
... there were no correlations to disease parameters such as disease activity as measured by the disease activity score (DAS), the presence and level of rheumatoid factors of IgA, IgM, or IgG class or ... phagocytosis of apoptotic cells and it is noteworthy that the plasma levels of sMer did not correlate with disease activity [15] Moreover, in most of the patients, the plasma concentrations of sMer ... data suggest that shedding of Mer is an active process in the SLE disease process and that the levels of sMer reflect disease activity Abbreviations ACR: American College of Rheumatology; ARA: American...
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