bevacizumab in advanced prostate cancer
Báo cáo sinh học: "Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review" pdf
... 42 43 in advanced cancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic ... cancer patients Many clinical trials have been conducted using active specific immunotherapy (ASI) in CRC, including autologous tumor cell vaccines, define-tumor protein vaccines, monoclonal antibodies ... suspected minimal residual colorectal cancer (suspected minimal residual CRC), and reviewed the objective clinical outcomes of ASI in advanced colorectal cancer (advanced CRC) during the past...
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Báo cáo khoa học: "Concurrent radiochemotherapy in advanced hypopharyngeal cancer" doc
... approach in patients with advanced hypopharyngeal cancer Concerning the radiotherapy technique in the treatment of hypopharyngeal cancer, we recommend the adoption of IMRT in the routine clinical ... routine laboratory studies Patients were staged according to the 2002 criteria of the American Joint Committee on Cancer [26] Written informed consent was obtained from the patients for including ... structures by using IMRT are reasonably expected to enable improvement in locoregional control in advanced hypopharyngeal cancer The improvement of locoregional control in advanced head and neck cancer...
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Báo cáo khoa học: "Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts" docx
... diluted in heparinized saline to 0.06 M) was inserted into the tail vein of the mice The mice were placed in an adapted cradle and put into the coil, before being placed in the scanner During image ... RT in preclinical studies [19,21] Promising results have been demonstrated in clinical studies in sarcoma [20], as well as in locally advanced non-small cell lung cancer and head and neck cancer ... portrayed in Figure No adverse effects, including skin toxicities, were observed in any of the experimental groups Treatment monitoring using DCE MRI Following Brix modeling of contrast kinetics,...
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báo cáo khoa học: "Evaluation of HER2 and p53 expression in predicting response to docetaxel-based first-line chemotherapy in advanced breast cancer" docx
... positive staining of p53 in a representative case of high-grade (G3) ductal carcinoma Immunostaining shows a clear and wide nuclear staining in an high grade (G3) invasive ductal carcinoma Original ... categories: no staining, or weak staining in fewer than 10% of the tumor cells (0); weak staining in part of the membrane in more than 10% of the tumor cells (1+); complete staining of the membrane ... of cancer and the second leading cause of cancer death in women in the USA [1] and its incidence is increasing in many countries, including Italy [2] thus representing a major health problem To...
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Báo cáo y học: "Chemotherapy in advanced bladder cancer: current status and future" pdf
... months [49] Paclitaxel-carboplatin-gemcitabine triplet was investigated in two phase II trials involving patients in the first line in one trial, and in 1st/2nd lines in another trial ORRs and CR ... cell carcinoma and in the second line treatment of GIST (gastrointestinal stromal tumors) after failure of imatinib Sunitinib has been tested in bladder cancer as single agent, in combination ... treatment in first line and second line in different metastatic tumors In bladder TCC, bevacizumab (15 mg/kg on day 1) was evaluated in first line treatment in combination with GC protocol (gemcitabine...
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Báo cáo y học: " Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients" pdf
... cloning these into the pCR4-TOPO vector (Invitrogen) For each PCR, positive control plasmids containing the R- or Q-sequence were included Recombinant Proteins, Immunization Recombinant proteins ... carcinoma or other cancers (reviewed by zur Hausen, 2009 [18]), infectious agents causing inflammatory (precancerous) lesions are suspected to be involved in the pathogenesis of prostate carcinoma ... RR homozygous In total, 146 sera from prostate cancer patients and healthy control individuals were tested negative for antibodies binding recombinant XMRV gp70 and Gag proteins in ELISA, although...
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Investigating the superoxide mediated survival pathway in the prostate cancer cell line LNCaP
... result in cell death The delicate redox balance is kept in check, and is often the deciding factor in determining cell fate in these cancer cells 1.6 PROSTATE CANCER Prostate cancer, the cancerous ... still not clearly defined In particular, the increased amounts of O2˙ˉ reported in prostate cancer cell lines indicate a likely role for O2˙ˉ in promoting survival that is undefined The aim of this ... 75 phosphorylation, increasing Bcl-xL expression and preventing Bax activation We also show evidence that Pim-1 was the main effector in O2˙ˉ signaling; maintaining Bad serine 75 phosphorylation...
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Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 1
... necessary in order for another PH domain-containing serine/threonine kinase identified as phosphoinositide-dependent kinase (PDK1) to phosphorylates Akt on Thr308 within its activation loop Binding ... role in apoptotic cell death in mammalian cells Besides mediating apoptosis in the intrinsic pathway, it also amplifies the extrinsic apoptotic pathways in certain cell types, making it the point ... CLL/lymphoma Bcl-x long form Bcl-2 homology BH3-interacting domain agonist Bcl-2 interacting mediator of cell death Bovine serum albumin C-terminal kinase domain Diethyldithiocarbamate Dimethyl sulfoxide...
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Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 2
... tyrosine kinase inhibitors that function by blocking the ATP acceptor site (lysine 721) located within the receptor’s intracellular kinase domain (Levitzki and Gazit 1995) The EGFR kinase inhibitor, ... targeting the PI3K-Akt pathway alone Perifosine, an oral alkylphospholipid was demonstrated to decrease Akt activation and induce apoptosis in various cancer cell lines including prostate cancer ... mediate PI3K-independent survival in prostate cancer cell lines (Yang et al 2003) However, our findings show that incubation with 10% serum or EGF did not increase Bcl-2 and Bcl-xL in LNCaP even...
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EXPRESSION ANALYSIS AND FUNCTIONAL STUDY OF HS3ST3B1 IN HUMAN PROSTATE CANCER
... prognostic indicator, seminal vesicle invasion, is defined as cancer invading into the muscular coat of the seminal vesicle (Ohori et al., 1993) In most cases, it occurs in glands with EPE (Epstein et ... fibronectin 3.4 Immunohistochemical analysis of HS3ST3B1 in 77 prostate cancer 3.4.1 Clinicopathological parameters of prostate 77 cancer patients in study 3.4.2 Expression of HS3ST3B1 in prostate cancer ... gene involved in heparan sulphate biosynthesis, was verified in prostate cancer cell lines LNCaP and PC-3 Silencing of this gene was then carried out in normal prostate epithelial cell line RWPE-1...
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Báo cáo khoa học: " Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study" docx
... colorectal cancer as well as in the adjuvant setting in colon cancers [8-14] Furthermore, capecitabine has been investigated in various protocols for rectal and other gastrointestinal cancers in combination ... shown to increase the efficacy of therapy in metastatic colorectal cancer [27] It is postulated that combining bevacizumab with chemoradiation may increase antitumour efficacy by maximizing inhibition ... evaluating preoperative capecitabine and oxaliplatin reported a pCR rate of 10% while studies investigating preoperative capecitabine, oxaliplatin and bevacizumab found rates of 24-36% [32-34] In...
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ADVANCES IN PROSTATE CANCER docx
... Activation in Prostate Cancer 589 Luis A Espinoza VII VIII Contents Section Cell Adhesion Proteins in Prostate Cancer 617 Chapter 25 Integrins in Prostate Cancer Invasion and Metastasis 619 Paulynn Chin ... of all prostate cancer cases The risk of getting prostate cancer increases nearly exponentially with increasing age This makes prostate cancer one of the most distinctive cancers in aging popu‐ ... of Prostate Cancer 331 Chapter 14 Stem Cells and Prostate Cancer 333 Vildan Bozok Çetintaş, Bur in Tezcanlı Kaymaz and Buket Kosova Chapter 15 Salinomycin-Induced Apoptosis in Human Prostate Cancer...
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báo cáo hóa học:" Can urinary exosomes act as treatment response markers in prostate cancer?" ppt
... produced by LNCaP -prostate cancer cell line Prostate cancer cell lines (LNCaP and DU145), as indicated, were maintained in culture as a source of positive-control prostate cancer exosomes (for ... of urine (for at least 18 hours at 37°C) (Figure 6c) Discussion We present the findings of a pilot study, investigating urinary exosomes in prostate cancer patients We had two main aims in the ... loading Bands for prostate- derived proteins PSA or PSMA were evident in patients (p1, p7, p8, p9, p10), indicating that at least some of the exosomes present in the urine were of prostate origin...
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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx
... Against HLA-A24-positive AMACR-positive Prostate Cancer Cell Lines To confirm that CTLs induced with AMACR peptides could exert cytotoxicity against AMACR-expressing prostate cancer cell lines in ... immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous tissue (Figure 2C) These data indicated that AMACR had a mostly cancer- specific expression ... Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Surgically resected prostate cancer tissue...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot
... receptor tyrosine kinase inhibitor ZD1839 in non-small cell lung cancer and other solid tumors Clin Cancer Res., 9: 2040-2048, 2003 Clin Cancer Res 2003, 9:1990-1994 Jaeschke R, Singer J, Guyatt ... 12-item prostate cancer subscale (PCS) to assess symptoms and problems specific to prostate cancer In addition, the 26-item Trial Outcome Index (TOI) was computed by combining the physical wellbeing, ... T, Doyle-Lindrud S, Beers S, Goodin S, Rubin E, DiPaola RS: A phase I trial of weekly paclitaxel, 13- cis-retinoic acid, and interferon alpha in patients with prostate cancer and other advanced...
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Báo cáo hóa học: " Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab" doc
... both as single agent or in combination: a 2-hour intravenous infusion at 400 mg/m2 followed by weekly 1hour infusion of 250 mg/m2 In the GOIM study Cetuximab was administrated in combination with ... Figure PFS in four group of patients For corresponding lines see the key in figure Group A: +GCN/1st line; Group B: -GCN/1st line; Group C: +GCN/more lines; Group D: - GCN/more lines; (+: increased; ... antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal xenografts Clin Cancer Res 2002, 8:994-1003 Dittmann K, Mayer C, Rodemann HP: Inhibition of radiation-induced EGFR...
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Báo cáo sinh học: " Downregulation of APOBEC3G by Xenotropic Murine Leukemia-Virus Related Virus (XMRV) in Prostate Cancer Cells docx
... replicate in these cells Findings This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines We demonstrate the presence of A3G in prostate ... cell lines specifically in LNCaP cells [3,18] In addition, the prostate cancer cell line 22Rv1 has been shown to be chronically infected with XMRV and produces highly infectious virus [19] Since ... media containing FBS were added After 1–2 weeks, XMRV infection was confirmed by detecting XMRV p30 protein by using goat polyclonal anti-Rauscher MLV p30 Gag in uninfected (−) and XMRV infected...
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