... each permutation, the p-values were re-computed andthe number of genes significant at the 0.001 level was noted The significance level ofthe global test was the proportion ofthe permutations ... largest variance over the samples of all such orthogonal linear combinations, and so on The samples were first centered by their means and standardized by their norms, and then the multi-dimensional ... intergenerational and comparative microRNA profiling ofthe primary melanocytic neoplasms of adults and young adults We observed distinct miRNA profiles in the primary melanocytic neoplasms of adults and young...
... Cancer Center of Sun Yat-Sen University All the patients underwent radical surgery, and none of them had undergone either chemotherapy or radiotherapy before the collection ofthe samples The histopathologic ... Committee of our institution Patients were informed ofthe investigational nature ofthe study and provided their written informed consent The count of tryptase-positive mast cells in the cancer ... (Figure andTable 1) Relationships betweenthe distribution of mast cells and clinicopathologic characteristics We used the chi-square test to assess the relationships betweenthe distribution of mast...
... Cancer Center of Sun Yat-Sen University All the patients underwent radical surgery, and none of them had undergone either chemotherapy or radiotherapy before the collection ofthe samples The histopathologic ... Committee of our institution Patients were informed ofthe investigational nature ofthe study and provided their written informed consent The count of tryptase-positive mast cells in the cancer ... (Figure andTable 1) Relationships betweenthe distribution of mast cells and clinicopathologic characteristics We used the chi-square test to assess the relationships betweenthe distribution of mast...
... ofthe structure ofthe roots of q-Bernoulli polynomials,” to appear in Journal of Computational and Applied Mathematics [15] C S Ryoo, T Kim, and R P Agarwal, “A numerical investigation ofthe ... powers In the recent paper [10], Kim and Rim constructed (h, q)-extensions ofthe twisted Euler numbers and polynomials They also defined (h, q)generalizations ofthe twisted zeta function and L-series ... Distribution and structure ofthe zeros In this section, we investigate the zeros ofthe twisted q-Euler polynomials En,q,w (z) by using computer Let w = e2πi/N in C We plot the zeros of En,q,w...
... exceeded the circumference ofthe crown This author reported that the width of spruce root systems in the Hronec locality was wider by 94 cm than the width ofthe crown On the other hand, Konôpka ... correlation betweenthe aboveground parameters andthe thickness of root plates in the two localities In general, it can be supposed that there is a correlation betweenthe aboveground parts andthe ... that the growth ability of roots fades away since the age of 80 years; and that the root systems of trees at the age of 80 years were the same as those 120 years old According to our results, the...
... staff and students at the Centre for Sleep Research, and (iv) the efforts of Adam Elshaug and Jenny Roy who assayed the urine samples with the assistance of Associate Professor David Kennaway and ... plastic bottle At the end ofthe sleep period, participants voided urine into the bottle and marked the final level of urine on the bottle with a permanent marker (The volume of urine produced ... amount of sleep between successive work periods, particularly between consecutive night shifts when they must attempt to sleep during the daytime [24] The aim ofthe current study was to examine the...
... free-rider problem, andthe theory ofthe corporation The Bell Journal of Economics (Spring): 42-64 Hermalin, B., and M S Weisbach 1988 The determinants of board composition The Rand Journal of Economics ... with a value of one if the chairperson ofthe board holds the managerial positions of CEO or president and a value of zero otherwise; BLOCKHLD = the cumulative percentage of outstanding common ... (1985) and Shivdasani (1993) Because the function ofthe chairpersonof the boardis to runboardof director meetings and oversee the process of hiring, firing, evaluating and compensating the CEO,...
... Review ofthe theories related to cohesion and translation - Analysis and synthesis ofthe collected data Design ofthe Study The thesis consists of three parts: Part I: Introduction states the ... for success of this translation andthe failure ofthe other There have been some works that analysed and contrasted cohesion between English and Vietnamese so far The purpose of these works ... teaching and learning translation in general and teaching and learning cohesion in particular Scope ofthe study The study focuses on the textual equivalence betweenThe Gift ofthe Magi by O Henry and...
... of ISP andthe extramembranous cd2 helix of cytochrome b are important for maintaining the structure ofthe hinge region and, by consequence, the movement ofthe headgroup andthe integrity of ... activity ofthe complex The mutation could also affect the binding ofthe ISP to the bc1 complex and distort the Qo site Our data showed that, in the mutant, the bc1 activity was severely decreased The ... that the increased rigidity ofthe hinge region increased the activation energy, and that the movement ofthe ISP would become the rate-limiting step ofthe Qo site reaction [14] In yeast, the...
... about the thermodynamics and kinetics ofthe binding of guanidines and N-hydroxyguanidines to iNOS Removal ofthe a-amino or a-carboxylate moiety of l-Arg has important effects on the ability ofthe ... series, the kcat value for the production of NO from the oxidation ofthe N-hydroxyguanidines varied by less than a factor 2, whereas the kcat value for the production of NO from the oxidation ofthe ... bulge betweenthe two heme propionates in contact with the heme andthe side chain of a conserved valine (V338) The decrease ofthe affinity of homo-l-Arg and homoNOHA compared with l-Arg and NOHA...
... but then terminated by the fall of Arthedain There the matter ends until the Fourth Age andthe return ofthe King The Northern Realm is gradually restored and Elessar rules both Gondor and Arnor ... depopulated lands (Cardolan, Enedwaith and Calenardhon) There is a description ofthe impact ofthe disaster on one area of close co-operation, the port-town of Tharbad: " until the coming ofthe Great ... 1944 with the death ofthe Ondoher and his three sons: Arvedui claims the throne of Gondor, but his right is rejected by the Council of Gondor (because of pride, and fear perhaps of another Kin-Strife)...
... contacts betweenthe backbone carbonyl oxygen ofthe Tyr1 ˚ group and Oe2Glu229 (TMH V, 3.22 A) and OThr220 ˚ , andthe last bidentate hydrogen bond of 3.30 A betweenthe Oe1 and Oe2Glu310 (EL-3) and ... Cys and His) located on the surface ofthe binding site, and this polarization effect can be obtained by using the QM description ofthe ligand Looking at the electronic structure ofthe ligands ... TMH V and TMH VI, giving rise to the breaking ofthe hydrogen bonds with Ala240 and Asp147, and by the presence of only one lengthened hydrogen bond, between OPhe4 and Oc1Thr218 (EL-2) ˚ of 3.52...
... result ofthe absence of a disulfide bond between Cys191 and Cys220, which is conserved in the neutrophil serine proteases HNE and PR3 The presence of a Glu at position 226 at the bottom ofthe CG ... result ofthe presence of negatively-charged residues at P2 and P2¢ that are not accommodated within the b2-tryptase active site because ofthe presence of Asp147 and Asp143 within the S2 andthe ... S1¢ pocket on the top ofthe Cys42-Cys58 loop is bordered by His57 to the west andthe aliphatic part ofthe Lys40 side-chain to the east [2] (Fig 1) As a result, the P1¢ specificity of chymase could...
... HSQC and NOESY spectra of MNK5 with and without the poly(His) tag shows that there is no detectable interaction betweenthe tag andthe remainder ofthe protein and that the solution structure of ... the interaction between HAH1 and two different soluble domains of ATP7A: the second (MNK2 hereafter) andthe fifth (MNK5 hereafter) The solution structure of both the apo- and copper(I)-form of ... unlikely also in the case of ATP7B The selectivity, if any, for the interaction of one ofthe six metalbinding domains with the chaperone should thus result from the global conformation ofthe entire...
... true if and only if the act of G doing a at t is ezecutable, andthe relation G E N ( a , / / , G , t ) is true if and only if the act of G doing a at t generates the act of G doing// at t The function ... call the former sense the data-structure view of plans, andthe latter the mental phenomenon view of plans Work in plan synthesis (e.g., Fikes and Nilsson [8], Sacerdoti [15], Wilkins [18], and ... consisting of doing the set of acts { e l , , a n - l } at t2 Note that all these are simultaneous acts; this is a consequence ofthe restriction to simple plans The right-hand side of (P1) corresponds...
... where , sp , and n are the standard deviation ofthe R R R percentage change of an exchange rate, the average spread, andthe number of quotations within the tth halfhour interval, andthe system ... (1990) and Laux and Ng (1991) support the second The second relationship also supports the model of Brock and Kleidon (1990) where the link between variations in demand andthe variability of prices ... trading and volatility at the opening of markets can be explained along the lines ofthe Admati and Pfleiderer (1988) theory, the different behaviour ofthe two currencies in different markets at the...
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... better understand the mechanism of action of HRSV neutralizing antibodies andthe impact of resistance to these antibodies upon the fusion activity ofthe F protein A summary of these results ... assays PB and ND performed the flow cytometry LG conducted sitedirected mutagenesis ofthe HRSV F protein AD and RS participated in the design, oversight ofthe conduct ofthe experiments, and interpretation ... insights into the function ofthe F protein, and help in the selection and development of clinical candidates, such as ch101F, for next generation antibody-based prophylaxis and therapy for HRSV...
... better understand the mechanism of action of HRSV neutralizing antibodies andthe impact of resistance to these antibodies upon the fusion activity ofthe F protein A summary of these results ... assays PB and ND performed the flow cytometry LG conducted sitedirected mutagenesis ofthe HRSV F protein AD and RS participated in the design, oversight ofthe conduct ofthe experiments, and interpretation ... insights into the function ofthe F protein, and help in the selection and development of clinical candidates, such as ch101F, for next generation antibody-based prophylaxis and therapy for HRSV...