bending moments reactions and thrust due to symmetrical distributed load q within some portion of the arch y 4fx l x 1 l2 tables a 13 a 15
The NCI Strategic Plan for Leading the Nation To Eliminate the Suffering and Death Due to Cancer pdf
... composed of stromal cells, the extracellular matrix, growth factors, and other proteins produced locally and systemically It plays a critical role in tumor initiation and progression and can limit the ... clinical trials informatics platform A highly interactive and optimally coordinated cancer clinical trials system will facilitate the effective conduct of small Phase I clinical trials for safety ... development, validation, and utilization of these critical assays and tools > Rapidly deploy these resources in clinical trials of new agents and apply the knowledge gained to develop subsequent...
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Health Education to Villages: An integrated approach to reduce childhood mortality and morbidity due to diarrhoea and dehydration; Maharashtra, India 2005 – 2010 pptx
... must target the female while she is still in school • Toilets and latrines In Maharashtra, 85% of rural households and 54% of all households have no access at all to a toilet facility While the ... and the use of oral rehydration therapy (ORT) .1 The purpose of this plan of action is to improve the health, and therefore the quality of life, of all citizens, especially mothers and their children ... families • Mass media 70% of all women in Maharashtra are regularly exposed to some form of mass media, and growing numbers of villagers are gaining access to television and radio If all the available...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 1) pptx
... abnormality allows excessive complement activation, with bouts of production of membrane attack complex capable of severely damaging normal cells General Clinical and Laboratory Features The clinical ... preferential site of hemolysis; in some cases the liver may be enlarged as well In all severe congenital forms of HA, skeletal changes may be noted due to over-activity of the bone marrow (although they ... is appropriate to consider what they have in common Table 10 1 -1 Classification of Hemolytic Anemiasa Intracorpuscular Defects Hereditary Hemoglobinopathies Extracorpuscular Factors Familial hemolytic...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 2) docx
... amount of hemoglobin in the cytoplasm (to a final level of 340 g /L, i.e., about mM) goes hand in hand with the gradual loss of cellular organelles and of biosynthetic abilities In the end the erythroid ... in essence, any sort of metabolic failure will eventually lead either to structural damage to the membrane or to failure of the cation pump In either case the life span of the red cell is reduced, ... most enzymes gradually decreases as red cells age Another consequence of the relative simplicity of red cells is that they have a very limited range of ways to manifest distress under hardship:...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 3) pptx
... frequent blood transfusions Chronic iron overload will cause secondary hemochromatosis; this will cause damage, particularly to the liver, eventually leading to cirrhosis, and to the heart muscle, ... that the life span of red cells is reduced (compared to the normal value of about 12 0 days) is a red cell survival study, which can be carried out by labeling the red cells with 51 Cr and measuring ... eventually causing heart failure The increased activity of the bone marrow also entails an increased requirement for erythropoietic factors, particularly folic acid Compensated Hemolysis versus HA...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 5) ppt
... extracellular domains of many of these proteins are heavily glycosylated, and they carry antigenic determinants that correspond to blood groups Underneath the membrane, and tangential to it, ... abnormalities are almost invariably inherited mutations, and thus diseases of the membrane-cytoskeleton complex belong to the category of inherited hemolytic anemias Before the red cells lyse, they often ... spherocytosis (HS) and hereditary elliptocytosis (HE) Their molecular basis has been elucidated Hereditary Spherocytosis This is a relatively common type of hemolytic anemia, with an estimated frequency...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 6) doc
... for majority of HS SLC 4A 1 7q2 1 Band HS (anion (dominant) channel) Mutations of this gene may account for ~25% of HS Southea st Polymorp Asian hic mutation ovalocytosis (deletion of (dominant) amino ... (dominant) amino acids); clinically asymptomatic; protective against Plasmodium falciparum EPB 41 1p33-p34.2 Band 4 .1 HE (dominant) Mutations of this gene account for about 5% of mostly HE, with prominent ... Rhesu Chronic Very rare; s antigen nonspherocytic associated with hemolytic total loss of all anemia Rh antigens Note: HS, hereditary spherocytosis; HE, hereditary elliptocytosis ...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 7) docx
... that of HS However, an asymptomatic form, referred to as Southeast Asian ovalocytosis, has a frequency of up to 7% in certain populations, presumably as a result of malaria selection Stomatocytosis ... central pallor Hemolysis is usually relatively mild Splenectomy is contraindicated as it has been followed in a majority of cases by severe thromboembolic complications Enzyme Abnormalities When there ... evidence-based) are as follows Avoid splenectomy in mild cases Delay splenectomy until at least years of age, after the risk of severe sepsis has peaked imperative, Antipneumococcal whereas vaccination...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 8) pdf
... synthase 2 0q1 1 γ- Ver y rare 6p12 Glutamylcystein CN S Ver y rare CN S e synthase Cytochro 2 2q1 3 me b5 reductase 31 qter Rar e CN S Methemo globinemia rather than hemolysis Nu cleotide Adenylate ... Diphosph oglycerate 7q3 1q3 4 Ver Erythrocy y rare tosis rather than mutase (DPGM) Phosphog lycerate hemolysis Xq13 kinase Ver y rare CN S, NM May benefit (PGK) from splenectomy Pyruvate 1q2 1 kinase (PK) ... (PFK) Aldolase 1 6q2 2 -24 Triose Ver y rare 12 p13 phosphate Ver y rare CN S isomerase (TPI) (severe), NM Glycerald 12 p13 Ver My ehyde 3- 31 p13 .1 y rare opathy phosphate dehydrogenase (GAPD) Diphosph...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 9) ppsx
... enzyme by quantitative assays carried out in only a few specialized laboratories If a particular molecular abnormality is already known in the family, then of course one could test directly for ... inactivation, heterozygous females are genetic mosaics, with a highly variable ratio of G6PD-normal to G6PDdeficient cells and an equally variable degree of clinical expression; some heterozygotes ... directly and via reduced glutathione (GSH), defends these cells against oxidative stress G6PD deficiency is a prime example of an HA due to interaction between an intracorpuscular and an extracorpuscular...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 10) pps
... of triggers: (1) fava beans, (2) infections, and (3) drugs (Table 10 1-5) Typically, a hemolytic attack starts with malaise, weakness, and abdominal or lumbar pain After an interval of several ... to extremely severe, usually normocytic and normochromic, and due partly to intravascular hemolysis; hence, it is associated with hemoglobinemia, hemoglobinuria, and low or absent plasma haptoglobin ... clinically asymptomatic throughout their lifetime However, all of them have an increased risk of developing neonatal jaundice (NNJ) and a risk of developing acute HA when challenged by a number of...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 11) doc
... Others Sulfadim idine Sulfadiazi ne Dapsone Antibacterial/anti Cotrimoxazole biotics Ciproflo xacin Nalidixic acid Chloramp henicol Norfloxa cin pAminosalicylic acid Nitrofurantoin Niridazole ... Antipyretic/analg esics Acetanilide Acetylsa Acetylsali licylic acid high cylic acid 3 g/d) Phenazopyridin Acetamino e (Pyridium) phen Phenacetin Other Naphthalene Vitamin K analogues ... exacerbations mediated (PNH) Flow Exacerba (C)- cytometry display destruction of CD59(–) CD59(–) to tions due to C a activation red through any red cell population pathway cells Paroxysmal Acute...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 12) doc
... are also vulnerable to acute oxidative damage, and therefore the same agents (see Table 10 1-5) that can cause acute HA in people with the ordinary type of G6PD deficiency will cause severe exacerbations ... usually with a history of NNJ, who may present with anemia or unexplained jaundice, or because of gallstones later in life The spleen may be enlarged The severity of anemia ranges from borderline ... of GSH metabolism are exceedingly rare, but each one of them can give rise to chronic HA (Table 10 1-4) A rare, peculiar, usually self-limited severe HA of the first month of life, called infantile...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 13) pptx
... familial HUS Acquired Hemolytic Anemia Mechanical Destruction of Red Cells Although red cells are characterized by the remarkable deformability that enables them to squeeze through capillaries narrower ... pathway following damage to endothelial cells in the kidney, one of the results will be brisk hemolysis Thus, the much more common Shiga toxin–related HUS can be regarded as a phenocopy of familial ... autoimmune HA (see below) Usually HA would gradually subside once methyldopa was discontinued Nucleosides may also cause hemolysis by depletion of ATP Ribavirin, a drug used in the treatment of hepatitis...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 14) pps
... some cases the nature of the antibody is such (usually an IgM antibody) that the antigen-antibody complex on the surface of red cells is able to activate complement (C) As a result, a large amount ... circulating monocytes can take part in this process, most of the phagocytosis-mediated red cell destruction takes place in the spleen and liver, and it is therefore called extravascular hemolysis ... amount of membrane attack complex will form, and the red cells may be destroyed directly, known as intravascular hemolysis Figure 10 1-7 Mechanism of antibody-mediated immune destruction of red cells...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 15) potx
... form of AIHA were called warm antibodies In mild forms of CAD, avoidance of exposure to cold may be all that is needed to enable the patient to live with a reasonably comfortable quality of life, ... prominent the more the body is exposed to cold The antibody is usually an IgM, usually has an anti-I specificity (the I antigen is present on the red cells of almost everyone), and may have a very high ... subsequently, recovery is the rule Cold Agglutinin Disease (CAD) This designation is used for a form of chronic AIHA that usually affects the elderly and has special clinical and pathologic features...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 16) ppt
... is mildly or moderately elevated, LDH is typically markedly elevated (values in the thousands are common), and haptoglobin is usually undetectable All these findings make the diagnosis of HA compelling ... the case of red cells and at least 20% of the total in the case of granulocytes Pathophysiology Hemolysis in PNH is due to an intrinsic abnormality of the red cell, which makes it exquisitely ... secondary to severe neutropenia and hemorrhage secondary to severe thrombocytopenia PNH may evolve into aplastic anemia (AA), and PNH may manifest itself in patients who previously had AA Rarely...
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Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 17) potx
... one-half of the patients Eculizumab administered intravenously at q2 wk intervals also ameliorated the anemia in most patients and dramatically improved their quality of life Figure 10 1-9 Therapeutic ... immunosuppressive treatment with antilymphocyte globulin (ALG or ATG) and cyclosporine A may be indicated Although no formal trial has ever been conducted, this approach has helped particularly to relieve severe ... excellent removal of white cells are routinely used, the traditional washing of red cells, which aimed to avoid white cell reactions triggering hemolysis, is no longer necessary and considered wasteful...
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Báo cáo y học: "Misdiagnosis and undiagnosis due to pattern similarity in Chinese medicine: a stochastic simulation study using pattern differentiation algorithm" pdf
... cross-table was built by simultaneous classification of dual patterns into the categories of similarity S and according to the cumulative combinations of the Four Examinations The null hypothesis was ... (simulation of manifestation profiles; cutoffestimation for N %; pattern identification with F% and N %-cutoff of simulated cases; and statistical analysis) Additionally, MPSA and PDA are composed of ... http://www.cmjournal.org/content/6 /1/ 1 Page of 13 Table Cross-table of simulated cases and controls classified simultaneously by pattern differentiation outcome and the incremental combination of the Four Examinations Pattern...
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![Báo cáo khoa học: A dimer of the FeS cluster biosynthesis protein IscA from cyanobacteria binds a [2Fe2S] cluster between two protomers and transfers it to [2Fe2S] and [4Fe4S] apo proteins ppt](https://media.store123doc.com/images/document/14/rc/tl/small_tlm1396203606.jpg)
Báo cáo khoa học: A dimer of the FeS cluster biosynthesis protein IscA from cyanobacteria binds a [2Fe2S] cluster between two protomers and transfers it to [2Fe2S] and [4Fe4S] apo proteins ppt
... coli BL 21( DE3)/pLysS/pISCA1; lane 3, IscA1 after ammonium sulfate precipitation; lane 4, IscA1 after hydrophobic interaction chromatography; lane 5, IscA1 after hydroxy apatite chromatography In ... Further studies are required to clarify the role of residue C44 Replacement of C 110 and C 112 led to a complete loss of cluster-binding ability of IscA Since the Mossbauer data ¨ indicated an all-cysteine ... Slr1 417 (Synechocystis IscA1) NP_440066, Athal1 (Arabidopsis thaliana IscA1) AC007067.4, P_purp (Porphyra purpurea) NP_053827, Athal2 (Arabidopsis thaliana IscA2) AC005825.3, Athal3 (Arabidopsis...
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