behavioral and cognitive modeling of the human brain
WHEN THINGS GO WRONG – DISEASES AND DISORDERS OF THE HUMAN BRAIN docx
Ngày tải lên :
28/06/2014, 11:20
... think, see and hear, and to distinguish the ugly and the beautiful, the bad and the good, pleasant and unpleasant It is the brain too which is the seat of madness and delirium, of the fears and frights ... disorders and diseases of the brain, the advances in brain research provide hope in the form of their own understanding of what is going wrong and in the form of advances in novel therapies which ... volumes of the head and medial surface of the hippocampus and the dorsal and ventral surfaces of the amygdala Volumes of these subregions declined with age in the GTS group but not in controls, so the...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
Ngày tải lên :
15/02/2014, 01:20
... II The hood domain is mainly built up by residues from the C-terminus and consists of a two-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig 1A) The ... Lys173 interacts with both O6 and N7 (Fig 1C) The 2¢OH of the ribose is hydrogen bonded to the main chain and the side chain of Asp142 (Fig 1C) Both hydroxyl groups of the ribose are involved in ... Asp142, 2¢ and 3¢OH of the ribose and three water molecules with ˚ coordination distances of approximately 2.4 A The phosphate of the GMP is hydrogen bonded to main chain and side chain atoms of amino...
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Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin docx
Ngày tải lên :
16/03/2014, 18:20
... for the wild type (WT) and mutant Tms The uncertainties listed are the standard errors of the mean and included the uncertainty in the determination of protein concentrations The values are the ... probe Thus, the analysis of the melting profile of human Tm was enhanced by the use of different probes The mutations affect the stability of the protein Heller et al ([19] and references therein) ... parameters for the thermal-induced unfolding of wild type (WT) and mutant Tms The values are the mean ± standard deviation of at least three experiments Tm1 is the midpoint of the thermal transition...
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Báo cáo khoa học: Molecular cloning and functional expression of the human sodium channel b1B subunit, a novel splicing variant of the b1 subunit potx
Ngày tải lên :
16/03/2014, 23:20
... based on the rat b1A C-terminal sequence However, these attempts failed to clone the human b1A subunit from cDNA libraries of adrenal gland, brain and fetal brain BLAST searches of the human genomic ... significantly in the presence or absence of the b1B subunit, whereas, under the same conditions, the rate of inactivation was increased in the presence of the b1 subunit The effects of b1B were further assessed ... showed that the b1B transcript is abundant in human brain and skeletal muscle (Fig 2A), and present at a very low level Fig Northern blot analysis of the gene expression of human b1B (A,B) and b1...
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Báo cáo khoa học: The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene pot
Ngày tải lên :
30/03/2014, 09:20
... acids, the Ets domain, the CIDD and the C-terminal domain The fragment of cDNA included in the bait used for two-hybrid screening of the brain cDNA library included amino acids 96–510 at the C-terminus ... indicating the crucial importance of these two Ets motifs [15] In addition to controlling the level of gene expression, Ets factors may direct the choice of the promoter elements in play, and therefore, ... implicated in the development of AD because of its role in cleavage of the amyloid precursor protein (APP) and the production of Ab peptide, which is central to the pathogenesis of AD [9] Similarly,...
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Báo cáo khoa học: Expression and characterization of soluble forms of the extracellular domains of the b, c and e subunits of the human muscle acetylcholine receptor pot
Ngày tải lên :
30/03/2014, 10:20
... contains the major part of the binding site for the cholinergic ligands The two sites are nonequivalent, one being formed at the interface between one a subunit and the c ⁄ e subunits and the other ... report, we present the expression and characterization of the ECDs of the b, c and e subunits of the human muscle AChR We describe their expression in a soluble, glycosylated form and in satisfactory ... Purification and deglycosylation of the AChR ECDs (A) Schematic representation of the constructs used for expression of the b1–221, c1–218 and e1–219 ECDs of the human AChR in yeast P pastoris The arrowhead...
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Báo cáo khoa học: Characterization of the 5¢ untranslated region of a and b isoforms of the human thromboxane A2 receptor (TP) Differential promoter utilization by the TP isoforms doc
Ngày tải lên :
31/03/2014, 09:20
... the current study, we sought to investigate the molecular basis of the differential expression of TPa and TPb isoforms Our initial aim was to map the patterns of exon usage in the 5¢ UTR of the ... number of the diverse superfamily of GPCRs, not least among the prostanoid receptor subfamily of GPCRs [53] The EP3 subtype of the PGE2 receptors is one of the most heavily spliced among all of the ... Ó FEBS 2002 Analysis of the TPa and TPb mRNAs (Eur J Biochem 269) 4059 investigating the expression of the mRNAs encoding the TPs throughout a range of cell and tissues of particular relevance...
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báo cáo hóa học:" Biomechanical and system analysis of the human femoral bone: correlation and anatomical approach" docx
Ngày tải lên :
20/06/2014, 00:20
... of division of the meaning of each linear parameter on the meaning of the transverse diameter of the femoral diaphysis) In this case, the deviation of the measurement becomes unimportant Furthermore, ... in the 1st and 3rd classes; in the 4th class, the parameter is related to the vertical diameter of the head and the transverse size of the proximal epiphysis The fourth group characterizes the ... Transverse size of the proximal epiphysis - intertrochanteric distance - Diaphysis-neck angle - Anteversio of the neck - Rotation of the head - The length of the lateral condyle - The length of the medial...
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Modeling of the human upper airway from multimodal 3d dentofacial images
Ngày tải lên :
09/09/2015, 08:13
... studies of the segmentation of the upper airway are reviewed The objectives and outline of the thesis are then presented and this is followed by the contributions of the thesis 1.1 Motivation The human ... are the main opening of the airway to outside The nose is a structure of soft and hard tissues covering the front part of the nasal cavity The nasal cavity is the empty space above and behind the ... above the level of the vocal cords The main components of the human upper airway are the nose and nasal cavity, paranasal sinus, oral cavity, and pharynx The paranasal sinus is the 12 group of air-filled...
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Patient specific finite element modeling of the human lumbar motion segment
Ngày tải lên :
28/11/2015, 13:32
... Patient-specificity of a finite element model of the lumbar spine in both geometry and material property proves crucial to the study of the pathogenesis of lumbar spinal disorders and to the enhancement of the ... view of the limitations of manual meshing a number of automatic meshing techniques have been developed The geometrical information of the modeling subject is obtained either through the use of the ... on the fundamentals of spine anatomy which is important to the understanding of the subsequently presented works Literature reviews on the finite element modeling of the lumbar motion segment and...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
Ngày tải lên :
21/02/2014, 15:20
... structures of the human and porcine pancreatic lipases for the open form and on the horse pancreatic lipase for the closed form [16,18,19,30] For homology modeling, the 11 C-terminal residues of LPL ... Model structure of human LPL All model structures of dimeric human LPL were constructed using the INSIGHT II program and were based on the crystal structures of the human, porcine, and horse PLs ... illustrates the overall saddle shape of the dimeric structure and the key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top of the hollow (Fig 1A) The...
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the speed of visual processing of complex objects in the human brain. sensitivity to image properties, the influence of aging, optical factors and individual differences.
Ngày tải lên :
22/12/2014, 20:09
... (EEG) to measure the speed of visual processing in the brain 1.2 Properties of the visual system in primate and human brain 12 1.2.1 Hierarchical organisation of the visual system ... visual object processing in the human and monkey brain, followed by an overview of the current state of knowledge concerning the aging brain and how various cortical and optical factors might contribute ... in the ERPs 11 Literature Review 1.2 PROPERTIES OF THE VISUAL SYSTEM IN PRIMATE AND HUMAN BRAIN Understanding the visual system‘s structure and function is vital to understanding how, when and...
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Contrastive analysis on english and vietnames proverbs referring to parts of the human body
Ngày tải lên :
12/12/2013, 00:03
... body The position of proverbs referring to part of the human body Parts of the human body 21 21 21 The classification of parts of the human body according to position Graduation thesis ... understand the equality, sympathy of the husband and wise the function of education is to contribute to directing the peoples feelings towards the good orientation in the relationship of the husband ... diversified (multiple form) The classification of parts of the human body according to the position In the system of the proverbs, the system of words referring to parts of the human body is divided...
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The transference of meaning through class of words denoting parts of the human body in english and vietnames
Ngày tải lên :
18/12/2013, 21:45
... earth The hand of a child - The hand of a lock The heart of a man - The heart of a matter 37 The tongue of a man - The tongue of a shoe The tooth of a person - The tooth of a comb The head of a ... hands of a farm 13 The heel of a person - The heel of the hand 14 One's leg - The leg of a trip 15 One's brain - The brains of a family 16 The bosom of a person - The bosom of the church 17 The ... The head of the page The scar left on one's kin - The scars of war The arm of a person - The arm of jacket 10 One's breast - The chest 11 One's foot - The foot of sock 12 One's hands - The hands...
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Tài liệu Báo cáo khoa học: Molecular modeling and functional characterization of the monomeric primase–polymerase domain from the Sulfolobus solfataricus plasmid pIT3 doc
Ngày tải lên :
18/02/2014, 18:20
... a4-helix to the b4 strand and the b9 strand to the b10 strand at the bottom of the Zn-stem loop in the pRN1 prim–pol structure However, because the Zn-stem loop is a fairly self-standing structure ... 70 and 80 °C between 190 and 260 nm with a step increase of 0.2 nm, and a bandwidth of nm Thermal stability of Rep245 was measured by incubating the protein at 60, 70 and 80 °C for 30 and then ... the two-metal-ion mechanism of both RNA and DNA synthesis [17] In a previous study, we reported the findings of an analysis of the complete sequence of the cryptic plasmid pIT3 isolated from the...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
Ngày tải lên :
19/02/2014, 06:20
... in these eukaryotic and archaeal proteins (Fig 1A) Like the case of bacterial RecA, the L1 and L2 loops of the eukaryotic Rad51 proteins face A Roles of the HsRad51 L1 and L2 loops inside of their ... Results Strategy of mutational analysis In order to study the functions of the L1 and L2 loops of HsRad51, we examined the effect of replacing the aromatic residues in the L1 and L2 loops with ... monomer of poly(dT), showing that the changes were mainly due to the binding of the first DNA, while the binding of the second DNA had less influence (Fig 5A) To ensure that the estimation of the protein:poly(dT)...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
Ngày tải lên :
19/02/2014, 07:20
... compares the studied network with randomized versions of it with the same size and degree distribution The so-called Z-score quantifies the difference between the studied network and an ensemble of randomized ... functions, and topological features retain functionality and phylogeny However, the nature of the connections between these factors needs to be understood at the level of the protein domain The global ... from any other If dmin (Pi, Pj) is the length of the shortest path connecting proteins Pi and Pj, then L is defined as: Compared with pure random ER and SF networks, biomolecular webs show the characteristic...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
Ngày tải lên :
19/02/2014, 16:20
... consumption and to examine the possible role played by cells and molecules of the immunological system in hepatic injury and repair Understanding the interdependence between the metabolism of iron and ... proliferation of stelleate cells and synthesis of collagen [36,37], the in vitro data presented here may be relevant for understand some of the complex mechanisms responsible for the development of fibrosis ... loading of the liver epithelial cell line HepG2 influenced the expression of immune regulatory molecules known to function as ligands of selected subsets of T cells, such as MHC class I and II,...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
Ngày tải lên :
19/02/2014, 16:20
... and D; lane 1) and HEK293 (C and D; lane 2) cells The positions of the molecular size markers (kDa) are indicated to the left and right of the (C) and (D), respectively, whilst the position of ... regions of Prm3 The following lists the identities of the Prm3 gene fragments and corresponding plasmids generated in either pGL3Basic (pGL3b) or pGL3Enhancer (pGL3e) vectors and the identity of the ... Characterization of the 5¢ untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP) Differential promoter utilization by the TP isoforms Eur J Biochem 269, 4058–4073 26 Quandt...
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