... disorders Therefore, improving our understanding ofthe impact of RRT on acid–base disorders and gaining insights into the nature of such disorders and the mechanisms of action of RRT are important In ... control individuals in an intensivecareunit (P < 0.005; Fig 4) Accordingly, CVVHDF can be considered physiologically superior to IHD inthe correction of metabolic acidosis The overwhelming superiority ... renal failure patients dialysed intheintensivecareunit Am J Nephrol 1991, 11:44-47 Brivet F, Kleinknecht D, Loirat P: Acute renal failure inintensivecare units – causes, outcome, and prognostic...
... misleading to assume that [HCO3–] is an independent determinant of [H+] In fact, the independent determinants of [H+] inthe blood are the strong ion difference [SID], the total concentration of ... the net difference in their charges The [SID] is defined as the difference between the sum ofthe major cations (Na+, K+, Ca2+, Mg2+) and the sum ofthe major anions (Cl–, SO4–, lactate) inthe ... bicarbonate administration may cause a decrease in intracellular pH In fact, the findings of cellular and whole animal model studies examining the effects of bicarbonate infusion on intracellular...
... within the cells during correction The net effect of KCl administration is that the retained strong anion (Cl–) stays extracellullar, whereas most ofthe retained strong cation disappears into the ... extracellular SID and ATOT, the final determinants of metabolic acid–base status, toward the SID and ATOT ofthe infused fluid The CO2TOT of infused fluid is worth mentioning separately First, it ... 9:468-473 63 Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, for the SAFE Study Investigators: A comparison of albumin and saline for fluid resuscitation intheintensivecareunit N Engl...
... controlled for the limitations noted above when evaluating the ability ofthe SIG to predict mortality The findings of these two studies are unique inthe sense that they are the first reports of SIG ... account the physicochemical principles of either the decreased ratio of sodium to chloride or the decreased difference between them With regard to plasma, the addition of normal saline increases the ... resulting in a reduction inthe alkalinity of blood The Na+/Cl– ratio has been proposed as a simple way to delineate the contribution of chloride to the degree metabolic acidosis [30] In other...
... output in patients with various types of shock inthe ICU [1,14] In agreement with the findings reported by Jannuzzi and coworkers inthe present issue of Critical Care [1], previous investigators ... Competing interests The authors declare that they have no competing interests 17 Acknowledgements This work was supported by a grant ofthe Faculty of Clinical Medicine Mannheim, University of Heidelberg, ... regimens according to PAC information across the spectrum of critically ill patients Further clinical trials should lead to the establishment of treatment protocols for the use of PAC in this patient...
... their individual goals, like having an adequate income, receiving training, doing research, taking career steps, teaching, and so on Conflicts arise in this area when the goals or interests of ... responsibility ofthe ICU manager to instill inthe ICU staff a special sensitivity for these multidisciplinary interactions Internal leadership As the head ofthe ICU ( the boss’), the ICU manager ... lengthily discuss the indication for admittance, thereby ignoring the feelings of your nurses This style is known as the forcing style, or ‘win-lose’ At the other extreme is the wish to keep the relationship...
... intensive insulin therapy in adult intensivecare units: the Glucontrol study IntensiveCare Med 2009, 35:1738-1748 16 Dandona P, Chaudhuri A, Ghanim H, Mohanty P: Anti-inflammatory effects of ... insulin signalling [87] These cytokines activate numerous kinases that inhibit insulin signal transduction [88-91] TNF-α has been shown to induce the expression of SOCS-3 (Suppressor of cytokine ... between the 28-day mortality and the proportion of calories provided parenterally (P = 0.005), suggesting that the difference in outcome between the two Leuven Intensive Insulin Therapy Trials and the...
... Spencer RC, Hemmer M: The prevalence of nosocomial infection inintensivecare units in Europe: results ofthe European Prevalence of Infection inIntensiveCare (EPIC) Study; EPIC International Advisory ... Gaynes R: Antimicrobial resistance in isolates from inpatients and outpatients inthe United States: increasing importance oftheintensivecareunit Clin Infect Dis 1997, 24:211-215 Sieradzki ... times, or continuous infusions can increase the duration of time that the serum drug concentration remains above the minimum inhibitory concentration ofthe antibiotic, and can improve clinical and...
... Quinupristin/dalfopristin Quinuprisitn/dalfoprisitin is a combination of two streptogramins, quinupristin and dalfopristin (in a ratio of 30:70 w/w), that inhibit different sites in protein synthesis Each individual ... side chain on tigecycline enhances binding to the 30s ribosomal subunit, inhibiting protein synthesis and bacterial growth against a broad spectrum of pathogens, including MRSA [55] Tigecycline is ... infections are of nosocomial origin [26] Taking a closer look, ofthe 63% of patients presenting from the ‘community’, the majority had recent healthcare exposures, including hospitalization inthe previous...
... remit ofthe local ethics committee Prior to introduction of CPOE, local standards of prescribing existed specifying the tenets of good practice, including the avoidance ofthe use of abbreviations ... to investigate the impact of CPOE, without decision support, on MEs inthe critical care setting The data collected were viewed in terms of proportion of errors, patient outcomes arising from the ... non-intercepted and intercepted errors were combined) The limitations of this study and the potential for bias discussed previously must be borne in mind when interpreting these results Some of the...
... these units, usually on a one-week basis One month after the completion ofthe study, the ICIS was implemented inthe two other remaining units Approval ofthe ethics committee was obtained; informed ... overdose of a beta-blocker, where rapid intervention ofthe clinical pharmacist intercepted the administration of this overdose The nonintercepted potential ADEs were mainly dosing errors or incompleteness ... safety, they are not discussed in detail The incidence of intercepted MPEs was four times lower inthe C-U than inthe PB-U A few of these errors concerned problems with trailed zeros, but most of them...
... molecular characteristics of pathogens causing HAP intheIntensivecareunitof Bach Mai Hospital which is the area with the highest incidence density of healthcare associated infections among Vietnamese ... patients, positioning the patient supine with the head elevated 30–45 degrees, suctioning measures including continuous suctioning of subglottic secretions, and minimizing the use of sedating or paralytic ... characteristics of pathogens causing HAP These findings suggest areas for intervention and for developing guideline for prevention and control of HAP in HCFs THESIS STRUCTURE The thesis consists of 129...
... obtained during monitoring intheintensivecareunit (ICU) [5,6,8,9,11,13] When pericardial tamponade was suspected, 52% of our patients had a improvement ofthe CV SOFA score, with a rise in ... tamponade following cardiothoracic surgery intheintensivecareunit Journal of Cardiothoracic Surgery 2011 6:79 Competing interests The authors declare that they have no competing interests Received: ... theintensivecareunit (ICU), in order to study predictors of success of rethoracotomy [9] The amount of pericardial fluid recovered at rethoracotomy was inthe same range as found in other...
... loudness ofthe alarms Analysing the significance ofthe alarm for the patient remains as the major difficulty commentary units have been conducted to examine the relevance of alarms in monitoring; they ... existing monitors intheintensivecareunit Crit Care Med 1997, 25:614–619 Chambrin MC, Ravaux P, Calvelo D, Jaborska A, Chopin C, Boniface B: Multicentric study of monitoring alarms inthe adult ... description ofthe signal composition is given in terms of its characteristics in time and frequency according to the level of priority, resulting in a sequence of notes in a distinctive rhythm...
... ofthe Intermountain Respiratory IntensiveCareUnit and ofthe ShockTrauma/Intermountain Respiratory ICU, and to the Respiratory Care Department ofthe LDS Hospital, for collaboration during the ... of demeaning the clinical training of students and house officers, I Competing interests None declared Acknowledgements I am indebted to the medical, nursing, and respiratory therapy staffs of ... dehydration, thereby confusing the evaluation ofthe state ofthe ECF and the state of hydration [68] Cardiovascular evaluation is also (inappropriately) included inthe evaluation of hydration, thereby...
... Japan) The treating clinicians were blinded to the PCT results, and those performing the PCT assays were blinded to the clinical status ofthe patient The PCT results were not available during the ... assessed for the presence of infection at admission, on day 2, and on the day of discharge or on the day of death Clinical assessment was the first step in diagnosing infection Cultures of urine, blood ... unselected population of patients suffering from a broad range of diseases in an intensivecareunit (ICU) Method The study was approved by the Institutional Ethics Committees ofthe Pamukkale University...
... life-sustaining support Crit Care Med 2001, 29: 197-201 20 Anonymous: A definition of irreversible coma Report ofthe Ad Hoc Committee ofthe Harvard Medical School to Examine the Definition of Brain ... Critical care: why there is no global bioethics J Med Philos 1998, 23:643-651 22 European Society ofIntensiveCare Medicine: International Consensus Conference inIntensiveCare Medicine: Preliminary ... aspects of end -of- life careinthe ICU exist and have been written about at great length We should not let the exciting challenge of resolving areas of disagreement dissuade us from working on interventions...
... Pitfalls of monitoring sedation inthe ICU with the bispectral index Anesthesiology 1998, 89:A461 Simmons LE, Riker RR, Prato BS, Fraser GL: Assessing sedation during intensivecareunit mechanical ... have been raised regarding the use of BIS inthe ICU concerning the widespread use of opioids (which reduces the validity of BIS) [15,16], interpretation difficulties in neurological diseases ... better information for sedation intheintensivecare unit? Crit Care Med 1999, 27:1663-1664 Frenzel D, Greim CA, Sommer C, Bauerle K, Roewer N: Is the bispectral index appropriate for monitoring the...
... serum insulin-like growth factor binding protein concentration both have AUCs ofthe ROC of about 0.8 (the latter being an indicator of hepatic insulin resistance or lack of insulin effect on the ... titrated intensive insulin therapy to maintain a blood glucose below 6.1 mmol/l throughout intensivecareThe observation by Vogelzang and coworkers [1] of a slightly better AUC ofthe ROC when the ... lower the risk for hypoglycaemia We anxiously await the arrival of such devices and their ability to optimize life-saving intensive insulin therapy inthe ICU Until this becomes a reality, insulin...
... important intheintensive deep venous Patient factors considered by respondents to make acare unit setting thrombosis (DVT) clinically important intheintensivecareunit setting The scale ... important intheintensivecareunit setting thrombosis (DVT)considered by respondents to make a deep venous venous thrombosis (DVT) clinically important intheintensivecareunit setting The scale ... substantial clinical importance inthe ICU, whereas the significance of these thrombi may be debated by clinicians working outside the ICU setting Strengths ofthe survey include comprehensive lists of...