based immunotherapy of cancer d
Báo cáo sinh học: "Review of the 25th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (now the Society for Immunotherapy of Cancer)" potx
... J.M Melief, MD, PhD (Leiden University Medical Center) provided the second keynote address on therapeutic vaccination against HPV16-induced disease Dr Melief presented data that demonstrate that ... University of Pennsylvania) discussed in vivo modeling and detection of ovarian cancer vascular marker TEM1, which was observed in 99% of ovarian cancer specimens studied This vascular model, Dr Li ... Howard L Kaufman, MD (Rush University Medical Center) announced a new iSBTc/SITC initiative: the development of cancer immunotherapy guidelines These guidelines will provide evidence -based criteria...
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báo cáo hóa học:" Review of the 25th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (now the Society for Immunotherapy of Cancer)" pot
... J.M Melief, MD, PhD (Leiden University Medical Center) provided the second keynote address on therapeutic vaccination against HPV16-induced disease Dr Melief presented data that demonstrate that ... University of Pennsylvania) discussed in vivo modeling and detection of ovarian cancer vascular marker TEM1, which was observed in 99% of ovarian cancer specimens studied This vascular model, Dr Li ... Howard L Kaufman, MD (Rush University Medical Center) announced a new iSBTc/SITC initiative: the development of cancer immunotherapy guidelines These guidelines will provide evidence -based criteria...
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Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx
... structure of SM3 in complex with TSAPDTRPAPGST (RCSB PDB entry 1SM3) Resolved residues of the peptide ligand are colored red (AAPDTRPAP) The binding site of the antibody is colored black Residues ... grade were obtained from Merck (Darmstadt, Germany) The glycopeptides [29] and the monoclonal antibody SM3 [1] were prepared as described NMR Experiments All spectra were recorded on Bruker DRX ... corresponds to a ligand to protein ratio of 20 : For STD experiments the ligand to protein ratio was raised to 150 : (2.88 lmol, 4.8 mM PDT(O-a -D- GalNAc)RP) Peptide or glycopeptide were added to...
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báo cáo hóa học:" Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy – a case report" doc
... presence of CD3+ and CD45+ cells was used as an indicator of T cell infiltration and the prevalence of CD4+, CD8+, CD56+ cells as indicators of T helper, T cytotoxic and NK cells, respectively and CD1a ... levels of CD56 and CD94 gradually dropped but could be enhanced by additional stimulation cycles In summary and in line with the data of the phase I clinical trial, a comparative analysis of leukapheresis ... content, the number of thrombocytes, and the proportion of lymphocyte subpopulations such as CD3+, CD3+/CD4+and CD3+/CD8+ T cells, CD19+ B cells, CD3+/CD16/56+ NKlike T cells, and CD3-/CD16/56+ NK cells...
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Báo cáo hóa học: " Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer" pot
... interpreted MS data, drafted manuscript, AP - designed mathematical modeling, drafted manuscript, RT designed and interpreted clinical part of the study, drafted manuscript, PW designed and interpreted ... modeling and statistical analyses, LM - performed experiments, interpreted results, KB - collected and interpreted clinical data, EN - collected and interpreted clinical data, MS - designed and ... addressed the question of detecting therapy-related changes in the mass profiles registered for blood samples collected from breast cancer patients SELDI-ToF analysis of the plasma proteome of...
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báo cáo hóa học:" The ability of cancer-specific and generic preference-based instruments to discriminate across clinical and self-reported measures of cancer severities" doc
... Canada Authors’ contributions PT conceived and designed the study, oversaw all stages of data collection and entry, done the analysis, and drafted the manuscript SP gave feedback on design and ... median, mean and standard deviation (SD) of the different QOL measures; the latter provided the estimates to calculate a sample size for the main study Based on results from the pilot study and ... HUI2/3 is derived from Canadian general public, the EQ- 5D and SF- 6D are based on a non-Canadian population Furthermore, the scoring functions of the MAU preference -based instruments were derived from...
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báo cáo khoa học: " Microarray-based analysis of microRNA expression in breast cancer stem cells" doc
... conceived of the study, and participated in its design and drafted the manuscript RL participated in the study design and carried out the FACS and microarray analysis JQ and JJ participated in the ... analysis and manuscript drafting.ZC and SZ conceived of the study, and participated in its design and coordination and helped to draft the manuscript All authors have read and approved the final ... tumors developed from × 105 and × 106 MCF-7 cells and from × 103 and × 104 BCSCs 24-well plates on top of irradiated NIH/3T3 feeder cells At day 3, the number of adherent cells increased, and three...
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báo cáo khoa học:" The ability of cancer-specific and generic preference-based instruments to discriminate across clinical and self-reported measures of cancer severities" pot
... Canada Authors’ contributions PT conceived and designed the study, oversaw all stages of data collection and entry, done the analysis, and drafted the manuscript SP gave feedback on design and ... median, mean and standard deviation (SD) of the different QOL measures; the latter provided the estimates to calculate a sample size for the main study Based on results from the pilot study and ... HUI2/3 is derived from Canadian general public, the EQ- 5D and SF- 6D are based on a non-Canadian population Furthermore, the scoring functions of the MAU preference -based instruments were derived from...
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Báo cáo y học: " Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy" pps
... erythroid-derived-2 related factor (Nrf2)-induced antioxidant gene products [8,38,40-46] The anticarcinogenic effects induced by curcumin in cancer cells are mediated via the modulation of multiple ... grade neutropenia and one grade diarrhea at a dose of 8000 mg/day of curcumin, combined with the poor acceptability of this high dose of curcumin (16 capsules/day) by two patients has led to define ... with 5-fluorouracil and oxaliplatin, induced a marked reduction in cancer stem cell-like cells, as indicated by a decrease in the expression levels of CD133, CD44, CD166 and EGFR as well as their...
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Báo cáo y học: "Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays" ppsx
... threshold In this study we used an mBAF threshold of 0.97 and a triplet sum threshold of 0.8 for Illumina data For Affymetrix data, we used an mBAF threshold of 0.9 and a triplet sum threshold of ... approach Additional data file is a table describing results using triplet filtering Additional data file is a document describing the generation and analysis of the simulated data set Additional data ... compared to other methods, we created a simulated data set based on experimental 550k Illumina data for HapMap sample NA06991 (as described in Additional data file 3) Briefly, to the diploid HapMap...
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Vitamin e TPGS based nanomedicine for multimodality treatment of cancer
... OF ABBREVIATIONS ACN AUC CLSM CMC CNT CSC DCC DCL/DXT DCM DCU DI DLS DMAP DMEM DMSO DNA EDC EDTA EE EGFR EPR FA/FOL FBS FDA FESEM FETEM FITC FR HER2 H NMR HPLC IC50 IO LLS mAb MDR MPS MRI MTD ... N,N-dicyclohexylurea deionized dynamic light scattering 4-dimethylaminopyridine Dulbecco’s Modified Eagle’s Medium dimethyl sulfoxide deoxyribonucleic acid N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride ... controlled and the enhanced anti -cancer effect is studied Chapter introduces the work of multimodality treatment of cancer with herceptin conjugated, thermomagnetic iron oxides and docetaxel loaded...
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Proteomics based identification of potential protein biomarkers for epithelial ovarian cancer
... serine hydroxymethyl transferase CV Coefficients of variance DCC Deleted in colorectal cancer DMSO Dimethyl sulfoxide XIV DNA Deoxy ribonucleic acid DSRB Domain Specific Review Board DTT Dithiothreitol ... the proteomics -based methods including surface enhanced laser desorption/ionisation time of flight (SELDI-TOF), two dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionisation ... with limited success The identification of proteins released into the cyst fluid of EOC could provide the basis for the discovery of possible candidate protein markers with diagnostic and prognostic...
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Immunotherapy of bladder cancer
... Chemically induced bladder cancer Bladder cancer can be induced in animals by adding arylamine chemicals into drinking water or the diet The two most commonly used murine bladder cancer cell lines ... treatment of superficial bladder cancer From the clinical point of view, therefore, therapeutic targeting of superficial bladder cancers in an in vivo model of liposome-mediated bladder-directed gene ... or 5% of its total bladder cancer research fund of $27.2 million in developing scientific bladder cancer model systems 1.4.1 Various models used in bladder cancer research The animal models that...
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Sensor-based navigation of a mobile robot in an indoor environment
... lead to a degradation of the accuracy and the richness of the information Some constraints are added to the intrinsic drawbacks of these methods caused by: • the imprecision or lack of knowledge ... (1.58 rad/s) By applying this method, a saturation of the growth of the weights is obtained without any degradation of the residual quadratic error and the quality of the control is maintained even ... done by fusing outputs coming from both modules as a function of a degree of recognition of the memorized scene This paper is organized as follows: first the used mobile robot is described and...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... were measured in erythrocytes Urine was collected for analysis of malondialdehyde (MDA) by HPLC and 8-oxo-deoxyguanosine (8-oxo-dG) by ELISA Endogenous and induced DNA damage were measured by single-cell ... apoptosis, as evidenced by downregulation of the expression of calmolulin-dependent kinases, cdk4 and cdk6, cyclin D1 and cyclin D3 Approximately half of the berries evaluated, including those of Vaccinium, ... glucuronide and methyl metabolites were identified in intestine and urine Ingestion of either C3G or Mirtoselect reduced adenoma load dose dependently At the highest doses of C3G and Mirtoselect, adenoma...
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06 ON TAYLOR MODEL BASED INTEGRATION OF ODES
... and Taylor model methods are reviewed Interval methods for ODEs are presented in Section The naive Taylor model method is described in Section 4, which is followed by a discussion of Taylor model ... Taylor Model Based Integration of ODEs · August 18, 2006 21 [13] J Hoefkens, M Berz, and K Makino, Verified high-order integration of DAEs and higher-order ODEs, in Scientific Computing, Validated Numerics ... removes the dependency problem and simplifies the verification step The success of the Taylor model based integration method depends on the successful reduction of the excess introduced in the shrink...
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10 on taylor model based integration of ODEs neuer 2006
... Model Based Integration of ODEs Interval Arithmetic and Taylor Models Verified Integration of ODEs Taylor Model Methods for ODEs Verified Integration of Linear ODEs Introduction Interval Methods ... Model Based Integration of ODEs Interval Arithmetic and Taylor Models Verified Integration of ODEs Taylor Model Methods for ODEs Verified Integration of Linear ODEs Introduction Interval Methods ... Model Based Integration of ODEs Interval Arithmetic and Taylor Models Verified Integration of ODEs Taylor Model Methods for ODEs Verified Integration of Linear ODEs Introduction Interval Methods...
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Tài liệu Báo cáo khoa học: Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay docx
... isolated and purified N-glycans were deuterium exchanged using 99% D2 O (three times) and dried by lyophilization The dried substance were dissolved in 400 lL of D2 O (100%) and transferred to a ... 2AB, separated them into oligosaccharide pools and quantified these pools using HPLC N-glycans from fetuin were labeled and used as a standard to ensure a standardized analysis Additionally, to ... 0.5 13 0.4 0.3 120 130 determined by the label and independent of the attributes of the glycan to which it is attached Accordingly, we aimed to determine the amount of individual cRBC glycans by...
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Tài liệu Environmental and Occupational Causes of Cancer doc
... and leukemia (3.8%) rose in women.a ,5 In addition, the incidence of childhood leukemia and brain cancer has been rising steadily in the past decade With the exception of thyroid and kidney cancers, ... Research on Cancer **Suspected evidence of a causal link is based on our assessment that results of epidemiologic studies is mixed, yet positive findings from well-designed and conducted studies warrant ... considered an established lung carcinogen, new evidence from a case-control study in Belgium suggests it is a risk for bladder cancer as well The odds of developing bladder cancer among individuals...
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