b 1165 literary patron and poet of france
Báo cáo y học: "Epidemiology and Prevention of Hepatitis B Virus Infection"
... population based samples of adequate size on a consensus definition of eCHB and using standard HBV DNA assays is needed to estimate the true prevalence of e-CHB and its associated HBV variants and the ... Quantitative analysis of HBV DNA level and HBeAg titer in hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies J Med Virol ... to interferon therapy and disease progress HBeAg-negative CHB HBeAg-negative chronic hepatitis B (e-CHB), characterized by HBV DNA levels detectable by nonamplified assays and continued necroinflammation...
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Tài liệu ICE-CAVES OF FRANCE AND SWITZERLAND pptx
... wretched state of wet and cold, and Renaud went off to bed, and imbibed abundant and super-abundant kirsch, at least, when drawn thence the next morning, his manner left no doubt about either the ... find the grave of a companion; so that I should probably have made a laborious collection of the bones of thebos domesticus This belief of the bergers respecting the cows is supported by several ... remains of columns, and showing the thickness of the bottom of the stream to be about feet only The arch of entrance had evidently been almost closed by a succession of large columns, but these...
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Tài liệu Báo cáo khoa học: The role in the substrate specificity and catalysis of residues forming the substrate aglycone-binding site of a b-glycosidase docx
... Substrate Km (mM) kcat (s)1) E190A NPbfuc NPbglc NPbgal NPbxyl MUbglc NPbfuc NPbglc NPbgal NPbxyl MUbglc NPbfuc NPbglc NPbgal NPbxyl MUbglc NPbfuc NPbglc NPbgal NPbxyl MUbglc NPbfuc NPbglc NPbgal ... catalysis, probably by stabilizing the ESà complex of the glycosylation step [15,19] Besides that, structural data from the complexes of ZmGlu1 and SbDhr1 with their natural substrates (dimboa-glc and ... specificity of a b- glycosidase L M F Mendonca and S R Marana ¸ Results and Discussion Role of residues E190, E194, K201 and M453 in aglycone binding The spatial structures of ZmGlu1, SbDhr1 and BglB revealed...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... residues of one of the three sides of sbwAFP or six residues of one of two sides of TmAFP The strands that make up the three, parallel b- sheets of the protein are designated PB1, PB2 or PB3 for sbwAFP ... dynamics of each protein, and present a comparison of sbwAFP and TmAFP with each other and with proteins that have a similar fold Structure of sbwAFP and TmAFP The structure of sbwAFP has been determined ... accessible surface area of 1180 A2 with a ˚ pseudo-rectangular face of 6.5 · 15 A The b- helical fold in this case consists of only one b- sheet face with six b- strands but like sbwAFP the b- strands...
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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C ppt
... populations, members of the public, and policy-makers There is insufficient understanding about the extent and seriousness of this public-health problem, so inadequate public resources are being allocated ... problems occurred with this vaccine in 2008 (adult and dialysis formulations of Recombivax HB) and 2009 (pediatric formulations of Recombivax HB and Pediatric Engerix -B) A shortage was avoided because ... hepatitis B and hepatitis C and related liver cirrhosis and cancer, the extent of ongoing risk behaviors, and the impact of HIV coinfection and other cofactors Assess the role of state and local...
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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C doc
... populations, members of the public, and policy-makers here is insufficient understanding about the extent and seriousness T of this public-health problem, so inadequate public resources are being allocated ... problems occurred with this vaccine in 2008 (adult and dialysis formulations of Recombivax HB) and 2009 (pediatric formulations of Recombivax HB and Pediatric Engerix -B) A shortage was avoided because ... million HBV HCV HIV/AIDS About 21% About 75% About 65% 14,016 12,000 3,000 Deaths in 2006 Related to Infectiona ,b No No Yes VaccinePreventable Birth, blood, sex Birth, blood, sex Birth, blood,...
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CATHEDRALS AND CLOISTERS OF THE SOUTH OF FRANCE ppt
... of war or of unrestful expectation of war Many Abbeys were yet to be established; many merely in process of foundation Wandering brothers were naturally beset by the dangers and temptations of ... Ciotat, and Agde, and explored a part of Africa and Northern Europe; and at the fall of the Roman Empire it became, by very virtue of its riches and safe harbour, the envy and the prey of a succession ... of the period, such pillage, has never been seen since war began Officers, soldiers, followers, and volunteers were so overburdened with booty as to be incommoded thereby And after this brigandage,...
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Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx
... polypeptide backbone of BACE-1 is shown as a ribbon diagram The N-lobe and C-lobe of the bilobed aspartic proteinase structure are shown in blue and yellow, respectively The inhibitor bound between ... both b- and c-secretases are membrane-bound aspartic proteinases (see text for full details) (B) Sites of cleavage of APP by b- and c-secretases to form Ab peptides The sites of the juxtamembrane ... 2009 FEBS 1851 Biology and chemistry of b- secretase (BACE-1) C E Hunt and A J Turner A B Fig The crystal structure of BACE-1 complexed to the peptide-based inhibitor OM99-2 (A) Stereoview of the...
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Báo cáo khoa học: High resolution structure and catalysis of O-acetylserine sulfhydrylase isozyme B from Escherichia coli pot
... CysM(salmo), and those of subunits B and D of CysM(RKE), resemble each other closely (Fig 5) However, a most surprising deviation of the B- factor distribution occurs in subunits A and C of CysM(RKE) ... the thiol position of TNB to a small region above the plane of the acrylate double bond As a result of this constraint and of the spacious active center pocket of CysM, TNB was placed rather ... 68 and 140 near PLP TNB was always freshly prepared in 50 mm Hepes pH 7.0 by adding mm dithiothreitol and 0.5 mm S,S¢-bis(5-thio2-nitrobenzoate) (DTNB) to yield mm TNB The absorption of TNB was...
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Báo cáo khoa học: Recruitment of transcription complexes to the b-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells docx
... span introns, with the exception of Rex-1, and the size of each RT-PCR product is as follows: Rex-1, 600 bp; b- actin, 480 bp; ec-globin, 400 bp; bmaj, 220 bp None of the samples showed genomic ... regions of the LCR (HS2 and HS3) but not at the ec- and bmajor-globin genes in undifferentiated ES cells (day 0, Fig 3) indicating that dimethylation of H3K4 and recruitment of RNA Pol II and TBP ... Engel JD, Becker PB & Bungert J (2001) Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly Mol Cell Biol 21, 2629–2640 FEBS Journal...
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Báo cáo khoa học: Identification and characterization of B¢¢-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues Evidence for an independent N-terminal splice variant of PR130 and an extended human PR48 protein pot
... Sozzi, G., Croce, C.M., Barbanti-Brodano, G., Russo, G & Negrini, M (2000) Low frequency of alterations of the a (PPP2R1A-) and b (PPP2R 1B) isoforms of the subunit A of the serine-threonine phosphatase ... shown), in both human and Xenopus lysates, which recognises the PR65 a and b isoforms equally well The best anti-C monoclonal was found to be F2 6A10, and it recognizes PP2AC in rabbit, mouse and Xenopus ... (accession number AL555389 being the longest) Figure 3B shows an alignment of the first 340 bp of cDNA sequences of human PR48 (accession number: AF135016), the first 868 bp of Xenopus PR70 and this...
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Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt
... a, b and c denote the three subunits of oxaloacetate decarboxylase Ó FEBS 2002 3000 M Schmid et al (Eur J Biochem 269) Table Effects of OadB mutations on Na+ binding characteristics, inhibition ... Sequencing Kit and the ABI PRISM 310 genetic analyzer from Applied Biosystems Construction of mutant N373D and double mutant N373D/D203N in the b subunit Fig Topology model of the b subunit emphasizing ... surface and with the D203/N373 and Y229/S382 pairs in proper geometries for binding of Na+ ions Decarboxylation apparently only works by Na+ binding to both centers because all substitutions of D203...
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Báo cáo khoa học: Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance ppt
... main chain B- factor (A2) ˚ Average side chain B- factor (A2) ˚ Average ligand B- factor (A2) BGC1a ˚ Average ligand B- factor (A2) BGC 2b ˚ Average ligand B- factor (A2) L3-1c ˚ Average ligand B- factor ... indicated by the black bars and transglucosylation activities by grey bars Note that the double mutant was inactive in both assays Production of enzyme variants Recombinant native Exg and the E292Q ... (labelled +2) (B) Cut-away view of L3 binding in the active site pocket showing the Phe-Phe clamp and the F229A mutation Carbohydrate binding subsites are labelled )1, +1 and +2 Glycosidic bond...
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Báo cáo khoa học: Purification and characterization of cathepsin B-like cysteine protease from cotyledons of daikon radish, Raphanus sativus docx
... Alignment of occluding loop sequences of plant CBCP from daikon (DDBJ accession number AB377273), A thaliana (DDBJ accession number AF370193), rice (DDBJ accession number AY916493), barley (DDBJ accession ... (cpr-6; DDBJ accession number L39894), T congolense-1 (TcoCB1; DDBJ accession number EU233643) and T congolense-6 (TcoCB6; DDBJ accession number EU233648) His110 and His111 (human cathepsin B numbering), ... cathepsin B [16,32] CA074 is an irreversible inhibitor of cathepsin B, so the secondorder rate constants of inactivation of daikon CBCP and human cathepsin B by CA074 were compared When Boc-Leu-Arg-Arg-MCA...
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Báo cáo khoa học: Identification and expression of the first nonmammalian amyloid-b precursor-like protein APLP2 in the amphibian Xenopus laevis ppt
... have been reported for the carboxy-terminal fragments of both APLP1 and [37] The physiological roles of APLP1 and have been less extensively studied, probably because they appear not to be involved ... localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer’s disease EMBO J 6, 3627–3632 Shivers, B. D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K & Seeburg, ... using maximum likelihood and Bayesian methods (A) PROTML (B) TREE-PUZZLE and (C) MRBAYES The trees all display the same topology The lengths of the branches in trees (A) and (B) are representative...
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Báo cáo khoa học: Injection of poly(b-L-malate) into the plasmodium of Physarum polycephalum shortens the cell cycle and increases the growth rate pot
... ± 1 5b 350 ± 25c 63 ± 1 4b 350 ± 25c 460 ± 9 0b 1000 ± 6 0b 47 ± 1 5b Not detectableb Not detectableb 60 ± 15c High M3CVIII 200 ± 7 5b 450 ± 45c 189 ± 2 0b 340 ± 28c 550 ± 6 0b 1730 ± 15 0b 18 ± 3b 270 ... 2 5b 130 ± 1 6b 260 ± 15c Very high High Low Not detectable Not detectable 4.8 0.2 1.8 2.0 a b Presumed genotype Microplamodia c Macroplasmodia: G2-phase ± ± ± ± ± 1b 1b 0.0 5b 0. 2b 0.5c Ó FEBS ... in rabbit was from Calbiochem All anti-histone immunoglobulins bound to histones purified from P polycephalum [17] in ELISA and Western blotting The specificity was characterized by Western blotting...
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Báo cáo khoa học: Detection and characterization of a novel extracellular fungal enzyme that catalyzes the specific and hydrolytic cleavage of lignin guaiacylglycerol b-aryl ether linkages pdf
... of metabolites Reactions were initiated by the addition of 100 ll of a solution of enzyme (200 lgÆmL)1) to 0.9 mL of a solution of 50 lg of substrate in 10% (v/v) dimethyl sulfoxide and incubated ... Phylogenetic tree of 2BW-1 based on 18S rDNA sequence comparisons of sequences of 18S rDNA and drawn using software The numbers on some branches refer to confidence levels estimated by bootstrap analysis ... measurement of activity is described above To examine the enzymatic incorporation of 18O2 and 18O-labeled water into GG, reactions were initiated by the addition of 20 lL of a Enzymic reaction and analysis...
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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C pdf
... hepatitis B and hepatitis C are important public health problems and that there are several barriers to prevention and control efforts, such as a lack of knowledge and awareness about chronic ... Section, Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland Randall R Mayer Chief, Bureau of HIV, STD, and Hepatitis, Iowa Department of Public Health, Des Moines, ... providers, and the public, especially among members of specific at-risk populations room as soon as they are stable and washed School-entry mandates have been shown to increase hepatitis B vaccination...
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Báo cáo khoa học: The b-N-acetylglucosaminidases NAG1 and NAG2 are essential for growth of Trichoderma atroviride on chitin doc
... blotting Hybridization and labelling of the probe by PCR were performed using the DIG non-radioactive system (Roche) The 1.5 kb nag2 probe was amplified using primers A and B (Table 1) A 4.6 kb hybridizing ... distinct subgroups of family 18 chitinases FEBS J 272, 5923–5939 Seidl V, Schmoll M, Scherm B, Balmas V, Seiboth B, Migheli Q & Kubicek CP (2006) Antagonism of Pythium blight of zucchini by Hypocrea ... carbon sources by quantification of the numbers of spores formed on agar plates, but again no significant influence of the loss of nag1 and nag2 could be detected The only exception was the carbon...
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Báo cáo khoa học: Dynamics of a-synuclein aggregation and inhibition of pore-like oligomer development by b-synuclein doc
... about the effects of membrane lipids on b- syn structure In this context, a recent study has analyzed by NMR the micelle-bound structure and dynamics of b- and c-syn [41] Thus, better understanding ... modeled b- and b- syn, and b- and a-syn heterodimeric interactions Firstly, theoretical docking of various molecular dynamics conformers of a-syn to conformers of b- syn was performed All of the docked ... kcalÆmol)1, Table 1) This supports the possibility that b- syn might be able to interrupt the assembly of propagating a-syn homodimers at various stages of the oligomerization process b- syn blocks the...
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