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average accuracies of different statistical learning classification systems for the prediction of cyp3a4 substrates non substrates by using independent validation sets

Machine learning approach in pharmacokinetics and toxicity prediction

Machine learning approach in pharmacokinetics and toxicity prediction

Cao đẳng - Đại học

... xiv Table 6.4 Average accuracies of different statistical learning classification systems for the prediction of CYP3A4 substrates/ non -substrates by using independent validation sets .133 ... Average accuracies of 10 groups of SVM classification systems for the prediction of CYP3A4 substrates/ non -substrates by using independent validation sets .134 Table 6.6 Comparison of ... SVM prediction accuracy for the substrates and non -substrates of P-gp by using independent validation sets 89 Table 4.6 SVM prediction accuracy of the substrates and non -substrates of Pglycoprotein...
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establish an anaerobic batch system by using guideline vdi 4630 and determine the biogas yield of different substrates in food processing villages

establish an anaerobic batch system by using guideline vdi 4630 and determine the biogas yield of different substrates in food processing villages

Khoa học tự nhiên

... The biogas yield (per amount of substrate, per VS of inoculum, per COD of substrate) and the degradability of different substrates will be evaluated Objective The aim of this thesis is from learning ... Description of the batchtests for investigating the quality of six inoculums Table 3-3: Description of the batchtests for investigating the biogas potential of different substrates ... reduced by the fermentation, the degradation of the organic acids also helps to reduce the corrosion of the plant The total nitrogen content is not reduced by the fermentation process The increase...
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Báo cáo y học:

Báo cáo y học: "Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts"

Y học thưởng thức

... position for a certain period of time before the final prosthesis is implanted [17,20,30,33,34] The function of the spacer is on the one hand to release the antibiotic into the infected bed of the ... re-implantation The disadvantage of the cemented revision technique is related to the fact that the osseous bed of the prosthesis has not only been enlarged by the loosening of the primary prosthesis ... antibiotic-loaded cement of the spacer and used for the systemic treatment is chosen on the basis of the sensitivity of the bacterium causing the infection Since the use of several antibiotics...
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Consumer acceptance of cheese,influence of different testing conditions

Consumer acceptance of cheese,influence of different testing conditions

Nông nghiệp

... different For the central location test the overlap is the strongest, while for the in-home test the overlap is the weakest For the laboratory testing, the mid group overlaps with both the high ... conclusion as for the full analysis, indicating no effect of the order of the testing situation Table shows data from the in-home testing The majority of the consumers (80%) tasted the cheese samples ... preference pattern for these cheeses The consumers in our study rated the same set of cheeses three times A possible reason for no effect of the testing situation could therefore be that the consumers...
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Evaluation of different weather files on energy analysis of buildings

Evaluation of different weather files on energy analysis of buildings

Vật lý

... obviously depends on both the quality of the data and on the sophistication of the simulation Of these data, those concerning the construction of the building and of the HVAC system are well defined ... certain The influence of the internal loads uncertainty on the final result depends on the time scale of the simulation and on the size of the simulation domain, since the increase of either or ... the effect the simulation domain size and the climate data have on the accuracy of the energy demands of a rather large complex of buildings To this aim, the energy demands of the buildings of...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt

Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt

Báo cáo khoa học

... performed after analysis by bidimensional PAGE The antibody recognition of the proteins performed on the same filter was prevented by the SouthWestern treatment Therefore, identification of the ... recognized the more basic form of eEF1A, whereas a very weak interaction was found for the isoform of eEF1A focusing at a pH of 9.0 The recognition seemed highly specific because, under these experimental ... 270) 3259 cells, the presence of two different clusters of eEF1A isoforms (cluster and cluster 2) The apparent pI of cluster ( pH 9.0), was calculated theoretically by considering the pH gradient...
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Improvement of different vaccine delivery systems for cancer therapy pptx

Improvement of different vaccine delivery systems for cancer therapy pptx

Sức khỏe giới tính

... between the vaccine and different APCs at the site of injection Hence, the routes of administration and formulation of DNA clearly affect the therapeutic response by altering immune pathway Among the ... Furthermore, VP22 enables spreading of the antigenic peptide to the cells surrounding the transfected cells [66] Efforts have been made to increase the potency of DNA vaccines by exploiting the ... malignant gliomas The Page 16 of 20 objective was to determine the safety and induction of the immune response using these vaccinations Therefore, NPs can contribute to a better design of medical applications...
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EVALUATION OF DIFFERENT TYPES OF CHEST SYMPTOMS FOR DIAGNOSING PULMONARY TUBERCULOSIS CASES IN COMMUNITY SURVEYS pot

EVALUATION OF DIFFERENT TYPES OF CHEST SYMPTOMS FOR DIAGNOSING PULMONARY TUBERCULOSIS CASES IN COMMUNITY SURVEYS pot

Sức khỏe giới tính

... two-third of the cases whereas CXR alone picked up more than three-fourth of the cases With either method the prevalence was underestimated by one-third in the former method and about one-fifth in the ... respectively The yield of cases according to the interval between the onset of cough and the time of elicitation of cough is given in Table-3 It could be seen that proportion of the cases yielded ... staff of Bacteriology Department for reporting the results The authors thank the staff of Statistics and Electronic Data Processing (EDP) Divisions of the Epidemiology Unit for data management The...
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Báo cáo khoa học: Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane pot

Báo cáo khoa học: Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane pot

Báo cáo khoa học

... groups Among the other ions m ⁄ z of 2654.8, 2694.8 and 2717.4 indicates the presence of the anhydro form and mono- and di-sodiated form of the molecular ion 2672.8 (Fig 4A) Among other characteristic ... 1541.6 are mono- and di-sodiated forms of the de-O-acylated LOS and the ion with m ⁄ z of 1479.6 is the anhydrous form of the de-O-acylated LOS The ion 1277.6 is the de-protonated molecular ion ... consisted of a linker (Glc-Kdo2)-lipid A structure The phenotype of this mutant was examined to investigate the roles of different moieties of the LOS molecule in biological activities of the M catarrhalis...
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Báo cáo khoa học: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a pdf

Báo cáo khoa học: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a pdf

Báo cáo khoa học

... [36–39], a subset of which is also cleaved by DPP8 [40] This study investigated the relative abilities of recombinant human FAP to catalyse the degradation of known DPP4 substrates of the gastrointestinal ... consistent with the loss of the N-terminal dipeptide Tyr-Ala from GRF No further breakdown of either peptide was observed up to 72 h, and neither peptide showed breakdown at 37 °C in the absence of protease ... This is the first identification of natural substrates of FAP dipeptidyl peptidase activity NPY, BNP, substance P and PYY were the most efficient FAP substrates, and the first hormone substrates of FAP...
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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf

Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf

Báo cáo khoa học

... maltosa) Another advantage of the P450 bypass is the circumvention of H2O2 formation by the fatty alcohol oxidase However, the overoxidation cascade requires 210 three molecules of NADPH, potentially ... biosynthetic genes are located in a gene cluster and three of them are P450 enzymes The FUM6 protein (CYP505B1) intervenes in one of the first steps in fumonisin synthesis by hydroxylation of the ... hydroxylation, whereas the third, FUM15 (CYP617F1), is suggested to be responsible for the synthesis of low levels of a fumonisin isoform [47] Well-studied examples of bacterial polyketides are the antifungal...
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Báo cáo khoa học:

Báo cáo khoa học: "Are These Documents Written from Different Perspectives? A Test of Different Perspectives Based On Statistical Distribution Divergence" ppt

Báo cáo khoa học

... separated from the distribution divergence of SP, DT, and ST document collection pairs The little the overlap of the range of distribution divergence, the sharper the test of different perspectives ... labeled as either Palestinian or Israeli by the editors The second perspective corpus consists of the transcripts of the three Bush-Kerry presidential debates in 2004 The transcripts are from the website ... pairs of different perspectives and document collection pairs of the same perspective and others We thus evaluate the proposed test of different perspectives in the following four types of document...
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Báo cáo Y học: Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin Characterization of different PAI-1 mutants pdf

Báo cáo Y học: Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin Characterization of different PAI-1 mutants pdf

Báo cáo khoa học

... but for the PAI-1 mutants a different maximum for the speci®c activity may exist Furthermore, within the time frame of determination of the amount of active PAI-1 in a given preparation to the ... is used in the SPR analysis, another as yet unknown part of active PAI-1 converts to the latent form and thus cannot bind to Vn anymore Therefore, the analysis of the interaction of PAI-1 and, ... Sato for È stimulating discussions Part of this work was supported by grants of the Graduiertenkolleg 333, the Sonderforschungsbereich 469 (A4), and the Sonderforschungsbereich 456 (B9) of the...
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shape-controllable synthesis of ultrafine zno powders of different

shape-controllable synthesis of ultrafine zno powders of different

Cao đẳng - Đại học

... regular crystal form and high purity The EDS pattern was performed on one of the ZnO flowerlike structures, and the composition analysis of the powder showed the existence of Zn and O (from the sample), ... micro-rods of the flower-like structures grew more regular In summary, the influences of the reaction temperature, the OHÀ/Zn2þ mol ratio and the reaction time on the morphologies of the ultrafine ... damaged and the microrods were yielded out, as shown in Fig 2(c) This could be confirmed by the residual flower-like structure in Fig 2(c), from the center of which the residual of the stripping of those...
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Báo cáo sinh học:

Báo cáo sinh học: " Comparisons of the M1 genome segments and encoded µ2 proteins of different reovirus isolates" pptx

Điện - Điện tử

... as in the Nibert laboratory clone of T3D [23] For the previous study we had already examined the factories of T2J and some of the nine other isolates used for M1 sequencing above We nonetheless ... enhances the rate of DNA polymerization [42] The SH2 domain of tyrosine kinases was the highest score hit for the conserved regions of µ2 with FingerPRINTScan Four of the five motifs in the 100 ... newly examined the factories of all ten isolates in the present study, using the same stocks used for sequencing T3C12 was the only one of these isolates that formed globular factories; the remainder,...
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Báo cáo sinh học:

Báo cáo sinh học: " Susceptibility of different leukocyte cell types to Vaccinia virus infection" potx

Điện - Điện tử

... participated in the drafting of the manuscript LS and GR performed the preparation of PBLs, carried out the flow cytometry and elaborated the data GR participated in the interpretation of the data and ... state of the cell In addition to cellular factors, genetic differences in the virus might influence the efficiency and fate of the infection For instance, cellular nucleotide pools can be one of the ... influence the infection rate of PBL cells Those might include a variety of such as the accessibility and amount of receptors, ability to internalize the virus, and the metabolic state of the cell...
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báo cáo hóa học:

báo cáo hóa học:" Effect of different cuff widths on the motor nerve conduction of the median nerve: an experimental study" doc

Hóa học - Dầu khí

... with the former The possible causative factor that resulted in the present results could be the area of the nerve being compressed by the tourniquet As the area of the nerve compressed under the ... http://www.josr-online.com/content/3/1/1 The results of the present study suggest that the inflation pressure for occlusion of blood supply should not be the only factor while considering the safety of the width of the cuff ... whereas it was 82.96% ± 16.33 for the cm cuff The release of the tourniquet allowed these values to return to normal, the amount of time required for the same varied i.e the conduction velocity took...
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báo cáo hóa học:

báo cáo hóa học:" Comparisons of the M1 genome segments and encoded µ2 proteins of different reovirus isolates" doc

Hóa học - Dầu khí

... as in the Nibert laboratory clone of T3D [23] For the previous study we had already examined the factories of T2J and some of the nine other isolates used for M1 sequencing above We nonetheless ... enhances the rate of DNA polymerization [42] The SH2 domain of tyrosine kinases was the highest score hit for the conserved regions of µ2 with FingerPRINTScan Four of the five motifs in the 100 ... newly examined the factories of all ten isolates in the present study, using the same stocks used for sequencing T3C12 was the only one of these isolates that formed globular factories; the remainder,...
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