avandra the ever forking path
The ubiquitin-proteasome pathway in cell cycle control
... during mitotic exit On the other hand, the inhibition of Cdh1 at the G1–S phase transition allows the accumulation of S phase cyclins, which in turn promotes the biosynthesis of Cdc20 via transcription ... (APC/C) and/or the subsequent G1 interval (Table 1) Typically, the APC/C recognizes targets whose destruction at the population level is mandated at the times when the APC/C is active, from the metaphase-anaphase ... and then effects the processive attachment of ubiquitin monomers first to lysines on the targeted protein and then to lysines of previously attached ubiquitins The activation of ubiquitin by the...
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Tài liệu Báo cáo khoa học: Isoprenoid biosynthesis via the methylerythritol phosphate pathway Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase ppt
... confirm this hypothesis, the influence of the concentrations of NADP+ and MEP 5, the substrates of the reverse reaction, and of NADPH and DXP 3, the products of the reaction, on the total amount ... 1) The influence of the nature of the divalent cation was, however, more pronounced for methylerythrose phosphate In the presence of Mn2+, the binding of the aldehyde was less efficient than in the ... NADPH-dependent reduction of the oxo group to give the final product In the reactions catalyzed by the two enzymes, the ketol-acid and the DXP isomeroreductase, the formation of the expected intermediates,...
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Your Guide to the Breast Cancer Pathology Report pptx
... tissue is removed from the body to check for cancer These are called pathology reports Each report has the results of the studies done on the removed tissue The information in these reports will ... centimeters (cm) The size of the cancer is one of the factors that determines the stage of the breast cancer When surgery is done to remove the whole cancer, the surgeon tries to take out all of the cancer ... way They may stay in the place where they started to grow, or they may grow into the normal tissue around them Cancer cells may also spread beyond the breast This is what the inside of a breast...
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Báo cáo khoa học: Prediction of missing enzyme genes in a bacterial metabolic network Reconstruction of the lysine-degradation pathway ofPseudomonas aeruginosa doc
... semialdehyde fi glutarate The second pathway is known to exist for P aeruginosa [32] However, several of the enzyme genes involved have not been identified, therefore we focused on the second pathway, which ... gene to the missing enzyme EC 4.1.1.18 However, there are many hypothetical proteins with high candidate scores in the list given in Table 2, so there is a possibility that one of these hypothetical ... parameter In this study the parameter h is set to 105 This means that, the larger the distance between two genes along the chromosome, the smaller the value of the similarity score The resulting kernel...
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Báo cáo khoa học: Increased NADPH concentration obtained by metabolic engineering of the pentose phosphate pathway in Aspergillus niger docx
... 6-phosphate is a branching point to several pathways It leads to the pentose phosphate pathway, glycolysis and the pathways for biosynthesis of cell wall components The Aspergillus niger gene encoding ... increase of synthesis of pyridine nucleotide cofactors, as the total pool of these increased Whether the synthesis is regulated by the NADPH concentration remains speculation The G6PDH overproducing ... all the variables in this quadrant are positively correlated to NADPH in the two PCs The variables in the third quadrant are all negatively correlated to NADPH in the two PCs The variables in the...
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Báo cáo khoa học: Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin⁄26S proteasome-mediated proteolysis potx
... roles in the interaction with the DSK2 homolog from the respective species, we decided to test the hydrophobic patches within the UBLs of the DSK2 homologs for their involvement in the interaction ... critical for the interaction S5a in parentheses is the designated name for the human RPN10 homolog d IF, the interface regions on the UBL–UBA factors that are involved in binding with the docking ... regarding the biochemical properties of the major ubiquitin receptors from different species, in terms of their selectivity for linkage types and the lengths of the ubiquitin chains and their associated...
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Báo cáo khoa học: Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway potx
... However, all the above-mentioned structural changes in receptor glycans are located in the core portion of N-glycan, and whether alteration of the terminal residue on the outer chain of either ... whether the SLex level of InR on insulin-responsive cells in diabetic patients was changed This may reveal the role of the sugar chains on InR in the pathogenesis of diabetes In summary, the ... receptor; IP, immunoprecipitation by the antibody to the protein indicated at the right; WB, western immunoblot with the antibody to the compound indicated at the right (A), (C) and (D) are representative...
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Báo cáo khoa học: Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence doc
... phosphate pathway (PPP) This is rather surprising because the PPP plays several key roles in the cell metabolism Apart from supplying the cell with precursors for amino acid and nucleotide biosynthesis, ... the cytosolic NADP+ ⁄ NADPH balance In order to maintain this balance, the flux through the oxidative branch of the PPP is usually much larger than the drain on PPP metabolites for the biosynthesis ... additional reversible TK-catalyzed reaction (r.4) Although the stoichiometric neutral reactions have no effect on the mass balances set up over the system, they influence the labeling pattern of the metabolite...
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Báo cáo khoa học: Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 pdf
... in the mutant First, there is an increase in the negative charge in the active site and, second, breaking the salt bridge would alter the quaternary structure of the protein and therefore the ... demonstrated that the mutation did not alter the tetrameric behavior of the protein, indicating that the mutation affected the catalytic machinery directly, rather than the oligomeric state of the enzyme ... catalysis The alignment of the small CMLEs from different members of the Rhizobiales with these sequences demonstrated that in A radiobacter S2 (and the other member of the Rhizobiales), the amino...
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the mit press paths to a green world the political economy of the global environment apr 2005
... capture the societal debates about environment and political economy rather than just the academic debates over the theories of the political economy of the environment Naturally, given the breadth ... and there is every reason to expect these trends will continue Economist Julian Simon sums up the case: The standard of living has risen along with the size of the world’s population since the ... each of us, wherever we live, to reach around the world farther, faster, deeper, and cheaper than ever before and at the same time allows the world to reach into each of us farther, faster, deeper,...
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báo cáo hóa học:" Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer" pptx
... from the greater curvature of the antrum and the midpoint of the greater curvature of the gastric body via endoscopic biopsy In the patients with cancer two specimens were obtained from the cancerous ... were diagnosed for the first time during the enrollment period and their blood samples were collected before they received any treatment such as surgery, chemotherapy or radiotherapy This research ... however, the utility of the evaluation of HMGB1 over-expression in tissue is somewhat limited because of the relatively higher-risk, invasiveness and high cost of the procedures used to obtain the...
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báo cáo hóa học: " Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway" doc
... HS performed the experiments and interpreted the data; LT and SCL designed the experiments, analyzed the data and wrote the paper All authors read and approved the final version of the manuscript ... significant, reflecting the results obtained with microarray (see Figure 6A) Taken together, these results demonstrate that the PI3K/Akt pathway significantly contributes to the differential gene ... 9) These results are consistent with the role of PI3K/Akt upstream of NF-κB or MAPK in the astrocyte signal transduction cascades Summary and hypothesis Our results show that the PI3K/Akt pathway...
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báo cáo hóa học:" The integrated care pathway reduced the number of hospital days by half: a prospective comparative study of patients with acute hip fracture" doc
... but there is enough supporting evidence to justify further research [17] The aim of the present study was to evaluate the effectiveness of an ICP in patients with an acute fracture of the hip The ... remained on the orthopaedic ward until they had attained an ADL level equivalent to their pre-fracture level, or until they did not progress further in their rehabilitation No patient in the intervention ... other wards Before the start of the intervention, staff in the emergency room and radiology department was encouraged to attend and treat these patients rapidly so they could be admitted to the...
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báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt
... that the actions of the Akt pathway are more pronounced than the Erk pathway in granulosa cells and vice versa in the in theca cells None the less, administration of inhibitors of these pathways ... follicles were cut open and the theca and adherent granulosa cells peeled from the stroma The granulosa cells were then gently scraped from the theca and the granulosa and theca cells were snap frozen ... affected by the inhibitors However, it is possible that the inhibitors might have diffused through the granulosa layer of cells into the theca layer and affect signalling pathways there Thus the significant...
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The Willing MisfitA Path to Healthy Selfhood By Derek Pearson potx
... when all around them tells them that the vision is wrong; that they should be what the social collective expects of them (and not the least resistant is their own beliefs in the life they know!) ... when they use drugs or alcohol to stupefy themselves, they neutralize their enhanced perceptiveness along with their problems The main difference between them and others is that they don't have the ... ‘going all the way’ Others might find some of the material useful in their lives, but stop short of going the whole hog But I think there’s something in this book for everybody - Whether the reader...
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Báo cáo lâm nghiệp: "Use of stem diameter variations for detecting the effects of pathogens on plant water status" pptx
... of PDA only At the end of the experiment isolations were made from all the plants to confirm the presence of the pathogens in the inoculated plants Reisolations were made from the point of inoculation ... recorded during the experiment raw data were corrected to the (zero) value Three parameters same were RESULTS At the end of the experiment, the pathogens successfully reisolated from the inoculated ... necrosis of the bark and vascular tissues They averaged 10 cm in length at the end of the experiment stem The stem diameter evolution of plants for the different treatments during the experiment...
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Báo cáo y học: "A short review on the aetiology and pathophysiology of alcoholism" ppt
... reward the substance offers, as well as the reinforcement caused by the repeated substance use The mesolimbic pathway is considered crucial for the reward procedure This pathway starts from the ... according the same theory As far as modelling is concerned, the model of the parents, especially the parent of the same sex seems to be significant Operant conditioning is related to the increase ... appears through modification of the functional activity of the proteins that are already inside the neuron or through the influence of alcohol on their 'real' quantity in the neuron [30] http://www.annals-general-psychiatry.com/content/8/1/10...
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Báo cáo lâm nghiệp: " Assessment of the contributions of glycolysis and the pentose phosphate pathway to glucose respiration in ectomycorrhizas and non-mycorrhizal roots of spruce (Picea abies L. Karsten)" docx
... tissues suggest that the contribution of the pentose phosphate pathway to respiration is higher in the fungal component than in the plant tissues The fact that the pentose phosphate path- higher in ... 38% of the carbohydrate oxidation was via the pentose phosphate pathway and 62% was via glycolysis On the other hand, 50% of the glucose metabolism from mycorrhizal roots was catalyzed by the pentose ... Assuming that the same chitin/protein ratio in the mycelial cords of Hebeloma sp and the fungal component of the ectomycorrhizas, then approximately 50% of the protein in the ectomycorrhizas...
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Báo cáo y học: "The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthrits" pps
... from patients with RA Taken together, these data suggest the potential utility of the pathway-selective ER ligand WAY-169916 and other compounds in its class in the treatment of RA Materials and ... this compound [27] These data provide evidence that the non-steroidal, pathway-selective ER ligand, WAY169916, and other compounds in its class might be therapeutically useful in the treatment of ... mg/kg rapidly converts the chronic diarrhea that these rats experience to a normal stool [27] If the disease is allowed to progress, they begin to show symptoms of arthritis In these settings, treatment...
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Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity" pot
... autoimmunity On the one hand, the induction of apoptosis as a result of the infection may lead to molecular modification of host components, including Ago and/or Dicer On the other hand, the association ... in a variety of systemic rheumatic diseases [6] The elucidation of the molecular identity of the Su antigen will facilitate the determination of the diagnostic and/or prognostic value of anti-Su ... This hypothesis is supported by several studies demonstrating Page of (page number not for citation purposes) that the molecular modifications are essential for the early recognition by the immune...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25