assembly structure and regulation of intermediate filaments
STRUCTURE AND REGULATION OF YEAST GLYCOGEN SYNTHASE
... the crystal and thus its contribution to the structure factor and the phase angle The structure factor of a isomorphous derivative (FPH) is related to the sum of the structure factor of the protein ... Pathway for the biosynthesis and degradation of glycogen Figure Regulation of glycogen metabolism in skeletal muscle Figure Transcriptional and enzymatic regulation of glycogen metabolism in ... INTRODUCTION A Glycogen Structure of glycogen Glycogen, a branched polymer of glucose serves as one of the major repositories of carbon and energy in eukaryotes The linear polymerization of glycogen is...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... repeat and relative expression of the HD gene We then determined the structure of the mouse CB1 gene and determined that transcription of the CB1 gene was affected in striatal neurons of transgenic ... CB1 promoter, we determined the sequence and structure of the 5¢-end of cDNAs corresponding to full-length mature CB1 mRNA and deduced the structure of the CB1 gene by comparing the cDNA sequences ... (C and D) are shown For each series of protection reactions, 10 pg of undigested probe control (P) and a no target control that consists of 400 pg of probe combined with excess yeast RNA and...
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Báo cáo khoa học: Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase pptx
... Kd of 500 nm In the presence of ANP, ECD dimerization was strongly enhanced (Kd 10 nm) [18] Crystal structures of the ECD with and without ANP We have determined the crystal structures of ... determination of the native structures in the absence of crystal contacts and in solution conditions closer to those of the native environment The three-dimensional reconstructions of the apo-ECD dimer and ... The actual and detailed mechanism of GC activation by ANP, namely the signal transduction mechanism, must await determination of NPRA’s GCD structure and ultimately the structure of full-length...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... implications of the cycle of histone acetylation and deacetylation that accompanies cycles of transcription, and highlight the special significance of histone H4 lysine 16 acetylation Active chromatin and ... functions of PARP-1 are activated in the presence of NAD+ it mediates the PARylation of both histones and PARP-1 itself, and thereby promotes decondensation of higher order chromatin structure ... with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130] However, in human cells depletion of MOF, but not Tip60, results in reduced global levels of AcH4-K16 and defective...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were generated by PCR and cloned ... downstream of v-KIND overexpression [12]) enhances the activity of MAP2 to bind to microtubules and promote their assembly [18], and that the inhibition of JNK1 (such as downstream of v-KIND knockdown ... series of GST-fused deletions of the CD2-1 region (Fig 3E) and examined the interactions between bacterially expressed proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the...
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Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
... Scientific Fund of the Ministry of Education, Science and Culture of Japan (G.T.); the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation ... of miR-221 and miR-222 in PC12 cells, and that this induction is dependent on sustained activation of the ERK1 ⁄ pathway [20] Furthermore, the induction of miR-34a depends on the activation of ... Indeed, several examples of feedback regulation that involve miRNAs have been reported Below, we attempt to summarize our recent understanding of feedback regulation of signal cascades that involve...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
... patterns and processes at different levels of biological organization: from the life histories of individuals, to the structure and dynamics of populations and communities, to the fluxes and pools of ... measuring and understanding the roles of different kinds of organisms in the flux and storage of elements in ecosystems The total biomass per unit area, W, is simply the sum of the body mass of all ... abundances and turnover of populations, the allocation of resources among coexisting species, and the fluxes and pools of energy and materials in ecosystems These exchanges are direct consequences of...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
... form of cyprosin was processed in different isoforms by the excision of the prosegment and of most of the PSI [21] Conversely to what has been found in vivo [31], heavy and light chains of the ... representation of the structure of the PSI domain of barley prophytepsin [25] (N-terminal domain, blue; C-terminal domain, red) (C) Model structure of the PSI domain of cardosin A based on the crystal structure ... by the prosegment, but also by the 13 residues of the N-terminal of the mature enzyme and by the ÔflapÕ The anchorage of the prosegment and of part of the N-terminus in the active site cleft is...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... analysis of the DNA of different Conus species has already revealed a large number of a-conotoxin sequences [45] and the identification of further specific nAChR ligands is likely The advantage of a ... consisting of the extracellular ligand-binding domain of the a6 subunit and the transmembrane and intracellular domains of the a3 subunit was used in this study PIA selectively blocks rat and human ... determination of the subunit composition of the nAChRs involved has been hindered by the lack of selective ligands and imperfect correlations between the characteristics of native and heterologously...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... the structure and PDB code shown below each panel (A) Overlap of isoform 337 with the structure of the longer isoform CfAFP-501 using the main chain of residues Thr23fiAsn90 in isoform 337 and ... other and with proteins that have a similar fold Structure of sbwAFP and TmAFP The structure of sbwAFP has been determined by X-ray ˚ crystallography to 2.5 A and by NMR at both 30 °C and °C ... method and PDB code shown below each panel (A) Overlap of X-ray structure with °C NMR structure using the main chain of residues Ser12fiThr70 in the structure alignment (B) Overlap of the X-ray structure...
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Tài liệu Báo cáo khoa học: Complete subunit sequences, structure and evolution of the 6 · 6-mer hemocyanin from the common house centipede, Scutigera coleoptrata pptx
... hemocyanin of which the complete molecular structure is known This allows us to compare structure, and intra- and intermolecular evolution of hemocyanins from Myriapoda, Crustacea and Chelicerata ... composed of 12 HcA, 12 HcB, six HcC and six HcD polypeptides Thus the basic building block of the hemocyanin, the hexamer, most likely contains two copies of each HcA and HcB, and single copies of ... assignment of the HcA clone to the major sequence of the upper hemocyanin band in the SDS/PAGE gel (Fig 1) Two nonmatching amino acids at positions (Glu instead of Cys) and (Ala instead of Pro)...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... longer-chain (and nonglobular) versions of the structure of the Bowman±Birk inhibitor in Fig The X-ray crystal structure pi2 reveals that the /,w angles of most of the residues of the Bowman±Birk ... form of b strand [18] The positive bands at » 1675 cm)1 in the amide I region of the ROA spectra of b- and j-casein, which originate mainly in the peptide C O stretch, are characteristic of disordered ... the theme of PPII structure and rheomorphism is explored by a comparative ROA study, supplemented with DSC, of caseins, synucleins and tau, together with several mutants of a-synuclein and tau...
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Tài liệu Báo cáo khoa học: "The Structure and Process of Talking About Doing" pdf
... study of problem solving action and report: I) the collected of data on problem solving and talk about problem solving, 2) development of a process model of these behaviors, and 3) use of coding ... problem solving from a record of the problem solving report and a record of moves made Then, we use this extracted trace to evaluate our model of the role of point of view in problem solving SUMMARY ... organization of the problem ("point of view"), and systematic multl-utterance structures used to express the forms of inference used to solve the problem ("Justificatlon argument structures")...
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Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... and fD are the mass fractions of monomer and dimer, respectively, and RgM and RgD are the radii of gyration for the monomer and dimer, respectively Missing pieces of crystallographic models were ... 1) Radius of gyration, model fitting and analysis For a mixture of monomeric and dimeric scattering species, the radius of gyration is given by: R2 ¼ fM R2 þ fD R2 g gM gD ð7Þ where fM and fD are ... scattering of monomeric arrestin, the forward scattering from a mixture of monomers and dimers is: Ið0ÞTotal ¼ fM Ið0ÞM þ 2fD Ið0ÞM ð1Þ where fM and fD are the mass fractions of monomer and dimer,...
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Tài liệu Báo cáo Y học: Characterization and regulation of yeast Ca2+-dependent phosphatidylethanolamine-phospholipase D activity docx
... pattern and extent of stimulation of the membrane and soluble yeast PtdEtnPLD activity by Ca2+ and their inhibition by other divalent cations is highly comparable The mechanism of action of Ca2+ ... promoter region of INO1 and other genes that are part of the INO1 regulon [45] As regulation of phospholipid biosynthesis and degradation are likely to be coordinated, it was of interest to examine ... both wild-type and spo14D cells Future identification of the PtdEtn-PLD gene and analysis of its promoter region will allow examination of its transcriptional regulation by inositol and the possible...
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Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
... macrophages and lymphocytes are able to produce a higher amount of anandamide and/ or 2-AG [21,23–26] IgE-dependent stimulation of RBL-2H3 cells also leads to the formation of anandamide and of its ... Purification and quantification of endocannabinoids The extraction, purification and quantification of anandamide, 2-AG and PalEtn from immature and mature dendritic cells requires a set of different ... dehydrogenase and FAAH were selected on the basis of the sequence of the FAAH gene (NCBI accession number AF098010) by including the introns 5476–6026 and 6173–6296, and of the sequence of the glyceraldehyde-3-phosphate...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... solution structure of the C-domain (A) Stereo view of the ensemble of the final 48 calculated structures Twenty-four structures of the closed protein conformer are shown in red, and 24 structures of ... of eRF1 Fig S11 The Ramachandran map plot (/ and w torsion angles for the protein backbone) of all 24 conformers of the NMR families of solution structures of the closed and open conformers of ... structure calculation for the open and closed conformers of the C-terminal domain of human eRF1 Fig S3 NOE map of the minidomain (residues 329– 372) of human eRF1 NMR structure and function of...
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Báo cáo khoa học: Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid pdf
... Comparison of the positions of the tip of domain IV in all available EF-G structures in the PDB The structures were superimposed on the basis of domains I and II Looking from the direction of the ... helices AV and BV at the surface of domain V Gly621 and Gly617 are in the area of contact with the 1095 and 2473 regions of 23S RNA The two helices are facing the ribosome, and the four-stranded b-sheet ... thermophilus EF-G structures, wild type and various mutants, domains III, IV and V display a movement relative to domains I and II, resulting in a shift of the ˚ tip of domain IV of up to A [14,16]...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc
... identification and distribution of TLP genes in nature, the structural and functional characterization of the TLP from various organisms, and the evolution of TLP and transthyretin The identification of TLPs ... structures of these proteins, all tetrameric, showed significant similarity to the published structures of transthyretin By way of example, a comparison of the structure of S dublin TLP with the structures ... in TLP structures as a result of alterations to the formation of hydrogen bonds between strands The carbonyls of residues V104 and P105 (zebrafish TLP numbering), in the middle of b-strand G,...
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