arpansa apos s regulatory role in the protection of the environment from ionising radiation licensing the remediation of abandoned uranium mine workings in kakadu national park
... workshops were held to allow for detailed discussion of each of these subjects This symposium was the third in a series The first International Symposium on Ionising Radiation: Protectionofthe ... establishing an international consensus on this issue, and its involvement inthe organization of this symposium, and the publication of these proceedings, are examples of its activity in this ... and the spawning biomass increases to ~350 te The initial sharp rise and decline inthe ray spawning biomass is probably the consequence of a mismatch between the age/size distribution ofthe starting...
... following Coomassie blue staining is shown as a loading control (lc) For comparison purposes, DAI expression in murine small intestine tissue is shown (+) To determine if glial cells express DAI in ... comparison purposes, DAI expression in murine small intestine tissue is shown (+) Representative results are shown for one of three separate experiments Furthermore, we assessed glial DAI expression ... in situ, we first assessed the expression of this viral sensor in ex vivo microglia/macrophages and astrocytes isolated from uninfected mouse brain tissue As shown in Figure 3A, whole brain homogenates...
... sister She never behaves with respect to the other Just because she is her sister – except perhaps in those cases when her mother says, “Give in to her.” Inthe game of sisters playing at “sisters,” ... are sisters: they are dressed alike, they walk about holding hands – in short, they enact whatever emphasizes their relationship as sisters visa-vis adults and strangers The elder, holding the ... the other sister inthe whole play situation.) Only actions that fit these rules are acceptable inthe play situation Inthe game a situation is chosen that stresses the fact that these girls...
... existence of splice sites in both the sense and antisense orientations The 5'ss was searched as 'gtnngn' or 'gcangn' (because these were shown to be active splice sites [5]) The 3'ss was searched ... not spliced, but compete for the binding of splicing factors Such competition may alter mRNA splicing ofthe flanking exons, such as shifting the splicing ofthe surrounding exons from constitutive ... withinoffilebased onboth accessions, confirming site of and 4cancer-specificcellthe alternative specificthetissue-specDNAheresplice of Aluthe forsense/antisenseofandmouse familiesandofoftabledescribing in...
... lane 4), therefore confirming the interaction of these two proteins previously observed biochemically [37] or using a yeast two-hybrid assay [39] Interestingly, inthe M2H system, the interaction ... Movies are presented at ten frames per second, representing a speed increase of ·40 Statistical analysis was performed using the graphpad prism, version (GraphPad Software, Inc., San Diego, CA, USA) ... with GRASP55 We next sought to define the nature ofthe GRASP55 binding site inthe MT1-MMP ICD pACT plasmids driving the expression of MT1-MMP ICDs containing single-, double- and triple-point mutations...
... thousands of persons detained as “special interest” immigration detainees (so-called special interest INS detainees),74 as material witnesses,75 and as persons detained without trial as alleged security ... various German lawyers inthe German Ministry of Justice, high-level executive positions outside the Ministry, and the courts inthe 193 0s and 194 0s that were addressed in informing detail inThe ... authorizing a short list, maybe or techniques: use of dogs; stress positions; loud music; deprivation of food; keeping the lights on, those kinds of things And then a handwritten message over to the side...
... in uence the binding ofthe first glucose unit ofthe aglycone On the other hand, M453 may be positioned in subsite +2 because these residues in uence the binding ofthe second glucose unit ofthe ... Previous studies using oligocellodextrins showed that diverse b-glycosidases have a different number of subsites forming their aglycone-binding sites [15] Nevertheless, just recently the structures ... affect the binding ofthe glycone within the Sfbgly active site This hypothesis was further investigated by determining thein uence on the glycone binding ofthe Sfbgly interactions with the aglycone...
... 58 As histidine residues are central to copper binding in many proteins they probably form part ofthe copper binding sites in this protein Although there are four histidines inthe C-terminal, ... Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) inthe hippocampus of patients with Alzheimer s disease, parkinsonism-dementia complex on Guam, and senile dementia ... myoclonic seizures and undergo an extensive loss of Purkinje cells They provide a reasonably good model for the disease The transcripts that were consistently increased in brain tissue from CSTB-deficient...
... prevent the synthesis ofthe new cuticle fromthe hypodermis and/or ecdysis ofthe old cuticle This assumption is supported by the fact that PPase-activated PPi hydrolysis is essential to maintain the ... (NaF, S- 7920; Sigma) was tested inthe present study The L3 extracts were assayed inthe standard reaction mixture for PPi hydrolysis, inthe presence of increasing concentrations of NaF The PPase ... tissues, such as the body wall, gut epithelium and reproductive organs, of adult female worms suggests a critical roleofthe enzyme in these organs The presence of AsPPase in embryonated eggs,...
... a substantial amount ofthe L-arabinose residues (14%) in soy arabinogalactan is present as terminal residues [21], suggesting that of these arabinogalactans, soy arabinogalactan is the most ... containing carbon sources as indicated in Fig Expression of galA was only detected inthe presence of sugar beet pectin, whereas expression of lacA was detected inthe presence of L-arabinose, ... of both linear and L-arabinose-substituted galactan side chains of pectin This is in agreement with a previous study in which the synergy of enzymes degrading the pectin side chains was studied...
... to assess the effects ofthe glycone moiety in this way as none of these compounds were substrates These data indicate that ¯avonoid-3-glycosides are not substrates for CBG DISCUSSION Fig Structures ... supernatant was estimated by activity measurement assays using 4NPGlc as substrate Expression of cbg-1 in P pastoris and isolation of reCBG Large-scale expression was achieved using 250 mL cultures in L ... Furthermore, we examined the speci®city of reCBG with respect to the glycone moiety using a series of NP derivatives The enzyme catalysed the release of 4NP from six ofthe 11 4-substituted substrates...
... that the PX domain of p47phox binds intramolecularly to the SH3 domain inthe same protein, and that this intramolecular interaction suppresses the lipid-binding activity ofthe PX domain inthe ... expansion during adipogenesis Proc Natl Acad Sci USA 100, 850–855 39 Ponting CP (1996) Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains? ... that in mature adipocytes, suggesting that expression of fad49 is predominant in preadipocytes As expression of fad49 was observed in skeletal muscle, we analyzed the expression levels of fad49...
... was prepared as described [26] The other substrates were obtained in dry organic solvents inthe presence of organic base (pyridine, N-methylmorpholine) The solvents used for the synthesis ofthe ... determines the position ofthe substrate within the S1 ¢-binding subsite O atoms ofthe main chain CO groups of LeuB387 and TrpB240, Od1 atom of AsnB241, and Oc atom of SerB386 and is expected to stabilize ... residues This part ofthe enzyme can be considered as its S1 ¢ binding subsite Substrate binding induces conformational changes involving the ArgA145PheA146 fragment ofthe protein chain, acting...
... (Opioids & Related Disorders, 2009) Opioids act directly on the central nervous system ofthe brain, resulting in feelings of euphoria These feelings and the physical and psychoactive affects ofthe ... agents as well as non-opioid alternatives as the first pain intervention whether or not opioid analgesics use is justified If opiate use is justified, the NP should discuss the risks and benefits ... system and imposed devastating consequences to individuals and families The Social Construction Theory was selected as a framework for understanding these complex issues Social Construction Theory...
... binding sites were identified by proteinÆDNA gel mobilityshift assays To assess the biological significance of these regulatory elements inthe response to glucocorticoids, the concurrence ofthe ... and the C/EBP responsiveness was investigated inthe rat liver upon synthetic glucocorticoid administration The hypothesis of a cause–effect relationship is suggested by the time-course analysis ... using T4 polynucleotide kinase test for unequal N (Spjotvoll/Stoline test) All analysis were performed using the StatSoft Inc (1995) STATISTICA FOR WINDOWS software Nuclear extracts Results Isolation...
... scales is essential both for describing the distribution of organisms and for understanding the roles of organisms in ecosystem function Issues of scale may be especially important for understanding ... as possible so as to generate a series of questions or sow the seeds of thought in future generations of mycologists Given the estimate of more than 1.5 million fungal species possibly in existence ... populations of plants and animals inthe ecosystem The effect of fungi on other organisms and the effects of other organisms on fungi are important aspects of community analysis in any ecosystem In...
... fromthe same parental strain, we first addressed the question ofthe specific roleof DIM A and DIM B inthe resistance of cells to SDS We demonstrated that the occurrence of comparable amounts of ... mutant strain were present inthe spleen of these mice For the determination ofthe number of PMM56 bacteria present inthe spleen of these four mice, we thus chose a value of 50 CFU per spleen The ... developments in our understanding ofthe biosynthetic pathway of DIMs have provided the means to investigate the contribution of these compounds to the biology of M tuberculosis Considerable efforts, started...