... that the erosion is the primary lesion and the redness and scale are secondary, while the correct interpretation would be that thepatient has a pruritic eczematous dermatitis with erosions caused ... differential diagnosis (Table 52-4) For instance, the finding of scaling papules (present in patients with psoriasis or atopic dermatitis) places thepatient in a different diagnostic category than ... important to differentiate primary from secondary skin lesions If the examiner focuses on linear erosions overlying an area of erythema and scaling, he or she may incorrectly assume that the erosion...
... elicits the desire to scratch Pruritus is often the predominant symptom of inflammatory skin diseases (e.g., atopic dermatitis, allergic contact dermatitis); it is also commonly associated with ... epidermal atrophy) Scar: A change in the skin secondary to trauma or inflammation Sites may be erythematous, hypopigmented, or hyperpigmented depending on their age or character Sites on hair-bearing ... conditions that can be associated with pruritus include chronic renal disease, cholestasis, pregnancy, malignancy, thyroid disease, polycythemia vera, and delusions of parasitosis Figure 52-3 A schematic...
... hospitalized patientwith a generalized erythematous exanthem is more likely to have a drug eruption than is a patientwith a similar rash limited tothe sun-exposed portions of the face Once the distribution ... patientwith cutaneous small vessel vasculitis (Courtesy of Robert Swerlick, MD; with permission.)[newpage] APPROACHTOTHE PATIENT: SKIN DISORDER In examining the skin it is usually advisable to ... as completely as possible This will minimize chances of missing important individual skin lesions and make it possibleto assess the distribution of the eruption accurately Thepatient should first...
... The distribution of some common dermatologic diseases and lesions Figure 52-7 Psoriasis This papulosquamous skin disease is characterized by small and large erythematous papules and plaques with...
... contrast, lesions with a generalized arrangement are common and suggest a systemic etiology Figure 52-9 Erythema multiforme This eruption is characterized by multiple erythematous plaques with a target ... usually represents a hypersensitivity reaction to drugs (e.g., sulfonylamides) or infections (e.g., HSV) (Courtesy of the Yale Resident's Slide Collection; with permission.) Figure 52-10 ...
... against the surface of the skin and rotated with downward pressure until it penetrates tothe subcutaneous tissue The circular biopsy is then lifted with forceps, and the bottom is cut with iris ... area of skin is anesthetized with 1% lidocaine with or without epinephrine The skin lesion in question can be excised or saucerized with a scalpel or removed by punch biopsy In the latter technique, ... History of allergies Presence of photosensitivity Review of systems Family history (particularly relevant for patients with melanoma, atopy, psoriasis, or acne) 10 Social, sexual, or travel history...
... to document sensitivity to a specific antigen In this procedure, a battery of suspected allergens is applied tothepatient' s back under occlusive dressings and allowed to remain in contact with ... best performed by physicians with special expertise in patch testing and is often helpful in the evaluation of patients with chronic dermatitis FURTHER READINGS Dermatology Lexicon Project: www.futurehealth.rochester.edu/dlp2/ ... designed to assess whether a skin lesion will blanch with pressure as, for example, in determining whether a red lesion is hemorrhagic or simply blood-filled Urticaria (Fig 52-11) will blanch with...
... same as the prognosis of the person with aortic stenosis who develops the first symptoms of congestive heart failure (median survival, ~8 months) However, thepatientwith heart disease may ... cancer patient feels that he or she, and not just a body part, is diseased The Magnitude of the Problem No nationwide cancer registry exists; therefore, the incidence of cancer is estimated on the ... selection to seek advantage over normal cells in a recapitulation of evolution One consequence of the traitorous behavior of cancer cells is that thepatient feels betrayed by his or her body The cancer...
... The past medical history may alert the physician tothe presence of underlying diseases that may affect the choice of therapy or the side effects of treatment The social history may reveal occupational ... predisposition and point out the need to begin surveillance or other preventive therapy for unaffected siblings of thepatientThe review of systems may suggest early symptoms of metastatic disease or a paraneoplastic ... 77-3 Patient Management Important information is obtained from every portion of the routine history and physical examination The duration of symptoms may reveal the chronicity of diseaseThe past...
... Against Cancer and the American Joint Committee on Cancer (AJCC) The TNM classification is an anatomically based system that categorizes the tumor on the basis of the size of the primary tumor ... other prognostic factors have been identified (Chaps 104, 105, and 106) In addition to tumor burden, a second major determinant of treatment outcome is the physiologic reserve of thepatient Patients ... are likely to fare worse, stage for stage, than fully active patients Physiologic reserve is a determinant of how a patient is likely to cope withthe physiologic stresses imposed by the cancer...
... Internet.2 The skilled physician also has much to offer thepatient for whom curative therapy is no longer an option Often a combination of guilt and frustration over the inability to cure thepatient ... and the pressure of a busy schedule greatly limit the time a physician spends with a patient who is receiving only palliative care Resist these forces In addition tothe medicines administered to ... complications of both thedisease and its treatment as well as the complex psychosocial problems associated with cancer In the short term during a course of curative therapy, thepatient' s functional...
... most patients who are cured of cancer return to normal lives Supportive Care In many ways, the success of cancer therapy depends on the success of the supportive care Failure to control the symptoms ... nonjudgmental, so that patients are more likely to discuss withthe physician what they are actually doing The appearance of unexpected toxicity may be an indication that a supplemental therapy is being ... persists, the multidisciplinary team discusses a new salvage treatment plan If thepatient has been rendered disease- free by the original treatment, thepatient is followed regularly for disease...
... on which to indicate the severity of the pain The clinical condition is often dynamic, making it necessary to reassess thepatient frequently Pain therapy should not be withheld while the cause ... signals in the chemoreceptor trigger zone in the medulla, the cerebral cortex, and peripherally in the intestinal tract lead to stimulation of the vomiting center in the medulla, the motor center ... caused by chemotherapy (Chap 81) Its severity can be predicted from the drugs used to treat the cancer Three forms of emesis are recognized on the basis of their timing with regard tothe noxious...
... Sexual dysfunction is highly prevalent and needs to be discussed openly withthepatient An empathetic health care team is sensitive tothe individual patient' s needs and permits negotiation where ... adversely affect the course of treatment Cancer survivors have other sets of difficulties Patients may have fears associated withthe termination of a treatment they associate with their continued ... that cancer therapy is substantially more toxic and less effective in the face of malnutrition Nevertheless, it remains unclear whether nutritional intervention can alter the natural history Unless...
... affected by the diagnosis and is coping with it is an important goal of patient management It is best to speak frankly withthepatient and the family regarding the likely course of disease These discussions ... How to Care for Family and Friends at Home that teaches an approachto successful problem-solving in home care With appropriate planning, it should be possibleto provide thepatientwiththe ... difficult for the physician as well as for thepatient and family The critical features of the interaction are to reassure thepatient and family that everything that can be done to provide comfort...
... on thepatient' s chart or photodocumented, if observable withthe fundus camera, for future reference cooperative.81 The optometrist should tell thepatient that the risk associated withthe ... epithelium becomes more visible in the area of the tear due tothe loss of the overlying retina If the edge of the dialysis remains close tothe RPE, then the tear may not be discovered unless ... of the American public and are often the first health care practitioners to diagnose patients with diseases of the retina This Optometric Clinical Practice Guideline for Care of thePatient with...
... in the induction of cytokines, including tumor necrosis factor, and the phosphate residue at the 4¢-position is a critical site for the activity [24] Therefore, the monophosphoryl lipid A in the ... Cleavage F indicated the chain length of the fatty acid on the acyoxyacyl group to be mainly 15, confirming the result of the compositional analysis In the minor triacylated lipid A, the fragmentation ... moiety in LPS To analyze the structure of the OPS moiety, the hydrophilic products from the acetic acid hydrolysate of LPS were separated by gel-filtration chromatography to give the highmolecular-mass...
... Approachtothe Patient: Acute Febrile Illness A physician must have a consistent approachto acutely ill patients Even before the history is elicited and a physical ... should be performed for patients withpossible acute endocarditis Asplenic patients should have a blood smear examined to confirm the presence of Howell-Jolly bodies (indicating the absence of splenic ... bacteria; these patients can have >106 organisms per milliliter of blood (compared with 10 4/mL in patients with an intact spleen) Blood smears from patients at risk for severe parasitic disease, ...
... (U.S.), Either: Atovaqu one and 01, 204 with fewer side or effects Treatmen Atovaquone t (750 mg q12h) plus with doxycycline c Azithromycin (100 mg bid ) (500-mg loading for potential dose, then 250 ... fludrocortisoneb or may improve outcome in Cefepime (2 g patients with q12h) septic shock Overwhel ming Streptoc post- occus g q12h) plus splenectomy pneumoniae, sepsis Haemophilus influenzae, If a ... If thepatient is >50 years old or 76 has comorbid disease, add ampicillin (2 g q4h) for Listeria coverage Vancomycin (1 g q12h) Dexamet hasone (10 mg q6h x days) improves outcome adult in patients...