application of pharmacokinetic modeling to understand the mechanism of action of endocrine disrupting chemicals
A NATIONWIDE SURVEY OF ENDOCRINE DISRUPTING CHEMICALS IN SOURCE AND DRINKING WATERS IN JAPAN
... difference of river flow affecting the dilution rate Table summarized the results from pesticides and other synthetic chemicals Malathion, methomyl, and benomyl were detected In spite of the prohibited ... 5, 2, and of the samples, respectively The maximum concentration of DEHP was 0.00026 mg/l, and that of DBP was 0.00018 mg/l The concentrations of DEHP was much lower than 0.008 mg/l, the WHO guideline ... Since the Ministry of Environment has been conducting risk assessment of DEHP and some other EDCs from 2000 (Ueda, 2000), risk evaluation of these chemicals should be conducted in a few years The...
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Báo cáo khoa học: "Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes" pdf
... detcartxe saw ANR latoT RCP-TR dna noitcartxe ANR latoT )ynamreG ,acieL( epocsorcim thgil a rednu devresbo dna ,nisoe dna nilyxotameh htiw deniats ,)ynamreG ,acieL( emotorcim yrator a htiw sessenkciht ... eraC rof ediuG‘ htiw ecnailpmoc ni detcudnoc erew stnemirepxe lamina llA doirep emas eht rof )elcihev eht( lio nroc deviecer slamina lortnoC )ASU( amgiS morf deniatbo erew slacimehc llA skeew rof ... noitomorP hcraeseR cisaB ,DRHEOM[ tnemnrevoG naeroK eht yb dednuf tnarG noitadnuoF hcraeseR aeroK a yb detroppus saw krow sihT stnemgdelwonkcA setset ni sCDE suonegoxe fo stceffe latnemirted rof...
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Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc
... show that the data fit well with the individual determination of flux control coefficients by PFK, PK and LDH The role of the las operon is discussed on the basis of the distribution of flux control ... under the control of a synthetic promoter 2294 The relative PFK activity in strain CS1929 was found to increase to over 160% of the wild-type level, whereas the relative LDH activity was reduced to ... possible to compare the flux controls of the individual enzymes with that of a simultaneous modulation of all the las enzymes, i.e to J J J J test whether: Clas ¼ CPFK þ CPK þ CLDH With respect to...
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Agent-based and analytical modeling to evaluate the effectiveness of greenbelts potx
... from the top of the lattice to the bottom The width of the landscape, X Size, is increased by the value of w to allow comparison between runs Therefore, in all ABM experiments the total number of ... until the total number of agents equals the total number of cells to the left of the greenbelt This is equivalent to the constraint on the mathematical model that g!M (Section 2.1) We then recorded ... recorded whether or not any of the agents located to the right of the greenbelt To measure the degree to which the greenbelt served to forestall development beyond the greenbelt in both of our 2D...
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Báo cáo sinh học: "Comparative embryology without a microscope: using genomic approaches to understand the evolution of development" potx
... Although these genome-scale analyses [3-7] are beginning to provide insights into the action of selection across development, the approach faces several challenges One is that expression levels of ... Reconstruction of Darwin’s Theory Chicago: University of Chicago Press; 1992 Raff RA: The Shape of Life: Genes, Development, and the Evolution of Animal Form Chicago: University of Chicago Press; ... development is the result of adaptation between each species is calculated as a proxy for functional divergence relative to the underlying mutation rate One can then search for differences in the average...
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Báo cáo khoa học: "Veterinary decision making in relation to metritis - a qualitative approach to understand the background for variation and bias in veterinary medical records"
... motivated to collect valid data at the herd level They perceive the collection of the data in and of itself as the basis for taking relevant action at the farm They may skip the process of systematic ... levels/categories of motivation At the level of the individual cow, the veterinarians seemed to base their treatment decisions on the cow's characteristics They focussed generally on the practical use of the ... to 'justifying,' i.e., adjusting of the score to fit to the treatment decision This category of veterinarians based the treatment decision on an overall evaluation of the case, irrespective of...
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Báo cáo khoa học: The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties ) comparative modeling to probe the molecular basis pdf
... leading to build-up of NADH, which was not expected, as the levels of cofactor should be sufficient to sustain the lactate flux Therefore, there must be an additional factor acting as an inhibitor of ... interactions Examination of the model of the R state of LDH shows a much higher density of positive charge in the region of contact between the monomers than in LDHB, particularly in the region of ... sought to understand the strong pH dependence of the kinetic parameters of LDHB as compared to the insensitive behavior displayed by LDH in terms of the structural differences between the two...
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Investigation of phytoplankton as an overlooked marine source of natural endocrine disrupting chemicals
... 2.2 Schematic of stock phytoplankton cells maintaining Figure 2.3 EGS incubator for maintaining stocks of phytoplankton Figure 2.4 EGS incubator used for mass culture of phytoplankton Figure 2.5 ... LargeIscale!Cultivation !of! Phytoplankton! .!41! 2.2.6! Phytoplankton!Growth!and!Bioactivity!Monitoring! !42! 2.2.7! Harvest !of! the! Phytoplankton!Culture!Samples! !43! 2.2.7.1! SPE!Extraction !of! Phytoplankton!Cultures! ... source of endocrine- disrupting chemicals The primary objective of this study is to investigate the main causes that attribute to the AR and ER bioactivities of Singapore seawaters and to confirm...
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Removal of endocrine disrupting compounds in municipal wastewater by membrane bioreactor (MBR) systems
... percentage of total E2-Eq, and the contribution of the quantified levels of phenolic xenoestrogens to total estrogenic activity in the sewage was 0.7-4.3%, and made no further contribution to the total ... at the wrong time or to an excessive extent (agonistic effect) • They may bind to the receptor but not activate it Instead the presence of the chemical on the receptor will prevent binding of the ... thousands of compounds Some of the synthetic organic compounds that are common in treated wastewater have been shown in laboratory studies to induce endocrine disrupting effects These endocrine disrupting...
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Determination of endocrine disrupting compounds in environmental samples using microextraction combined with gas chromatography mass spectrometry
... (109,400 tons) of oil were spilled worldwide into marine and terrestrial environments as the result of over 250 incidents The Port of Singapore is the one of the world’s busiest, where the total ... layer, and the micro drop of the acceptor phase is suspended in the organic phase directly from the tip of the syringe needle With the help of stirring, the analytes are extracted from the donor ... was added to the 32 seawater samples Addition of acetone improved the extraction The optimum amount of acetone was studied Figure 2.1.6 shows the solvent effect in HS-SPME; the extraction yield...
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The application of games in teaching grammar with reference to tieng anh 10 textbook at ha trung high school, thanh hoa province
... find that the games guided by their teacher are easy to understand, 18.4% of the students sometimes don’t understand the rule of the games, and 0.5% of the students don’t know how to play the games ... them all The picture draws a man and a woman in the clothes store 17 The teacher asks the students to work in groups They have to show the differences between sentences, about the form and the ... 2 Given the rationale and the aims of the study, it is necessary to limit the study to the areas which are manageable Benefits of the application of games in teaching grammar create the effectiveness...
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Tài liệu Mapping TOEFL® iBT Scores to the CEFR: An Application of Standard ... pdf
... Purpose • Identify scores on TOEFL® iBT corresponding to the six proficiency levels of the CEFR – A1 and A2 (Basic) – B1 and B2 (Independent) – C1 and C2 (Proficient) • Focus on candidates ... range of topics in field of interest Sustains conversation with degree of fluency and spontaneity Takes listener and cultural context into account Speaks without causing undue stress to the listener ... Angoff Approach • What is the probability that a “just qualified” A2, B2, C2 candidate would know the correct answer? Or • How many of 100 JQCs would know the correct answer? • Three rounds of...
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AN ACTION RESEARCH ON THE APPLICATION OF COOPERATIVE LEARNING TO TEACHING SPEAKING TO THE SECOND YEAR SUDENTS AT THE DEPARTMENT OF ENGLISH, GIA LAI TEACHERS' TRAINING COLLEGE
... experts with the same topic meet in a corner of the classroom to learn about their topic Then they prepare a brief presentation on the material and return to their base teams They teach their base ... by the tendency of some learners to dominate the group, while others speak very little or not at all • Mother-tongue use: When all, or a number of the learners share the same mother tongue, they ... the collaboration of many individuals (the actors, the director, the editor, the scriptwriter, the cinematographer…ect.) who not only try to fulfill their duties, but also share the responsibilities,...
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Slide an investigation into some approaches to vocabulary teaching and learning and the application of games in teaching and learning vocabulary at pre – intermediate level at foreign language center – haiphong university
... (Wilkins, 1972, p.111) Rationale Aims of the study Scope of the study Methods of the study Design of the study Research questions: What is the present situation of teaching and learning vocabulary ... encourage learners to interact and communicate with one another When taking part in the games learners have to talk to express or exchange their ideas with their partners It can lead to better word ... 1997) Through interaction with others, learners can get help from each other on the meaning of unfamiliar words, including vocabulary items they not know (Nation and Newton, 1977, p.244) Part...
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Tài liệu Which Bank Is the “Central” Bank? An Application of Markov Theory to the Canadian Large Value Transfer System doc
... transactions in the LVTS from October 1st 2005 to October 31st 2006 This data set consists of 272 days in which the LVTS was running The participants in the sample consist of members of the LVTS ... vector is our prediction for the distribution of daily liquidity The bank with the highest value in the stationary vector is predicted to hold the most liquidity throughout the day and is thus the ... order of magnitude) The BCLs are fairly symmetric since the minimum through the 50th percentile of absolute differences of the BCLs between pairs of banks are zero and even the 75 percentile of the...
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Tài liệu A Matter of Security The Application of Attachment Theory to Forensic Psychiatry and Psychotherapy pptx
... corresponding to the feeling of anger (the idea of anger rather than the experience of anger) may be used to simulate and so to infer the THE DEVELOPMENTAL ROOTS OF VIOLENCE IN THE FAILURE OF MENTALIZATION ... months of age (Tomasello 1999) infants begin to differentiate actions from their outcomes and to think about actions as means to an end This is the beginning of their understanding of themselves ... Thomas 2000) The explosives they brought with them, had they detonated, would have put the death toll into the hundreds During the attack, the boys excitedly discussed which of their classmates...
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Tài liệu Effect modification of air pollution on Urinary 8-Hydroxy-2’-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions ppt
... 145 (48.82) *The sum of the subjects in each genotype may not add up to the total number of subjects due to missing genotyping data Missing genotyping is due to a variable number of samples for ... significance of interaction terms of individual SNP and pollutant The current version of MTP allows one to identify the significance of a group of candidate variables to reduce the false discovery rate ... rate meanwhile adjusting for a group of fixed covariates We used MTP to identify the significance of the group of interaction terms Because the current version of MTP in R can only include one term...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25