apoptosis by zinc deficiency
Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... leads to apoptosis [41,42], and mitochondria is influenced by proapoptotic signal transduction through the JNK pathway [43] As the activation of p38 is an essential step for apoptosis induced by hydrogen ... stimulate stressinduced apoptosis by negative regulation of Hsp70/Hsc70 chaperone that is required for suppression of apoptosis In conclusion, we showed here that Hsp105a enhances apoptosis at or upstream ... pathways are activated by cellular stresses and inflammatory cytokines, resulting in growth arrest and apoptosis, and have been implicated as key regulators of stress-induced apoptosis in many cell...
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Báo cáo Y học: High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences doc
... B1 and B2 chains were from Life Technologies Inc Zinc analysis Laminin zinc content was assayed by atomic absorption spectroscopy using elemental zinc standards (0–2 p.p.m.) Laminin was assayed ... SDS/PAGE sample buffer by boiling for min, proteins were resolved by means of 7.5% SDS/PAGE and analysed by immunoblotting with monoclonal anti-(P-Tyr) antibody followed by alkaline phosphatase ... harvested by centrifugation for 10 at 2000 g Cells were solubilized by boiling in SDS sample buffer for and the extracted proteins were resolved by means of 7.5% SDS/ PAGE followed by immunoblotting...
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Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt
... p53, p73 and HIPK2 in apoptosis Yes-associated protein (YAP1), also becomes phosphorylated by c-Abl This phosphorylation mark is essential to drive p73-mediated apoptosis by focussing the co-activator ... damage caused by treatment with cisplatin by competing with its E3 ubiquitin ligase Itch for p73 binding Accordingly, YAP1 downregulation by RNA interference decreases induction of apoptosis in ... c-Abl is sequestered to the cytoplasm by its interaction with 14-3-3f, which becomes phosphorylated by c-Jun N-terminal kinase (JNK) upon damage caused by treatment with adriamycin, thus triggering...
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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx
... is stabilized by dimethylsulfoxide in a concentration-dependent fashion Our results indicate that in vitro c-secretase cleavage of APP substrates is inhibited by zinc and that zinc increases ... a low affinity Ab interaction with zinc [23] Secondly, just as zinc is the most potent metal mediating Ab aggregation, we found that c-secretase inhibition by zinc was approximately 10 times more ... same buffer with or without zinc The fractions were analysed by anti-FLAG western blot for C101-3FLAG immunoreactivity with the resulting C101-3FLAG signal quantified by image densitometry This...
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Báo cáo hóa học: " Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing of Toll-like receptor-4" potx
... hyperglycemia-induced apoptosis is poorly understood, cell death by apoptosis is reportedly the predominant damage in diabetic cardiomyopathy [6] Moreover, diabetes increases cardiac apoptosis in animals ... is capable of inducing apoptosis in cardiomyocytes [16-18] Apoptosis is one of the earliest indicators of cardiomyopathy in the diabetic heart and accordingly, we measured apoptosis in STZ-treated ... hyperglycemia-induced apoptosis in myocardial tissue by gene silencing of TLR4 Accumulating evidence suggests that activation of the TLR4 pathway is associated with myocardial apoptosis [12] We explored...
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Báo cáo y học: "Dasatinib preferentially induces apoptosis by inhibiting Lyn kinase in nilotinib-resistant chronic myeloid leukemia cell line" pot
... Cell growth inhibition by dasatinib and cellular signaling in a nilotinib resistant cell line (A) K562NR cells exposed to dasatinib or nilotinib for 72-hrs were quantitated by cell proliferation ... doi:10.1186/1756-8722-4-32 Cite this article as: Okabe et al.: Dasatinib preferentially induces apoptosis by inhibiting Lyn kinase in nilotinib-resistant chronic myeloid leukemia cell line Journal ... supported by a “High-Tech Research Center” Project for private universities: matching fund subsidy from the MEXT (Ministry of Education, Culture, Sports, Science and Technology), and by the “UniversityIndustry...
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báo cáo khoa học: "Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature" docx
... intramedullary destruction of RBC as evidenced by the fact that both hemolysis and pancytopenia as well as the hyperhomocysteinemia were all corrected by cobalamin treatments It is also evident that ... blood smears in our cases may be explained by the susceptibility of structurally defective megaloblastic erythrocytes to endothelial damage caused by hyperhomocysteinemia when compared to structurally ... of homocysteine levels We report here three cases of severe hyperhomocysteinemia caused by vitamin B12 deficiency and MTHFR gene mutations and hemolysis that completely resolved after vitamin...
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Báo cáo y học: " Neuropathy caused by B12 deficiency in a patient with ileal tuberculosis: A case report" doc
... http://www.jmedicalcasereports.com/content/2/1/90 brospinal fluid examination and chest X-ray were also normal B12 deficiency was documented by serum vitamin B12 level
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Báo cáo khoa học: " Inactivation of respiratory syncytial virus by zinc finger reactive compounds" ppsx
... described, and it reveals that RSV inactivation by AT-2 in accompanied by modification of the M2-1 protein The fact that a compound acting by covalently modifying zinc finger motif containing proteins ... as reactive towards the zinc finger motif in the NC proteins might also react with the zinc finger motif of the M2-1 protein of RSV Therefore, we have tested some of the zinc finger reactive compounds ... protein Several research groups have demonstrated that zinc finger reactive compounds that inactivate retroviruses so by targeting their zinc finger motif containing nucleocapsid proteins These...
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Retrovirology Research BioMed Central Open Access HIV-1 TAR miRNA protects against apoptosis by ppt
... then harvested and apoptosis was determined by AnnexinV/PI staining followed by flow cytometry (Fig 6) Treatment of the HeLaT4 or HLM-1 cells with antagomir caused no change in apoptosis or cell-cycle ... data suggested that the TAR miRNA prevented apoptosis by down-regulating both ERCC1 and IER3 Induction of apoptosis via serum starvation is mediated by p53 Activation of p53 induces the expression ... linked to evasion of the immune response (downregulation of MHC by Nef), resistance to apoptosis (Nef), induction of apoptosis in bystander cells (Tat and VPR), alterations in cell cycle and replication...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... Ac-DEVD-CHO (10 or 20 lM) for 96 h (F) Inhibition of apoptosis by Ac-DEVD-CHO AO ⁄ EB, apoptosis measured by AO ⁄ EB staining; Hoechst, apoptosis measured by Hoechst 33258 staining Results are means ± ... Quantitative analysis of GW9662 inhibition of adipocyte apoptosis AO ⁄ EB, apoptosis measured by AO ⁄ EB staining; Hoe ⁄ B.F, apoptosis measured by Hoechst 33258 staining Results are means ± SDs of ... agonist-induced apoptosis [26,27] In the present study, we investigated PPARc agonist-induced adipocyte apoptosis by using 3T3-L1 adipocytes and rat primary adipocytes Adipocyte apoptosis could be induced by...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... of MAPKs that are activated by treatment of cells with cytokines or by exposure of cells to a variety of stresses [19–21] JNK activity has been implicated in both apoptosis and survival signaling ... controlled by both protein kinases and protein phosphatases [22–24] Various types of stimuli activate JNK through phosphorylation by the dual-specificity kinase MKK4 or MKK7 [18,25] By contrast, ... growth ⁄ survival signaling cascades leads to apoptosis of cancer cells However, there are no studies addressing the role of JNK in apoptosis induced by EGFR tyrosine kinase inhibitors Here, we...
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Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc
... Apoptosis by TRAIL and proteasome inihibitors H Hetschko et al caused by inherent and potent apoptosis resistance [3] Clearly, overcoming this resistance by approaches designed ... TRAIL-induced apoptosis can be efficiently reactivated in TRAIL-resistant malignant glioma cell lines by combined treatment with PIs Furthermore, we show that reactivation of TRAILinduced apoptosis by proteasome ... ª 2008 FEBS 1931 Apoptosis by TRAIL and proteasome inihibitors H Hetschko et al B A C Fig The JNK ⁄ c-Jun signaling pathway contributes to DR5 induction and apoptosis induced by TRAIL plus PIs...
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Tài liệu Báo cáo khoa học: Interferon-a induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand ppt
... polypeptide chain initiation by TRAIL precedes apoptosis by several hours The requirement for caspase-8 activity in MCF-7 cells, as revealed by the inhibitor studies, is confirmed by the inability of caspase-8-deficient ... Borden EC (2003) Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis Apoptosis 8, 237–249 Abadie A & Wietzerbin J (2003) Involvement of TNFrelated apoptosis- inducing ... inhibition of protein synthesis by TNFa [2] However, it is possible that other eIF2a kinases are also stimulated by TRAIL Relationship of translational inhibition to apoptosis A striking synergistic...
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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
... whether EGF is capable of protecting cells from apoptosis via this AP1 activation route In this study we found that EGF prevented apoptosis induced by the chemotherapeutic agent adriamycin (ADR; ... caspase is intimately associated with the initiation of apoptosis, EGF seems to exert its protective action against ADR-induced apoptosis by suppressing caspase activity via stabilization of the ... rescue TMK-1 cells from apoptosis induced by the DNAdamaging agent ADR Pretreatment of the cells with 10 or 100 ngÆmL)1 EGF for 48 h markedly suppressed the cell death induced by 10 or 20 lm ADR,...
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Tài liệu Báo cáo Y học: Progressive apoptosis in chorion laeve trophoblast cells of human fetal membrane tissues during in vitro incubation is suppressed by antioxidative reagents pptx
... TNFa-induced U937 cell apoptosis by maintaining mitochondrial integrity and function [43], and ricin-induced apoptosis of U937 cells by maintaining an intracellular reducing condition by acting as a ... Consequently, it can be assumed that apoptosis suppression by glucocorticoid may be connected to the mechanism of its anti-inflammatory function, and that apoptosis suppression by glucocorticoid in the tissue ... associated with ROS produced by mitochondria [27], that the generation of ROS in mitochondria was activated by TNFa [28] and that apoptosis could be blocked or delayed by antioxidants such as NAC...
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Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc
... (data not shown) Enhancement by p300 of transcription from the Dnmt1 promoter that is induced by Sp3 The transcriptional coactivator p300 mediates growth arrest by catalyzing histone acetylation ... stimulated by either pPacSp1 or pPacUSp3 (Fig 4C,D) These results indicate that both Sp1 and Sp3 enhanced transcription from the Dnmt1 promoter Independent activation of the Dnmt1 promoter by Sp1 ... cis-element in the promoter of the gene for Dnmt1 Therefore, we next examined whether activation by Sp1 or by Sp3 affect expression of the gene for Dnmt1 In an attempt to identify whether Sp1 and Sp3...
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Báo cáo khoa học: Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis pot
... activated by reactive oxygen species (ROS), and that this is followed by the induction of apoptosis [4–6] ERK-dependent apoptosis induced by ROS has been recognized in several pathological conditions, ... in ROS levels and apoptosis in rat primary hepatocytes [22,23] In addition, we recently reported that ROS-activated ERK induces BimEL transactivation, followed by hepatocyte apoptosis [15] This ... mercaptosuccinic acid was suppressed by transfection with siRNAs against c-Fos and c-Jun (Fig 4B) Increases in BimEL levels caused by ATZ + mercaptosuccinic acid were also attenuated by c-Fos or c-Jun knockdown...
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Báo cáo khoa học: Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic b-cells ppt
... protects thymocytes from apoptosis mediated by CD95 and CD3 Nature 385, 350–353 Wisdom R, Johnson R, S & Moore C (1999) c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms ... induces b-cell apoptosis The inhibitory effect of SB203580 was incomplete, however, indicating that p38-kinase activation is not the only mechanism by which hA induces b-cell apoptosis We detected ... hA-evoked b-cell apoptosis Increased phosphorylation of ATF-2 in response to hA treatment is catalyzed mainly by p38 kinase We examined protein expression and phosphorylation of ATF-2 by p38 kinase...
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Báo cáo khoa học: Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin pptx
... induction of HaCaT cell apoptosis by VOSO4 was promoted through the induction of both c-fos and nCLU, the expression of which was affected by Bcl-2 A Fos-mediated vanadium-induced apoptosis Overexpression ... and apoptosis We also explored the possible involvement of the c-fos oncogene or CLU in vanadiummodulated cell responses We report that vanadiuminduced apoptosis of HaCaT cells was mediated by ... fragmentation, producing a DNA ladder characteristic of cells undergoing apoptosis, at all concentrations studied Induction of apoptosis by VOSO4 in HaCaT cells was evident at 25 lm and became more pronounced...
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