animal models of heart failure

Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx

Ngày tải lên : 16/02/2014, 09:20

... 1391 Animal models of Alzheimer’s disease O Philipson et al Transgenic animal models Models devoid of any disease-causing APP mutations Animal models expressing wild-type (wt) human APP are of ... aggregation in transgenic models and post mortem AD brain are poor natural animal models of AD, but intracerebroventricular infusion of Ab [15] or lipopolysaccharide in such animals has been used ... functional studies with animal models of AD Concluding remarks and future perspectives Transgenic techniques have revolutionized our ability to develop animal models of AD, and also contributed...

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Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx

Ngày tải lên : 15/03/2014, 10:20

... orthologue of CCM2) Zebrafish with loss -of- function mutations in san or vtn share a common phenotype with fish lacking heart of glass (heg) Although mutations in the human orthologue of heart of glass ... to developing animal models of CCM disease Classically, a CCM consists of a cluster of dilated blood vessels [12,13] Each vessel in the cluster is grossly dilated, earning the name of a cavern; ... not considered in the category of animal models of disease, one can view the field of human genetics as probing a vast natural mutagenesis screen involving billions of individual organisms As in...

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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc

Ngày tải lên : 18/06/2014, 15:20

... by the use of germ line p53 inactivation alters immune system function in a number of significant ways in these animals, limiting the use of these models for evaluating the effect of anti-tumor ... function of specific genes of interest and thus exploit defined genetic lesions to produce more biologically correct models of CNS cancers that result from activation and/or inactivation of endogenous ... critical immunologic functions Specific to the current discussion of the immune system, Table 1: A summary of existing animal models of brain tumors Tumorigenesis Method Implantation Genetic Technique...

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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot

Ngày tải lên : 09/08/2014, 01:22

... experimental animal models through the expression of herpes simplex virus thymidine kinase (HSV-Tk) in cells of animals and then injecting the animals with 2′-fluoro-2′-deoxy-1-beta-Darabinofuranosyl-5-iodo-uracil ... of formation of the immunological synapse, a specific supramolecular pattern of receptors involved in immune cell communication, in vivo [42,43] Two-photon microscopy One of the limitations of ... combination of molecular genetics and noninvasive imaging: the presence of the HSV-Tk gene can mark a specific cell population in a specific state of activation based on the activity of the promoter...

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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf

Ngày tải lên : 09/08/2014, 01:24

... investigation in animal models of arthritis This review focuses on the gene therapeutic strategies of restoring the cytokine balance and genetic synovectomy in animal models of RA, as summarized ... independently in animal models of arthritis Recent human trials of IL-1Ra revealed moderate efficacy, probably because of poor pharmacokinetics and the 100- to 1000-fold excess of this molecule ... leucocytes in RA and animal models of arthritis Okamoto and coworkers [72] showed that FasL is capable of Fas-mediated apoptosis of human RA synoviocytes Adenoviral gene transfer of TRAIL into rabbit...

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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc

Ngày tải lên : 09/08/2014, 10:23

... varying patterns of expression [14] Extracellular domains of FGFRs consist of three immunoglobulin-like loops (loop I, loop II, and loop III) Alternative mRNA splicing of loop III of FGFR1 to FGFR3 ... and progression of OA The purpose of the present study was to examine whether FGF8 is involved in the destruction of cartilage in OA models Initially, a rabbit meniscectomy model of OA, in which ... FGF8f specifically out of the four human FGF8 isoforms, and showed little binding to other members of the FGF family Neutralizing activity of KM1334 was shown by the blocking of FGF8b binding to...

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Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps

Ngày tải lên : 09/08/2014, 14:20

... to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction of disease by the usual immunisation ... R: Dissection of the genetic complexity of arthritis using animal models Immunol Lett 2005, 103:86-91 Rosenthal N, Brown S: The mouse ascending: perspectives for human-disease models Nat Cell ... strengthens the validity of previous studies of the PGIA model in different laboratories, and throws down the gauntlet as a challenge to research groups that use inbred strains of mice as models for other...

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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot

Ngày tải lên : 09/08/2014, 14:22

... likely that IC models mimic part of the RA pathology There is growing interest in the use of passive IC models, together with a range of transgenic knockouts, to identify Page of 10 (page number ... 14 The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to ... identification of its role in subgroups of RA with a distinct T cell signature Increasing support for a pathogenic role of autoantibodies in RA has shifted the interest of researchers to passive IC models...

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ABC of heart failure History and epidemiology - part 1 potx

Ngày tải lên : 10/08/2014, 15:20

... mild heart failure and include patients treated with diuretics who not have heart failure Incidence of heart failure The Framingham data show an age adjusted annual incidence of heart failure of ... longitudinal source of data on the epidemiology of heart failure Contemporary studies of the epidemiology of heart failure in United Kingdom Study Diagnostic criteria Hillingdon heart failure study ... studies of the epidemiology of heart failure and left ventricular dysfunction have been conducted, including a study of the incidence of heart failure in one west London district (Hillingdon heart failure...

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ABC of heart failure History and epidemiology - part 3 doc

Ngày tải lên : 10/08/2014, 15:20

... with heart failure Lancet 1997;349:747-52 x Remme WJ The treatment of heart failure The Task Force of the Working Group on Heart Failure of the European Society of Cardiology Eur Heart J 1997;18:736-53 ... course of alcoholic cardiomyopathy Ann Intern Med 1974;80:293-7 x The Task Force of the Working Group on Heart Failure of the European Society of Cardiology Guidelines on the treatment of heart failure ... the natural course of chronic heart failure The Munich mild heart failure study showed that ACE inhibitors combined with standard treatment slowed the progression of heart failure in patients...

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ABC of heart failure History and epidemiology - part 4 ppt

Ngày tải lên : 10/08/2014, 15:20

... mortality Nurse management of heart failure has implications for the provision of care in patients with chronic heart failure, sharing the increasing burden of heart failure Specialist nurses ... Downloaded from bmj.com on October 2006 ABC of heart failure Heart failure in general practice F D R Hobbs, R C Davis, G Y H Lip Management of heart failure in general practice has been hampered ... that only 29% of 122 patients referred to a “rapid access” clinic with a new diagnosis of heart failure fully met the definition of heart failure approved by the European Society of Cardiology—that...

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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx

Ngày tải lên : 11/08/2014, 03:20

... end of both inflammatory models, a panel of cytokines was analyzed in blood At sacrifice whole blood was collected from the heart of the animals and plasma was obtained by centrifugation 25 μl of ... accommodation and care of animals were in accordance with the provisions of EEC Council Directive 86/609 Animals were allowed to acclimate for week before the beginning of the experiments All ... right paws were used as reaction index for the individual animal A cut-off of 25 seconds was used to avoid tissue damage in case of absence of response Automated Von Frey test Mechanical allodynia...

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