androgen receptor biology in prostate cancer

Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx

... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination ... training, testing and validating the network showed curve flattening after a few training epochs, this indicated that no overtraining occurred However, if such a model is to be applied on clinical ... cannula with saline-diluted Gd-DTPA (Magnevist ® , Schering, Berlin, Germany) was inserted into the tail vein Dynamic T1-weighted (T1W) imaging was acquired by performing 20 minutes of dynamic...

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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps

Danh mục: Báo cáo khoa học

... pCX-shh-IG injection (arrowheadindicated in (c) and (d), also magnified in the inlets) (C) The pCX-shh-IG-injected prostate tissue sections were stained strongly for Hedgehog protein in PIN and CaP, in ... control prostate (arrowhead-indicated in (a)) and in PIN and CaP lesions of the pCXshh-IG-injected prostates (arrowhead-indicated in (b) and (c)) All luminal cells (arrowhead-indicated in (d)) ... with tumor initiation and progression in the pCX-shh-IG-injected prostate (arrow-indicated in (b), (c) and (d)), in contrast to the normal P63+ cells in the pCX-IG-injected prostate (indicated...

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The androgen receptor centric transcriptional network in prostate cancer

Danh mục: Thạc sĩ - Cao học

... distinct functional domains, namely, a N-terminal domain (NTD) containing transcriptional activation units (AF-1 and AF-5), a DNA binding domain (DBD) where four-cysteine zinc-binding domains ... Defined Role of ETS proteins in Prostate Cancers (Kumar-Sinha et al., 2008) 28 1.9 Reduced Androgen Signaling in Advanced Metastatic Prostate Cancers A partial attenuation of androgen signaling ... 1.7.2 The Androgen Response Elements and other Motifs in ARBS Like other DNA binding transcription factors, the AR DNA binding domain is mainly responsible for determining its DNA binding specificity...

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CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF TRACE AMOUNT OF SEX HORMONE RECEPTOR ACTIVE COMPOUNDS IN PROSTATE CANCER RELATED BIOLOGICAL SAMPLES

Danh mục: Thạc sĩ - Cao học

... Tower Block, Main Auditorium, Singapore.) xxvii Chapter Introduction 1.1 Common Occurrence of Prostate Cancer (PCa) in Men Prostate cancer (PCa) is the most widely diagnosed cancer in men worldwide ... Based on the Singapore Cancer Registry, PCa is ranked as the third most commonly diagnosed cancers in men but ranked sixth in cancer- causing deaths in Singapore between 2008 to 2012 In addition, ... PSA levels exceeding ng/mL is associated with increased risk of having prostate cancer (Aslan et al., 2011; Prostate cancer , 2012; Huang et al., 2014) However, since an increase in PSA levels...

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ADVANCES IN PROSTATE CANCER docx

Danh mục: Cao đẳng - Đại học

... of all prostate cancer cases The risk of getting prostate cancer increases nearly exponentially with increasing age This makes prostate cancer one of the most distinctive cancers in aging popu‐ ... of Androgen Receptor 463 Chapter 19 Expression and Function of Stromal Androgen Receptor in Prostate Cancer 465 Mandeep Singh and Peng Lee Chapter 20 Prostate Cancer Progression to Androgen Independent ... Prostate Cancer 617 Chapter 25 Integrins in Prostate Cancer Invasion and Metastasis 619 Paulynn Chin Suyin, Joanne Louise Dickinson and Adele Frances Holloway Chapter 26 The Role of E-Cadherin-Catenin...

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Báo cáo Y học: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells pot

Danh mục: Báo cáo khoa học

... and C-C chemokine receptors Chemokines [27,28] and angiotensin II [29] have both shown growth-inhibiting properties with different cancers Interestingly, an orphan receptor (GPR41 in the rat), ... progestin administration was thus associated with the beginning of growth inhibition by progestins GPR30 mRNA is regulated according to the dose of progestin, which also correlated with progestin-induced ... signiﬁcant RESULTS Cloning of genes, the expression of which is altered during progestin-induced growth inhibition To study genes associated with progestin-induced growth inhibition, a comparison...

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báo cáo hóa học:" Can urinary exosomes act as treatment response markers in prostate cancer?" ppt

Danh mục: Hóa học - Dầu khí

... produced by LNCaP -prostate cancer cell line Prostate cancer cell lines (LNCaP and DU145), as indicated, were maintained in culture as a source of positive-control prostate cancer exosomes (for ... of urine (for at least 18 hours at 37°C) (Figure 6c) Discussion We present the findings of a pilot study, investigating urinary exosomes in prostate cancer patients We had two main aims in the ... loading Bands for prostate- derived proteins PSA or PSMA were evident in patients (p1, p7, p8, p9, p10), indicating that at least some of the exosomes present in the urine were of prostate origin...

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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx

Danh mục: Hóa học - Dầu khí

... Against HLA-A24-positive AMACR-positive Prostate Cancer Cell Lines To confirm that CTLs induced with AMACR peptides could exert cytotoxicity against AMACR-expressing prostate cancer cell lines in ... immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous tissue (Figure 2C) These data indicated that AMACR had a mostly cancer- specific expression ... Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Surgically resected prostate cancer tissue...

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Báo cáo sinh học: " Downregulation of APOBEC3G by Xenotropic Murine Leukemia-Virus Related Virus (XMRV) in Prostate Cancer Cells docx

Danh mục: Hóa học - Dầu khí

... replicate in these cells Findings This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines We demonstrate the presence of A3G in prostate ... cell lines specifically in LNCaP cells [3,18] In addition, the prostate cancer cell line 22Rv1 has been shown to be chronically infected with XMRV and produces highly infectious virus [19] Since ... media containing FBS were added After 1–2 weeks, XMRV infection was confirmed by detecting XMRV p30 protein by using goat polyclonal anti-Rauscher MLV p30 Gag in uninfected (−) and XMRV infected...

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Báo cáo sinh học: " Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx

Danh mục: Hóa học - Dầu khí

... MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus areas ... interacting with TGase-4 using immunoprecipitation of proteins from the prostate gland, we identified a small panel of proteins that interacted with TGase-4, including RON (the HGF-like protein receptor) ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the...

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báo cáo hóa học:" Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx

Danh mục: Hóa học - Dầu khí

... MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus areas ... interacting with TGase-4 using immunoprecipitation of proteins from the prostate gland, we identified a small panel of proteins that interacted with TGase-4, including RON (the HGF-like protein receptor) ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the...

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báo cáo hóa học:" Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival" doc

Danh mục: Hóa học - Dầu khí

... studies investigating the influence of both lifestyle-related and genetic factors in relation to ovarian cancer risk in general and to AR-defined subtypes in particular Abbreviations AR: Androgen Receptor; ... carcinomas arise within the fimbrial tubal epithelium [10,17,18] Our findings indicate that malignant transformation could involve a downregulation of AR in certain EOC cases AR expression in ... serous carcinoma that originates in the distal fallopian tube J Pathol 2007, 211:26-35 doi: 10.1186/1757-2215-3-14 Cite this article as: Nodin et al., Increased androgen receptor expression in serous...

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Báo cáo khoa học: "Choline PET based dose-painting in prostate cancer - Modelling of dose effects" potx

Danh mục: Báo cáo khoa học

... value concerning the primary detection and the staging of prostate cancer [27] In principle, signal-generation is based on an increased choline metabolism in prostate cancer leading to an increased ... planning in prostate cancer Q J Nucl Med Mol Imag 2009, 53(2):245-268 28 Reske SN, Blumstein NM, Glatting G: [C-11]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy ... [39] In such a geometrical setting it is defined as: TCP  e  n i SFi i SF i is the surviving fraction within the single subvolume with the running index i (ranging from to m = V/vi) Using the...

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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot

Danh mục: Báo cáo khoa học

... inhibitors of the PI3K/Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate cancer cell lines Up to now our data revealed that ErPC3 is a potent inhibitor ... lost or inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) ... paradigmatic intravenously applicable alkylphosphocholine ErPC3 potently induces apoptosis in prostate cancer cells in vitro These findings corroborate earlier reports on high efficacy of ErPC3 in human...

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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt

Danh mục: Báo cáo khoa học

... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became a major concern in prostate cancer; ... participating in the non-self recognition of prostate cancer cells Thus we can hypothesize, according to results of Hurwitz et al [12] that the enhanced immune function, involving resting and terminally ... with a Becton Dickinson LSRII instrument (BD Biosciences) We included single-stain controls for further offline compensation Measurement and subsequent analysis was performed using FACSDiva (BD...

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Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot

Danh mục: Báo cáo khoa học

... FCS-containing media during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression ... Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways Int ... anti -prostate cancer activity in vitro and in vivo Clin Cancer Res 2004, 10:5282-5292 Ouchi H, Ishiguro H, Ikeda N, Hori M, Kubota Y, Uemura H: Genistein induces cell growth inhibition in prostate...

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Báo cáo khoa học: "Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking" pps

Danh mục: Báo cáo khoa học

... Kemmerling L, Born EJ, Mini R, Greiner RH, Aebersold DM: Daily organ tracking in intensitymodulated radiotherapy of prostate cancer using an electronic portal imaging device with a dose saving acquisition ... always during RT Twenty-six patients received combined androgen blockade (CAB) consisting of antiandrogen and gonadotropin releasing hormone analogue (GnRH) Three patients received antiandrogen ... summarized in Table Incidence of single symptoms (dysuria, incontinence, retention, frequency/urgency, hematuria) as well as the highest toxicity occurred in a given patient concluding all single...

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Báo cáo khoa học: " Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy" docx

Danh mục: Báo cáo khoa học

... performed on-line by repositioning the target according to the internal markers, moving the treatment couch manually To calculate the minimum required margin width around the clinical target ... 90%inthe median values (lines percentile 75% values10%variability, prostate line), format, Measured deviations in and Measured deviations in LR, SI and AP directions in a box plot format, showing ... the interobserver variability is low Therefore implanted markers and EPID based methods are used for targeting in radiotherapy of prostate cancer with increasing frequency Our results provide information...

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