and spin labeled sulfonamides as probe for carbonic anhydrase ix
Hydrophobic and hydrophilic substituted polyphosphazenes as scaffolds for liver cell growth
Ngày tải lên :
22/10/2015, 21:14
... class of inorganic polymer with the general formula of [NPR]2, was studied in this thesis as it has different chemical side group which can be easily modified and used to control the chemical and ... Characterization data for substituted polyphosphazenes by using elemental analyzer, GPC and DSC 62 Table 4.4: C and O atomic percentage from EDX results for PPHOS for different areas as shown in ... structural analysis, such as skin, heart valves and bone since 1989 Also, cell processing has been consolidated whilst stem cell research has expanded In contrast, bioartificial organs and encapsulated...
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Tài liệu Toilet design for rural areas and separated urine collection as a fertilizer source pptx
Ngày tải lên :
16/01/2014, 17:20
... guidebook as a basic knowledge for farmers, rural development staff and local governments in fixative designing and building available low-cost toilets The document emphasizes to reduce soil and water ... reports and community data records from ADCOM, Water and Sanitation Program, East Asia and the Pacific Toilet designs for rural areas and ... 3: Toilet classification, treatment and reuse system Toilet designs for rural areas and separated urine collection as a fertilizer...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
Ngày tải lên :
19/02/2014, 12:20
... Heinrich ganglia neurons and bovine chromaffin cells and assumed to Betz for his support and for critical reading of the manuscript be selective for a3b2 and a3b4 interfaces and unable to inhibit ... increase in potency as arise primarily from a3b2 and a3b4 nAChRs Activity on well as a shift in selectivity: while PnIA inhibited an a-BTXa7 nAChRs was excluded for two reasons: (a) EpI and sensitive ... addiction and neurological disorders such as Parkinson’s and Alzheimer’s disease For the nonselective nAChR agonist nicotine, analgesic, anxiolytic and cytoprotective properties are seen, as well as...
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Báo cáo khoa học: 2-Pyrimidinone as a probe for studying the EcoRII DNA methyltransferase–substrate interaction docx
Ngày tải lên :
07/03/2014, 15:20
... temperature and 10 at C The reaction mixtures ể FEBS 2004 2-Pyrimidinone as a probe for DNA methyltransferase (Eur J Biochem 271) 2393 were analysed by 8% native PAGE for h at 120 V The gel was prerun for ... not essential for recognition of DNA by M.EcoRII as was suggested for several other MTases, as base ipping probably occurs with any base at the target position [26] However, in the case of the M.EcoRII ... 02-04-48790 and 02-04-06804) We thank S N Mikhailov for preparation of 2-pyrimidinone phosphoramidite, S Muller for oligoă nucleotide synthesis, S Klimas auskas for M.HhaI, A S Bhagwat for plasmid...
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Báo cáo khoa học: Homoadenosylcobalamins as probes for exploring the active sites of coenzyme B12-dependent diol dehydratase and ethanolamine ammonia-lyase docx
Ngày tải lên :
07/03/2014, 21:20
... 36–44% and 38% as active as AdoCbl in diol dehydratase [27,43,44] and glycerol dehydratase [44], respectively, but it serves as a strong competitive inhibitor for ethanolamine ammonia-lyase [44] and ... reductase [29] and a weak competitive inhibitor for methylmalonyl-CoA mutase [44] 2¢-DeoxyAdoCbl is 31%, 17%, and 5–13% as active as AdoCbl for diol dehydratase [38,45], glycerol dehydratase [41], ... homoadenosylcobalamins for diol dehydratase and ethanolamine ammonia-lyase It was shown that these analogues would be useful for obtaining information about the distance between Co and C5¢, which is critical for...
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Investigation of au and in as solvents for the growth of silicon nanowires on si(1 1 1)
Ngày tải lên :
16/03/2014, 15:17
... analyzed An explanation based on differences of solubilities of surface atoms in gold and indium and on the different surface energies of the bare and oxidized substrate as well as on the surface tension ... [13] As the surface tension of most liquids decreases in a nearly linear fashion with increasing temperature [14], there is a wide difference between the surface tension of the Au–Si alloy and ... explain the formation of smaller droplets in the case of gold than in the case of indium on a bare silicon surface, i.e after desorption step for indium Without desorption step, indium forms smaller...
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metal-organic framworks irmof-8, zif-9, mof-199 and irmof-3 as catalysts for friedel-crafts acylation, knoevenagel, azamichel and pall-knorr reactions
Ngày tải lên :
10/05/2014, 21:59
... 1-phenyl-1,4pentandione, and 1,2-dibenzoylethane, respectively It was found that the reaction occurred slowly for the case of 1-phenyl-1,4pentandione and 1,2-dibenzoylethane, while quantitative conversion was ... crystals (71% based on 2,6-napthalenedicarboxylic acid) was collected as IRMOF-8 - Purple cubic crystals (25% based on benzimidazole) was collected as ZIF-9 - Deep purple crystals (88% based on 1,3,5-benzenetricarboxylic ... technologies such as XRD, SEM, TEM, TGA, nitrogen adsorption/desorption isotherm, FT-IR, and AAS 2.2 Application of MOF in catalysis The IRMOF-8 was assessed for its activity as a solid acid catalyst...
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báo cáo hóa học:" Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer" docx
Ngày tải lên :
18/06/2014, 15:20
... the case of PR, and first documented sign of disease progression PFS and TTP were measured from the date of study entry until the date of disease progression or death, and survival was measured ... carcinoma Other NSCLC Site of disease Lung ± lymph nodes Lung and metastatic site Lung and ≥ metastatic sites Extra-pulmonary disease Previous surgery for neoplastic disease Yes Palliative Curative ... activity was assessed every two months according to WHO criteria A complete response (CR) was defined as the disappearance of all lesions and no appearance of new disease for at least weeks Partial...
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Báo cáo hóa học: " Circulating viral core and E1 antigen levels as supplemental markers for HCV Chronic hepatitis" doc
Ngày tải lên :
20/06/2014, 01:20
... measured by PCR and branched DNA assays [16] The same correlation was obtained for both ALT and AST with viral load [17] Contradictory results were reported [18-20] where significant inverse association ... reaction was incubated in the thermal cycler (T1; Whatman Biometra, Goettingen, Germany) at 42°C for 60 min, then the enzyme was inactivated and double stranded cDNA was denatured at 95°C for 10 and ... antigen and both enzymes and the correlation coefficient values were (A; r = 0.44, P value is 0.008) for ALT and (B; r = 0.47, P value is 0.003) for AST And also positive correlation between E1 and...
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Báo cáo hóa học: " Self-assembled monolayer of designed and synthesized triazinedithiolsilane molecule as interfacial adhesion enhancer for integrated circuit" pdf
Ngày tải lên :
21/06/2014, 01:20
... room temperature The substrate was dried with nitrogen gas and cured at 120°C for 20 Then, a Sn-PdII colloidal solution was used as a catalyst precursor [22], which was prepared via precise control ... schema and designed molecule (R = Cl; R’ = NH2(CH2)3; R” = CH2CH3; Rx = NH (CH2)3) to yield TESPA Yield was 75.6%, and m.p > 203°C Elemental analysis calculation for C12H23N4S2O3NaSi was: C, ... is uniform and compact The adhesion strength between TESPA SAM-coated epoxy resin and ELD copper film was up to 13.8 MPa, which could satisfy the purpose of TESPA SAM as adhesion enhancer and diffusion...
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Báo cáo hóa học: "Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol" potx
Ngày tải lên :
21/06/2014, 04:20
... mixture was incubated at 4°C for 30 and filtered The filtrate was filled into ampoules and sealed under nitrogen Particle size measurement Materials and methods Materials Propofol was purchased ... release Nevertheless, the release rate of mixed micelles was faster than that of CLE before the first 12 h, the release rate of the two formulations was comparable thereafter Overall, quick release ... evaporation method, and propofol-loaded plain and mixed micelles were prepared by simply mixing drug-free plain and mixed micelles and propofol, respectively Owing to the fact that size and size distribution...
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Báo cáo lâm nghiệp: "New insights in the recognition of the European ash species Fraxinus excelsior L. and Fraxinus angustifolia Vahl as useful tools for forest management" pdf
Ngày tải lên :
07/08/2014, 16:20
... Homology searches were performed using the BLAST algorithm at http://www.ncbi.nlm.nih.gov (National Center for Biotechnology Information), with programs blastn, tblastn and tblastx New primers were ... MarieElise Morand-Prieur, Jacqui Shykoff, Carol Baskin, Marc Masimbert and two anonymous reviewers for helpful comments on the manuscript and discussions, Francina Langa and Jérôme Artus (Pasteur Institute) ... rehydrated and sterilized seeds Germination was observed only for seeds of F angustifolia (for all progeny arrays) and St-Dyé and Tavaux seed lots Moreover, the mean germination rate was two-fold...
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Báo cáo y học: "Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus" pps
Ngày tải lên :
09/08/2014, 07:20
... two categories: class B (broadly reactive) and class R (restricted reactivity) We therefore see a possible therapeutic role for class R INH-ODNs as a means to suppress disease-specific autoimmune ... single-stranded CpGDNA [94] Thus, complex TLR9 ligands may need prior processing by DNA-specific enzymes (e.g helicases and/ or topoisomerases) in order to bind more avidly to the TLR9 and to initiate ... and pDCs, macrophages and MZ-B cells in mice, and pDCs, MZ-B cells and memory B cells in humans, which can respond directly and without priming to both single-stranded and more complex CpG-DNA...
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Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
Ngày tải lên :
09/08/2014, 14:22
... nephritis was inversely associated with anti-La (SS-B) and associated with anti-dsDNA It has been repeatedly shown that anti-dsDNA, single anti-Ro antibodies as well as Sm antibodies [10] are associated ... significantly increased frequency of CD19+/CD27high plasma cells and had a predictive value for disease activity that was greater than traditional humoral/clinical measurements (for example, anti-dsDNA, ... traditional measures of lupus nephritis activity was evaluated by Bauer and colleagues [25] Thirty patients were classified as having high or low IFN gene scores (15 patients each) and the association...
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báo cáo khoa học: " Using Mitrofanoff’s principle and Monti’s technique as a surgical option for bladder augmentation with a continent stoma: a case report" pps
Ngày tải lên :
11/08/2014, 00:22
... appendix has been a mainstay in the armamentarium of pediatric urologists Figure Association of Mitrofanoff’s principle and Monti’s technique Anastomosis of vascularized appendix (right) and ileal ... ileocystoplasty and, for patients unable or not adapted to intermittent catheterization, Mitrofanoff’s principle (in which the vascularized ileocecal appendix is anastomosed at the skin and bladder, ... stoma (reservoir) and who have an appendix that is too small to reach the skin Consent Written informed consent was obtained from the patient for publication of this case report and accompanying...
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Báo cáo khoa hoc:" Evaluation of triblock copolymeric micelles of δvalerolactone and poly (ethylene glycol) as a competent vector for doxorubicin delivery against cancer" doc
Ngày tải lên :
11/08/2014, 08:20
... plates and treatments containing μM DOX was given for 24 h Cells were then lysed and the total protein content was measured using Bradford’s reagent 50 μg of total protein was loaded for SDS-PAGE ... dishes and given treatment of 0.05 μM VEVDMs and 0.1 μM free DOX for 24 h Cells were harvested and fixed with 70% ethanol for h The fixed cells were then given RNAse A (100 mg/ml) treatment for ... and U87MG cells at 24, 48 and 72 h on incubation with the concentrations as indicated was analyzed using MTT assay All the measurements were done in six replicates The results are expressed as...
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Báo cáo y học: "Th2 cytokines and asthma Interleukin-9 as a therapeutic target for asthma" ppsx
Ngày tải lên :
12/08/2014, 18:20
... RC: review IL-9 was first suggested as an asthma candidate gene by unbiased genetic mapping studies on AHR and linkage homology in both humans and mice Cell biology in vitro has shown that IL-9 ... of the allergic asthmatic response Importantly, increased lung IL-9 expression in mice and humans is tightly and specifically associated with asthma and its risk factors; decreased IL-9 is protective ... as determined by immunocytochemistry and in situ hybridization, demonstrated a highly significant and specific association between the expression of this cytokine with asthma and AHR ([41], and...
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Báo cáo y học: " Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission" pdf
Ngày tải lên :
12/08/2014, 23:23
... consumed by people worldwide and is a generally recognized as a safe (GRAS) protein, HP-modified OVA has great potential for further development as an effective, safe and affordable microbicide Nonetheless, ... collected days post-infection and tested for p24 antigen by ELISA as described above A single-round HIV-1 infection assay was performed using HIV-1NL4-3 virions and TZM-bl cells as previously described ... HIV1IIIB, HIV-1MN, and gp105 from HIV-2ROD were obtained from Immunodiagnostics Inc (Woburn, MA) Mouse mAb NC-1 specific for the gp41 six-helix bundle was prepared and characterized as previously...
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Báo cáo y học: " Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults" ppsx
Ngày tải lên :
13/08/2014, 21:21
... (SEM), as well as median and 25th and 75th percentiles The Shapiro-Wilk test excluded a normal distribution for several values Therefore, the Mann-Whitney test was used for statistical evaluation For ... probands, postoperative patients showed an increased hemostasis potential Thromboelastometry variables were characterized by a shorter clotting time and clot-formation time, as well as increased ... 0.858; 0.10; 0.032 Values are given as mean and standard error of the mean as well as median and 25th and 75th percentiles (quartiles) The Mann-Whitney test was used for statistical evaluation Adamzik...
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