and occasionally muscle bone or cartilage with similar components their common denominator when successful is patency of arterial inflow and venous outflow associate the follow

báo cáo hóa học:" Establishment of an animal model of a pasteurized bone graft, with a preliminary analysis of muscle coverage or FGF-2 administration to the graft" potx

Ngày tải lên : 20/06/2014, 04:20

... analysis of the effect of the presence of muscle- covering to the pasteurized bone graft or the application of FGF-2 to pasteurized bone was carried out in terms of bone incorporation and bone absorption ... observed on the surface of the pasteurized bone (Fig 6E) or on the host bone (Fig 6F) The average score of bone formation and bone absorption on the grafted bone was -1.75 (severe bone absorption, ... (top) The status of the grafted bone is scaled and the average is given The scale is as follows: severe bone absorption (-2), mild bone absorption (-1), no change (0), single nodules of bone formation...

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Báo cáo y học: "Fully-spliced HIV-1 RNAs are reverse transcribed with similar efficiencies as the genomic RNA in virions and cells, but more efficiently in AZT-treated cells" ppt

Ngày tải lên : 13/08/2014, 09:21

... synthesis (Fig 4) At least two non-exclusive hypothesis could explain this resistance of FSpl RTion to AZT, either the reduced number of AZT sites within short template or the achievement of ... and production Gene Ther 2005, 12:1089-1098 Authors' contributions LH and MM have conceived the study and analyzed data LH performed the laboratory work with ZM help, and helped in drafting and ... including S Maurel and F Smagulova for helpful discussion We also thank C Isel for critical reading of the manuscript This work was supported by the CNRS, SIDACTION, ANRS and the Ministère de la Recherche...

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Tài liệu Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant ppt

Ngày tải lên : 19/02/2014, 06:20

... cases (72Q and 103Q), a broad distribution of the size of the inclusions was noticed Moreover, the percentage of cells presenting inclusions as well as the distribution of the size of the inclusions ... downstream of the initiator ATG in exon (Ex1) of the 67 exon-containing htt gene [5] Pathogenesis in HD correlates with the cleavage of mutated htt and the release of an N-terminal fragment bearing the ... on when the analysis was performed after transfection Therefore, all the following analyses were performed days after transfection At that time point, the size of the inclusions formed by either...

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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

Ngày tải lên : 19/02/2014, 07:20

... physiological role is uncertain In fact, the role and physiological advantages of the coexistence of several PPOs in the same micro-organism remain unknown The synthesis of melanin in micro-organisms has ... responsible for the catalytic properties of this PPO, and experiments on this are being carried out in our laboratory Apart from the interest of this novel tyrosinase as a model for the mechanism of catalytic ... virulence of the infective micro-organism, but it is also related to defensive roles in the infected cell, so that the place and time of triggering of melanogenesis must be key to the success of one of...

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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt

Ngày tải lên : 08/03/2014, 08:20

... receptor afﬁnity for the corresponding peptide [21,41] Indeed, the backbone conformation, the aromatic ring and the orientation (v1 and v2) of this phenylalanine have to be conserved for full ... been synthesized and their conformational preferences analysed by NMR spectroscopy These substituted SP analogues were tested for their resistance to enzymatic degradation, their afﬁnity for the ... representation of a-, b2- and b3-amino acids with the torsion angles /, h and w For the b2 and b3-amino acid substituted-SP analogues, the methyl side chain of b-HAla exhibits the same orientation as the...

11
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Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol pdf

Ngày tải lên : 23/03/2014, 07:20

... resistance can arise with mutation to Hsp90, with altered cochaperone function and with the loss of plasma membrane drug efﬂux pumps [35] The results of this study point to the two isoforms of ... differentiation, and evolution The other isoform, Hsp90a (in humans, a form with 86% identity and 93% similarity in sequence to Hsp90b), is generally stress-inducible and may therefore be a more cytoprotective ... deletion of the SLT2 gene in PP30[pHSC82] The LEU2 vectors pH90a (this study) and pH90b [35] were then inserted into this PP30slt2D, and this was followed by 5-ﬂuoroorotic acid curing of the pHSC82...

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Báo cáo khoa học: Cellular uptake of antisense oligonucleotides after complexing or conjugation with cell-penetrating model peptides pdf

Ngày tải lên : 23/03/2014, 21:21

... the incubation solutions in all cases and also in the lysates of the CHO-cells In the lysates of the LKB-Ez7 cells on the other hand partial splitting of the disulﬁde bond in the cell interior ... USA), and were normalized to the area of the internal standard ﬂuorescein in order to eliminate irregularities of injection, gel- and buffer status Quantitation was performed on the basis of the ... exposing bovine aortic endothelial cells to the 24- and 15-mer PTOs and their complexes and conjugates with I a Fig HPLC quantitation of the soluble portion of 0.5 lM solutions in NaCl/Pi of 24-mer...

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Báo cáo khoa học: Cholesterol interaction with the related steroidogenic acute regulatory lipid-transfer (START) domains of StAR (STARD1) and MLN64 (STARD3) ppt

Ngày tải lên : 30/03/2014, 04:20

... a conformation of the protein that is more resistant to trypsinolysis What is known about the cholesterol-binding site of the START domains of STARD1 and STARD3? The crystal structure of human ... molecule (Fig 6A) The roof of the cavity is mainly formed by the C-terminal a4-helix The access of cholesterol to this cavity may be enabled by conformational changes of the a4-helix and the adjacent ... (B) Then, the samples were UV-irradiated for 10 at °C The protein was cleaved by CNBr and further processed as described in the legend for Fig The asterisks mark the position of the 6.2 kDa band...

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báo cáo hóa học: " Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis" pptx

Ngày tải lên : 19/06/2014, 22:20

... Registry reported that the presence of vascular comorbidities linked to dyslipidemia was associated with an increased risk for disability progression in MS [22] The aim of this study therefore was ... neurodegenerative disorders, cerebrovascular disease, positive history of alcohol abuse, etc.), and insufficient quality of the MRI scan for quantitative analysis [24] MRI Analysis Quantitative MRI analysis ... logistic regression with sex as a factor and disease duration and lipid profile variable of interest The CE-LV, T2-LV and T1-LV data were normalized by cube-root transformation to reduce skew The...

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báo cáo hóa học: " Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke" pptx

Ngày tải lên : 19/06/2014, 22:20

... assess the strength of association between the low ficolin-3 and high CRP levels on the one hand and the unfavorable outcome of the disease on the other hand, we repeated the analysis as above in the ... The examination was indicated in the case of other vascular disorders or risk factors of vascular disorders None of the patients had definite residual signs and no symptoms suggesting acute ischemia ... secondary to the negative correlation between ficolin-3 on the one hand and the severity of ischemic stroke and the infarct size on the other hand, as discussed above It is well known that both the high...

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báo cáo hóa học:" Engagement of patients in religious and spiritual practices: Confirmatory results with the SpREUK-P 1.1 questionnaire as a tool of quality of life research" ppt

Ngày tải lên : 20/06/2014, 15:20

... involvement of the patients, and to connect their engagement with the SpR attitudes and their convictions how this may have an effect on the course of disease As the original SpREUK does neither ask for ... the measure of all things, and roots in the rationalism of the 18th Century and the free-thought movement of the 19th Century Secular Humanists reject the concept of a personal creator God, and ... developed The items of the scale HuP are related to the views of Secular Humanism [34,35] and the Philosophical resp Christian Humanism [36] Secular Humanism is an atheistic and naturalistic philosophy...

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báo cáo hóa học:" Content comparison of haemophilia specific patient-rated outcome measures with the international classification of functioning, disability and health (ICF, ICF-CY)" pdf

Ngày tải lên : 20/06/2014, 15:20

... overview of the number of the identified meaningful concepts and their distribution across the major components of the ICF/ICF-CY Out of the 365 concepts identified, 283 could be linked to the ICF/ICF-CY ... subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis Journal of Thrombosis and Haemostasis 2001, 85:560 ... factors’; the latter are not classified in the ICF because of the large social and cultural variance associated with them The units of the ICF classification are called categories; they are organized...

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Báo cáo lâm nghiệp: "Do trees use reserve or newly assimilated carbon for their defense reactions? A 13 C labeling approach with young Scots pines inoculated with a bark-beetle-associated fungus (Ophiostoma brunneo ciliatum" pptx

Ngày tải lên : 07/08/2014, 16:21

... δ13 C of many of these compounds; this increase was signiﬁcant for proteins and amino acids in the sapwood (Fig 5c), and for the amino acids and soluble sugars in the phloem (Fig 5d) Nonetheless, ... 241–248 [15] Delorme L., Lieutier F., Monoterpene composition of the preformed and induced resins of Scots pine, and their eﬀect on bark beetles and associated fungi, Eur J For Pathol 20 (1990) ... carbon around the points of attack [7] Synthesis of secondary metabolites is a very costly process in terms of energy and depends on the availability of carbohydrates close to the attack points...

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Báo cáo y học: "The clinical-familial correlates and naturalistic outcome of panic-disorder-agoraphobia with and without lifetime bipolar II comorbidity" potx

Ngày tải lên : 08/08/2014, 23:21

... present in 17% of the relatives with recurrent affective disorder compared with 3% of the relatives without recurrent major affective disorder These findings are consistent with the hypothesis that ... of PD with or without agoraphobia according to Diagnostic and Statistical Manual of Mental Disorders 3rd edn, revised (DSM-III-R) criteria, (2) absence of severe physical and laboratory abnormalities ... particular focus on the symptomatological characteristics of PD, the course of the illness and comorbidity with other mental disorders; and (4) affective temperaments according to Akiskal and Mallya [42]...

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Báo cáo y học: "The relationship between antipsychotic medication adherence and patient outcomes among individuals diagnosed with bipolar disorder: a retrospective study" doc

Ngày tải lên : 08/08/2014, 23:21

... acquisition of the data, interpretation of the data, and drafting of the manuscript MJL made substantial contributions to the analysis of the data, interpretation of the data and drafting of the ... reduction in the risk of an ER visit for any cause, with an MPR of at least 0.75 associated with a 16% lower risk of visiting the ER (p < 0.05) (Figure 3) Moreover, patients with an MPR of at least ... hospitalization or an ER visit with an accompanying diagnosis of bipolar disorder was also examined The observed results were generally consistent with the results from the analyses of the risk of mental health-related...

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502
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Báo cáo y học: "Disability and health-related quality of life in outpatients with generalised anxiety disorder treated in psychiatric clinics: is there still room for improvement" pdf

Ngày tải lên : 09/08/2014, 01:21

... LJ: The structure of the genetic and environmental risk factors for six major psychiatric disorders in women Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and ... which is in contrast with the 46.7% of patients with GAD suffering pain for the last month in our study The proportion of patients in this study with possible sleeping disorders, 30.1%, is clearly ... clearly superior to the proportion observed among the general population [47] and is in keeping with the figures observed by other authors for this disorder [45] It has been reported in many...

9
447
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Báo cáo y học: "More intrinsic parameters should be used in assessing degeneration of articular cartilage with quantitative ultrasound" doc

Ngày tải lên : 09/08/2014, 01:22

... list of related references meters of cartilage We also hope that clinicians in the field (or through collaboration with their engineer colleagues) fully understand the physical principles of the ... correlate with ICRS grades, making the result difficult to interpret because the speed of sound and the thickness both can contribute to the change of the interval Although the authors did discuss the ... orientation of the transducer (incidence angle of ultrasound beam), and curvature of the tissue surface besides the tissue state The echo duration can be affected by the characteristics of ultrasound...

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331
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Báo cáo khoa học: "Large volume unresectable locally advanced nonsmall cell lung cancer: acute toxicity and initial outcome results with rapid arc" potx

Ngày tải lên : 09/08/2014, 09:20

... in the upper quadrant, and with target volume: > 400 cm3 According to Liu et al [26] the motion of these lesions is lower than mm, therefore the use of 4D techniques is unnecessary Furthermore ... treatment characteristics Results of the DVH analysis are reported in Table for PTV and GTV, and in table for organs at risk and healthy tissue, together with the specific objectives Dosimetric ... remains poor both for locoregional failure and for distant metastatic disease Concurrent chemo-radiation is at present the standard of care Given that local recurrence is the leading cause of death...

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Báo cáo khoa học: " Quality of life and salivary output in patients with head-and-neck cancer five years after radiotherapy" pptx

Ngày tải lên : 09/08/2014, 10:21

... of the submandibular glands and/ or the minor salivary glands of the palate In our analysis neither the Dpar nor the Dsubm was conclusively associated with the xerostomia-specific items This is ... rate of

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Báo cáo khoa học: " Accelerated high-dose radiotherapy alone or combined with either concomitant or sequential chemotherapy; treatments of choice in patients with Non-Small Cell Lung Cancer" pps

Ngày tải lên : 09/08/2014, 10:21

... [55,56] Other factors which correlate with the risk for oesophagitis are the absolute maximum radiation dose, volume of the oesophagus receiving 35 Gy ore more (V35) and the length of the irradiated ... treated with high-dose radiotherapy with or without chemotherapy In 56 cases the radiotherapy was combined with concomitant cisplatin and in 26 cases with courses of neo-adjuvant cisplatin and gemcitabin ... Results of patients presenting with ECOG performance score of are poor, the median survival is months and no one survived years We conclude that high dose radiotherapy with or without chemotherapy is...

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