... level In view of these observations, we also investigated levels of MIH and CHH peptides inthe sinus gland and levels of transcripts in XO neurones during the moult cycle, to see whether significant ... receptors for MIH was suggested Levels of MIH and CHH inthe sinus gland during the moult cycle As individual SG from single crabs always contained almost identical profiles and quantities of peptides ... CHH secretion is a dynamic process Taking these observations into account, and given that CHH is about 10-fold less effective than MIH in repressing ecdysteroid synthesis [4], it now seems possible...
... means to monitor these changes with intact proteins in solution Furthermore, a close inspection of the results showed differences betweenthe apo-protein andthe holo-protein Interestingly, the ... reaction stage of the A domain Discussion The interaction of the PCP with its neighbouring domains in NRPS systems is crucial inthe catalytic cycle andinthe directed product assembly in these complex ... mutated Cys60 to phenylalanine because this is the most prominent residue at this position inthe closely related A domains of the tyrocidine and bacitracin NRPS Cys331 is part of the binding pocket...
... purposes) cholesterol, smoking, and creatinine) were also recorded The use of NSAIDs, DMARDs, and glucocorticoids was recorded by the study nurse at all assessments (the use of COX-2 inhibitors ... deals with missing values by assuming them to be missing at random without removing the individual from the dataset We investigated the change in NTproBNP levels over time and examined associations ... inthe linear regression analyses (Table 2) This significant association was also maintained inthe multivariate linear regression analyses, which included the interaction between age and gender...
... polymorphism, analyses of enzyme systems in eukaryotes reveal the existence of polymorphism in tissue-specific enzyme expression Various kinds of regulatory genes have different effects on tissue-specific, ... regions and three for the specific activity of the enzyme RESULTS Results of the analysis of 37 lines homozygous for the Amy allele and 19 s lines homozygous for the Amy allele with respect to the ... of the results In this way, the variability inthe number of active regions andthe specific activity of the enzyme, as parameters, were analysed within andbetweenthe Amy and Amy genotypes Line...
... commands of Stata (svylogit) using school as the stratum Results were very similar with both models and therefore inthe paper we present the results using the survey commands because their use ... marital status, number of brothers and sisters, mother s educational status, father s educational status, mother s employment status, father s employment status) Students were also asked to subjectively ... criteria using specially developed computerized algorithms [35] For screening purposes inthe first phase of the study we used the screening questions of the several symptom sections of the CIS-R The...
... of disease progression Several limitations to our study exist Because of the moderate sample size of the current study, cyst progression was defined simply as an increase in score, and thus included ... hypersignal, whereas a BML was an ill-defined hypersignal The assessments of subchondral bone cysts and BMLs were performed on the MRI slice that yielded the greatest lesion size The intensity and ... [6] No study has examined the presence of subchondral bone cysts at baseline as a risk factor for structural changesinthe knee The relationship between bone marrow lesions (BMLs) and subchondral...
... longitudinal studies Conclusions This cross-sectional study suggests that in older adults, serum levels of leptin in both sexes and IL-6 in women are positively associated with hip JSN The associations ... no disease and = most-severe disease) by using the Altman atlas [32], as previously described [33] Each score was arrived at by consensus between two readers who simultaneously assessed the radiograph, ... measurements Self-report of smoking status and diseases including rheumatoid arthritis, asthma, cardiovascular disease, and diabetes were recorded by questionnaire Hip pain was assessed by questionnaire...
... directly linked to NO release [43], it is possible that differences in shear stress profiles resulted inthe lack of associationbetween these two assessments inthe study by Arosio and colleagues [33] ... [44], as inthe Foster and colleagues study, but is eliminated when 0.5% sodium chloride is used [44], as inthe present study Thus, differences in protocol make comparing the findings of both studies ... patients with RA, suggesting that these assessments cannot be used interchangeably in this population Assessments of both vascular beds may provide more meaningful clinical information on vascular...
... perform a systematic literature review and meta-analysis (where appropriate) of RCTs and observational studies to assess theassociationbetween systemic GC therapy andthe risk of infection in patients ... characteristics of the studies Extracted data were cross-checked against notes made by both reviewers during the eligibility assessment, with resolution by discussion inthe few instances of disagreement ... case-control studies) Discussion RCTs and observational studies generated different estimates of infection risk associated with GC therapy The RCT meta-analysis suggested a null association between...
... food and exercise diaries online, in return for a monthly subscription charge The service is a self-help tool assisting the user in recording diet and exercise and charting their progress towards ... interventions Obes Rev 2009, 10:671-680 38 Ballor DL, Keesey RE: A meta-analysis of the factors affecting exerciseinduced changesin body mass, fat mass and fat-free mass in males and females Int J Obes ... features, and allow participants to be selective about the tools they use Several studies have examined which features of Internet weight loss programmes are associated with successful weight loss in...
... When using total assets as a discriminating variable, results are consistent with the size of the firm as one of the main determinants of voluntary disclosures Bigger companies disclose considerably ... companies inthe sample The descriptive evidence for these variables is consistent with prior work and reveals a wide cross-sectional variation across the sample firms Method We study theassociation ... a business inthe best interests of shareholders, limiting agency costs and favoring the survival of corporations (Fama & Jensen, 1983) The board of directors is one of the most important internal...
... respectively Stream water samples were collected at the middle parts of the grove from points Sampling points St.1 and St.2 are inthe same stream, and sampling point St.3 is inthe other stream ... The two streams flow together to be one stream andthe sampling point St.4 is situated inthe joined stream, which is the only stream that flows into the reservoir The reservoir water was also ... citrus grove were investigated and their behaviorsinthe collecting reservoirs were discussed The main results obtained from the investigation are as follows: 1) Nitrogen concentration in grove soil...
... was possibly caused by a differing mean inthe second cohort As this is not in line with the other results, the findings should be interpreted with caution The same as lip line heights during spontaneous ... interesting finding was that the age -related decrease in lip line height during spontaneous smiling was considerably less than inthe natural rest position It was also interesting to note that inthe ... quartiles, and ranges of mandibular lip line heights in millimetres relative to the gingival margin for the lower incisors, canine, premolars, and first molar The grey shaded areas represent the gingiva...
... CytOX subunits during hypoxia We also tested the level of mRNA for subunit VIIa, which is expressed as isolog H and L The L isolog is ubiquitously expressed in all the tissues whereas the H isolog ... ADP and succinate as described inthe Materials and methods section Hexokinase and phosphofructokinase activities were measured inthe cytosolic fractions Isocitrate dehydrogenase and NADH:ubiqinone ... The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents Role for Nrf1 in gamma-gcs (1) and gss expression in mouse fibroblasts...
... were measured using laser-flash-induced absorbance changes of photosystem I at 820 nm Unless stated otherwise, the experimental setup and programmes ´ used inthe analysis were as in Hervas et al ... temperatures, the plant and cyanobacterial systems show similar rates DISCUSSION To our knowledge, the work described here andintherelated publications [1,7] is the first kinetic analysis of thein ... DHà and –TDSà [14] Comparison between P laminosum and spinach The response to ionic strength of the reaction between P laminosum plastocyanin and photosystem I was in marked contrast with the...
... the induced-fit hypothesis by Koshland, it is well established that the interactions between an enzyme and its substrate induce conformational changes at the active site In most cases, these conformational ... carried out inthe presence of SDS as the only denaturing agent could reveal: (a) reinforcements of monomer associations, as only the strongest associations could survive the denaturing agent; and (b) ... could induce global conformational changesinthe intact holoenzyme, reinforcing our starting hypothesis Evidence has also been obtained suggesting differences between these conformations before and...
... Asp25 and Asp25¢ also showed a small shift relative to their positions inthe other complexes, and less symmetrical interactions with the hydroxyl of indinavir (Table 5), as well as the close ... for indinavir Thechangesin protease structure and interactions with indinavir must be considered during the design of new inhibitors for resistant HIV Ó FEBS 2004 HIV protease crystal structures ... improved interactions with indinavir In contrast, PRL90M showed fewer van der Waals contacts with indinavir, the main chain atoms of residues 80–82 were further from the indinavir, andthe side chain...
... with the stance phase foot and continuing up to the hip, across the pelvis, and down the swing limb, andthe chain involves at least 12 degrees of freedom at the joints and scores of muscles The ... those measures Several of these studies have related these gait changes to falls,l8 rnobility,l9 and postfall anxiety.20 All of these studies have made inferences about the reasons for the observed ... degeneration in this fine motor control of the foot may result in problems of stumbling during swing andin rebalancing immediately after HC Numerous studies have addressed thechangesinthe gait...
... as a Bcl-2-interacting protein, and was the first human protein shown to be indispensable for autophagy [44] The interaction between Beclin and its binding partners regulates the initial steps ... is regulated by class I and class III phosphoinositide 3-kinases (PI3Ks) The PI3Ks generate lipid ‘second messengers’ that mediate signal transduction, and have been divided into four classes, ... and increasing the activities of caspase and caspase 7, resulting in apoptosis of mouse RAW264.7 macrophages [30] Other studies found that Hsp90b, but not Hsp90a, was associated with Bcl-2 during...
... AXOR12, KISS-1R) GPR103 (AQ27, SP9155) Decrease in vasopressin release Increase inthe release of ACTH, oxytocin, vasopressin and prolactin Increase inthe release of ACTH, oxytocin and prolactin ? ... neuroendocrine stress responses On the PrRP and RFRPs in metabolism and stress other hand, the administration of PrRP-neutralizing antibodies facilitates ACTH release in response to exercise, suggesting that ... of stress responses may depend upon the nature of stressful stimuli used Stressful stimuli affect food intake and increase energy expenditure On the other hand, food intake affects stress responses...