... to share this knowledge and use it in their schooling. 30 In most parts ofthe world, education is forthe most part the preserve ofthe few (elites). The choice of which language or dialect ... enable them to take active roles in their communities. Adult education is crucial and better placed to fight poverty than formal education because it is involved in theeducationofthe most ... to information andeducationofthe groups involved. Adult education does not only deal with issues ofeducation involving adults, but it also directly and indirectly influences the education...
... hydrogen bondsbetween K12 andthe side chains of N10 and Q64, which maintain the unusual Rama-chandran angles forthe K12 residue, and aRamachandran scatter plot forthe K12 resi-dues in 21 ... features ofthe Y74W* mutant of PfTIM need to be rationalized: (a) the reduced stability of the dimeric structure, and (b) the significantly lowervalue of kcat, suggesting an impairment ofthe catalyticefficiency ... nature. The growing body of sequence and structural data on these well-studiedenzymes affords an opportunity to evaluate the conse-quences of mutations. In the case of TIM, only nine of the 220–250...
... 129140 ê 2004 FEBS Theroleof helix 8 andofthe cytosolic C-termini in the internalization and signal transduction of B1 and B2bradykinin receptorsAlexander Faussner1, Alexandra Bauer1, ... beaccounted for by the amount of internalized agonist[20]. As the internalization is expressed in percentage of total binding, decreasing the binding affinity of the Roleof helix 8 and C-termini ... sitebecause the presence of detergent or membrane lipidsinfluences the formation of a helical structure. Theseauthors proposed that activation ofthe receptor, and subsequently ofthe G protein,...
... determine the pH optima, the ionization constants (pKa)ofthecatalyticglutamates (E187 and E399) in the ES complex and in the free enzyme (E) of Sfbgly50 mutants were determined. The pKES and pKEare ... R97 and E399 is probably a major cause ofthe shift in the pKa of E399. Therefore, R97 facilitates the ionization of the catalytic nucleophile by stabilizing its charged state.Fig. 5. Effect of ... result, the pH optimum ofthe Y331F mutant(7.0) is higher than that ofthe wild-type Sfbgly50 (6.2)(Fig. 5). The effect of this mutation on the E399 ionizationis the same as observed forthe mutation...
... specifications include mother’s and father’s age at the time ofthe child’s birth in quadratic, indicators of whether the mother or father is currently a smoker, indicator of whether the mother smoked during ... specifications include mother’s and father’s age at the time ofthe child’s birth in quadratic, indicators of whether the mother or father is currently a smoker, indicator of whether the mother smoked during ... levels of higher education. The LFS data, on the other hand, include a continuous educational measure. Table A1 in the Appendix compares the age at which mothers and fathers left full-time education...
... urea-induced and GdnHCl-inducedchanges in the secondary structure ofthe proteins, weanalyzed the UV CD spectra of MS2 and VLPs in the absence and presence of 5.0 m and 9.0 m urea and 3.5 m and 5.0 ... chang-es were analyzed by variation of spectral center of mass of trypto-phan emission in the absence of bis-ANS for (m) dlFG, (r ) sc-dlFG. and in the presence of bis-ANS for (e) sc-dlFG andthe return ... stability of genetic fusion ofthe two sub-units ofthe dlFG dimer using the variant named2CTdlFG, which takes advantage ofthe physical prox-imity ofthe N-terminus and C-termius ofthe twomonomers...
... primary factors of production, and the general exclusion or trivialization oftheroleof knowledge, was not limitedonly to the sphere of macroeconomics. The most compelling theories of international ... inclusion of various aspects of knowledge. Early extensions included human capital and skilled labor, and technology. The neo-technology theories focused on theroleof R&D and the creation of new ... of industrial clustering. The organizations ofthe first economy, either because of their charter to doresearch as in the case of universities and R&D laboratories, or as a by-product of...
... the roleof feedback under motor uncertainty, such as ismore typical in real-world situations. We added randomdelays to the hand motion before the onset of move-ment and before the onset of ... briefly before the start ofthe first trial,with full feedback sensibility, so that they could get usedto the control mechanism ofthe hand.Subjects performed the four blocks ofthe experimentover ... given trial i wetherefore define the grasp force, fi, as the average gripforce (in Newtons) applied to the object forthe duration of its elevation.Ramp Duration The duration ofthe c ontrol...
... this article as: Hughes-Fulford and Li: Theroleof FGF-2 and BMP-2in regulation of gene induction, cell proliferation and mineralization.Journal of Orthopaedic Surgery and Research 2011 6:8.Submit ... administration of adenoviralBMP-2 vector improves the formation of bone in osseous defects. GeneTher 2007, 14:1039-1044.Hughes-Fulford and Li Journal of Orthopaedic Surgery and Research 2011, ... 6:8http://www.josr-online.com/content/6/1/8Page 7 of 8 RESEARCH ARTICLE Open Access The roleof FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralizationMillie Hughes-Fulford1,2,3,4*, Chai-Fei...
... effi-ciency of bone growth factors FGF-2, TGFb, and PGE2markedly enhanced the synthesis ofthe total protein con-tent ofthe dishes (Table 1)Rate of proliferation was dependent on the specificGF. ... article as: Hughes-Fulford and Li: Theroleof FGF-2 and BMP-2in regulation of gene induction, cell proliferation and mineralization.Journal of Orthopaedic Surgery and Research 2011 6:8.Submit ... major role in wound healing [6,7].To evaluate the physiological activity of FGF-2 and other growth factors, we studied their relative ability toinfluence proliferation of osteoblasts at a site of...
... equality, the rule of law and respect forand protection of human rights […] Recognizing the need to strengthen the important roleof the United Nations in the prevention of violent conflicts, and ... for addressing poverty and vulnerability in all contexts. They have emerged from the growing realization of the need to put the poor and all aspects of their lives and means of living at the ... and […] condemns categorically the illegal exploitation ofthe natural resources and other sources of wealth ofthe Democratic Republic of the Congo, urges all States, especially those in the...