an overview from preclinical animal studies to the clinic
Overview of Plant Biotechnology from Its Early Roots to the Present
... constituents with antibiotic, anti-inflammatory, antiviral, anticancer, cardiovascular, and other activities Natural products are believed to play vital roles in the physiology and ecology of plants that ... order to search for new compounds not present in the intact plant, and finally to use plant cells for the isolation of enzymes that are responsible for the important metabolic pathways and to use them ... life in storage, and second, the fruit of this tomato could be left on the plant until optimally ripe Because of these attributes, FlavR Saver tomatoes are sold for premium prices Another successful...
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An asthma allergen specific animal model for the study of responses to dust mite allergen induced asthma
... in tolerance rather than induce an inflammatory response For example, the administration of ovalbumin (OVA) into the lung of mice had been shown to result in immunologic tolerance rather than an ... results of animal studies to clinical applications as asthma in humans appear to be a far more heterogeneous disease than in animal models The use of surrogate allergen like OVA in animal studies ... maturation (30) Therefore, in order for the lung DCs to induce an immune response to the allergen, both the antigen and a danger signal must be present to induce DC maturation and antigen presentation...
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Báo cáo y học: "An Avian Connection as a Catalyst to the 1918-1919 Influenza Pandemic"
... the pandemic was an animal virus, which crossed from one species to another to eventually infect humans Supporting Shope’s hypothesis of trans-species infection an incident occurred in an unrelated ... host it infects to fight the virus The first two factors are influenced by the genetics of the virus The last factor is dependent on the health of the host to regulate a response to the virus Garrett ... contagious, and was 88 able to take pieces of their host’s cellular membranes to allow them to evade the immunological responses of their host The 1918-1919 Pandemic The onset of the 1918-1919...
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Tài liệu Actions Against Abuse of the Global Financial System: Report from G7 Finance Ministers to the Heads of State and Government docx
... conduct an authoritative review of their financial procedures and controls and those of recipients, and to improve ways to strengthen safeguards on the use of their funds as well as governance and anti-corruption ... threaten the credibility and effectiveness of international financial institution (IFI) programs and the integrity of the IFIs themselves Thus, we urge the IMF and the World Bank to continue to conduct ... system If there is obscurity about their ownership, banks and other financial institutions may not be able to discover the identity of the beneficiary of the account and will be unable to meet their...
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Báo cáo khoa học: The signature amidase from Sulfolobus solfataricus belongs to the CX3C subgroup of enzymes cleaving both amides and nitriles Ser195 and Cys145 are predicted to be the active site nucleophiles pot
... experimental analysis of the activity of the mutant SsAH-K96R on aliphatic amides and nitriles strengthens this hypothesis Another line of evidence comes from the results of the inhibition studies ... correctly positioned to perform catalysis with the Oc ˚ atom of Ser171 at about 2.8 A from the Oc atom of ˚ Ser195 and about 2.7 A from the amino group of Lys96 4718 The analysis of the structural ... Nevertheless their conclusions need to be experimentally verified In order to validate our hypothesis, we screened the activity of more than 40 SsAH mutants The mutants were obtained by random,...
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History Of Modern Philosophy From Nicolas of Cusa to the Present Time pot
... Aristotle to the transformed Aristotle of the Church and the distorted Aristotle of the schools Back to the sources, is the cry With the revival of the ancient languages and ancient books, the ... forms the antithesis to the supernatural, on the one hand, and to the historical, on the other This combination of the revealed and the historical will not appear strange, if we remember that the ... Mersenne, are from various theologians and mathematicians In the second edition there were added, further, the Seventh Objections, by the Jesuit Bourdin, and the Replies of the author thereto The four...
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CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx
... in the bones of the mother may be removed during the pregnancy and cause injury to the fetus [47] Some significant exposure during pregnancy may be more related to the presence of the rearrangement ... during pregnancy to inhibitors of topoisomerase II is a risk factor for the offspring of the pregnancy to develop ALL with the presence of genetic rearrangements MLL There are no studies that ... agent will have an affect to the extent of the intensity of the exposure and the degree of susceptibility to the disease or the intrinsic factors that modi‐ fy the form in which the child's bodily...
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straumann n. from primordial quantum fluctuations to the anisotropies of cmbr
... and some of the main results of the analysis are shown in Fig The data points in the top panel are the distance moduli relative to an empty uniformly expanding universe, ∆(m − M), and the redshifts ... at the time te + ∆te and is received at the time to + to , we obtain from the last equation to + to te +∆te dt = a(t) to te dt a(t) (27) For a small ∆te this gives to ∆te = a (to ) a(te ) The ... hadron soup The abundance of pions, for example, was so high that they nearly overlapped The pions, kaons and other hadrons soon began to decay and most of the nucleons and antinucleons annihilated,...
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from marx and mao to the market the economics and politics of agricultural transition mar 2006
... productivity from OB to OF and price reform increases it further from OF to OD (or first from OB to OC and then from OC to OD if the sequencing of the reforms is the other way around) Third, to what ... faced by the manager of the farm Assuming that the main contribution of the manager is ‘effort’, then the nature of the farm organization will determine the incentives for the manager to allocate ... fertilizer, tractor, land use, and animal stock are from FAO; labour data from Asian Development Bank, ILO, national statistics, World Bank 22 Pattern of Transition The input that best reflects the differences...
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báo cáo hóa học:" An application of principal component analysis to the clavicle and clavicle fixation devices" doc
... edited and evaluated the manuscript HM assisted in the design of the study, supervised the research, edited and evaluated the manuscript and provided clinical relevance and guidance for the study ... across the entire length of clavicle plates and pre-contouring them in more than one plane would improve anatomic fit and strength of the construct, these findings clearly supporting the soon -to- be-launched ... Six of the scans were from males and 15 from females, with an average age of 54 (range 20-85 years) Twelve were from the left side and nine from the right Biodata was available in all cases and...
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báo cáo khoa học: " Science, institutional archives and open access: an overview and a pilot survey on the Italian cancer research institutions" ppt
... metadata allow the user to surf the Internet from a link to another, starting from a single publication posted in a repository, to a researcher curriculum or to the data concerning the institution ... been translated into many languages and have become an international standard for indexing biomedical literature The Italian MeSH translation, carried on by the Istituto Superiore di Sanità, ... procedures to DSpace ISS XML schema and to Roberto Rizzo for revising the manuscript and bibliography according to the Instructions The authors are also very grateful to Norah May and Tania Merlino...
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báo cáo khoa học: " From GWAS to the clinic: risk factors for intracranial aneurysms" pdf
... pon erance and polycystic kidney disease are the main d risk factors On the other hand, only the size and site of the aneurysm, age and gender have been consistently identified as risk factors ... hypothesisbased and genes are selected on the basis of their known function and the assumption that they are involved in the development of the disease (so-called functional candi date genes) The ... denominator of the gene products of the candidate genes in the five intracranial loci seems to be involvement in cell proliferation Assuming a fourfold increase in the risk of intracranial aneurysm...
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Báo cáo y học: " An overview of treatment response rates to various anti-viral drugs in Pakistani Hepatitis B Virus infected patients" doc
... carrier residents and their clinical characteristics during long-term follow-up: the relevance to changes in the HBeAg/anti-HBe system Hepatol Res 2002, 24:1 Westland C, Delaney W, Yang H, Gibbs C, ... compared to genotypes E and G [48] The high prevalence of HBV genotype D and C in Pakistani population and its association with increased severity of the disease and resistance to the present therapies ... limited to support advantage of one therapy to be more effective than the others However, the response rate of 30-40% was reported by the administration of IFN-a for 6-12 months as compared to 10-20%...
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Báo cáo y học: "Thread embedded into penile tissue over time as an unusual hair thread tourniquet injury to the penis: a case report" doc
... Figure the ring1scar on the penis Thedorsolateral aspects and the exuberant granulation on The ring scar on the penis and the exuberant granulation on the dorsolateral aspects The skin distal to the ... transected, leading to the loss of sensation over the glans penis The corpus spongiosum may become transected, leading to urethrocutaneous fistulation The corpora carvanosa may also become transected, ... of the part distal to the tourniquet There was not even a discernible depression along the site of the tourniquet The ultimate location of the hair thread was immediately subcutaneous, as if the...
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Báo cáo y học: " Promoter addresses: revelations from oligonucleotide profiling applied to the Escherichia coli genome" ppsx
... words) The peak and the plateau together constitute the promoter The plateau is formed by class III oligonucleotides that have the capacity to bend DNA The facilitators are an integral part of the ... the manuscript PG is the group leader Acknowledgements The authors would like to thank Ms Anishetty for discussions, and to acknowledge the financial support given by Council for Scientific and ... Here, we analyze: the occurrence of the Pribnow box and its single base substitution relatives, the distribution of the Pribnow box within the -100 region, and the position-dependency of other bases...
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Báo cáo y học: "High mobility group box-1 protein - one step closer to the clinic" docx
... human setting, and assays should be carefully validated and compared between different laboratories in order to obtain reliable and consistent data Thus, the role for HMGB1 as a predictor of clinical ... HMG1 and HMG2 change the DNA helical structure Science 1978, 199: 1345-1346 Wang HC, Bloom O, Zhang MH, Vishnubhakat JM, Ombrellino M, Che JT, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue ... although HMGB1 may seem to be the first violinist under certain conditions, it is but one of the players in the inflammatory orchestra Competing of interests The author declares that they have no competing...
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báo cáo hóa học: " Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008" pot
... Hospital Anxiety and Depression Scale (HADS), and the General Health questionnaire (GHQ), and/or symptom measures such the Brief Pain Inventory (BPI), and the Symptom Distress Scale (SDS) Therefore the ... in the tables was simply to reflect the variance that existed in the instruments used and neither to convey their psychometric validity nor indicate that they were cancer-specific As such, the ... any financial support or grant for the study The author also is very grateful to both anonymous referees who reviewed the manuscript Their comments and suggestions improved the paper substantially...
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From interval analysis to taylor models an overview lohner
... that the observed overestimation (the area of the interval enclosure is twice the area of the range) is not a result of dependency, but of the enclosure of a non-interval shaped range into an interval ... the domain of integration into subintervals On each grid point, the flow of the given ODE is enclosed into a set with a certain geometric structure, for example an n-dimensional rectangle In the ... case, the shape of the flow has a different geometric design, so that the flow is wrapped into some larger set, which serves as initial set for the next time step To maintain the validity of the method,...
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Tài liệu An Aviator''''s Field Book Being the field reports of Oswald Bölcke, from August 1, 1914 to October 28, 1916 doc
... to avail themselves of airplanes to find the range for them The French were just at the time trying to get revenge for an attack we made the day before, and the artillery was very busy From there ... also got out to be able to fire at the retreating enemy to better advantage Again and again the French officers tried to close up their ranks, rally their men, and lead them anew to the attack ... They had been forced to land behind the enemy's line because their motor had stopped They were hardly down when the "Pisangs" (French peasants) came running toward them from every direction They...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25