an in vitro model of stroke induced epilepsy elucidation of the roles of glutamate and calcium in the induction and maintenance of stroke induced epileptogenesis
Báo cáo y học: "Gender differences and inflammation: an in vitro model of blood cells stimulation in prepubescent children" pptx
... drafted the manuscript FH, LH, SM, CH, FC, JD and NL participated in the design of the study GC and JD conceived of the study, and participated in its design and coordination All authors read and ... cytokine production [22] We have selected a direct stimulation with graded doses of LPS and Pokeweed Mitogen lectin as stimulants in vitro LPS -induced signalling in macrophages, and in other ... syndrome group had a significantly lower median production than females (p < 0.03) Increasing the concentration of LPS increased the median production of IL1 in females and in males (p < 0.036; p
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Báo cáo y học: "Gender differences and inflammation: an in vitro model of blood cells stimulation in prepubescent children" pot
... drafted the manuscript FH, LH, SM, CH, FC, JD and NL participated in the design of the study GC and JD conceived of the study, and participated in its design and coordination All authors read and ... cytokine production [22] We have selected a direct stimulation with graded doses of LPS and Pokeweed Mitogen lectin as stimulants in vitro LPS -induced signalling in macrophages, and in other ... syndrome group had a significantly lower median production than females (p < 0.03) Increasing the concentration of LPS increased the median production of IL1 in females and in males (p < 0.036; p
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Báo cáo y học: " Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma" ppsx
... experiments and helped in manuscript preparation SC participated in the design of the experiments, was involved in HASMC culture, performed in vitro cAMP studies and helped in the manuscript preparation ... participated in the design of the experiments and was involved in isolated human bronchial ring experiments SR participated to the in vitro studies MM was involved in isolated human bronchial ring experiments ... directly affected by LTD4 Relaxant responses to salbutamol in human bronchial rings The mean weight of the 24 bronchial rings was 91 ± mg The mean resting force and the mean normalizedresponse to carbachol...
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Báo cáo y học: "Propofol: neuroprotection in an in vitro model of traumatic brain injury" pot
... coordination and helped to draft the manuscript JW, MF and SR helped to draft the manuscript MC conceived of the study, participated in the study design and coordination and helped to draft the manuscript ... shown The continuous line is the mean value, and the dotted lines are the upper and lower bounds of the SEM The data demonstrates the continuous low level of injury throughout the slices prior ... The mean value and the standard error of the mean (SEM) were calculated for the trauma intensities of the slices in each group using SPSS software version 16.0 (SPSS Inc., Chicago, IL, USA) The...
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Báo cáo y học: " Effect of transverse gap-junction channels on transverse propagation in an enlarged PSpice model of cardiac muscle" pps
... cells A10 and B10, B1 and C1, C10 and D10, D1 and E1, E10 and F10, F1 and G1, G10 and H10, H1 and I1, I10 and J10 Assuming that each gj-channel has a conductance of 100 pS, these channels corresponded ... positioned in a zigzag pattern across the 10 × 10 model These were located between cells A10 and B10, B1 and C1, C10 and D10, D1 and E1, E10 and F10, F1 and G1, G10 and H10, H1 and I1, I10 and J10 In ... (1000 channels) RBT is the bundle termination resistance at each end of the bundle, and has the standard value 1.0 KΩ The standard values for Rjc and Rjct are 25 MΩ (50 MΩ ÷ in parallel) The standard...
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Báo cáo y học: "CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model" pdf
... activity, including phagocytosis, respiratory burst, and transendothelial and transepithelial chemotaxis induced by arginine-glycine-aspartic acid (RGD) containing synthetic peptides and protein [17] ... conceived of the study, participated in its design and coordination, participated in the interpretation of results, and predominantly drafted the manuscript All authors read and approved the final manuscript ... five membrane-spanning segments of CD47/IAP and the two membrane-spanning domains of the heterodimeric integrin form an ad hoc seven-transmembrane receptor that, with an adhesive ligand such as TSP,...
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Báo cáo y học: " Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury" doc
... bleomycin injection in WT mice, positive staining for IL-1 (A) was localized mainly in inflammatory cells and in vascular endothelium There was a marked reduction in the IL-1 immunostaining in the ... infiltration in the lung tissues in WT-animals The leukotrienes synthesis inhibition and the receptor blockade in bleomycin treated mice significantly reduced the fluid content (Fig 1f) and the ... 15) Induction of lung injury by bleomycin Mice received a single intratracheal instillation of saline (0.9%) or saline containing bleomycin sulphate (1 mg/kg body weight) in a volume of 50 μl and...
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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"
... of PBS containing the known concentration of the drug and 2.5 mmol of ATP, 2.5 mmol MgCl2 and 2.5 mmol of CaCl2, gently mixing to avoid hemolysis and incubation for 15 http://www.medsci.org Int ... addition of 1ml methanol, mixed well and vortexed for 15 minute and then centrifuged at 13000 rpm for 15 minutes The supernatant is taken and filtered using 0.22 Millipore disposable filters and then ... results 226 Loading efficiency at 25oC The effect of concentration and incubation time on the percent of drug loading is shown in figures and at 25ºC and at 37ºC The percent is of drug loading was started...
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Báo cáo khoa học: "Proximity in Context: an empirically grounded computational model of proximity for processing topological spatial expressions∗" docx
... landmark L cen- In this equation the absolute proximity for a point P and a landmark L is a function of both the distance between the point and the location of the landmark, and the salience of ... for the point in question In (3) the proximity of a given point to a selected landmark rises as that point’s distance from the landmark decreases (the closer the point is to the landmark, the ... the maximum distance between point L and any point in the scene 747 relative proximity to each landmark at each point For this we first select a landmark, and then iterate over each point in the...
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Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
... with a piece of gelatin sponge, Page of 10 the temporalis and overlying skin were sutured Animals were then placed in the supine position and a midline incision was made in the neck The bilateral ... comparing them to the standard curve to determine the copy number The process of calculating threshold cycles, preparing a standard curve, and determining the copy number was performed using system ... nestin and BrdU were performed to assess the property of NSC in cultures and track the migration and homing of allogeneic BrdUlabeled NSC in the host brain In addition to the expression of the class...
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Báo cáo sinh học: " Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: An experimental murine model" pot
... 76(9):4294-4303 Tekkanat KK, Maassab H, Berlin AA, Lincoln PM, Evanoff HL, Kaplan MH, Lukacs NW: Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory ... (control), and RSV A2 infected BALB/c (ᮀ) and C57BL/6 (◆) mice, to measure concentrations of pro-inflammatory cytokines (A) IFN-γ and (B)TNFα; and the chemokines (C) RANTES, (D) MIP-1α, and (E) ... shown) Acute and chronic inflammatory infiltrates, surrounding airways and vessels are demonstrated in RSV-inoculated mice of both strains, on days and 77 after inoculation (4C to F) during the acute...
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Báo cáo sinh học: " Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity" pptx
... Processing Kinetics of Core Protein Precursors To determine the optimal temperature and kinetics of processing of the core protein precursors in the in vitro cleavage assay, a time course of I7L-mediated ... (pI7LH241A) The extracts are prepared as described in the Materials and Methods The extracts are mixed and incubated with the substrates for hrs and then analyzed through SDS-PAGE and chemiluminescent ... to the adenovirus protease, the African swine fever virus protease, and an ubiquitin-degrading enzyme in yeast, as well as the identity of a catalytic triad composed of histidine, cysteine, and...
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báo cáo hóa học: " A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices" potx
... cell lines and in vivo models Furthermore, we wanted to examine the possibility of refining the model by taking into the account the experimental design involving the culture conditions and appropriate ... for checking the language of the manuscript and Mr Pasi Miettinen and Mrs Airi Boman for technical assistance This study was financially supported by the Academy of Finland and University of Kuopio ... antigen and are responsible for the production and release of a variety of cytokines and chemokines, interact with immune cells and are intimately involved in immunoregulation within the CNS...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... enzymes (FAAH, MAGL) and proteins involved in their transport, and intracellular trafficking [9] Increasing evidence suggests the involvement of the ECS in both the inflammatory and the neurodegenerative ... immunohistochemistry studies and participated in the interpretation of data and revising manuscript draft FC, FL and FD participated in the design of the study, interpretation of data and revision of manuscript ... in the EAE model by administering the synthetic cannabinoid WIN 5,212-2 [23] In the TMEVIDD model we showed that WIN 5,212-2 at the time of virus infection inhibited brain VCAM-1 expression and...
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báo cáo hóa học: " Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy" ppt
... pictures and drafted the manuscript GM participated in the design of the study and performed the statistical analysis HTA conceived of the study, and participated in its design and coordination and ... guidelines of the Institute for Laboratory Animal Research (Guide for the Care and Use of Laboratory Animals) in accordance with the ARVO Statement for the “Use of Animals in Ophthalmic and Vision ... directly involved in the formation of retinal NV in the later stages of the OIR model In this study, we investigated the temporal and spatial distribution of microglial cells during the different...
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báo cáo hóa học: " Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression" docx
... in the brain (A) Brain levels of the pro-inflammatory prostaglandin PGE2 (B), the anti-inflammatory one 15d-PGJ2 (C), and interleukin-1b (IL-1b) mRNA levels in control and after CMS in the brain ... of LPS and can activate brain TLR-4 inducing a neuroinflammatory response In order to clarify the origin of stress -induced activation of the TLR-4 pathway in CMS, we studied LPS and its binding ... both in humans and rodents, and is one of the earliest events in the stress-inflammation response in the brain [53,54] This transcription factor resides silent in the cytoplasm bound by an inhibitory...
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Báo cáo hóa học: "Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD)" potx
... activity of glandular and surface epithelial cells Proliferative activity of glandular and surface epithelial cells To assess the proliferative activity, an in vivo BrdU-assay and AgNOR-analysis ... using hematoxylin-eosin, alcian blue and the Periodic-Acid-Schiff (PAS) reaction Proliferative activity of glandular and surface epithelial cells In vivo Bromodeoxyuridine (BrdU)-assay An in ... Germany), weighing 350–400 g were used The animals were housed under standard laboratory conditions and fed ad libitum in accordance to the rules of the animal welfare act and the local animal committee...
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báo cáo hóa học:" Airborne particulate matter PM2.5 from Mexico City affects the generation of reactive oxygen species by blood neutrophils from asthmatics: an in vitro approach" docx
... exception of cluster shape in the fine fraction was found in all categories and accounted for less than 3% and 1.5% in the coarse and fine fractions, respectively The presence of Fe and Cu content into ... content into spherical and soot aggregates of the fine fraction indicates a combination of natural and anthropogenic sources influenced by smelter and incineration emissions in the study area Table ... triggers including viral infections and air pollutants may activate the production of ROS, thus resulting in inflammation in addition to the asthmatic symptoms [26] The maintenance of basal ROS...
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báo cáo hóa học:" Development of an in vitro three dimensional loading-measurement system for long bone fixation under multiple loading conditions: a technical description" potx
... rotation for the ostectomy, and negligible CrCa and LM bending rotation for the intact radius and the reduced osteotomy (Figure 6) The loading fixtures during axial and torsion testing were also ... that the line of action of the axial applied load would remain close to the central point on each end of the radius The authors' feel that the loading fixtures used and described in this manuscript, ... biomechanical characteristics of intact and two Association for the Study of Internal Fixation (ASIF) techniques for repair of an oblique fracture involving the distal (inferior) diaphysis of an...
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