an animal model of the extreme fragility of control over vulnerability to relapse in human addicts

báo cáo hóa học:" Establishment of an animal model of a pasteurized bone graft, with a preliminary analysis of muscle coverage or FGF-2 administration to the graft" potx

Ngày tải lên : 20/06/2014, 04:20

... plays an important role in osteoclastogenesis and angiogenesis [17] In the current study, during the course of the establishment of a pasteurized bone model in rats, a preliminary analysis of the ... over- absorption of the grafted bone or infection, may be due to the prolonged existence of pasteurized bone without remodeling In the hopes of guaranteeing the most favorable results, the establishment of an ... povidone-iodine After anesthetization was confirmed, a median parapatellar skin incision extending to the medial thigh was made The femur was reached through an incision into the knee joint capsule and...

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Báo cáo y học: "The laminin b1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma" potx

Ngày tải lên : 12/08/2014, 13:22

... [24,25] The specific role of laminins in ASM remodelling in vivo, however, remains to be determined Therefore, using a guinea pig model of chronic asthma, we explored the role of laminins in ASM remodelling ... remodelling in vivo, by treating the animals with the specific soluble laminin-competing peptide Tyr-Ile-Gly-Ser-Arg (YIGSR), a binding motif present in the b1 chain of laminins [26] Methods Animals ... laminin-211 [15] These inhibitory effects can be reversed using soluble YIGSR [15], a binding motif present in the laminin b1 chain [26] Similarly, in our study culturing human ASM cells on laminin-111...

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Báo cáo y học: "Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathwa" ppt

Ngày tải lên : 13/08/2014, 20:21

... is shown in Figure Animals were treated according to national guidelines and with permission of the Institutional Animal Care and Use Committee (Amsterdam, The Netherlands) A total of 31 male ... in humans is needed before these results can be translated to human medicine [49] Second, taking into account the possible gender differences with respect to PARP activation found in animal models ... given intraperitoneally (ip) and 70 mg/kg ketamine (Alfasan, Woerden, The Netherlands) intramuscularly Anesthesia was maintained with pentobarbital at 15 mg/kg every 30 minutes through an ip catheter...

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Báo cáo y học: "Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis" pptx

Ngày tải lên : 09/08/2014, 06:23

... types I and III and a change in the relative levels of the fibrilassociated SLRPs In particular there is decrease in synthesis of decorin and an increase in biglycan and lumican, with the latter ... Blotting for biglycan identified intact core protein (43 kDa) and a number of fragments (39, 32, 28 and 26 kDa) in all of the specimens There was an increase in staining intensity for all biglycan ... central to our understanding of the initiation and progression of osteoarthrits (OA) [16] An initial anabolic response of chondrocytes in OA includes an upregulation of mRNA levels for the major...

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Báo cáo y học: " Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury" doc

Ngày tải lên : 12/08/2014, 16:20

... accumulation of water in lung as an indicator of lung edema, (Fig 1f) and neutrophils infiltration in the lung tissues in WT-animals The leukotrienes synthesis inhibition and the receptor blockade in bleomycin ... for their anti-inflammatory properties to treat asthma and allergic rhinitis, are able in the bleomycin animal model of lung fibrosis to attenuate the acute lung injury and the evolution of fibrotic ... bleomycin injection in WT mice, positive staining for IL-1 (A) was localized mainly in inflammatory cells and in vascular endothelium There was a marked reduction in the IL-1 immunostaining in the...

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Báo cáo y học: "Evaluation of long-term antinociceptive properties of stabilized hyaluronic acid preparation (NASHA) in an animal model of repetitive joint pain" doc

Ngày tải lên : 12/08/2014, 17:22

... cut-off value of 250 g was defined Pain-related guarding behavior of the inflamed hindpaw was assessed by quantification of weight bearing towards the non-inflamed hindlimb using an incapacitance ... PGE2 in a total intra-articular injection volume of 50 μl The chosen bradykinin concentration was then verified in four bradykinin-naïve animals In order to establish that the model indeed indicates ... of days in this interval The total area was obtained by adding the values from all intervals (1 to 7, to 14, 14 to 28, and 28 to 56) The antinociceptive effect was then calculated as: antinociceptive...

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Báo cáo y học: "Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis" pps

Ngày tải lên : 12/08/2014, 18:20

... via intraperitoneal injection, the abdomen of each animal was prepared with 70% alcohol and incised in the midline Bacterial sepsis was induced by implanting one pellet in the right lower quadrant ... according to the above implantation protocol This high dose was chosen for its ability to induce a significant increase of ProCT at 12 h in the proceeding experiments Animals were killed in the ... which corresponds to the elution position of human procalcitonin (ProCT) [17] CT, calcitonin; CT:CCP-1, conjoined calcitonin:calcitonin carboxypeptide-I Molecular species of the total serum iCT...

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Báo cáo y học: "Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure" potx

Ngày tải lên : 13/08/2014, 13:20

... ballooning, steatosis, necrosis and the presence of neutrophils Hematoxylin and eosin appear to be increased in individuals with OSA, is due to the conversion of xanthine dehydrogenase (type D) into ... ischemia-reperfusion [18] in which there is activation of xanthine oxidase, leading to the formation free radicals and further imbalance between oxidants and antioxidants [4-6] The analysis of liver integrity ... significant increase in NO in these animals compared with SIH (Table 4) Several histological liver changes were also observed in animals of the IH-35 group - ballooning, steatosis, necrosis and the...

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An Animal Model of Pediatric Combined Pituitary Hormone Deficiency Disease

Ngày tải lên : 24/08/2014, 13:00

... the oral ectoderm with the dorsal cells of the pouch destined to populate the intermediate lobe of the pituitary and the ventral cells of the pouch acquiring an anterior pituitary cell fate The ... somatotropes, and lactotropes appearing in the dorsal side of the anterior lobe, the thyrotropes located in the central part of the lobe, and the gonadotropes occupying the ventral part of the anterior lobe ... LIM domains and the homeodomain (HD) are indicated by the boxes The numbering scheme for the LHX4 protein represented here begins with the first in- frame methionine in the human sequence: the p.P389T...

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An asthma allergen specific animal model for the study of responses to dust mite allergen induced asthma

Ngày tải lên : 15/09/2015, 21:56

... result in tolerance rather than induce an inflammatory response For example, the administration of ovalbumin (OVA) into the lung of mice had been shown to result in immunologic tolerance rather than ... been shown to inhibit the expression of histone deacetylase (HDAC) in alveolar macrophages, leading to the increase in transcription of genes encoding inflammatory cytokines (10) Changes to DNA methylation ... mediators can profoundly affect the permeability of the vascular endothelium, allowing the migration of circulating immune cells to migrate through the endothelium into the site of inflammation These...

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Báo cáo hóa học: " An analytical model for the intercell interference power in the downlink of wireless cellular networks" ppt

Ngày tải lên : 21/06/2014, 00:20

... pseudo-random number generators to generate sequences of ‘random’ numbers belonging to a fixed set of values In order to take into account the ignorance of the contribution of the highest interference ... define the interference gain-which will be denoted G-as being the sum of the channel power gains between the interested user and the N interferers, i.e., N G= n=1 at producing an accurate histogram ... although it can handle any other topology We validate the proposed methods by comparing the moments of the estimates to the exact moments of the distribution which can be derived analytically Using this...

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Báo cáo khoa học: " Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis" ppt

Ngày tải lên : 09/08/2014, 09:22

... caused by the animals rather than radiation The animals' health status was checked daily by the scientific investigators, the institutional animal care personnel and reviewed daily with the staff ... 0.05) The TGF-β1 values correlated with the degree of skin injury and fibrosis seen at the end the study The quantity of TGF-β1 in the skin of unirradiated C57/BL6 and TSK mice did not change ... increase in the number of TGF-β binding motifs resulting in more efficient binding of TGF-β [15] Also the altered FBN-1 containing microfibrils become unstable and undergo proteolysis readily in comparison...

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báo cáo khoa học: "Computing genetic evaluations through application of generalized least squares to an animal model" pot

Ngày tải lên : 09/08/2014, 22:22

... to 20 p 100 of the animal equations needed by the full animal model A « » Recursive prediction allows further reduction of the number of equations to be solved by evaluating only animals of interest ... by the equation where a vector of n ones, i is the mean of y, Ki i a is the vector of additive genetic effects (breeding values) of animals with records in y,, random with mean zero and variance ... variance A and a;, l i e is the vector of residuals, random with mean zero and variance Iu’ i is The breeding value of the k’&dquo; animal in a, can be represented as where a! and afare breeding values...

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Báo cáo y học: " Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy" pptx

Ngày tải lên : 12/08/2014, 23:23

... Mg 2+ ions, thereby interfering with the chelating function of the inhibitor, and not by affecting the affinity of the metal or by affecting direct contacts of the inhibitor with the enzyme [53] ... given the influence of the two metal ions in the binding site The Induced Fit Docking (IFD) protocol [70] was then employed in this study to accurately predict ligand binding modes and concomitant ... based on the conformation of the homologous region in HIV-1 CCD The coordinates of the two Mg2+ ions and of the viral DNA in the HIV-1 model were also spliced into the SIVmac251 CCD, leading to a...

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Báo cáo y học: "Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndrome" potx

Ngày tải lên : 13/08/2014, 11:22

... participated in the design of the study, and collected the data during the experiments BL and PG analysed the data and performed the statistical analysis VD participated in the design and the coordination ... pause to obtain the value of the inspiratory plateau airway pressure (Pins) and a 10 s expiratory pause to obtain the end-expiratory airway pressure (Pexp) The value of Crs was obtained by dividing ... between PaO2 and static compliance of the respiratory sysand static compliance of the respiratory system (Crs) conditions of the present study, but may not be warranted in the clinical setting It could...

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Báo cáo sinh học: " Fuzzy classification of phantom parent groups in an animal model" pptx

Ngày tải lên : 14/08/2014, 13:21

... simulated as the sum of an overall mean, the animal' s breeding value and a random residual An animal' s breeding value was generated as the sum of the parent average and a Mendelian sampling deviation ... Genetic model The infinitesimal model assumes that an animal' s breeding value is the sum of the parent average and a Mendelian sampling deviation that resembles the random process of sampling parental ... merit of all animals can be written as a linear function of the additive genetic effects of phantom parents and Mendelian sampling deviations Genetic groups Inclusion of genetic groups in the model...

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Báo cáo sinh học: "Univariate and multivariate parameter estimates for milk production traits using an animal model. I. Description and results of REML analyses" pptx

Ngày tải lên : 14/08/2014, 20:20

... analyses 3) into 5, and subsets (for L L and L ,, 12 respectively), and for 4) into 10 groups of 10 herds For the univariate analyses and the analyses using a repeatability model, the standard errors ... insufficient information about the sampling (co)variances of the variance components (a weighting according to the number of records in the analysis was tried and showed differences between weighted and ... unweighted means of the order of 1% of, tl,1e mean) : It was not clear how to combine the different estimates efficiently into one overall (9 x 9) covariance matrix, since there was insufficient information...

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Báo cáo sinh học: "Univariate and multivariate parameter estimates for milk production traits using an animal model. II. Efficiency of selection when using simplified covariance structures" docx

Ngày tải lên : 14/08/2014, 20:20

... vector x, then = linear combinations of the observations, a linear combination of the variables in marginal economic value for any of the production traits product of the relative expression of that ... linear combination of the traits explains most of the variation in the aggregate breeding value To reduce computations (further) it would be of interest to find a minimum number of independent traits ... not independent moment matrices; A and E are highly correlated and the determinant of A is zero An alternative is to transform A and E into a between and within sire covariance matrix (B and...

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An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx

Ngày tải lên : 07/03/2014, 10:20

... having full faith in the jump-timing aspect of the model Finally, by letting a ¼ and b ¼ 0, we reduce the set P to a singleton that contains only the reference model Effectively, this is the standard ... In the Bayesian interpretation, lÃ and kÃ are a part of the investor’s prior It is important to point out that without using information from the options market, it is hard for the investor to ... uncertainty averse in the sense of Knight (1921) and Ellsberg (1961), then the uncertainty about rare events will eventually find its way into financial prices in the form of a premium To formally investigate...

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Báo cáo khoa học: "AN EMPIRICAL MODEL OF ACKNOWLEDGMENT" docx

Ngày tải lên : 17/03/2014, 09:20

... signal understanding and acceptance of both the previous exchange and the previous utterance The canonical patterns of the self *other * ackn class, as listed in Table 1, include inform *ackn ... acknowledgment In interpreting these utterances, identification of the appropriate acknowledgment function affects the state of the dialogue model and thus plays an important role in determining an appropriate ... understanding and production of domain and control utterances are closely linked; they thus cannot be implemented as independent mechanisms in an SLS For example, giving directions involves presenting...

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