... Cantini F, Hunder GG Polymyalgia rheumatica and giant- cellarteritis Lancet 2008;234–45 Gran JT Some thoughts about the etiopathogenesis of temporal arteritis a review Scand J Rheumatol 2002;31:1–5 ... in PMR and GCA Table Characteristics of polymyalgia rheumatica (PMR) patients by history of giant- cellarteritis (GCA) Characteristic No GCA (N = 35) GCA (N = 5) P-value Age (years) Men (N (%)) ... Weekly corticosteroid dose (mg) Continuous 5-year corticosteroid therapy (N (%)) History of giantcellarteritis (N (%)) Time since appearance of PMR symptoms (months) PMR activity score Morning...
... self-tolerance in giantcellarteritis J Exp Med 2004, 199:173-183 Gonzalez-Gay MA, Amoli MM, Garcia-Porrua C, Ollier WE: Genetic markers of disease susceptibility and severity in giantcellarteritis ... resistance in giantcellarteritis Ann Rheum Dis 1998, 57:380-382 Mattey DL, Hajeer AH, Dababneh A, Thomson W, Gonzalez-Gay MA, Garcia-Porrua C, Ollier WE: Association of giantcellarteritis and ... HLA-DR4 alleles are associated with giantcellarteritis J Rheumatol 2002, 29:2148-2153 Salvarani C, Gabriel SE, O'Fallon WM, Hunder GG: The incidence of giantcellarteritis in Olmsted County, Minnesota...
... cranial arteritis (giant cell arteritis) Eur J Med Res 2003, 8:1-7 29 Karassa FB, Matsagas MI, Schmidt WA, Ioannidis JP: Meta-analysis: test performance of ultrasonography for giant- cellarteritis ... halo sign 41 100 CDS, colour duplex ultrasonography; GCA, giantcellarteritis ESR, erythrocyte sedimentation rate; GCA, giantcellarteritis Page of (page number not for citation purposes) Arthritis ... stenosis in aapatient without giantcellarteritis The peak systolic velocity (left panel) becomes temporal artery trunk indicative of stenosis in patient without giantcellarteritis at least double...
... eye seminated visceral giantcellarteritis However, this is unlikely as Lie [6], who coined this entity, reported on four male cases none of whom had symptomatic temporal arteritis and all were ... Abbreviations BD: twice a day; C-RP: C-reactive protein; ESR: erythrocyte sedimentation rate; GCA: giantcell arteritis; nocte: at night; OD: once daily; OM: once in the morning Consent Written informed ... approved the final manuscript References Ghanchi FD, Dutton GN: Current concepts in giantcell (temporal) arteritis Surv Ophthalmol 1997, 42:99-123 Chrousos GA, Kattah JC, Beck RW, Cleary PA:...
... Olshen RA, Goronzy JJ, Weyand CM: Th17 and Th1 T -cell responses in giantcellarteritis Circulation 2010, 121:906-915 Nordborg E, Nordborg C: Giantcell arteritis: epidemiological clues to its pathogenesis ... JJ: T cells in arteritis and atherosclerosis Curr Opin Lipidol 2008, 19:469-477 Weyand CM, Schonberger J, Oppitz U, Hunder NN, Hicok KC, Goronzy JJ: Distinct vascular lesions in giantcellarteritis ... arteritis share identical T cell clonotypes J Exp Med 1994, 179:951-960 Weyand CM, Younge BR, Goronzy JJ: IFN-gamma and IL-17: the two faces of T -cell pathology in giantcellarteritis Curr Opin Rheumatol...
... with giantcellarteritis Additional file 3: Supplemental Figure S1 One-dimensional immunoblot IgG reactivity from giantcellarteritis patients with vascular smooth muscle cell proteins Serum samples ... serum of giantcellarteritis patients Protein extract is from vascular smooth muscle cells (VSMCs) (A) IgG reactivity to lamin in five different pools of sera from three giantcellarteritis ... from patients with giantcellarteritis Protein extract is from vascular smooth muscle cells (VSMCs) (A) IgG reactivities of five different pools of sera from three giantcellarteritis patients...
... FBS When the cells reached confluency, the primary cultures were scraped and subcultured After several passages, the multinucleated giant cells and monocyte/macrophage-like round cells progressively ... monocyte-like cells and MNCs at the site of bone destruction Because monocyte-like cells and MNCs in GCTs express CD68 [16], we investigated whether Flt-1 co-localized with CD68-positive cells in GCT samples ... VEGF receptors in giantcell tumors (GCTs) of bone Surgical specimens were fixed in formalin and serially sectioned (a) VEGF was expressed in stromal cells (arrows), monocyte-like cells (arrowheads)...
... 225-242 Goldenberg RR, Campbell CJ, Bonfiglio M: Giant- cell tumor of bone An analysis of two hundred and eighteen cases J Bone Joint Surg Am 1970, 52(4):619-64 Szendröi M: Giant- cell tumour of bone ... Recurrence of giant- cell tumors of the long bones after curettage and packing with cement J Bone Joint Surg Am 1994, 76(12):1827-33 Campanacci M, Baldini N, Boriani S, Sudanese A: Giant- cell tumor ... AA: Giantcell tumour of the distal radius: wide resection and reconstruction by non-vascularised proximal fibular autograft Ann Acad Med Singapore 2009, 38(10):900-4 22 Campanacci M: Giant- cell...
... FBS When the cells reached confluency, the primary cultures were scraped and subcultured After several passages, the multinucleated giant cells and monocyte/macrophage-like round cells progressively ... monocyte-like cells and MNCs at the site of bone destruction Because monocyte-like cells and MNCs in GCTs express CD68 [16], we investigated whether Flt-1 co-localized with CD68-positive cells in GCT samples ... VEGF receptors in giantcell tumors (GCTs) of bone Surgical specimens were fixed in formalin and serially sectioned (a) VEGF was expressed in stromal cells (arrows), monocyte-like cells (arrowheads)...
... 225-242 Goldenberg RR, Campbell CJ, Bonfiglio M: Giant- cell tumor of bone An analysis of two hundred and eighteen cases J Bone Joint Surg Am 1970, 52(4):619-64 Szendröi M: Giant- cell tumour of bone ... Recurrence of giant- cell tumors of the long bones after curettage and packing with cement J Bone Joint Surg Am 1994, 76(12):1827-33 Campanacci M, Baldini N, Boriani S, Sudanese A: Giant- cell tumor ... AA: Giantcell tumour of the distal radius: wide resection and reconstruction by non-vascularised proximal fibular autograft Ann Acad Med Singapore 2009, 38(10):900-4 22 Campanacci M: Giant- cell...
... studies reported on these lesions Giantcell lesions constituted (09%) of the 77 jaw lesions Among the giantcell lesions encountered in our study, central giantcell granulomas (Figure 8) were ... giantcell granuloma showing vascular fibroblastic stroma and multinucleated giant cells H&E 10× Page of from other tumors developing in the oral cavity and facial bones [3] While the giantcell ... tumors and giantcell lesions of the jaws Mullapudi et al World Journal of Surgical Oncology 2011, 9:68 http://www.wjso.com/content/9/1/68 Page of Table Shows odontogenic tumors and giantcell lesions...
... Zlotecki R, Reith J, Scarborough MT: Giantcell tumor of the pelvis and sacrum Clin Orthop Rel Res 2004, 423:196-207 Goldenberg RR, Campbell CJ, Bonfiglio M: Giantcell tumor of bone: An analysis ... foci inside benign giantcell tumors has been described also in a small number of patients [24,25], and pulmonary metastases can be found in 2-9% of patients with benign giantcell tumors [5,26-28] ... growth of giantcell tumors but also decreases pain and other neurological symptoms of the patients resulting in improved quality of life Considering the radiographic outcome of giantcell tumors...
... composed of round to polygonal cells Some were spindle cells and some were multinucleated giant cells (Figure 2B) The diagnosis of localized tenosynovial giantcell tumor of the tendon sheath ... right the showSagittal T1-weighted giantcell tumor anterior toankleankle Sagittal T1-weighted spin-echo MRI of the right ankle showing a well delineated giantcell tumor anterior to the ankle ... Athanasou NA: Giant- cell tumour of the tendon sheath in the foot and ankle J Bone Joint Surg Br 2002, 84(7):1000-1003 Rao AS, Vigorita VJ: Pigmented villonodular synovitis (giantcell tumor of...
... carcinoma of giantcell type with osteoclast-like giant cells and sarcomatoid dedifferentiation Gallbladder carcinomas with osteoclast-like giant cells should be distinguished from giantcell carcinomas ... giant cells [7–12] In addition, some anaplastic, spindle and giantcell carcinomas of the gallbladder and extrahepatic bile ducts show numerous osteoclast-like giant cells that may simulate giant ... diffusely arranged giant cells, with scattered multinucleated cells The multinucleated cells were morphologically and immunohistochemically compared to those of primary giantcell tumours as well...
... clinical samples 39 2.4.3 Hcp1 levels in clinical samples 40 2.4.4 Affinity of Hcp1 for primary immune cells and cell lines 41 2.4.5 Binding of anti- human CD98 antibody to RAW 264.7 cells ... secretion system cluster (T6SS1) facilitates subsequent cell fusion events leading to the formation of multinucleated giant cells (MNGCs) and eventually cell death 64 With respect to pathogenic mechanism ... FACS tubes The target cells U937, a myelomonocytic cell line, were incubated with ng of Hcp1 per 0.5 x 10 cells at 37 oC for hr, under gentle rotation in R10 The coated cells were washed once...
... rely on AMP for efficient activation of AMPK; it was proposed either that AMPKK, like AMPK itself, was allosterically regulated by AMP or that binding of AMP to AMPK made AMPK a better AMPKK substrate ... Low AMP/ ATP High AMP/ ATP or leptin or adiponectin Inactive α β α β γ AMP γ AMPK LKB1 Protein phosphatase STRAD MO25 26.2 Journal of Biology 2003, AMPKK P P Thr172 Thr172 β α β γ AMP α γ AMP Maximally ... Although AMP was originally identified as an allosteric activator of AMPK, the regulation of AMPK by AMP is complex Thus, AMP also inhibits dephosphorylation and deactivation of the kinase, and AMP...
... analysis of biopsy of Merkel cell carcinoma (A) Photomicrograph showing that Merkel cell carcinoma tumor cells are surrounded by intense inflammation with lymphocytes, plasma cells, and histiocytes ... histogenesis of MCC is controversial Possible cells of origin include the epidermal Merkel cell, a dermal Merkel cell equivalent, a neural-crest-derived cell of the amine precursor uptake Less commonly, ... the biopsy sample showed a tumoral infiltration of the dermis by rounded monomorphic cells of medium size with scant cytoplasm, round nuclei, and small nucleoli, clumps of a small cell tumor,...
... polymerase chain reaction analysis of the gamma T -cell receptor rearrangement showed monoclonality of the T cells, which raised the possibility of Tcell lymphoma Infiltration by lymphocytes stained ... diaphragm, involving giant kidneys (Figure 2) A kidney biopsy showed effacement of the renal structure by diffuse leukocytic infiltrate, represented mostly by elongated cells with marked artifactual ... hyperglobulinemia, generalized lymphadenopathy, giant kidneys and the findings in the lymph node biopsy were consistent with the diagnosis of angioimmunoblastic T -cell lymphoma The patient underwent a...
... elsewhere Cell samples and DNA extraction Samples used in this study were obtained from three Holstein bulls between to years old Three types of cell samples were selected for this experiment Sperm cells ... kept at 4°C Amplified Methylation Polymorphism Polymerase Chain Reaction (AMP PCR) The PCR reaction consisted of DNA sample (genomic or digested template), Taq polymerase enzyme (AmpliTaq® Stoffel ... indicate the digestion resistant marker found in every cell sample from bull number and in sperm DNA sample from bull number Table Summary of the AMP PCR markers found in sperm DNA Bull Total marker...