... management of acute respiratory distress syndrome related to Influenza A (H1N1) virus pneumonia in a pregnant woman Intensive Care Med 2010, 36 :37 3 -37 4 Agarwal R, Reddy C, Aggarrwal AN, Gupta D: ... Alameda Professor Hernâni Monteiro; 430 3-451 Porto, Portugal 2Faculdade de Medicina da Universidade Porto, São João Hospital, Alameda Professor Hernâni Monteiro; 430 3-451 Porto, Portugal Rello J, Rodríguez ... uploads/Document/ 63/ WEB_CHEMIN_5410_12586241 43. pdf ] Published: 19 March 2010 References Brochard L: Noninvasive ventilation for acute respiratory failure JAMA 2002, 288: 932 - 935 doi:10.1186/cc8896 Cite this...
... to other diseases, and some processes are so closely related that the diagnosis may be complex Patients may seem to suffer from two or three related diseases simultaneously, or one diagnosis may ... purpura or due to splenomegaly), and granulocytes (as in the immune leukopenias) Hematopoietic failure syndromes are classified by dominant morphologic features of the bone marrow (Table 102-1) ... Low blood counts in the marrow failure diseases result from deficient hematopoiesis, as distinguished from blood count depression...
... diet and in the environment The association between marrow failure and other chemicals is much less well substantiated Drugs (Table 102 -3) Many chemotherapeutic drugs have marrow suppression as ... the introduction of chloramphenicol was perceived to have created an epidemic of aplastic anemia, its diminished use was not followed by a changed frequency of marrow failure) Risk estimates are ... especially in industries where benzene is used for a secondary purpose, usually as a solvent Benzenerelated blood diseases have declined with regulation of industrial exposure Although benzene is...
... eosinophilic fasciitis, which is characterized by painful induration of subcutaneous tissues (Chap 31 6) Pancytopenia with marrow hypoplasia can also occur in systemic lupus erythematosus Pregnancy ... cooperate in a repair complex to maintain telomere length In Shwachman-Diamond syndrome, marrow failure is seen with pancreatic insufficiency and malabsorption; most patients have compound heterozygous...
... cellular macromolecules For example, derivative hydroquinones and quinolones are responsible for benzene-induced tissue injury Excessive generation of toxic intermediates or failure to detoxify the ... repair complex (TERC and TERT) can be identified in some adults with apparently acquired marrow failure and without physical anomalies or typical family history Aplastic anemia does not appear ... such as high doses of radiation and toxic chemicals For the more common idiosyncratic reaction to modest doses of medical drugs, altered drug metabolism has been invoked as a likely mechanism The...
... (interferon γ and tumor necrosis factor) Interferon and tumor necrosis factor induce Fas expression on CD34 cells, leading to apoptotic cell death; localization of activated T cells to bone marrow and ... of hematologic diseases or blood abnormalities may indicate a constitutional etiology of marrow failure Physical Examination Petechiae and ecchymoses are typical, and retinal hemorrhages may be...
... myeloblasts Granulomas (in cellular specimens) may indicate an infectious etiology of the marrow failure Ancillary Studies Chromosome breakage studies of peripheral blood using diepoxybutane or ... younger adults to exclude Fanconi's anemia Genetic analysis applicable to the constitutional marrow failure states is available in some laboratories Chromosome studies of bone marrow cells are often ... chest radiograph (Table 102-1) Diagnostic problems can occur with atypical presentations and among related hematologic diseases While pancytopenia is most common, some patients with bone marrow hypocellularity...
... found within the family and serve as well Far more available are other alternative donors, either unrelated but histocompatible volunteers or closely but not perfectly matched family members Survival ... in blood counts Horse ATG is given at 40 mg/kg per day for days; rabbit ALG is administered at 3. 5 mg/kg per day for days For ATG, anaphylaxis is a rare but occasionally fatal complication; allergy ... equivalent with transplantation and immunosuppression However, successful transplant cures marrow failure, while patients who recover adequate blood counts after immunosuppression remain at risk...
... to avoid secondary hemochromatosis Pure Red Cell Aplasia Other, more restricted forms of marrow failure occur, in which only a single circulating cell type is affected and the aregenerative marrow ... of these syndromes, is usually a complication of medical drug use (with agents similar to those related to aplastic anemia), either by a mechanism of direct chemical toxicity or by immune destruction ... antibodies or lymphocytes and can respond to immunosuppressive therapies In all the single lineage failure syndromes, progression to pancytopenia or leukemia is unusual ...
... symptoms are mediated by immune complex deposition Figure 102-2 Pathognomonic cells in marrow failure syndromes A Giant pronormoblast, the cytopathic effect of B19 parvovirus infection of the...
... abnormalities are not random (loss of all or part of 5, 7, and 20, trisomy of 8) and may be related to etiology (11q 23 following topoisomerase II inhibitors); chronic myelomonocytic leukemia is often ... with the probability of leukemic transformation and survival Mutations of N-ras (an oncogene), p 53 and IRF-1 (tumor suppressor genes), Bcl-2 (an antiapoptotic gene), and others have been reported ... have T cell activity directed to the cytogenetically aberrant clone Sideroblastic anemia may be related to mutations in mitochondrial genes; ineffective erythropoiesis and disordered iron metabolism...
... or 11 marrow blasts (%) Scores 21 30 % Intermediat e-1 0.5– 1.0 Intermediat e-2 1.5– 2.0 High a ≥2.5 Good, normal, -Y, del(5q), del (20q); poor, complex ( 3 abnormalities) or chromosome abnormalities; ... and increase in the number of blasts are all poor prognostic indicators The outlook in therapy -related MDS, regardless of type, is very poor, and most patients will progress within a few months ... pancytopenia and not due to leukemic transformation; perhaps one-third will succumb to other diseases unrelated to their MDS Precipitous worsening of pancytopenia, acquisition of new chromosomal abnormalities...
... Hematol 37 :30 , 2000 [PMID: 10676909] Molldrem J et al: Treatment of bone marrow failure of myelodysplastic syndrome with antithymocyte globulin Ann Intern Med 137 :156, 2002 [PMID: 1216 036 3] Silverman ... of lenalidomide in myelodysplastic syndromes N Engl J Med 35 2:549, 2005 [PMID: 157 034 20] Young NS, Brown KE: Parvovirus B19 N Engl J Med 35 0:586, 2004 [PMID: 14762186] ——— et al: Current concepts ... Haematol 111:1010, 2000 [PMID: 11167 735 ] Lipton JM: Diamond Blackfan anemia: New paradigms for a "not so pure" inherited red cell aplasia Semin Hematol 43: 167, 2006 [PMID: 16822459] List A et...
... with intractable circulatory failure resulting from septic shock Crit Care Med 2000, 28 :35 81 -35 87 Piccini P, Dan M, Barbacini S, Carraro R, Lieta E, Marafon S, Zamperetti N, Brendolan A, D’Intini ... Aegerter P, Jardin F: Early veno-venous haemodiafiltration for sepsis -related multiple organ failure Crit Care 2005, 9:R755-R7 63 Marecaux G, Pinsky MR, Dupont E, Kahn R J, Vincent JL: Blood lactate ... factors in acute renal failure due to sepsis Results of a prospective multicentre study The French Study Group on Acute Renal Failure Nephrol Dial Transplant 1996, 11:2 93- 299 11 Smith L, Kumar...