amos of mirnas synthesis

The Art of 21 Synthesis Organic

Ngày tải lên : 29/04/2013, 10:27

... that the total synthesis of each molecule reflects the limits of the power of the art and science of organic synthesis at the time of the accomplishment One of the most notable of the many elegant ... interested in the synthesis of cephalosporin C and, by 1965, they completed the first total synthesis of the molecule.[30] This total synthesis of cephalosporin C was the sole topic of Woodwards ... direction of Professor P A Magriotis, in 1994, working on the synthesis of novel enediyne antibiotics He joined Professor K C Nicolaous group in 1996, and was involved in the total synthesis of epothilones...

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Comparison of Two Synthesis Routes to Obtain Gold Nanoparticlesin Polyimide

Ngày tải lên : 18/09/2013, 21:27

... substructure of the cross sections to gain information on the size and dispersion of the GNPs in the membranes Influence of the Synthesis Method on the GNP Properties An important parameter of GNPs ... the in situ synthesis methods often lead to a better dispersion and less aggregation of the GNPs compared to the use of presynthesized GNPs.4,6 For the ISR membranes, the amount of GNPs in the ... incorporation of preformed PVPprotected GNPs into a PI membrane and the in situ synthesis of GNPs inside a PI membrane matrix In both cases, GNPs are obtained with an average size of nm in the top layer of...

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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

Ngày tải lên : 14/02/2014, 22:20

... place following exposure of liver cells to FFAs Interruption of TAG synthesis in conditions of excess availability of SFAs is the key point in the molecular mechanism of SFA-induced lipotoxicity ... TAG synthesis It is suggested that the creation of a pool of oversaturated lipid intermediates makes these molecules inaccessible to the enzymes of TAG synthesis, whereas a certain degree of unsaturation ... expression of activating transcription factor (ATF4) and of CCAAT ⁄ enhancer-binding protein homologous protein (CHOP) proteins downstream of eIF2a were observed (Fig 4A), indicating the initiation of...

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Tài liệu Báo cáo khoa học: Interferon-a induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand ppt

Ngày tải lên : 19/02/2014, 06:20

... regulates the extent of formation of the eIF4F initiation complex and hence the rate of 5¢-cap-dependent protein synthesis [4–6] Exposure to IFNs often alters the sensitivity of cells to agents ... the extent of apoptosis but also the ability of TRAIL to regulate the initiation of translation at the level of eIF2a phosphorylation and 4E-BP1 dephosphorylation Control of protein synthesis ... Effects of IFNa treatment on the sensitivity of cells to inhibition of protein synthesis by TRAIL We have previously shown that protein synthesis is rapidly downregulated following exposure of cells...

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Tài liệu Báo cáo khoa học: "An Empirical Study of Information Synthesis Tasks" doc

Ngày tải lên : 20/02/2014, 15:20

... conclusions of this work Creation of an Information Synthesis testbed We refer to Information Synthesis as the process of generating a topic-oriented report from a nontrivial amount of relevant, ... summaries consist of a) picking the ﬁrst n sentences out of a set of selected documents (with different values for n and different sets of documents) and b) taking the full content of a few documents ... is the native language of the subjects recruited for the manual generation of reports Out of the CLEF topic set, we have chosen the eight topics with the largest number of documents manually judged...

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Tài liệu stanislaus von moos le corbusier elements of a synthesis docx

Ngày tải lên : 21/02/2014, 09:20

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Báo cáo khoa học: Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide pot

Ngày tải lên : 07/03/2014, 12:20

... of IRP2 associated with an increase of ferritin synthesis [20,37] Here, we examined the kinetics of ferritin synthesis and changes in RNA-binding activities of IRPs in response to SNP exposure ... IRP-independent effects of NO+ on Ft synthesis M Mikhael et al Discussion Fig hDFO does not block the induction of ferritin synthesis in SNP-treated RAW 264.7 cells (A); effects of various control ... Arosio P (1988) Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site A study of iron uptake and ferro-oxidase activity of human liver, recombinant...

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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc

Ngày tải lên : 08/03/2014, 09:20

... activity of HAS in intact cells Furthermore, we show that MU does not directly inhibit the processes of transcription or translation of HAS, but that a possible novel mechanism of inhibition of HA synthesis ... the method of Bradford [31], and the results were conﬁrmed by SDS/PAGE analysis of all the samples, according to the method of Laemmli [32] Assay of cell-free HA synthesis Cell-free HA synthesis ... shown) The effect of several analogues of MU on the HA synthesis in FM100 cells was also examined The inhibition of HA production was not observed except in the case of the sodium salt of MU (MU-Na),...

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Báo cáo "Another method of logic synthesis of digital counting circuits " pptx

Ngày tải lên : 14/03/2014, 13:20

... (8) (10) 61 Another method of logic synthesis of Obviously now the value of set E shows the complete parameters of periodical as well as frequency existence of forms of circuit functions (from ... 3) 59 Another method of logic synthesis of Table Circuit function with input state R3, of RS - FF - Counter with k = 6, = to 64, in which: P is the periodical existence of circuit function form ... same form Figure describes the appearance of form and form on axis Figure 3: Description of form and form on axis 57 Another method of logic synthesis of From figure we can see that if = 2,...

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Báo cáo khoa học: Insect cytokine, growth-blocking peptide, is a primary regulator of melanin-synthesis enzymes in armyworm larval cuticle pptx

Ngày tải lên : 16/03/2014, 11:20

... GBP contributes to the enhancement of gene expression for two key enzymes of melanin synthesis, TH and DDC, and by further examining the mechanism of enhancement of expression for both enzymes in ... to northern blot of total RNAs from dorsal (D) and ventral (V) integuments rRNA TH and DDC Analysis of ~ kb of the 5¢-ﬂanking region of both enzyme genes showed the presence of ﬁve common cis-elements ... incubation of the dorsal integument with GBP enhanced the expression levels of both genes Incubation of isolated tissues with nm GBP elevated the expression levels of both genes, whereas the addition of...

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Báo cáo "Another method of logic synthesis of digital counting circuits " potx

Ngày tải lên : 22/03/2014, 11:20

... (8) (10) 61 Another method of logic synthesis of Obviously now the value of set E shows the complete parameters of periodical as well as frequency existence of forms of circuit functions (from ... 3) 59 Another method of logic synthesis of Table Circuit function with input state R3, of RS - FF - Counter with k = 6, = to 64, in which: P is the periodical existence of circuit function form ... same form Figure describes the appearance of form and form on axis Figure 3: Description of form and form on axis 57 Another method of logic synthesis of From figure we can see that if = 2,...

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Báo cáo khoa học: A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G1 cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors pdf

Ngày tải lên : 23/03/2014, 07:20

... of huge amounts of lipids in the transgenic hepatocytes may contribute to the inhibition of cell growth Effects of endogenous SREBP-1 on cell growth To determine the physiological relevance of ... Cloning of promoter of cdk inhibitor and transfection and luciferase assay A SacI–XhoI fragment of human p16 INK4A, an NheI–HindIII fragment of human p19INK4D, and a BglII–HindIII fragment of mouse ... changes The level of induction of nuclear SREBPs in these cell lines was reported to be physiological, as the amounts of the transgene products were comparable with the levels of endogenous SREBPs...

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Báo cáo khoa học: An intermediate step in the evolution of ATPases ) the F1F0-ATPase from Acetobacterium woodii contains F-type and V-type rotor subunits and is capable of ATP synthesis Michael Fritz and Volker Muller ¨ docx

Ngày tải lên : 23/03/2014, 09:20

... 60 mL of buffer B luminol), and solution B (10 mL of dimethylsulfoxide containing 11 mg of p-hydroxycoumaric acid)] Blot membranes were incubated in a mixture of mL of solution A, 400 lL of solution ... the isolation of membrane vesicles, 20–25 g of cells (wet mass) was suspended in 200 mL of 50 mm Tris ⁄ HCI, 10 mm MgCI2, and 420 mm sucrose (pH 7.5) (buffer A) After addition of g of lysozyme ... number of hairpins in V0 and F0, the rotor of V1V0ATPases has only half the number of ion-binding sites This is seen as the reason for the apparent inability of V1V0-ATPases to catalyze ATP synthesis...

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Báo cáo khoa học: p53-induced inhibition of protein synthesis is independent of apoptosis pdf

Ngày tải lên : 23/03/2014, 18:20

... regulation of protein synthesis is simply a consequence of either the impairment of cell cycle progression or the induction of apoptosis, both of which are associated with inhibition of translation ... Ó FEBS 2003 Regulation of protein synthesis by p53 (Eur J Biochem 270) 3125 Fig Activation of p53 results in rapid impairment of protein synthesis that precedes the loss of cell viability and ... microscopically after a total of 10 days and were scored for the number of clones that had proliferated Measurement of protein synthesis rates Overall rates of protein synthesis were measured by...

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Specific and sensitive quantitative RT-PCR of miRNAs with DNA primers doc

Ngày tải lên : 23/03/2014, 22:20

... 100 ng of RNA in a final volume of 10 μl including μl of 10x poly(A) polymerase buffer, 0.1 mM of ATP, μM of RT-primer, 0.1 mM of each deoxynucleotide (dATP, dCTP, dGTP and dTTP), 100 units of MuLV ... concentration of 0.2 ng/μl salmon sperm DNA C Extrapolation of Cq as function of the log10 of the number of templates for the same experiment as in B was a straight line (R2 = 0.9993) with slope of -3.341 ... freedom of primer design and specificity of the LNA-based method Optimization of primer Tm and high specificity of the PCR reaction is achieved by adding a tail to each of the PCR primers Page of...

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Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden potx

Ngày tải lên : 29/03/2014, 21:20

... of the C-terminal activation domain of UBF [28], underscoring the importance of UBF phosphorylation in the control of rRNA synthesis In addition to transcription initiation, phosphorylation of ... prevent formation of the stem–loop structure impair binding of pRNA to TIP5 and abolish nucleolar targeting of NoRC [69] Analysis of the silencing capacity of wild-type or mutant forms of pRNA revealed ... phosphorylation of TAFI110, a subunit of SL1 that nucleates PIC assembly, causes shutdown of rDNA transcription during mitosis Mitotic phosphorylation of TAFI110 at Thr852 impairs the ability of SL1 to...

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Báo cáo khoa học: Genome-wide identiﬁcation of glucosinolate synthesis genes in Brassica rapa potx

Ngày tải lên : 29/03/2014, 23:20

... bp downstream of BrST5b-4 (Fig 2B) However, we did not consider this as another copy of BrST5b because of the presence of only a small amount of remainder sequence as a result of a massive deletion ... Academy of Agricultural Science, RDA, Korea Journal compilation ª 2009 FEBS Y.-X Zang et al Glucosinolate biosynthesis genes in Brassica rapa Fig Biosynthesis pathways of the three major groups of ... cabbage cultivars not produce detectable levels of glucoraphanin To date, most of the structural genes responsible for the biosynthesis of the three groups of glucosinolates 3560 Y.-X Zang et al have...

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Báo cáo khoa học: Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa ⁄ fa rats pptx

Ngày tải lên : 30/03/2014, 11:20

... slope of the double log plot of glycogen synthesis against phosphorylase-a 1994 Fig Sensitivity of glycogen synthesis to phosphorylase-a as a function of glucose concentration Glycogen synthesis ... glycogen synthase and inhibition of glycogen synthesis The rate of glycogen synthesis, but not the activity of glycogen synthase, inversely correlated with the activity of phosphorylase-a in hepatocytes ... hepatocytes (Fig 2C) Effects of activity and concentration of phosphorylase-a on glycogen synthesis To test the role of the phosphorylated form of phosphorylase independently of changes in total phosphorylase...

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Báo cáo Y học: The processivity and ﬁdelity of DNA synthesis exhibited by the reverse transcriptase of bovine leukemia virus pot

Ngày tải lên : 31/03/2014, 21:21

... inhibitors of other RTs such as that of HIV [12] In the present study we have extended the investigation of BLV RT by an in vitro analysis of the processivity and the fidelity of DNA synthesis ... one round of DNA synthesis is permitted, all RTs synthesize less, as well as shorter, product when compared with multiple-round synthesis (Fig 1) The analysis of the processivity of DNA synthesis ... much lower processivity of 24% The fidelity of DNA synthesis All our previous studies with a variety of retroviral RTs have shown that the parameters for fidelity of DNA synthesis in vitro (i.e...

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benoiton - chemistry of peptide synthesis (crc, 2006)

Ngày tải lên : 03/04/2014, 12:14

... the synthesis of peptides Part The use of anhydrides of N-acylated amino acids and derivatives of inorganic acids Ann Chem 572, 190, 1951 17 J Meienhofer The mixed carbonic anhydride method of ... 2-Alkoxy-5(4H)-Oxazolones as Intermediates in Reactions of N-Alkoxycarbonylamino Acids 17 Revision of the Central Tenet of Peptide Synthesis 18 Strategies for the Synthesis of Enantiomerically Pure Peptides ... Types of Target Peptides and Anchoring Linkages 139 Protecting Group Combinations for Solid-Phase Synthesis .140 Features of Synthesis Using Boc/Bzl Chemistry 140 Features of Synthesis...

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